Physical activity and cognition in young-onset Parkinson's disease

Journal article


Biddiscombe, Karen J., Ong, Ben, Kalinowski, Pawel and Pike, Kerryn E.. (2020) Physical activity and cognition in young-onset Parkinson's disease. Acta Neurologica Scandinavica. 142(2), pp. 151-160. https://doi.org/10.1111/ane.13256
AuthorsBiddiscombe, Karen J., Ong, Ben, Kalinowski, Pawel and Pike, Kerryn E.
Abstract

Background
A relationship has been observed between physical activity and cognition in older‐onset Parkinson's disease, as well as improvements in cognition after a physical activity intervention. To date, this has not been investigated in young‐onset Parkinson's disease (YOPD).

Objectives
To examine the baseline relationship between physical activity and cognition in YOPD; and to examine whether a physical activity intervention can improve cognition in YOPD.

Methods
Two interrelated online studies were conducted. In the first study, 132 participants with YOPD completed self‐reported measures of physical activity, and objective and subjective measures of cognition. A subset of 38 participants was then randomly allocated to either a six‐week physical activity intervention or control condition. Following the intervention, participants repeated the objective and subjective cognitive measures.

Results
No relationship was found between self‐reported physical activity and objective cognition; however, there was a relationship between physical activity and subjective cognition. Similarly, following the intervention subjective improvements were found for concentration, attention, and processing speed, but not for memory. Furthermore, medium effect sizes were evident for objective measures of processing speed and small‐medium effect sizes for planning and cognitive flexibility, although statistical significance was not reached.

Conclusions
In this first study investigating physical activity and cognition in YOPD, the results suggest that increased physical activity relates to improved processing speed and attention. Replication is recommended with a larger sample size. A longer, more intense physical activity manipulation and utilizing the study's strengths of online recruitment and intervention delivery are also recommended.

Keywordscognition; early-onset Parkinson's disease; intervention; non-motor symptoms; physical activity
Year2020
JournalActa Neurologica Scandinavica
Journal citation142 (2), pp. 151-160
PublisherWiley-Blackwell Publishing, Inc.
ISSN0001-6314
Digital Object Identifier (DOI)https://doi.org/10.1111/ane.13256
Scopus EID2-s2.0-85084852526
Research or scholarlyResearch
Page range151-160
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online18 May 2020
Publication process dates
Accepted26 Apr 2020
Deposited04 May 2021
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https://acuresearchbank.acu.edu.au/item/8vz58/physical-activity-and-cognition-in-young-onset-parkinson-s-disease

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