Omega-3 polyunsaturated fatty acids mitigate palmitate-induced impairments in skeletal muscle cell viability and differentiation

Journal article

Tachtsis, Bill, Whitfield, Jamie, Hawley, John A. and Hoffman, Nolan J.. (2020). Omega-3 polyunsaturated fatty acids mitigate palmitate-induced impairments in skeletal muscle cell viability and differentiation. Frontiers in Physiology. 11, pp. 1-13. https://doi.org/10.3389/fphys.2020.00563
AuthorsTachtsis, Bill, Whitfield, Jamie, Hawley, John A. and Hoffman, Nolan J.
Abstract

Accumulation of excess saturated free fatty acids such as palmitate (PAL) in skeletal muscle leads to reductions in mitochondrial integrity, cell viability and differentiation. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) counteract PAL-induced lipid accumulation. EPA and DHA, as well as the n-3 PUFA docosapentaenoic acid (DPA), may therefore mitigate PAL-induced lipotoxicity to promote skeletal muscle cell survival and differentiation. C2C12 myoblasts were treated with 50 μM EPA, DPA, or DHA in the absence or presence of 500 μM PAL for 16 h either prior to myoblast analysis or induction of differentiation. Myoblast viability and markers of apoptosis, endoplasmic reticulum (ER) stress and myotube differentiation capacity were investigated using fluorescence microscopy and immunoblotting. High-resolution respirometry was used to assess mitochondrial function and membrane integrity. PAL induced cell death via apoptosis and increased protein content of ER stress markers BiP and CHOP. EPA, DPA, and DHA co-treatment maintained cell viability, prevented PAL-induced apoptosis and attenuated PAL-induced increases in BiP, whereas only DPA prevented increases in CHOP. PAL subsequently reduced protein content of the differentiation marker myogenin and inhibited myotube formation, and all n-3 PUFAs promoted myotube formation in the presence of PAL. Furthermore, DPA prevented PAL-induced release of cytochrome c and maintained mitochondrial integrity. These findings demonstrate the n-3 PUFAs EPA, DPA and DHA elicit similar protective effects against PAL-induced impairments in muscle cell viability and differentiation. Mechanistically, the protective effects of DPA against PAL lipotoxicity are attributable in part to its ability to maintain mitochondrial respiratory capacity via mitigating PAL-induced loss of mitochondrial membrane integrity.

Keywordsn-3 PUFA; EPA; DPA; DHA; saturated fatty acid; myoblast; myotube; mitochondria
Year2020
JournalFrontiers in Physiology
Journal citation11, pp. 1-13
PublisherFrontiers Research Foundation
ISSN1664-042X
Digital Object Identifier (DOI)https://doi.org/10.3389/fphys.2020.00563
Scopus EID2-s2.0-85086576737
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-13
FunderAustralian Catholic University (ACU)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online03 Jun 2020
Publication process dates
Accepted07 May 2020
Deposited03 May 2021
Grant IDACURF/2016000363
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Effects of providing high-fat versus high-carbohydrate meals on daily and postprandial physical activity and glucose patterns: a randomised controlled trial
Parr, Evelyn, Devlin, Brooke, Callahan, Marcus J., Radford, Bridget, Blankenship, Jennifer M., Dunstan, David and Hawley, John. (2018). Effects of providing high-fat versus high-carbohydrate meals on daily and postprandial physical activity and glucose patterns: a randomised controlled trial. Nutrients. 10(5), pp. 1 - 16. https://doi.org/10.3390/nu10050557
High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice
Burchfield, James G., Kebede, Melkam A., Meoli, Christopher C., Stockli, Jacqueline, Whitworth, P. Tess, Wright, Amanda L., Hoffman, Nolan John, Minard, Annabel Y., Ma, Xiuquan, Krycer, James R., Nelson, Marin E., Tan, Shi-Xlong, Yau, Belinda, Thomas, Kristen C., Wee, Natalie K.Y., Khor, Ee-Cheng, Enriquez, Ronaldo F., Vissel, Bryce, Biden, Trevor J., ... Fazakerley, Daniel J.. (2018). High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice. Journal of Biological Chemistry. 293(15), pp. 5731 - 5745. https://doi.org/10.1074/jbc.RA117.000808
Impact of first meal size during prolonged sitting on postprandial glycaemia in individuals with prediabetes: a randomised, crossover study
Parr, Evelyn, Devlin, Brooke, Pinto, Samuel, Dunstan, David and Hawley, John. (2018). Impact of first meal size during prolonged sitting on postprandial glycaemia in individuals with prediabetes: a randomised, crossover study. Nutrients. 10(6), pp. 1 - 15. https://doi.org/10.3390/nu10060733
Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance
Fazakerley, Daniel J., Chaudhuri, Rima, Yang, Pengyi, Maghzal, Ghassan J., Thomas, Kristen C., Krycer, James R., Humphrey, Sean J., Parker, Benjamin, Fisher-Wellman, Kelsey H., Meoli, Christopher C., Hoffman, Nolan, Diskin, Ciana, Burchfield, James G., Cowley, Mark J., Kaplan, Warren, Modrusan, Zora, Kolumam, Ganesh, Yang, Jean Y. H., Chen, Daniel L., ... James, David E.. (2018). Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance. eLife. 7, pp. 1 - 38. https://doi.org/10.7554/eLife.32111
Interactive roles for AMPK and glycogen from cellular energy sensing to exercise metabolism
Janzen, Natalie, Whitfield, Jamie and Hoffman, Nolan. (2018). Interactive roles for AMPK and glycogen from cellular energy sensing to exercise metabolism. International Journal of Molecular Sciences. 19(11), pp. 1 - 18. https://doi.org/10.3390/ijms19113344
Effects of creatine and carbohydrate loading on cycling time trial performance
Tomcik, Kristyen A., Camera, Donny, Bone, Julia L. L., Ross, Meg, Jeacocke, N. A., Tachtsis, Bill, Senden, Joan M., Van Loon, Luc, Hawley, John and Burke, Louise. (2018). Effects of creatine and carbohydrate loading on cycling time trial performance. Medicine and Science in Sports and Exercise. 50(1), pp. 141 - 150. https://doi.org/10.1249/MSS.0000000000001401
Sending the signal: Muscle glycogen availability as a regulator of training adaptation
Hawley, John A.. (2018). Sending the signal: Muscle glycogen availability as a regulator of training adaptation. In In B. Spiegelman (Ed.). Hormones, metabolism and the benefits of exercise pp. 43 - 55 Springer Nature. https://doi.org/10.1007/978-3-319-72790-5_4
Swifter, higher, stronger: what's on the menu?
Burke, Louise M. and Hawley, John A.. (2018). Swifter, higher, stronger: what's on the menu? Science. 362(6416), pp. 781 - 787. https://doi.org/10.1126/science.aau2093
Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration
Tachtsis, Bill, Camera, Donny and Lacham-Kaplan, Orly. (2018). Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration. Nutrients. 10(3), p. 309. https://doi.org/10.3390/nu10030309
Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction
Murphy, Caoileann, Shankaran, Mahalakshmi, Churchward-Venne, T. A., Mitchell, Cameron J., Kolar, Nathan M., Burke, Louise, Hawley, John, Kassis, Amira, Karagounis, Leonidas G., Li, Kelvin, King, Chelsea, Hellerstein, Marc and Phillips, S. M.. (2018). Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction. The Journal of Physiology. 596(11), pp. 2091 - 2120. https://doi.org/10.1113/JP275246
Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration
Tachtsis, Bill, Camera, Donny and Lacham-Kaplan, Orly. (2018). Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration. Nutrients. 10(3), pp. 1 - 20. https://doi.org/10.3390/nu10030309
Protein availability and satellite cell dynamics in skeletal muscle
Shamim, Baubak, Hawley, John and Camera, Donny. (2018). Protein availability and satellite cell dynamics in skeletal muscle. Sports Medicine. 48(6), pp. 1329 - 1343. https://doi.org/10.1007/s40279-018-0883-7
Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle
Sato, Shogo, Evelyn, Parr B., Devlin, Brooke L., Hawley, John A. and Sassone-Corsi, Paolo. (2018). Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle. Molecular Metabolism. 16, pp. 1-11. https://doi.org/10.1016/j.molmet.2018.06.008
Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport
Burke, Louise, Hawley, John, Jeukendrup, A. E., Morton, James P., Stellingwerff, T. and Maughan, Ronald J.. (2018). Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport. International Journal of Sport Nutrition and Exercise Metabolism. 28(5), pp. 451 - 463. https://doi.org/10.1123/ijsnem.2018-0289
Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges
Perry, Christopher G. R. and Hawley, John. (2018). Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges. Cold Spring Harbor Perspectives in Medicine. 8(9), pp. 1 - 15. https://doi.org/10.1101/cshperspect.a029686
Adaptations to concurrent training in combination with high protein availability: A comparative trial in healthy, recreationally active men
Shamim, Baubak, Devlin, Brooke L., Timmins, Ryan G., Tofari, Paul, Dow, Connor Lee, Coffey, Vernon G., Hawley, John A. and Camera, Donny M.. (2018). Adaptations to concurrent training in combination with high protein availability: A comparative trial in healthy, recreationally active men. Sports Medicine. 48(12), pp. 2869 - 2883. https://doi.org/10.1007/s40279-018-0999-9
High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans
Leckey, Jill J., Hoffman, Nolan J., Parr, Evelyn B., Devlin, Brooke L., Trewin, Adam J., Stepto, Nigel K., Morton, James P., Burke, Louise M. and Hawley, John A.. (2018). High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB Journal. 32(6), pp. 2979-2991. https://doi.org/10.1096/fj.201700993R
Maximizing cellular adaptation to endurance exercise in skeletal muscle
Hawley, John, Lundby, Carsten, Cotter, James D. and Burke, Louise. (2018). Maximizing cellular adaptation to endurance exercise in skeletal muscle. Cell Metabolism. 27(5), pp. 962 - 976. https://doi.org/10.1016/j.cmet.2018.04.014
Post-exercise muscle glycogen resynthesis in humans
Burke, Louise M., van Loon, Luc J. C. and Hawley, John A.. (2017). Post-exercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055-1067. https://doi.org/0.1152/japplphysiol.00860.2016
Ketone diester ingestion impairs time-trial performance in professional cyclists
Leckey, Jill J., Ross, Megan L., Quod, Marc, Hawley, John A. and Burke, Louise M.. (2017). Ketone diester ingestion impairs time-trial performance in professional cyclists. Frontiers in Physiology. 8(OCT), pp. 1 - 10. https://doi.org/10.3389/fphys.2017.00806
Fenugreek increases insulin-stimulated creatine content in l6C11 muscle myotubes
Tomcik, Kristyen, Smiles, William, Camera, Donny, Hugel, Helmut M., Hawley, John and Watts, Rani. (2017). Fenugreek increases insulin-stimulated creatine content in l6C11 muscle myotubes. European Journal of Nutrition. 56(3), pp. 973 - 979. https://doi.org/10.1007/s00394-015-1145-1
Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise
Smiles, William J., Conceição, Miguel S., Telles, Guilherme D., Chacon-Mikahil, Mara P. T., Cavaglieri, Cláudia R., Vechin, Felipe C., Libardi, Cleiton A., Hawley, John A. and Camera, Donny M.. (2017). Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise. European Journal of Applied Physiology. 117(2), pp. 345-358. https://doi.org/10.1007/s00421-016-3530-8
Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance
Callahan, Marcus J., Parr, Evelyn B., Hawley, John A. and Burke, Louise M.. (2017). Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance. International Journal of Sport Nutrition and Exercise Metabolism. 27(3), pp. 271-278. https://doi.org/10.1123/ijsnem.2016-0228
Metabolomic analysis of insulin resistance across different mouse strains and diets
Stockli, Jacqueline, Fisher-Wellman, Kelsey H., Chaudhuri, Rima, Zeng, Xiao-Yi, Fazakerley, Daniel J., Meoli, Christopher C., Thomas, Kristen C., Hoffman, Nolan, Mangiafico, Salvatore P., Xirouchaki, Chrysovalantou E., Yang, Chieh H., Ilkayeva, Olga, Wong, Kari, Cooney, Gregory J., Andrikopoulos, Sofianos, Muoio, Deborah M. and James, David E.. (2017). Metabolomic analysis of insulin resistance across different mouse strains and diets. Journal of Biological Chemistry. 292(47), pp. 19135 - 19145. https://doi.org/10.1074/jbc.M117.818351
Alpha-Linolenic acid and exercise training independently, and additively, decrease blood pressure and prevent diastolic dysfunction in obese Zucker rats
Barbeau, Pierre-Andre, Holloway, Tanya M., Whitfield, Jamie, Baechler, Brittany L., Quadrilatero, Joe, van Loon, Luc J. C., Chabowski, Adrian and Holloway, Graham P.. (2017). Alpha-Linolenic acid and exercise training independently, and additively, decrease blood pressure and prevent diastolic dysfunction in obese Zucker rats. The Journal of Physiology. 595(13), pp. 4351 - 4364. https://doi.org/10.1113/JP274036
Glucagon receptor knockout mice are protected against acute olanzapine-induced hyperglycemia
Castellani, Laura N., Peppler, Willem T., Sutton, Charles D., Whitfield, Jamie, Charron, Maureen J. and Wright, David C.. (2017). Glucagon receptor knockout mice are protected against acute olanzapine-induced hyperglycemia. Psychoneuroendocrinology. 82, pp. 38 - 45. https://doi.org/10.1016/j.psyneuen.2017.05.005
Postexercise muscle glycogen resynthesis in humans
Burke, Louise, Van Loon, Luc and Hawley, John. (2017). Postexercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055 - 1067. https://doi.org/10.1152/japplphysiol.00860.2016
Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges
Perry, Christopher G. R. and Hawley, John. (2017). Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges. In In J. R. Zierath, M. J. Joyner and J. A. Hawley (Ed.). The biology of exercise: A subject collection from Cold Spring Harbor Persepectives in Medicine pp. 73 - 87 Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a029686
Concurrent exercise training: Do opposites distract?
Coffey, Vernon and Hawley, John. (2017). Concurrent exercise training: Do opposites distract? The Journal of Physiology. 595(9), pp. 2883 - 2896. https://doi.org/10.1113/JP272270
Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers
Burke, Louise, Ross, Megan L.L., Garvican, Laura A., Welvaert, Marijke, Heikura, Ida A., Forbes, Sara G., Mirtschin, Jo, Cato, Louise E., Strobel, Nicki, Sharma, Avish P. and Hawley, John. (2017). Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers. The Journal of Physiology. 595(9), pp. 2785 - 2807. https://doi.org/10.1113/JP273230
Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise
Camera, Donny M., Burniston, Jatin G., Pogson, Mark A., Smiles, William J. and Hawley, John A.. (2017). Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise. The FASEB Journal. 31(12), pp. 5478-5494. https://doi.org/10.1096/fj.201700531R
Beetroot juice increases human muscle force without changing Ca2+-handling proteins
Whitfield, Jamie, Gamu, Daniel, Heigenhauser, George J. F., van Loon, Luc J. C., Spriet, Lawrence L., Tupling, A. Russell and Holloway, Graham P.. (2017). Beetroot juice increases human muscle force without changing Ca2+-handling proteins. Medicine and Science in Sports and Exercise. 49(10), pp. 2016 - 2024. https://doi.org/10.1249/MSS.0000000000001321
Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans
Laker, R. C., Garde, C., Camera, Donny, Smiles, William, Zierath, J. R., Hawley, John and Barrès, R.. (2017). Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans. Scientific Reports. 7(1), pp. 1 - 12. https://doi.org/10.1038/s41598-017-15420-7
Commentaries on Viewpoint: A time for exercise: the exercise window
Boule, Normand G., Terada, Tasuku, Francois, Monique E., Hawley, John, Cotter, James D., Kruse, Nicholas T., McDonald, Matthew W., Olver, T D., Paoli, Antonio, Sacchetti, Massimo, Di Luigi, Luigi, van Dijk, Jan W., Van Loon, Luc, Yardley, Jane E., DiPietro, Loretta, Gribok, Andrei and Rumpler, William. (2017). Commentaries on Viewpoint: A time for exercise: the exercise window. Journal of Applied Physiology. 122(1), pp. 210 - 213. https://doi.org/10.1152/japplphysiol.00938.2016
Omics and exercise : Global approaches for mapping exercise biological networks
Hoffman, Nolan John. (2017). Omics and exercise : Global approaches for mapping exercise biological networks. Cold Spring Harbor Perspectives in Medicine. 7(10), pp. 1-17. https://doi.org/10.1101/cshperspect.a029884
Sprinting toward fitness
Gibala, M. J. and Hawley, John. (2017). Sprinting toward fitness. Cell Metabolism. 25(5), pp. 988 - 990. https://doi.org/10.1016/j.cmet.2017.04.030
Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity
Pinto, Samuel K., Lamon, Séverine, Stephenson, Erin J., Kalanon, M., Mikovic, Jasmine, Koch, L G., Britton, S. L., Hawley, John and Camera, Donny. (2017). Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. American Journal of Physiology - Endocrinology and Metabolism. 313(3), pp. 335 - 343. https://doi.org/10.1152/ajpendo.00043.2017
Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats
Whitfield, Jamie, Paglialunga, Sabina, Smith, Brennan K., Miotto, Paula M., Simnett, Genevieve, Robson, Holly L., Jain, Swati S., Herbst, Eric A. F., Desjardins, Eric M., Dyck, David J., Spriet, Lawrence L., Steinberg, Gregory R. and Holloway, Graham P.. (2017). Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats. Journal of Biological Chemistry. 292(40), pp. 16653 - 16664. https://doi.org/10.1074/jbc.M117.806786
Postexercise high-fat feeding suppresses p70S6K1 activity in human skeletal muscle
Hammond, Kelly M., Impey, Samuel G., Currell, Kevin, Mitchell, Nigel, Shepherd, Sam O., Jeromson, Stewart, Hawley, John A., Close, Graeme L., Hamilton, Lee D., Sharples, Adam P. and Morton, James P.. (2016). Postexercise high-fat feeding suppresses p70S6K1 activity in human skeletal muscle. Medicine and Science in Sports and Exercise. 48(11), pp. 2108-2117. https://doi.org/10.1249/MSS.0000000000001009
Adaptations to prolonged, intense endurance training in human skeletal muscle
Hawley, J. A. (2016). Adaptations to prolonged, intense endurance training in human skeletal muscle. In In I Mujika and Y Le Meur (Ed.). Endurance Training pp. 119-126 Inigo Mujika.
Update on the effects of physical activity on insulin sensitivity in humans
Bird, Stephen R. and Hawley, John. (2016). Update on the effects of physical activity on insulin sensitivity in humans. 2(1), pp. 1 - 26. https://doi.org/10.1136/bmjsem-2016-000143
Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles
Lingham, Anthony R., Hawley, John A., Greaves, Tamar, Jackson, Neale, Antolasic, Frank and Hugel, Helmut M.. (2016). Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles. Polyhedron. 120, pp. 175 - 179. https://doi.org/10.1016/j.poly.2016.09.011
Carbohydrate dependence during prolonged simulated cycling time trials
Torrens, Samuel L., Areta, José L., Parr, Evelyn B. and Hawley, John A.. (2016). Carbohydrate dependence during prolonged simulated cycling time trials. European Journal of Applied Physiology. 116(4), pp. 781-790. https://doi.org/10.1007/s00421-016-3333-y
Acute endurance exercise induces nuclear p53 abundance in human skeletal muscle
Tachtsis, Bill, Smiles, William, Lane, Steven C., Hawley, John Alan and Camera, Donny Michael. (2016). Acute endurance exercise induces nuclear p53 abundance in human skeletal muscle. Frontiers in Physiology. 7(144), pp. 1 - 10. https://doi.org/10.3389/fphys.2016.00144
Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention
Parr, Evelyn B., Camera, Donny M., Burke, Louise M., Phillips, Stuart M., Coffey, Vernon G. and Hawley, John Alan. (2016). Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention. PLoS ONE. 11(4), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0152545
Altering fatty acid availability does not impair prolonged, continuous running to fatigue: Evidence for carbohydrate dependence
Leckey, Jill, Burke, Louise Mary, Morton, James P. and Hawley, John Alan. (2016). Altering fatty acid availability does not impair prolonged, continuous running to fatigue: Evidence for carbohydrate dependence. Journal of Applied Physiology. 120(2), pp. 107 - 113. https://doi.org/10.1152/japplphysiol.00855.2015
mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3
Kleinert, Maximilian, Parker, Benjamin L., Chaudhuri, Rima, Fazakerley, Daniel J., Serup, Annette, Thomas, Kristen C., Krycer, James R., Sylow, Lykke, Fritzen, Andreas M., Hoffman, Nolan John, Jeppesen, Jacob, Schjerling, Peter, Ruegg, Markus A., Kiens, Bente, James, David E. and Richter, Erik A.. (2016). mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Molecular Metabolism. 5(8), pp. 646 - 655. https://doi.org/10.1016/j.molmet.2016.06.007
Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough
Camera, Donny and Hawley, John. (2016). Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough. Journal of Applied Physiology. 121(2), pp. 598 - 598. https://doi.org/10.1152/japplphysiol.00509.2016
Exercise-induced skeletal muscle signaling pathways and human athletic performance
Camera, Donny Michael, Smiles, William J. and Hawley, John Alan. (2016). Exercise-induced skeletal muscle signaling pathways and human athletic performance. Free Radical Biology & Medicine. 98, pp. 131 - 143. https://doi.org/10.1016/j.freeradbiomed.2016.02.007
Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle
Lee-Young, Robert S., Hoffman, Nolan John, Murphy, Kate T., Henstridge, Darren C., Samocha-Bonet, Dorit, Siebel, Andrew L., Iliades, Peter, Zivanovic, Borivoj, Hong, Yet H., Colgan, Timothy D., Kraakman, Michael J., Bruce, Clinton R., Gregorevic, Paul, McConell, Glenn K., Lynch, Gordon S., Drummond, Grant R., Kingwell, Bronwyn A., Greenfield, Jerry R. and Febbraio, Mark A.. (2016). Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle. Molecular Metabolism. 5(11), pp. 1083 - 1091. https://doi.org/10.1016/j.molmet.2016.09.002
Effects of skeletal muscle energy availability on protein turnover responses to exercise
Smiles, William J., Hawley, John Alan and Camera, Donny Michael. (2016). Effects of skeletal muscle energy availability on protein turnover responses to exercise. Journal of Experimental Biology. 219(Pt 2), pp. 214 - 225. https://doi.org/10.1242/jeb.125104
Periodization of carbohydrate intake: Short-term effect on performance
Marquet, Laurie-Anne, Hausswirth, Christophe, Molle, Odeline, Hawley, John A., Burke, Louise M., Tiollier, Eve and Brisswalter, Jeanick. (2016). Periodization of carbohydrate intake: Short-term effect on performance. Nutrients. 8(12), pp. 1 - 13. https://doi.org/10.3390/nu8120755
A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity
Parr, Evelyn B., Coffey, Vernon Glenn, Cato, Louise E., Phillips, Stuart M., Burke, Louise Mary and Hawley, John Alan. (2016). A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity. Obesity. 24(5), pp. 1035 - 1045. https://doi.org/10.1002/oby.21451
Metabolism: One step forward for exercise
Hawley, John Alan and Krook, Anna. (2016). Metabolism: One step forward for exercise. Nature Reviews Endocrinology. 12(1), pp. 7 - 8. https://doi.org/10.1038/nrendo.2015.201
Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy
Smiles, William J., Parr, Evelyn B., Coffey, Vernon G., Lacham-Kaplan, Orly, Hawley, John Alan and Camera, Donny Michael. (2016). Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy. American Journal of Physiology - Endocrinology and Metabolism. 311(5), pp. E836 - E849. https://doi.org/10.1152/ajpendo.00303.2016
Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction
Conceição, Miguel Soares, Chacon-Mikahil, Mara Patricia Traina, Telles, Guilherme Defante, Libardi, Cleiton Augusto, Júnior, Edson Manoel Mendes, Vechin, Felipe Cassaro, Lugani de Andrade, André Luis, Gáspari, Arthur Fernandes, Brum, Patrícia Chakur, Cavaglieri, Cláudia Regina, Serag, Sara, Spiegelman, Bruce M., Hawley, John A. and Camera, Donny M.. (2016). Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction. Medicine and Science in Sports and Exercise. 16(4809), pp. 1699-1707. https://doi.org/10.1249/MSS.0000000000000970
SnapShot: Exercise metabolism
Egan, Brendan, Hawley, John Alan and Zierath, Juleen R.. (2016). SnapShot: Exercise metabolism. Cell Metabolism. 24(2), pp. 342 - 342. https://doi.org/10.1016/j.cmet.2016.07.013
Selective modulation of microRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle
Camera, Donny Michael, Ong, Jun N., Coffey, Vernon Glenn and Hawley, John Alan. (2016). Selective modulation of microRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle. Frontiers in Physiology. 7(Mar), pp. 1 - 8. https://doi.org/10.3389/fphys.2016.00087
Enhanced endurance performance by periodization of CHO intake: "Sleep Low" strategy
Marquet, Laurie-Anne, Brisswalter, Jeanick, Louis, Julien, Tiollier, Eve, Burke, Louise Mary, Hawley, John Alan and Hausswirth, Christophe. (2016). Enhanced endurance performance by periodization of CHO intake: "Sleep Low" strategy. Medicine and Science in Sports and Exercise. 48(4), pp. 663 - 672. https://doi.org/10.1249/MSS.0000000000000823
Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle
Whitfield, J., Ludzki, A., Heigenhauser, G. J. F., Senden, Joan M. G., Verdijk, Lex B., van Loon, Luc J. C., Spriet, L. L. and Holloway, Graham P.. (2016). Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle. Journal of Physiology. 594(2), pp. 421 - 435. https://doi.org/10.1113/JP270844
Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit
Smiles, William J., Areta, José L., Coffey, Vernon G., Phillips, Stuart M., Moore, Daniel R., Stellingwerff, Trent, Burke, Louise M., Hawley, John A. and Camera, Donny M.. (2015). Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309(5), pp. R603-R612. https://doi.org/10.1152/ajpregu.00413.2014
Carbohydrate dependence during prolonged, intense endurance exercise
Hawley, John and Leckey, Jill. (2015). Carbohydrate dependence during prolonged, intense endurance exercise. Sports Medicine: reviews of applied medicine and science in sport and exercise. 45, pp. 5 - 12. https://doi.org/10.1007/s40279-015-0400-1
Carbohydrate availability and exercise training adaptation : Too much of a good thing?
Bartlett, Jonathan, Hawley, John and Morton, James. (2015). Carbohydrate availability and exercise training adaptation : Too much of a good thing? European Journal of Sport Science. 15(1), pp. 3 - 12. https://doi.org/10.1080/17461391.2014.920926
Nutritional strategies to enhance fat oxidation during aerobic exercise
Burke, Louise and Hawley, John. (2015). Nutritional strategies to enhance fat oxidation during aerobic exercise. In In L. Burke and V. Deakin (Ed.). Clinical sports nutrition pp. 463 - 492 McGraw-Hill Education (Australia) Pty Ltd.
Global phosphoproteomic analysis of human skeletal muscle reveals a network of exercise-regulated kinases and AMPK substrates
Hoffman, Nolan John, Parker, Benjamin L., Chaudhuri, Rima, Fisher-Wellman, Kelsey H., Kleinert, Maximilian, Humphrey, Sean J., Yang, Pengyi, Holliday, Mira, Trefely, Sophie, Fazakerley, Daniel J., Stöckli, Jacqueline, Burchfield, James G., Jensen, Thomas E., Jothi, Raja, Kiens, Bente, Wojtaszewski, Jørgen F. P., Richter, Erik A. and James, David E.. (2015). Global phosphoproteomic analysis of human skeletal muscle reveals a network of exercise-regulated kinases and AMPK substrates. Cell Metabolism. 22(5), pp. 922 - 935. https://doi.org/10.1016/j.cmet.2015.09.001
Taurine and skeletal muscle function
Spriet, Lawrence L. and Whitfield, Jamie. (2015). Taurine and skeletal muscle function. Current Opinion in Clinical Nutrition and Metabolic Care. 18(1), pp. 96 - 101. https://doi.org/10.1097/MCO.0000000000000135
Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells
Rogers, Samuel, McLoy, Rachel A., Parker, Benjamin L., Chaudhuri, Rima, Gayevskiy, Velimir, Hoffman, Nolan John, Watkins, D. Neil, Daly, Roger J., James, David E. and Burgess, Andrew. (2015). Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells. Data in Brief. 5, pp. 45 - 52. https://doi.org/10.1016/j.dib.2015.08.010
Need for measures of satellite cell activation along with muscle protein synthesis?
Camera, Donny and Hawley, John. (2015). Need for measures of satellite cell activation along with muscle protein synthesis? Journal of Applied Physiology. 118(4), pp. 500 - 500. https://doi.org/10.1152/japplphysiol.00609.2014.
Activation of AMPK alpha2 is not required for mitochondrial FAT/CD36 accumulation during exercise
Monaco, Cynthia, Whitfield, Jamie, Jain, Swati S., Spriet, Lawrence L., Bonen, Arend and Holloway, Graham P.. (2015). Activation of AMPK alpha2 is not required for mitochondrial FAT/CD36 accumulation during exercise. PLoS ONE. 10(5), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0126122
The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle
Stockli, Jacqueline, Meoli, Christopher C., Hoffman, Nolan John, Fazakerley, Daniel J., Pant, Himani, Cleasby, Mark E., Ma, Xiuquan, Kleinert, Maximilian, Brandon, Amanda E., Lopez, Jamie A., Cooney, Gregory J. and James, David E.. (2015). The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle. Diabetes. 64(6), pp. 1914 - 1922. https://doi.org/10.2337/db13-1489
Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs
McLoy, Rachael A., Parker, Benjamin L., Rogers, Samuel, Chaudhuri, Rima, Gayevskiy, Velimir, Hoffman, Nolan John, Ali, Naveid, Watkins, D. Neil, Daly, Roger J., James, David E., Lorca, Thierry, Castro, Anna and Burgess, Andrew. (2015). Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs. Molecular and Cellular Proteomics. 14(8), pp. 2194 - 2212. https://doi.org/10.1074/mcp.M114.046938
PhosphOrtholog: A web-based tool for cross-species mapping of orthologous protein post-translational modifications
Chaudhuri, Rima, Sadrieh, Arash, Hoffman, Nolan J., Parker, Benjamin L., Humphrey, Sean J., Stockli, Jacqueline, Hill, Adam P., James, David E. and Yang, Jean Yee Hwa. (2015). PhosphOrtholog: A web-based tool for cross-species mapping of orthologous protein post-translational modifications. BMC Genomics. 16(617), pp. 1 - 14. https://doi.org/10.1186/s12864-015-1820-x
Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training
Parr, Evelyn, Camera, Donny, Areta, José, Burke, Louise, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training. PLoS ONE. 9(2), pp. 1 - 9. https://doi.org/10.1371/journal.pone.0088384
Ramping up the signal : Promoting endurance training adaptation in skeletal muscle by nutritional manipulation
Hawley, John and Morton, James. (2014). Ramping up the signal : Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41(8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246
Structural basis for phosphorylation and lysine acetylation cross-talk in a kinase motif associated with myocardial ischemia and cardioprotection
Parker, Benjamin L., Shepherd, Nicholas E., Trefely, Sophie, Hoffman, Nolan John, White, Melanie Y., Engholm-Keller, Kasper, Hambly, Brett D., Larsen, Martin R., James, David E. and Cordwell, Stuart J.. (2014). Structural basis for phosphorylation and lysine acetylation cross-talk in a kinase motif associated with myocardial ischemia and cardioprotection. Journal of Biological Chemistry. 289(37), pp. 25890 - 25906. https://doi.org/10.1074/jbc.M114.556035
Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation
Mokbel, Nancy, Hoffman, Nolan John, Girgis, Christian M., Small, Lewin, Turner, Nigel, Daly, Roger J., Cooney, Gregory J. and Holt, Lowenna J.. (2014). Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation. Journal of Cellular Physiology. 229(11), pp. 1753 - 1764. https://doi.org/10.1002/jcp.24628
Variable effects of 12 weeks of omega-3 supplementation on resting skeletal muscle metabolism
Gerling, Christopher J., Whitfield, Jamie, Mukai, Kazutaka and Spriet, Lawrence L.. (2014). Variable effects of 12 weeks of omega-3 supplementation on resting skeletal muscle metabolism. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 1083 - 1091. https://doi.org/10.1139/apnm-2014-0049
Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance
Lane, Stephen C., Hawley, John, Desbrow, Ben, Jones, Andrew M., Blackwell, James R., Ross, Megan L. L., Zemski, Adam J. and Burke, Louise. (2014). Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance. 39(9), pp. 1050 - 1057. https://doi.org/10.1139/apnm-2013-0336
'Exercise snacks' before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance
Francois, Monique, Baldi, James, Manning, Patrick, Lucas, Samuel, Hawley, John Alan, Williams, Michael and Cotter, James. (2014). 'Exercise snacks' before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia. 57(7), pp. 1437 - 1445. https://doi.org/10.1007/s00125-014-3244-6
Mitochondrial function in metabolic health: A genetic and environmental tug of war
Stephenson, Erin and Hawley, John Alan. (2014). Mitochondrial function in metabolic health: A genetic and environmental tug of war. Biochimica et Biophysica Acta. 1840(4), pp. 1285 - 1294. https://doi.org/10.1016/j.bbagen.2013.12.004
Structural basis for phosphorylation and lysine acetylation crosstalk in a kinase motif associated with myocardial ischemia and cardioprotection
Parker, Benjamin L., Shepherd, Nicholas E., Trefely, Sophie, Hoffman, Nolan John, White, Melanie Y., Engholm-Keller, Kasper, Hambly, Brett D., Larsen, Martin R., James, David E. and Cordwell, Stuart J.. (2014). Structural basis for phosphorylation and lysine acetylation crosstalk in a kinase motif associated with myocardial ischemia and cardioprotection. Journal of Biological Chemistry. 289(37), pp. 25890 - 25906. https://doi.org/10.1074/jbc.M114.556035
Transient silencing of a type IV P-type ATpase results in decreased GLUT4 translocation and altered signaling of MAPK and PI3K pathways
Hurst, Sarah, Hoffman, Nolan, Elmendorf, Jeffrey and Dhar, Madhu. (2014). Transient silencing of a type IV P-type ATpase results in decreased GLUT4 translocation and altered signaling of MAPK and PI3K pathways. In Obesity Epidemic pp. 1 - 21 CreateSpace Independent Publishing Platform.
Single and combined effects of betroot juice and caffeine supplementation on cycling time trial performance
Lane, Stephen, Hawley, John, Desbrow, Ben, Jones, Andrew, Blackwell, James, Ross, Megan, Zemski, Adam and Burke, Louise. (2014). Single and combined effects of betroot juice and caffeine supplementation on cycling time trial performance. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 1050 - 1057. https://doi.org/10.1139/apnm-2013-0336
Chromium enhances insulin responsiveness via AMPK
Hoffman, Nolan John, Penque, Brent A., Habegger, Kirk M., Sealls, Whitney, Tackett, Lixuan and Elmendorf, Jeffrey S.. (2014). Chromium enhances insulin responsiveness via AMPK. Journal of Nutritional Biochemistry. 25(5), pp. 565 - 572. https://doi.org/10.1016/j.jnutbio.2014.01.007
Beyond muscle hypertrophy: Why dietary protein is important for endurance athletes
Moore, Daniel, Camera, Donny, Areta, José and Hawley, John A.. (2014). Beyond muscle hypertrophy: Why dietary protein is important for endurance athletes. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 987 - 997. https://doi.org/10.1139/apnm-2013-0591
Integrative Biology of Exercise
Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R.. (2014). Integrative Biology of Exercise. Cell. 159(4), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029
Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle
Herbst, E. A. F., Paglialunga, S., Gerling, C., Whitfield, Jamie, Mukai, K., Chabowski, Adrian, Heigenhauser, G. J. F., Spriet, L. L. and Holloway, Graham P.. (2014). Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle. The Journal of Physiology. 592(6), pp. 1341 - 1352. https://doi.org/10.1113/jphysiol.2013.267336
The relationship between exercise, nutrition and type 2 diabetes
Stephenson, Erin J., Smiles, William and Hawley, John Alan. (2014). The relationship between exercise, nutrition and type 2 diabetes. Medicine and Sport Science. 60, pp. 1 - 10. https://doi.org/10.1159/000357331
Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells
Areta, José, Hawley, John A., Ye, Ji-Ming, Chan, M. H. Stanley and Coffey, Vernon. (2014). Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells. Nutrition Research. 34(11), pp. 1000 - 1007. https://doi.org/10.1016/j.nutres.2014.09.011
Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit
Areta, José, Burke, Louise, Camera, Donny, West, Daniel, Crawshay, Siobhan, Moore, Daniel, Stellingwerff, Trent, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Endocrinology and Metabolism. 306(8), pp. E989 - E997. https://doi.org/10.1152/ajpendo.00590.2013
Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation
Hawley, John Alan and Morton, James. (2014). Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41(8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246
Beetroot juice supplementation does not improve performance of elite 1500-m runners
Boorsma, Robert K., Whitfield, Jamie and Spriet, Lawrence L.. (2014). Beetroot juice supplementation does not improve performance of elite 1500-m runners. Medicine and Science in Sports and Exercise. 46(12), pp. 2326 - 2334. https://doi.org/10.1249/MSS.0000000000000364
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
Rao, Rajesh, Long, Jonathan, White, James, Svensson, Katrin, Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark, Ruas, Jorge, Wrann, Christiane, Lo, James, Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce. (2014). Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157(6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065
Integrative biology of exercise
Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R.. (2014). Integrative biology of exercise. Cell. 159(6), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029
Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
Rao, Rajesh, Long, Jonathan Z., White, James P., Svensson, Katrin J., Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark P., Ruas, Jorge L., Wrann, Christine D., Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce M.. (2014). Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis. Cell. 157(6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065
Acute changes to biomarkers as a consequence of prolonged strenuous running
Bird, Stephen R., Linden, Matthew and Hawley, John Alan. (2014). Acute changes to biomarkers as a consequence of prolonged strenuous running. Annals of Clinical Biochemistry. 51(2), pp. 137 - 150. https://doi.org/10.1177/0004563213492147
Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men
Skleryk, J, Karagounis, Leonidas, Hawley, John, Sharman, Matthew, Laursen, Paul and Watson, Greg. (2013). Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. https://doi.org/10.1111/dom.12150
Nutritional strategies to modulate the adaptive response to endurance training
Hawley, John Alan. (2013). Nutritional strategies to modulate the adaptive response to endurance training. Nestle Nutrition Institute Workshop Series. 75, pp. 1 - 14. https://doi.org/10.1159/000345813
Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity
Stephenson, Erin, Lessard, Sarah, Rivas, Donato, Watt, Matthew, Yaspelkis III, Ben, Koch, Lauren, Britton, Steven and Hawley, John. (2013). Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00544.2012
Caffeine ingestion and cycling power output in a low or normal muscle glycogen state
Lane, Suzanne, Areta, José, Bird, S, Coffey, Vernon, Burke, Louise, Desbrow, B, Karagounis, L and Hawley, John A.. (2013). Caffeine ingestion and cycling power output in a low or normal muscle glycogen state. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0b013e31828af183
Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state
Lane, Stephen, Bird, S, Burke, Louise and Hawley, John. (2013). Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state. Applied Physiology, Nutrition and Metabolism. https://doi.org/10.1139/apnm-2012-0300
Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment
Frangioudakis, Georgia, Diakanastasis, Barbara, Liao, Bing-Qing M., Saville, Jennifer T., Hoffman, Nolan John, Mitchell, Todd W. and Schmitz-Peiffer, Carsten. (2013). Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment. Diabetologia. 56(12), pp. 2697 - 2701. https://doi.org/10.1007/s00125-013-3035-5
ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue
Kosari, Samin, Camera, Donny Michael, Hawley, John Alan, Stebbing, Martin and Badoer, Emilio. (2013). ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue. International Journal of Physiology, Pathophysiology and Pharmacology. 5(3), pp. 184 - 189.
Preexercise aminoacidemia and muscle protein synthesis after resistance exercise
Burke, Louise, Hawley, John, Ross, M, Moore, Daniel, Phillips, S, Slater, G, Stellingwerff, T, Tipton, K, Garnham, A and Coffey, Vernon. (2012). Preexercise aminoacidemia and muscle protein synthesis after resistance exercise. Medicine and Science in Sports and Exercise. 44(10), pp. 1968 - 1977. https://doi.org/10.1249/MSS.0b013e31825d28fa
AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol
Hoffman, Nolan John, Habegger, Kirk M., Ridenour, Colin M., Broznick, Joseph T. and Elmendon, Jeffrey S.. (2012). AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol. Endocrinology. 153(5), pp. 2130 - 2141. https://doi.org/10.1210/en.2011-2099
Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet
Stephenson, E, Camera, Donny, Jenkins, T, Kosari, S, Lee, Joohyung, Hawley, John and Stepto, N. (2012). Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet. American Journal of Physiology - Endocrinology and Metabolism. 302(12), pp. E1541 - E1549. https://doi.org/10.1152/ajpendo.00590.2011
What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet
Hawley, John and Gibala, M. (2012). What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet. Diabetologia. 55(3), pp. 535 - 539. https://doi.org/10.1007/s00125-012-2460-1
Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males
Moore, Daniel, Areta, José, Coffey, Vernon, Stellingwerff, Trent, Phillips, Stuart, Burke, Louise, Cleroux, Marilyn, Godin, Jean-Philippe and Hawley, John Alan. (2012). Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males. Nutrition and Metabolism. 9(91), pp. 1 - 5. https://doi.org/10.1186/1743-7075-9-91
Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1?
Stephenson, E, Stepto, N, Koch, L, Britton, S and Hawley, John. (2012). Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1? Journal of Applied Physiology. 113(9), pp. 1403 - 1412. https://doi.org/10.1152/japplphysiol.00788.2012
Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley
Gibala, M. J., Little, John, Macdonald, M. J. and Hawley, John. (2012). Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley. The Journal of Physiology. 590(14), pp. 3391 - 3391. https://doi.org/10.1113/jphysiol.2012.235127
Preexercise nutrient timing in endurance activity
Broad, E., Karagounis, L. and Hawley, John Alan. (2012). Preexercise nutrient timing in endurance activity. In In C. M. Kerksick (Ed.). Nutrient Timing: Metabolic Optimization for Health, Performance, and Recovery pp. 118 - 118 Taylor & Francis.
Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state
West, D, Burd, N, Churchward-Venne, T, Camera, Donny, Mitchell, Cameron, Baker, S, Hawley, John, Coffey, Vernon and Phillips, S. (2012). Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state. Journal of Applied Physiology. 112(11), pp. 1805 - 1813. https://doi.org/10.1152/japplphysiol.00170.2012
Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise
Camera, Donny, West, D, Burd, N, Phillips, S, Garnham, A, Hawley, John and Coffey, Vernon. (2012). Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise. Journal of Applied Physiology. 113(2), pp. 206 - 214. https://doi.org/10.1152/japplphysiol.00395.2012
Physiological adaptations to low-volume, high-intensity interval training in health and disease
Gibala, M, Little, John, Macdonald, M and Hawley, John. (2012). Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology. 590(5), pp. 1077 - 1084. https://doi.org/10.1113/jphysiol.2011.224725
Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints
Coffey, Vernon, Moore, Daniel, Burd, N, Rerecich, T, Stellingwerff, T, Garnham, A, Phillips, S and Hawley, John. (2011). Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints. European Journal of Applied Physiology. 111(7), pp. 1473 - 1483. https://doi.org/10.1007/s00421-010-1768-0
Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis
Hoffman, Nolan John and Elmendorf, Jeffrey S.. (2011). Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis. Trends in Endocrinology and Metabolism. 22(3), pp. 110 - 116. https://doi.org/10.1016/j.tem.2010.12.001
Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise
West, D, Burd, N, Coffey, Vernon, Baker, S, Burke, Louise, Hawley, John, Moore, Daniel, Stellingwerff, T and Phillips, S. (2011). Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. American Journal of Clinical Nutrition: A journal reporting the practical application of our world-wide knowledge of nutrition. 94(3), pp. 795 - 803. https://doi.org/10.3945/ajcn.111.013722
Nutritional modulation of training-induced skeletal muscle adaptations
Hawley, John, Burke, Louise, Phillips, S and Spriet, L. (2011). Nutritional modulation of training-induced skeletal muscle adaptations. Journal of Applied Physiology. 110(3), pp. 834 - 845. https://doi.org/10.1152/japplphysiol.00949.2010
Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle
Abbiss, Chris, Karagounis, L, Laursen, P, Peiffer, J, Martin, D, Hawley, John, Fatehee, N and Martin, J.. (2011). Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle. Journal of Applied Physiology. 110(5), pp. 1248 - 1255. https://doi.org/10.1152/japplphysiol.01247.2010
Carbohydrates for training and competition
Burke, Louise, Hawley, John, Wong, S and Jeukendrup, A. (2011). Carbohydrates for training and competition. Journal of Sports Sciences. 29(Suppl 1), pp. S17 - S27. https://doi.org/10.1080/02640414.2011.585473
Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity
Lessard, S, Rivas, D, Stephenson, E, Yaspelkis, Koch, L, Britton, S, Hawley, John and III, B Yaspelkis. (2011). Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(1), pp. R175 - R182. https://doi.org/10.1152/ajpregu.00338.2010
Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle
Rivas, D, Lessard, S, Saito, M, Friedhuber, A, Koch, L, Britton, S, Yaspelkis III, B and Hawley, John. (2011). Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(4), pp. 835 - 843. https://doi.org/10.1152/ajpregu.00659.2010
Substrate oxidation
Hawley, John A.. (2010). Substrate oxidation. In In Connes, Philippe, Hue, Olivier and Perrey, Stéphane (Ed.). Exercise physiology : From a cellular to an integrative approach pp. 340-347 IOS Press.
The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet
Mitchell, Todd, Turner, Nigel, Else, Paul, Hulbert, Anthony and Hawley, John. (2010). The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet. International Journal of Molecular Sciences. 11(10), pp. 3954 - 3964. https://doi.org/10.3390/ijms11103954
Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper
Yeo, W, McGee, S, Carey, A, Paton, C, Garnham, A, Hargreaves, M and Hawley, John. (2010). Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper. Experimental Physiology. 95(2), pp. 351 - 358. https://doi.org/10.1113/expphysiol.2009.049353
Reply
Hawley, John and Martin, David. (2010). Reply. International Journal of Sports Physiology and Performance. 5(4), pp. 434 - 436.
Early time course of akt phosphorylation after endurance and resistance exercise
Camera, Donny, Edge, J, Short, M, Hawley, John and Coffey, Vernon. (2010). Early time course of akt phosphorylation after endurance and resistance exercise. Medicine and Science in Sports and Exercise. 42(10), pp. 1843 - 1852. https://doi.org/10.1249/MSS.0b013e3181d964e4
Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue
Camera, Donny, Anderson, Malcolm, Hawley, John and Carey, A. (2010). Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue. European Journal of Applied Physiology. 109(2), pp. 307 - 316. https://doi.org/10.1007/s00421-010-1356-3
Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle
Karagounis, L, Yaspelkis III, B, Reeder, D, Lancaster, G, Hawley, John and Coffey, Vernon. (2010). Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle. European Journal of Applied Physiology. 109(5), pp. 839 - 848. https://doi.org/10.1007/s00421-010-1427-5
Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation
Vucinic, L, Singh, I, Spargo, F, Hawley, John and Linden, M. (2010). Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 125(2), pp. 196 - 199. https://doi.org/10.1016/j.thromres.2009.11.015
Carbohydrate availability and training adaptation: Effects on cell metabolism
Hawley, John and Burke, Louise. (2010). Carbohydrate availability and training adaptation: Effects on cell metabolism. Exercise and Sport Sciences Reviews. 38(4), pp. 152 - 160. https://doi.org/10.1097/JES.0b013e3181f44dd9
Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling
Cox, Geoffrey, Clark, Sally, Cox, A, Halson, Shona, Hargreaves, M, Hawley, John, Jeacocke, N, Snow, Rod, Yeo, W and Burke, Louise. (2010). Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling. Journal of Applied Physiology. 109(1), pp. 126 - 134. https://doi.org/10.1152/japplphysiol.00950.2009
Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle
Yaspelkis III, B, Kvasha, I, Lessard, S, Rivas, D and Hawley, John. (2010). Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle. European Journal of Applied Physiology. 110(4), pp. 779 - 788. https://doi.org/10.1007/s00421-010-1559-7
Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury
Ross, M, Halson, Shona, Suzuki, K, Garnham, A, Hawley, John, Cameron-Smith, David and Peake, J. (2010). Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. Journal of Interferon and Cytokine Research. 30(5), pp. 329 - 337. https://doi.org/10.1089/jir.2009.0079
Skeletal muscle : increasing the size of the locomotor cell
Karagounis, L and Hawley, John. (2010). Skeletal muscle : increasing the size of the locomotor cell. The International Journal of Biochemistry and Cell Biology. 42(9), pp. 1376 - 1379. https://doi.org/10.1016/j.biocel.2010.05.013
Global gene expression in skeletal muscle from well-trained strength and endurance athletes
Stepto, Nigel K., Coffey, Vernon Glenn, Carey, Andrew L., Ponnampalam, Anna P., Canny, Benedict J., Powell, David and Hawley, John Alan. (2009). Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Medicine and Science in Sports and Exercise. 41(3), pp. 546 - 565. https://doi.org/10.1249/MSS.0b013e31818c6be9
Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle
Coffey, Vernon Glenn, Jemiolo, Bozena, Edge, Johann, Garnham, Andrew P., Trappe, Scott W. and Hawley, John Alan. (2009). Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297(5), pp. 1441 - 1451. https://doi.org/10.1152/ajpregu.00351.2009
Exercise intensity and insulin sensitivity: How low can you go?
Hawley, John Alan and Gibala, M. J.. (2009). Exercise intensity and insulin sensitivity: How low can you go? Diabetologia. 52(9), pp. 1709 - 1713. https://doi.org/10.1007/s00125-009-1425-5
Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
Rivas, Donato A., Yaspelkis, Ben B., Hawley, John Alan and Lessard, Sarah J.. (2009). Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. Journal of Endocrinology. 202(3), pp. 441 - 451. https://doi.org/10.1677/JOE-09-0202
Molecular responses to strength and endurance training: Are they incompatible?
Hawley, John Alan. (2009). Molecular responses to strength and endurance training: Are they incompatible? Applied Physiology, Nutrition and Metabolism. 34(3), pp. 355 - 361. https://doi.org/10.1139/H09-023
The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics
Karagounis, Leonidas G. and Hawley, John Alan. (2009). The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics. The International Journal of Biochemistry and Cell Biology. 41(12), pp. 2360 - 2363. https://doi.org/10.1016/j.biocel.2009.07.004
Exercise: It's the real thing!
Hawley, John Alan and Holloszy, J O.. (2009). Exercise: It's the real thing! Nutrition Reviews. 67(3), pp. 172 - 178. https://doi.org/10.1111/j.1753-4887.2009.00185.x
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity
Lessard, Sarah J., Rivas, Donato A., Chen, Zhu-Ping, van Denderen, Bryce J., Watt, Matthew J., Koch, Lauren G., Britton, Steven L., Kemp, Bruce Ernest and Hawley, John Alan. (2009). Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology. 150(11), pp. 4883 - 4891. https://doi.org/10.1210/en.2009-0158
Spectroscopic correlation analysis of NMR-based metabonomics in exercise science
Kirwan, Gemma M., Coffey, Vernon Glenn, Niere, Julie O., Hawley, John Alan and Adams, Michael J.. (2009). Spectroscopic correlation analysis of NMR-based metabonomics in exercise science. Analytica Chimica Acta. 652(1-2), pp. 173 - 179. https://doi.org/10.1016/j.aca.2009.07.011
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Coffey, Vernon Glenn, Pilegaard, Henriette, Garnham, Andrew P., O'Brien, Brendan J. and Hawley, John Alan. (2009). Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. Journal of Applied Physiology. 106(4), pp. 1187 - 1197. https://doi.org/10.1152/japplphysiol.91221.2008
Specificity of training adaptation: Time for a rethink?
Hawley, John Alan. (2008). Specificity of training adaptation: Time for a rethink? The Journal of Physiology. 586(1), pp. 1 - 2. https://doi.org/10.1113/jphysiol.2007.147397
Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes
Lessard, Sarah J. and Hawley, John Alan. (2008). Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes. In In J.A. Hawley and J. R. Zierath (Ed.). Physical activity and type 2 diabetes: Therapeutic effects and mechanisms of action pp. 203 - 214 Human Kinetics Publishers Inc..
The effects of polyphenols in olive leaves on platelet function
Singh, Indu, Mok, Michelle, Christensen, Anne-Marie, Turner, Alan H. and Hawley, John Alan. (2008). The effects of polyphenols in olive leaves on platelet function. Nutrition Metabolism and Cardiovascular Diseases. 18(2), pp. 127 - 132. https://doi.org/10.1016/j.numecd.2006.09.001
Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens
Yeo, Wee Kian, Paton, Carl D., Garnham, Andrew P., Burke, Louise M., Carey, Andrew L. and Hawley, John Alan. (2008). Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. Journal of Applied Physiology. 105(5), pp. 1462 - 1470. https://doi.org/10.1152/japplphysiol.90882.2008
Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
Reid, Julianne J. and Hawley, John Alan. (2008). Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise? Journal of Applied Physiology. 105(2), pp. 772 - 772. https://doi.org/10.1152/japplphysiol.90362.2008
Metabolic adaptations to training
Hawley, John Alan and Nader, Gustavo A.. (2008). Metabolic adaptations to training. In In M.P. Schwellnus (Ed.). Olympic textbook of medicine in sport pp. 78 - 87 Wiley-Blackwell.
Exercise training-induced improvements in insulin action
Hawley, John Alan and Lessard, S. J.. (2008). Exercise training-induced improvements in insulin action. Acta Physiologica. 192(1), pp. 127 - 135. https://doi.org/10.1111/j.1748-1716.2007.01783.x
Exercise-induced phospho-proteins in skeletal muscle
Deshmukh, A. S., Hawley, John Alan and Zierath, J. R.. (2008). Exercise-induced phospho-proteins in skeletal muscle. International Journal of Obesity. 32(SUPPL.4), pp. S18 - S23. https://doi.org/10.1038/ijo.2008.118
Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle
Saito, Misato, Lessard, S. J., Rivas, Donato A., Reeder, Donald W., Hawley, John Alan and Yaspelkis, Ben B.. (2008). Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism: Clinical and experimental. 57(9), pp. 1173 - 1180. https://doi.org/10.1016/j.metabol.2008.03.023
Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription
Hawley, John Alan. (2008). Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription. Journal of Applied Physiology. 104(4), pp. 1249 - 1249. https://doi.org/10.1152/japplphysiol.00047.2008
Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment
Singh, Indu, Carey, Andrew L., Watson, Nadine, Febbraio, Mark A. and Hawley, John Alan. (2008). Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment. European Journal of Nutrition. 47(7), pp. 387 - 392. https://doi.org/10.1007/s00394-008-0739-2
High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine
Pedersen, David J., Lessard, Sarah J., Coffey, Vernon Glenn, Churchley, Emmanuel G., Wootton, Andrew M., Ng, They, Watt, Matthew J. and Hawley, John Alan. (2008). High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. Journal of Applied Physiology. 105(1), pp. 7 - 13. https://doi.org/10.1152/japplphysiol.01121.2007
Overweight and obesity in Australia
Hawley, John Alan and Dunstan, David Wayne. (2008). Overweight and obesity in Australia. Medical Journal of Australia. 188(11), pp. 678 - 679.
Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
Yeo, Wee Kian, Lessard, Sarah J., Chen, Zhi-Ping, Garnham, Andrew P., Burke, Louise, Rivas, Donato A., Kemp, Bruce Ernest and Hawley, John Alan. (2008). Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. Journal of Applied Physiology. 105(5), pp. 1519 - 1526. https://doi.org/10.1152/japplphysiol.90540.2008
The battle against obesity - Attacking physical inactivity as a primary means of defense
Hawley, John and Dunstan, David. (2008). The battle against obesity - Attacking physical inactivity as a primary means of defense. Nature Reviews Endocrinology. 4(10), pp. 548 - 549. https://doi.org/10.1038/ncpendmet0918