Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk : The Tromso Study

Journal article

Sejrup, Joakim K., Morelli, Vania M., Løchen, Maja-Lisa, Njølstad, Inger, Mathiesen, Ellisiv B., Wilsgaard, Tom, Hansen, John-Bjarne and Brækkan, Sigrid K.. (2020). Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk : The Tromso Study. Research and Practice in Thrombosis and Haemostasis. 4(2), pp. 247-254. https://doi.org/10.1002/rth2.12306
AuthorsSejrup, Joakim K., Morelli, Vania M., Løchen, Maja-Lisa, Njølstad, Inger, Mathiesen, Ellisiv B., Wilsgaard, Tom, Hansen, John-Bjarne and Brækkan, Sigrid K.
Abstract

Background
The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated.

Aim
To study the combined effect of MI and prothrombotic SNPs on the risk of VTE.

Methods
Cases with incident VTE (n = 641) and a randomly sampled subcohort weighted for age (n = 1761) were identified from the 4 to 6 surveys of the Tromsø Study (1994‐2012). DNA was genotyped for rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) were estimated by categories of risk alleles and MI status.

Results
Patients with MI had a 1.4‐fold increased risk of VTE, and adjustments for the 5 SNPs, either alone or in combination, did not affect this relationship (adjusted HR, 1.52; 95% CI, 1.12‐2.07). In subjects without MI, an increased risk of VTE was observed for each of the individual SNPs (≥1 vs. 0 risk alleles), and the risk increased linearly with increasing number of risk alleles in the 5‐SNP score. The combination of MI and prothrombotic genotypes, either as individual SNPs or in the 5‐SNP score, did not result in an excess risk of VTE.

Conclusion
The relationship between MI and VTE was not explained by these 5 prothrombotic genotypes. Prothrombotic genotypes did not yield an excess risk of VTE in patients with MI.

Keywordsepidemiology; genetics; myocardial infarction; pulmonary embolism; risk factors; thromboembolism; venous
Year2020
JournalResearch and Practice in Thrombosis and Haemostasis
Journal citation4 (2), pp. 247-254
PublisherWiley-Blackwell Publishing Ltd.
ISSN2475-0379
Digital Object Identifier (DOI)https://doi.org/10.1002/rth2.12306
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range247-254
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online27 Jan 2020
Publication process dates
Accepted26 Dec 2019
Deposited30 Apr 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8vyzv/myocardial-infarction-prothrombotic-genotypes-and-venous-thrombosis-risk-the-tromso-study

Log in to edit

Download files

Publisher's version
OA_Sejrup_2020_Myocardial_infarction_prothrombotic_genotypes_and_venous.pdf
License: CC BY-NC-ND 4.0
File access level: Open

  • 74
    total views
  • 39
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality
Camen, Stephan, Ojeda, Francisco M., Niiranen, Teemu, Gianfagna, Francesco, Vishram-Nielsen, Julie K., Costanzo, Simona, Söderberg, Stefan, Vartiainen, Erkki, Donati, Maria Benedetta, Løchen, Maja-Lisa, Pasterkamp, Gerard, Magnussen, Christina, Kee, Frank, Jousilahti, Pekka, Hughes, Maria, Kontto, Jukka, Mathiesen, Ellisiv B., Koenig, Wolfgang, Palosaari, Tarja, ... the BiomarCaRE consortium. (2020). Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality. Europace. 22(4), pp. 522-529. https://doi.org/10.1093/europace/euz312
Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology
Massimo F Piepoli, Ana Abreu, Christian Albus, Marco Ambrosetti, Carlos Brotons, Alberico L Catapano, Ugo Corra, Bernard Cosyns, Christi Deaton, Ian Graham, Arno W Hoes, Maja-Lisa Løchen, Benedetta Matrone, Josep Redon, Naveed Sattar, Yvo Smulders and Monica Tiberi. (2020). Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology. European Journal of Preventative Cardiology. 27(2), pp. 181-205. https://doi.org/10.1177/2047487319893035
Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration
Renate B. Schnabel, Karl Georg Haeusler, Jeff S. Healey, Ben Freedman, Giuseppe Boriani, Johannes Brachmann, Axel Brandes, Alejandro Bustamante, Barbara Casadei, Harry J. Crijns, Wolfram Doehner, Gunnar Engstrom, Laurent Fauchier, Leif Friberg, David J. Gladstone, Taya V. Glotzer, Shinya Goto, Graeme J Hankey, Joseph A. Harbison, ... Bernard Yan. (2019). Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration. Circulation. 140(22), pp. 1834-1850. https://doi.org/10.1161/CIRCULATIONAHA.119.040267
Left atrial diameter, left ventricle indices, and association with all-cause mortality: Results from the population-based Tromso Study
Stylidis, Michael, Sharashova, Ekaterina, Wilsgaard, Tom, Leon, David A., Heggelund, Geir, Rösner, Assami, Njølstad, Inger, Løchen, Maja-Lisa and Schirmer, Henrik. (2019). Left atrial diameter, left ventricle indices, and association with all-cause mortality: Results from the population-based Tromso Study. Echocardiography. 36(3), pp. 439 - 450. https://doi.org/10.1111/echo.14270
Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study
Rinde, Ludvig B., Morelli, Vania M., Småbrekke, Birgit, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Njølstad, Inger, Wilsgaard, Tom, Smith, Erin F., Rosendaal, Frits R., Frazer, Kelly A., Brækkan, Sigrid Kufaas and Hansen, John-Bjarne. (2019). Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study. Journal of Thrombosis and Haemostasis. 17(5), pp. 749 - 758. https://doi.org/10.1111/jth.14410
Mild cognitive impairment impacts health outcomes of patients with atrial fibrillation undergoing a disease management intervention
Ball, Jocasta, Løchen, Maja-Lisa, Carrington, Melinda J., Wiley, Joshua and Stewart, Simon. (2018). Mild cognitive impairment impacts health outcomes of patients with atrial fibrillation undergoing a disease management intervention. Open Heart (online). 5(1), p. Article e000755. https://doi.org/10.1136/openhrt-2017-000755
Gender differences in the association of syndecan-4 with myocardial infarction: The population-based Tromso Study
Solbu, Marit D., Kolset, Svein O., Jenssen, Trond G., Wilsgaard, Tom, Løchen, Maja-Lisa, Mathiesen, Ellisiv B., Melsom, Toralf, Eriksen, Bjørn O. and Reine, Trine M.. (2018). Gender differences in the association of syndecan-4 with myocardial infarction: The population-based Tromso Study. Atherosclerosis. 278, pp. 166 - 173. https://doi.org/10.1016/j.atherosclerosis.2018.08.005
Data on gender contrasts in the risk of incident myocardial infarction by age: The Tromsø Study 1979-2012
Albrektsen, Grethe, Heuch, Ivar, Løchen, Maja-Lisa, Thelle, Dag Steinar, Wilsgaard, Tom, Njølstad, Inger and Bønaa, Kaare Harald. (2017). Data on gender contrasts in the risk of incident myocardial infarction by age: The Tromsø Study 1979-2012. Data in Brief. 13, pp. 779 - 784. https://doi.org/10.1016/j.dib.2017.07.001
Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
Gaksch, Martin, Jorde, Rolf, Grimnes, Guri, Joakimsen, Ragnar Martin, Schirmer, Henrik, Wilsgaard, Tom, Mathiesen, Ellisiv B., Njølstad, Inger, Løchen, Maja-Lisa, März, Winfried, Kleber, Marcus E., Tomaschitz, Andreas, Grübler, Martin, Eiriksdottir, Gudny, Gudmundsson, Elias F., Harris, Tamara B., Cotch, Mary F., Aspelund, Thor, Gudnason, Vilmundur, ... Pilz, Stefan. (2017). Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS ONE. 12(2), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0170791
Declining incidence of ischemic stroke: What is the impact of changing risk factors? The Tromsø Study 1995 to 2012
Vangen-Lønne, Anne M., Wilsgaard, Tom, Johnsen, Stein Harald, Løchen, Maja-Lisa, Njølstad, Inger and Mathiesen, Ellisiv B.. (2017). Declining incidence of ischemic stroke: What is the impact of changing risk factors? The Tromsø Study 1995 to 2012. Stroke. 48(3), pp. 544 - 550. https://doi.org/10.1161/STROKEAHA.116.014377
Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979-2012
Albrektsen, Grethe, Heuch, Ivar, Løchen, Maja-Lisa, Thelle, Dag Steinar, Wilsgaard, Tom, Njølstad, Inger and Bønaa, Kaare Harald. (2017). Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979-2012. Atherosclerosis. 261, pp. 52 - 59. https://doi.org/10.1016/j.atherosclerosis.2017.04.009
A new diagnosis of asthma or COPD is linked to smoking cessation - The Tromsø study
Danielsen, Signe Elise, Løchen, Maja-Lisa, Medbø, Astri, Vold, Monica Linea and Melbye, Hasse. (2016). A new diagnosis of asthma or COPD is linked to smoking cessation - The Tromsø study. The International Journal of Chronic Obstructive Pulmonary Disease. 11, pp. 1453 - 1458. https://doi.org/10.2147/Copd.S108046
Guía ESC 2016 sobre prevención de la enfermedad cardiovascular en la práctica clínica
Piepoli, Massimo F., Hoes, Arno W., Agewall, Stefan, Albus, Christian, Brotons, Carlos, Catapano, Alberico L., Cooney, Marie Therese, Corra, Ugo, Cosyns, Bernard, Deaton, Christi, Graham, Ian, Hall, Michael Stephen, Hobbs, F. D. Richard, Løchen, Maja-Lisa, Löllgen, Herbert, Marques-Vidal, Pedro, Perk, Joep, Prescott, Eva, Redon, Josep, ... Zamorano, José Luis. (2016). Guía ESC 2016 sobre prevención de la enfermedad cardiovascular en la práctica clínica. Revista Espanola de Cardiologia. 69(10), pp. 939.e1 - 939.e87. https://doi.org/10.1016/j.recesp.2016.09.004
Impact of incident myocardial infarction on the risk of venous thromboembolism: The Tromsø Study
Rinde, L. B., Lind, C., Smabrekke, B., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., Løchen, Maja-Lisa, Hald, E. M., Vik, A., Braekkan, Sigrid K. and Hansen, J.-B.. (2016). Impact of incident myocardial infarction on the risk of venous thromboembolism: The Tromsø Study. Journal of Thrombosis and Haemostasis. 14(6), pp. 1183 - 1191. https://doi.org/10.1111/jth.13329
Ischemic stroke and risk of venous thromboembolism in the general population: The Tromsø Study
Rinde, Ludvig B., Småbrekke, Birgit, Mathiesen, Ellisiv B., Løchen, Maja-Lisa, Njølstad, Inger, Hald, Erin M., Wilsgaard, Tom, Braekkan, Sigrid K. and Hansen, John-Bjarne. (2016). Ischemic stroke and risk of venous thromboembolism in the general population: The Tromsø Study. Journal of the American Heart Association. 5(11), pp. 1 - 9. https://doi.org/10.1161/JAHA.116.004311
Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population
Mannsverk, Jan, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Rasmussen, Knut, Thelle, Dag S., Njølstad, Inger, Hopstock, Laila Arnesdatter and Bønaa, Kaare Harald. (2016). Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population. Circulation. 133(1), pp. 74 - 81. https://doi.org/10.1161/CIRCULATIONAHA.115.016960
Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: The Tromsø Study
Sharashova, Ekaterina, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Njølstad, Inger and Brenn, Tormod. (2016). Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: The Tromsø Study. Journal of Epidemiology and Community Health. 70(9), pp. 902 - 909. https://doi.org/10.1136/jech-2015-206663
Temporal trends in incidence and case fatality of intracerebral hemorrhage: The Tromsø Study 1995-2012
Carlsson, Maria, Wilsgaard, Tom, Johnsen, Stein Harald, Vangen-Lønne, Anne Merete, Løchen, Maja-Lisa, Njølstad, Inger and Mathiesen, Ellisiv Bøgeberg. (2016). Temporal trends in incidence and case fatality of intracerebral hemorrhage: The Tromsø Study 1995-2012. Cerebrovascular Diseases Extra. 6(2), pp. 40 - 49. https://doi.org/10.1159/000447719
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study
Storhaug, Hilde M., Toft, Ingrid, Norvik, Jon V., Jenssen, Trond, Eriksen, Bjørn O., Melsom, Toralf, Løchen, Maja-Lisa and Solbu, Marit Dahl. (2015). Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study. BMC Nephrology. 16(210), pp. 1 - 10. https://doi.org/10.1186/S12882-015-0207-1
Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study
Enga, Kristin F., Rye-Holmboe, I., Hald, Erin M., Løchen, Maja-Lisa, Mathiesen, E. B., Njølstad, I., Wilsgaard, Tom, Braekkan, S. K. and Hansen, John-Bjarne. (2015). Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study. Journal of Thrombosis and Haemostasis. 13(1), pp. 10 - 16. https://doi.org/10.1111/jth.12762
Kvinnehjerter: En medisinsk fagbok om vanlige hjertesykdommer
Løchen, Maja-Lisa and Gerdts, Eva. (2015). Kvinnehjerter: En medisinsk fagbok om vanlige hjertesykdommer Gyldendal Norwegian Publishing.
Clinically significant novel biomarkers for prediction of first ever myocardial infarction: The Tromsø Study
Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Patwardhan, Anil, Rowe, Michael W., Schirmer, Henrik, Løchen, Maja-Lisa, Sudduth-Klinger, Julie, Hamren, Sarah, Bønaa, Kaare Harald and Njølstad, Inger. (2015). Clinically significant novel biomarkers for prediction of first ever myocardial infarction: The Tromsø Study. Circulation: Cardiovascular Genetics. 8(2), pp. 363 - 371. https://doi.org/10.1161/CIRCGENETICS.113.000630
Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population
Eriksen, B. O., Løchen, Maja-Lisa, Arntzen, Kjell A., Bertelsen, Geir, Eilertsen, Britt-Ann W., von Hanno, Therese, Herder, Marit, Jenssen, Trond G., Mathisen, Ulla D., Melsom, Toralf, Njølstad, Inger, Solbu, Marit D., Toft, Ingrid and Mathiesen, Ellisiv B.. (2014). Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population. Kidney International. 86(1), pp. 146 - 153. https://doi.org/10.1038/ki.2013.470
Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study
Hald, Erin M., Enga, Kristin F., Løchen, Maja-Lisa, Mathiesen, Ellisiv B., Njølstad, Inger, Wilsgaard, Tom, Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014). Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study. Journal of the American Heart Association. 3(1), pp. 1 - 7. https://doi.org/10.1161/JAHA.113.000483
Red cell distribution width is associated with incident myocardial infarction in a general population: The Tromsø Study
Skjelbakken, Tove, Lappegard, Jostein, Ellingsen, Trygve S., Barret-Connor, Elizabeth, Brox, Jan, Løchen, Maja-Lisa, Njølstad, Inger, Wilsgaard, Tom, Mathiesen, Ellisiv B., Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014). Red cell distribution width is associated with incident myocardial infarction in a general population: The Tromsø Study. Journal of the American Heart Association. 3(4), pp. 1 - 10. https://doi.org/10.1161/JAHA.114.001109
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
Holmen, Oddgeir L., Zhang, He, Fan, Yanbo, Hovelson, Daniel H., Schmidt, Ellen, Zhou, Wei, Guo, Yanhong, Zhang, Ji, Langhammer, Arnulf, Løchen, Maja-Lisa, Ganesh, Santhi K., Vatten, Lars, Skorpen, Frank, Dalen, Havard, Zhang, Jifeng, Pennathur, Subramaniam, Chen, Jin, Platou, Carl, Mathiesen, Ellisiv B., ... Willer, Cristen J.. (2014). Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature Genetics. 46(4), pp. 345 - 351. https://doi.org/10.1038/ng.2926
Long-term cardiovascular consequences of Rose angina at age 20-54 years: 29-years' follow-up of the Tromso Study
Graff-Iversen, Sidsel, Wilsgaard, Tom, Mathiesen, Ellisiv B., Njølstad, Inger and Løchen, Maja-Lisa. (2014). Long-term cardiovascular consequences of Rose angina at age 20-54 years: 29-years' follow-up of the Tromso Study. Journal of Epidemiology and Community Health. 68(8), pp. 754 - 759. https://doi.org/10.1136/jech-2013-203642
Carotid atherosclerosis predicts future myocardial infarction but not venous thromboembolism: The Tromsø Study
Hald, Erin M., Lijfering, Willem M., Mathiesen, Ellisiv B., Johnsen, Stein Harald, Løchen, Maja-Lisa, Njølstad, I., Wilsgaard, Tom, Rosendaal, Frits R., Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014). Carotid atherosclerosis predicts future myocardial infarction but not venous thromboembolism: The Tromsø Study. Arteriosclerosis Thrombosis and Vascular Biology. 34(1), pp. 226 - 230. https://doi.org/10.1161/Atvbaha.113.302162
QT interval and the risk of myocardial infarction and all-cause death: A cohort study
Lindekleiv, Haakon, Wilsgaard, Tom, Macfarlane, Peter W. and Løchen, Maja-Lisa. (2012). QT interval and the risk of myocardial infarction and all-cause death: A cohort study. Journal of Cardiovascular Electrophysiology. 23(8), pp. 846 - 852. https://doi.org/10.1111/j.1540-8167.2012.02308.x
Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromsø Study
Toft, Ingrid, Solbu, Marit, Kronborg, Jens, Mathisen, Ulla D., Eriksen, Bjørn O., Storhaug, Hilde, Melsom, Toralf, Løchen, Maja-Lisa, Mathiesen, E. B., Njølstad, Inger, Wilsgaard, Tom and Brox, Jan. (2012). Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromsø Study. Nephrology Dialysis Transplantation. 27(7), pp. 2780 - 2787. https://doi.org/10.1093/ndt/gfr751
Total and cause-specific mortality rates in a prospective study of community-acquired hepatitis C virus infection in northern Norway
Kristiansen, M. G., Løchen, Maja-Lisa, Guttenberg, T. J., Mortensen, L., Eriksen, B. O. and Florholmen, J.. (2011). Total and cause-specific mortality rates in a prospective study of community-acquired hepatitis C virus infection in northern Norway. Journal of Viral Hepatitis. 18(4), pp. 237 - 244. https://doi.org/10.1111/j.1365-2893.2010.01290.x
Incidence and mortality of aneurysmal subarachnoid hemorrhage in two Norwegian cohorts, 1984-2007
Sandvei, M. S., Mathiesen, E. B., Vatten, L. J., Müller, T. B., Lindekleiv, H., Ingebrigtsen, T., Njølstad, I., Wilsgaard, Tom, Løchen, Maja-Lisa, Vik, A. and Romundstad, P. R.. (2011). Incidence and mortality of aneurysmal subarachnoid hemorrhage in two Norwegian cohorts, 1984-2007. Neurology. 77(20), pp. 1833 - 1839. https://doi.org/10.1212/WNL.0b013e3182377de3
Sex differences in risk factors for aneurysmal subarachnoid hemorrhage: A cohort study
Lindekleiv, H., Sandvei, M. S., Njølstad, I., Løchen, Maja-Lisa, Romundstad, P. R., Vatten, L., Ingebrigtsen, T., Vik, A. and Mathiesen, E. B.. (2011). Sex differences in risk factors for aneurysmal subarachnoid hemorrhage: A cohort study. Neurology. 76(7), pp. 637 - 643. https://doi.org/10.1212/WNL.0b013e31820c30d3