Does high cardiorespiratory fitness confer some protection against pro-inflammatory responses after infection by SARS-CoV-2?
Zbinden-Foncea, Hermann, Francaux, Marc, Deldicque, Louise and Hawley, John A.. (2020). Does high cardiorespiratory fitness confer some protection against pro-inflammatory responses after infection by SARS-CoV-2? Obesity. 28(8), pp. 1378-1381. https://doi.org/10.1002/oby.22849
|Authors||Zbinden-Foncea, Hermann, Francaux, Marc, Deldicque, Louise and Hawley, John A.|
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) originated in China in late 2019 and has since spread rapidly to every continent in the world. This pandemic continues to cause widespread personal suffering, along with severe pressure on medical and health care providers. The symptoms of SARS‐CoV‐2 and the subsequent prognosis are worsened in individuals who have preexisting comorbidities prior to infection by the virus. Individuals with obesity or overweight, insulin resistance, and diabetes typically have chronic low‐grade inflammation characterized by increased levels of several proinflammatory cytokines and the inflammasome; this state predisposes to greater risk for infection along with more adverse outcomes. Here, we consider whether a high level of cardiorespiratory fitness induced by prior exercise training may confer some innate immune protection against COVID‐19 by attenuating the “cytokine storm syndrome” often experienced by “at risk” individuals.
|Journal citation||28 (8), pp. 1378-1381|
|Digital Object Identifier (DOI)||https://doi.org/10.1002/oby.22849|
|PubMed Central ID||PMC7264673|
|Open access||Published as ‘gold’ (paid) open access|
File Access Level
|Online||09 Jul 2020|
|Publication process dates|
|Accepted||21 Apr 2020|
|Deposited||27 Apr 2021|
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