Glucocorticoid administration restores salience network activity in patients with spider phobia

Journal article

Leila M Soravia, Simon Schwab, Nico Weber, Masahito Nakataki, Roland Wiest, Werner Strik, Markus Heinrichs, Dominique De Quervain and Andrea Federspiel. (2018). Glucocorticoid administration restores salience network activity in patients with spider phobia. Depression and Anxiety. 35(10), pp. 925-934. https://doi.org/10.1002/da.22806
AuthorsLeila M Soravia, Simon Schwab, Nico Weber, Masahito Nakataki, Roland Wiest, Werner Strik, Markus Heinrichs, Dominique De Quervain and Andrea Federspiel
Abstract

Background
Glucocorticoids reduce phobic fear in patients with anxiety disorders. Although the neurobiology of anxiety disorders is not fully understood, convergent structural and functional neuroimaging studies have identified abnormalities in various brain regions, including those in the salience network (SN) and default mode network (DMN). Here, we examine the effects of glucocorticoid administration on SN and DMN activity during the processing of phobic stimuli.

Methods
We use functional magnetic resonance imaging to record brain activity in 24 female patients with spider phobia who were administered either 20 mg of cortisol or placebo while viewing pictures of spiders. Fourteen healthy female participants were tested with the same task but without substance administration. Independent component analysis (ICA) performed during stimulus encoding identified the SN and DMN as exhibiting synchronized activation in diverse brain regions; thus, we examined the effects of cortisol on these networks. Furthermore, participants had to rate their level of fear at various time points.

Results
Glucocorticoids reduced phobic fear in patients with spider phobia. The ICA performed during stimulus encoding revealed that activity in the SN and DMN was reduced in placebo‐treated patients versus healthy controls. Brain activity in the SN, but not the DMN, was altered in cortisol‐ versus placebo‐treated patients to a level that was similar to that observed in healthy controls.

Conclusions
Activity in both the SN and DMN was reduced in patients with spider phobia. Cortisol administration altered the SN activity to a level that was comparable to that found in healthy controls. This alteration in SN activity might reflect the fear‐reducing effects of glucocorticoids in phobia.

Keywordsdefault mode network; fear; fMRI; glucocorticoids; phobia; salience network
Year2018
JournalDepression and Anxiety
Journal citation35 (10), pp. 925-934
PublisherWiley-Blackwell
ISSN1091-4269
Digital Object Identifier (DOI)https://doi.org/10.1002/da.22806
Scopus EID2-s2.0-85052491471
Publisher's version
File Access Level
Controlled
Publication process dates
Deposited11 May 2021
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Menstrual cycle phase affects discrimination of infant cuteness
Lobmaier, Janek S., Probst, Fabian, Perrett, David I. and Heinrichs, Markus. (2015). Menstrual cycle phase affects discrimination of infant cuteness. Hormones and Behavior. 70(April), pp. 1 - 6. https://doi.org/10.1016/j.yhbeh.2015.02.001
Effects of acute social stress on emotion processing in children
Chen, Frances S., Schmitz, Julian, Domes, Gregor, Tuschen-Caffier, Brunna and Heinrichs, Markus. (2014). Effects of acute social stress on emotion processing in children. Psychoneuroendocrinology. 40(1), pp. 91 - 95. https://doi.org/10.1016/j.psyneuen.2013.11.003
Oxytocin and the social brain: Neural mechanisms and perspectives in human research
Kanat, Manuela, Heinrichs, Markus and Domes, Gregor. (2014). Oxytocin and the social brain: Neural mechanisms and perspectives in human research. Brain Research. 1580(September), pp. 160 - 171. https://doi.org/10.1016/j.brainres.2013.11.003
Attachment style moderates the effects of oxytocin on social behaviors and cognitions during social rejection: Applying a research domain criteria framework to social anxiety
Fang, Angela, Hoge, Elizabeth A., Heinrichs, Markus and Hofmann, Stefan G.. (2014). Attachment style moderates the effects of oxytocin on social behaviors and cognitions during social rejection: Applying a research domain criteria framework to social anxiety. Clinical Psychological Science. 2(6), pp. 740 - 747. https://doi.org/10.1177/2167702614527948
Effects of a 12-week endurance training program on the physiological response to psychosocial stress in men: A randomized controlled trial
Klaperski, Sandra, von Dawans, Bernadette, Heinrichs, Markus and Fuchs, Reinhard. (2014). Effects of a 12-week endurance training program on the physiological response to psychosocial stress in men: A randomized controlled trial. Journal of Behavioral Medicine. 37(6), pp. 1118 - 1133. https://doi.org/10.1007/s10865-014-9562-9
Psychobiology of social support: The social dimension of stress buffering
Ditzen, Beate and Heinrichs, Markus. (2014). Psychobiology of social support: The social dimension of stress buffering. Restorative Neurology and Neuroscience. 32(1), pp. 149 - 162. https://doi.org/10.3233/RNN-139008
Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome
Domes, Gregor, Kumbier, Ekkehardt, Heinrichs, Markus and Herpertz, Sabine C.. (2014). Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome. Neuropsychopharmacology. 39(3), pp. 698 - 706. https://doi.org/10.1038/npp.2013.254
Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples
Behnia, Behnoush, Heinrichs, Markus, Bergmann, Wiebke, Jung, Stefanie, Germann, Janine, Schedlowski, Manfred, Hartmann, Uwe and Kruger, Tillmann H.C.. (2014). Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples. Hormones and Behavior. 65(3), pp. 308 - 318. https://doi.org/10.1016/j.yhbeh.2014.01.009
Oxytocin's impact on social face processing is stronger in homosexual than heterosexual men
Thienel, Matthias, Heinrichs, Markus, Fischer, Stefan, Ott, Volker, Born, Jan and Hallschmid, Manfred. (2014). Oxytocin's impact on social face processing is stronger in homosexual than heterosexual men. Psychoneuroendocrinology. 39(1), pp. 194 - 203. https://doi.org/10.1016/j.psyneuen.2013.09.013
MDMA enhances emotional empathy and prosocial behavior
Hysek, Cédric M., Schmid, Yasmin, Simmler, Linda D., Domes, Gregor, Heinrichs, Markus, Eisenegger, Christoph, Preller, Katrin H., Quednow, Boris B. and Liechti, Matthias E.. (2014). MDMA enhances emotional empathy and prosocial behavior. Social Cognitive and Affective Neuroscience. 9(11), pp. 1645 - 1652. https://doi.org/10.1093/scan/nst161
Intranasal oxytocin enhances positive self-attribution in healthy men
Colonnello, Valentina and Heinrichs, Markus. (2014). Intranasal oxytocin enhances positive self-attribution in healthy men. Journal of Psychosomatic Research. 77(5), pp. 415 - 419. https://doi.org/10.1016/j.jpsychores.2014.06.016
Oxytocin increases the likeability of physically formidable men
Chen, Frances S., Mayer, Jennifer, Mussweiler, Thomas and Heinrichs, Markus. (2014). Oxytocin increases the likeability of physically formidable men. Social Cognitive and Affective Neuroscience. 10(6), pp. 797 - 800. https://doi.org/10.1093/scan/nsu116
Glucocorticoids enhance in vivo exposure-based therapy of spider phobia
Soravia, Leila M., Heinrichs, Markus, Winzeler, Livia, Fisler, Melanie, Schmitt, Wolfgang, Horn, Helge, Dierks, Thomas, Strik, Werner, Hofmann, Stefan G. and de Quervain, Dominique J.-F.. (2014). Glucocorticoids enhance in vivo exposure-based therapy of spider phobia. Depression and Anxiety. 31(5), pp. 429 - 435. https://doi.org/10.1002/da.22219
Is stress affecting our ability to tune into others? Evidence for gender differences in the effects of stress on self-other distinction
Tomova, L., von Dawans, Bernadette, Heinrichs, Markus, Silani, G. and Lamm, C.. (2014). Is stress affecting our ability to tune into others? Evidence for gender differences in the effects of stress on self-other distinction. Psychoneuroendocrinology. 43, pp. 95 - 104. https://doi.org/10.1016/j.psyneuen.2014.02.006
Oxytocin differentially modulates eye gaze to naturalistic social signals of happiness and anger
Domes, Gregor, Steiner, Angela, Porges, Stephen W. and Heinrichs, Markus. (2013). Oxytocin differentially modulates eye gaze to naturalistic social signals of happiness and anger. Psychoneuroendocrinology. 38(7), pp. 1198 - 1202. https://doi.org/10.1016/j.psyneuen.2012.10.002
Epigenetic regulation of the oxytocin receptor gene: Implications for behavioral neuroscience
Kumsta, Robert, Hummel, Elisabeth, Chen, Frances S. and Heinrichs, Markus. (2013). Epigenetic regulation of the oxytocin receptor gene: Implications for behavioral neuroscience. Frontiers in Neuroscience. 7, pp. 1 - 6. https://doi.org/10.3389/fnins.2013.00083
Effects of intranasal oxytocin on pupil dilation indicate increased salience of socioaffective stimuli
Prehn, Kristin, Kazzer, Philipp, Lischke, Alexander, Heinrichs, Markus, Herpertz, Sabine C. and Domes, Gregor. (2013). Effects of intranasal oxytocin on pupil dilation indicate increased salience of socioaffective stimuli. Psychophysiology. 50(6), pp. 528 - 537. https://doi.org/10.1111/psyp.12042
Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict
Ditzen, Beate, Nater, Urs M., Schaer, Marcel, La Marca, Roberto, Bodenmann, Guy, Ehlert, Ulrike and Heinrichs, Markus. (2013). Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict. Social Cognitive and Affective Neuroscience. 8(8), pp. 897 - 902. https://doi.org/10.1093/scan/nss083
Oxytocin, stress and social behavior: Neurogenetics of the human oxytocin system
Kumsta, Robert and Heinrichs, Markus. (2013). Oxytocin, stress and social behavior: Neurogenetics of the human oxytocin system. Current Opinion in Neurobiology. 23(1), pp. 11 - 16. https://doi.org/10.1016/j.conb.2012.09.004
Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Domes, Gregor, Heinrichs, Markus, Kumbier, Ekkehardt, Grossmann, Annette, Hauenstein, Karlheinz and Herpertz, Sabine C.. (2013). Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder. Biological Psychiatry. 74(3), pp. 164 - 171. https://doi.org/10.1016/j.biopsych.2013.02.007
In the eye of the beholder: Eye contact increases resistance to persuasion
Chen, Frances S., Minson, Julia A., Schöne, Maren and Heinrichs, Markus. (2013). In the eye of the beholder: Eye contact increases resistance to persuasion. Psychological Science. 24(11), pp. 2254 - 2261. https://doi.org/10.1177/0956797613491968
Oxytocin reduces reward-driven food intake in humans
Ott, Volker, Finlayson, Graham, Lehnert, Hendrik, Heitmann, Birte, Heinrichs, Markus, Born, Jan and Hallschmid, Manfred. (2013). Oxytocin reduces reward-driven food intake in humans. Diabetes. 62(10), pp. 3418 - 3425. https://doi.org/10.2337/db13-0663
Oxytocin sharpens self-other perceptual boundary
Colonnello, Valentina, Chen, Frances S., Panksepp, Jaak and Heinrichs, Markus. (2013). Oxytocin sharpens self-other perceptual boundary. Psychoneuroendocrinology. 38(12), pp. 2996 - 3002. https://doi.org/10.1016/j.psyneuen.2013.08.010
Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans
Kumsta, Robert, Chen, Frances S., Pape, Hans-Christian and Heinrichs, Markus. (2013). Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans. Biological Psychology. 93(2), pp. 304 - 307. https://doi.org/10.1016/j.biopsycho.2013.02.018
Intranasal oxytocin increases covert attention to positive social cues
Domes, Gregor, Sibold, M., Schulze, L., Lischke, Alexander, Herpertz, Sabine C. and Heinrichs, Markus. (2013). Intranasal oxytocin increases covert attention to positive social cues. Psychological Medicine. 43(8), pp. 1747 - 1753. https://doi.org/10.1017/S0033291712002565
Does the level of physical exercise affect physiological and psychological responses to psychosocial stress in women?
Klaperski, Sandra, von Dawans, Bernadette, Heinrichs, Markus and Fuchs, Reinhard. (2013). Does the level of physical exercise affect physiological and psychological responses to psychosocial stress in women? Psychology of Sport and Exercise. 14(2), pp. 266 - 274. https://doi.org/10.1016/j.psychsport.2012.11.003
The social dimension of stress reactivity: Acute stress increases prosocial behavior in humans
von Dawans, Bernadette, Fischbacher, Urs, Kirschbaum, Clemens, Fehr, Ernst and Heinrichs, Markus. (2012). The social dimension of stress reactivity: Acute stress increases prosocial behavior in humans. Psychological Science. 23(6), pp. 651 - 660. https://doi.org/10.1177/0956797611431576
Oxytocin increases amygdala reactivity to threatening scenes in females
Lischke, Alexander, Gamer, Matthias, Berger, Christoph, Grossmann, Annette, Hauenstein, Karlheinz, Heinrichs, Markus, Herpertz, Sabine C. and Domes, Gregor. (2012). Oxytocin increases amygdala reactivity to threatening scenes in females. Psychoneuroendocrinology. 37(9), pp. 1431 - 1438. https://doi.org/10.1016/j.psyneuen.2012.01.011
Dyadic coping, insecure attachment, and cortisol stress recovery following experimentally induced stress
Meuwly, Nathalie, Bodenmann, Guy, Germann, Janine, Bradbury, Thomas N., Ditzen, Beate and Heinrichs, Markus. (2012). Dyadic coping, insecure attachment, and cortisol stress recovery following experimentally induced stress. Journal of Family Psychology. 26(6), pp. 937 - 947. https://doi.org/10.1037/a0030356
Oxytocin modulates neural reactivity to children's faces as a function of social salience
Wittfoth-Schardt, Dina, Gründing, Johanna, Wittfoth, Matthias, Lanfermann, Heinrich, Heinrichs, Markus, Domes, Gregor, Buchheim, Anna, Gündel, Harald and Waller, Christiane. (2012). Oxytocin modulates neural reactivity to children's faces as a function of social salience. Neuropsychopharmacology. 37(8), pp. 1799 - 1807. https://doi.org/10.1038/npp.2012.47
Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected
Lischke, Alexander, Berger, Christoph, Prehn, Kristin, Heinrichs, Markus, Herpertz, Sabine C. and Domes, Gregor. (2012). Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected. Psychoneuroendocrinology. 37(4), pp. 475 - 481. https://doi.org/10.1016/j.psyneuen.2011.07.015
Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda, Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C., Nathan, Pradeep J. and Pradeep,. (2012). Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. International Journal of Neuropsychopharmacology (print). 15(7), pp. 883 - 896. https://doi.org/10.1017/S1461145711001489
Oxytocin
Heinrichs, Markus, Chen, Frances S. and Domes, Gregor. (2012). Oxytocin. In In S. G. Hofmann (Ed.). Psychobiological approaches for anxiety disorders: Treatment combination strategies pp. 123 - 143 John Wiley & Sons. https://doi.org/10.1002/9781119945901.ch8
The Trier Social Stress Test for Groups (TSST-G): A new research tool for controlled simultaneous social stress exposure in a group format
von Dawans, Bernadette, Kirschbaum, Clemens and Heinrichs, Markus. (2011). The Trier Social Stress Test for Groups (TSST-G): A new research tool for controlled simultaneous social stress exposure in a group format. Psychoneuroendocrinology. 36(4), pp. 514 - 522. https://doi.org/10.1016/j.psyneuen.2010.08.004
Alexithymic traits and facial emotion recognition in borderline personality disorder
Domes, Gregor, Grabe, Hans Jörgen, Czieschnek, Daniela, Heinrichs, Markus and Herpertz, Sabine C.. (2011). Alexithymic traits and facial emotion recognition in borderline personality disorder. Psychotherapy and Psychosomatics. 80(6), pp. 383 - 385. https://doi.org/10.1159/000325828
Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
Chen, Frances S., Kumsta, Robert, von Dawans, Bernadette, Monakhov, Mikhail, Ebstein, Richard P. and Heinrichs, Markus. (2011). Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proceedings of the National Academy of Sciences of the United States of America. 108(50), pp. 19937 - 19942. https://doi.org/10.1073/pnas.1113079108
Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine
Meyer-Lindenberg, Andreas, Domes, Gregor, Kirsch, Peter and Heinrichs, Markus. (2011). Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nature Reviews Neuroscience. 12(9), pp. 524 - 538. https://doi.org/10.1038/nrn3044
Oxytocin increases recognition of masked emotional faces
Schulze, Lars, Lischke, Alexander, Greif, Jonas, Herpertz, Sabine C., Heinrichs, Markus and Domes, Gregor. (2011). Oxytocin increases recognition of masked emotional faces. Psychoneuroendocrinology. 36(9), pp. 1378 - 1382. https://doi.org/10.1016/j.psyneuen.2011.03.011
Prejudice and truth about the effect of testosterone on human bargaining behaviour
Eisenegger, C., Naef, M., Snozzi, R., Heinrichs, Markus and Fehr, Ernst. (2010). Prejudice and truth about the effect of testosterone on human bargaining behaviour. Nature. 463(7279), pp. 356 - 359. https://doi.org/10.1038/nature08711
Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda G., Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C. and Nathan, Pradeep. (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology. 35(12), pp. 2403 - 2413. https://doi.org/10.1038/npp.2010.123
Closeness in relationships as a mediator between sexual abuse in childhood or adolescence and psychopathological outcome in adulthood
Dimitrova, Nevena, Pierrehumbert, Blaise, Glatz, Nathalie, Torrisi, Raffaella, Heinrichs, Markus, Halfon, Oliver and Chouchena, Oliver. (2010). Closeness in relationships as a mediator between sexual abuse in childhood or adolescence and psychopathological outcome in adulthood. Clinical Psychology and Psychotherapy: an international journal of theory and practice. 17(3), pp. 183 - 195. https://doi.org/10.1002/cpp.650
Effects of intranasal oxytocin on emotional face processing in women
Domes, Gregor, Lischke, Alexander, Berger, Christoph, Grossmann, Annette, Hauenstein, Karlheinz, Heinrichs, Markus and Herpertz, Sabine C.. (2010). Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology. 35(1), pp. 83 - 93. https://doi.org/10.1016/j.psyneuen.2009.06.016
The neural correlates of sex differences in emotional reactivity and emotion regulation
Domes, Gregor, Schulze, L., Böttger, Moritz, Grossmann, Annette, Hauenstein, Karlheinz, Wirtz, Petra H., Heinrichs, Markus and Herpertz, Sabine C.. (2010). The neural correlates of sex differences in emotional reactivity and emotion regulation. Human Brain Mapping. 31(5), pp. 758 - 769. https://doi.org/10.1002/hbm.20903
Maternal cortisol in late pregnancy and hypothalamicpituitaryadrenal reactivity to psychosocial stress postpartum in women
Meinlschmidt, Gunther, Martin, Cyrill, Neumann, Inga D. and Heinrichs, Markus. (2010). Maternal cortisol in late pregnancy and hypothalamicpituitaryadrenal reactivity to psychosocial stress postpartum in women. Stress: the International Journal on the Biology of Stress. 13(2), pp. 163 - 171. https://doi.org/10.3109/10253890903128632
Oxytocin enhances the experience of attachment security
Buchheim, Anna, Heinrichs, Markus, George, Carol, Pokorny, Dan, Koops, Eva, Henningsen, Peter, O'Connor, Mary Frances and Gündel, Harald. (2009). Oxytocin enhances the experience of attachment security. Psychoneuroendocrinology. 34(9), pp. 1417 - 1422. https://doi.org/10.1016/j.psyneuen.2009.04.002
The influence of attachment on perceived stress and cortisol response to acute stress in women sexually abused in childhood or adolescence
Pierrehumbert, Blaise, Torrisi, Raffaella, Glatz, Nathalie, Dimitrova, Nevena, Heinrichs, Markus and Halfon, Oliver. (2009). The influence of attachment on perceived stress and cortisol response to acute stress in women sexually abused in childhood or adolescence. Psychoneuroendocrinology. 34(6), pp. 924 - 938. https://doi.org/10.1016/j.psyneuen.2009.01.006
The level of physical activity affects adrenal and cardiovascular reactivity to psychosocial stress
Rimmele, Ulrike, Seiler, Roland, Marti, Bernard, Wirtz, Petra H., Ehlert, Ulrike and Heinrichs, Markus. (2009). The level of physical activity affects adrenal and cardiovascular reactivity to psychosocial stress. Psychoneuroendocrinology. 34(2), pp. 190 - 198. https://doi.org/10.1016/j.psyneuen.2008.08.023
Oxytocin makes a face in memory familiar
Rimmele, Ulrike, Hediger, Karin, Heinrichs, Markus and Klaver, Peter. (2009). Oxytocin makes a face in memory familiar. Journal of Neuroscience. 29(1), pp. 38 - 42. https://doi.org/10.1523/JNEUROSCI.4260-08.2009
Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict
Ditzen, Beate, Schaer, Marcel, Gabriel, Barbara, Bodenmann, Guy, Ehlert, Ulrike and Heinrichs, Markus. (2009). Intranasal Oxytocin Increases Positive Communication and Reduces Cortisol Levels During Couple Conflict. Biological Psychiatry. 65(9), pp. 728 - 731. https://doi.org/10.1016/j.biopsych.2008.10.011
Glucocorticoids do not reduce subjective fear in healthy subjects exposed to social stress
Soravia, Leila M., De Quervain, Dominique and Heinrichs, Markus. (2009). Glucocorticoids do not reduce subjective fear in healthy subjects exposed to social stress. Biological Psychology. 81(3), pp. 184 - 188. https://doi.org/10.1016/j.biopsycho.2009.04.001
Oxytocin, vasopressin, and human social behavior
Heinrichs, Markus, von Dawans, Bernadette and Domes, Gregor. (2009). Oxytocin, vasopressin, and human social behavior. Frontiers in Neuroendocrinology. 30(4), pp. 548 - 557. https://doi.org/10.1016/j.yfrne.2009.05.005
Adult attachment and social support interact to reduce psychological but not cortisol responses to stress
Ditzen, Beate, Schmidt, Silke, Strauss, Bernhard, Nater, U M., Ehlert, Ulrike and Heinrichs, Markus. (2008). Adult attachment and social support interact to reduce psychological but not cortisol responses to stress. Journal of Psychosomatic Research. 64(5), pp. 479 - 486. https://doi.org/10.1016/j.jpsychores.2007.11.011
Effects of Oxytocin and Prosocial Behavior on Brain Responses to Direct and Vicariously Experienced Pain
Singer, Tania, Snozzi, R., Bird, Geoffrey, Petrovic, Predrag, Silani, G., Heinrichs, Markus and Dolan, Raymond J.. (2008). Effects of Oxytocin and Prosocial Behavior on Brain Responses to Direct and Vicariously Experienced Pain. Emotion. 8(6), pp. 781 - 791. https://doi.org/10.1037/a0014195
Oxytocin Shapes the Neural Circuitry of Trust and Trust Adaptation in Humans
Baumgartner, Thomas, Heinrichs, Markus, Vonlanthen, Aline, Fischbacher, Urs and Fehr, Ernst. (2008). Oxytocin Shapes the Neural Circuitry of Trust and Trust Adaptation in Humans. Neuron. 58(4), pp. 639 - 650. https://doi.org/10.1016/j.neuron.2008.04.009
The acute effects of intranasal oxytocin administration on endocrine and sexual function in males
Burri, Andrea, Heinrichs, Markus, Schedlowski, Manfred and Kruger, T. H. C.. (2008). The acute effects of intranasal oxytocin administration on endocrine and sexual function in males. Psychoneuroendocrinology. 33(5), pp. 591 - 600. https://doi.org/10.1016/j.psyneuen.2008.01.014
Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
Heinrichs, Markus and Domes, Gregor. (2008). Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans. Progress in Brain Research. 170, pp. 337 - 350. https://doi.org/10.1016/S0079-6123(08)00428-7
Oxytocin Improves "Mind-Reading" in Humans
Domes, Gregor, Heinrichs, Markus, Michel, Andre, Berger, Christoph and Herpertz, Sabine C.. (2007). Oxytocin Improves "Mind-Reading" in Humans. Biological Psychiatry. 61(6), pp. 731 - 733. https://doi.org/10.1016/j.biopsych.2006.07.015
Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence
Domes, Gregor, Heinrichs, Markus, Gläscher, Jan, Büchel, Christian, Braus, Dieter F. and Herpertz, Sabine C.. (2007). Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence. Biological Psychiatry. 62(10), pp. 1187 - 1190. https://doi.org/10.1016/j.biopsych.2007.03.025
Neuroendocrine mechanisms of stress and social interaction: Implications for mental disorders
Heinrichs, Markus and Gaab, Jens. (2007). Neuroendocrine mechanisms of stress and social interaction: Implications for mental disorders. Current Opinion in Psychiatry. 20(2), pp. 158 - 162. https://doi.org/10.1097/YCO.0b013e3280146a13
Emotional and cardiovascular reactions of couples during a couple-therapeutic intervention: A pilot study
Schaer, Marcel, Ditzen, Beate, Heinrichs, Markus and Bodenmann, Guy. (2007). Emotional and cardiovascular reactions of couples during a couple-therapeutic intervention: A pilot study. Zeitschrift fuer Klinische Psychologie und Psychotherapie: Forschung und Praxis. 36(4), pp. 251 - 260. https://doi.org/10.1026/1616-3443.36.4.251
Effects of different kinds of couple interaction on cortisol and heart rate responses to stress in women
Ditzen, Beate, Neumann, Inga D., Bodenmann, Guy, von Dawans, Bernadette, Turner, Rebecca A., Ehlert, Ulrike and Heinrichs, Markus. (2007). Effects of different kinds of couple interaction on cortisol and heart rate responses to stress in women. Psychoneuroendocrinology. 32(5), pp. 565 - 574. https://doi.org/10.1016/j.psyneuen.2007.03.011
Trained men show lower cortisol, heart rate and psychological responses to psychosocial stress compared with untrained men
Rimmele, Ulrike, Zellweger, Bea Costa, Marti, Bernard, Seiler, Roland, Mohiyeddini, Changiz, Ehlert, Ulrike and Heinrichs, Markus. (2007). Trained men show lower cortisol, heart rate and psychological responses to psychosocial stress compared with untrained men. Psychoneuroendocrinology. 32(6), pp. 627 - 635. https://doi.org/10.1016/j.psyneuen.2007.04.005
Glucocorticoids reduce phobic fear in humans
Soravia, Leila M., Heinrichs, Markus, Aerni, Amanda, Maroni, Caroline, Schelling, Gustav, Ehlert, Ulrike, Roozendaal, Benno and De Quervain, Dominique. (2006). Glucocorticoids reduce phobic fear in humans. Proceedings of the National Academy of Sciences of USA. 103(14), pp. 5585 - 5590. https://doi.org/10.1073/pnas.0509184103
Oxytocin increases trust in humans
Kosfeld, Michael, Heinrichs, Markus, Zak, Paul J., Fischbacher, Urs and Fehr, Ernst. (2005). Oxytocin increases trust in humans. Nature. 435(7042), pp. 673 - 676. https://doi.org/10.1038/nature03701
Predicting posttraumatic stress symptoms from pretraumatic risk factors: A 2-year prospective follow-up study in firefighters
Heinrichs, Markus, Wagner, D., Schoch, Walter, Soravia, Leila M., Hellhammer, Dirk H. and Ehlert, Ulrike. (2005). Predicting posttraumatic stress symptoms from pretraumatic risk factors: A 2-year prospective follow-up study in firefighters. American Journal of Psychiatry. 162(12), pp. 2276 - 2286. https://doi.org/10.1176/appi.ajp.162.12.2276
Selective amnesic effects of oxytocin on human memory
Heinrichs, Markus, Meinlschmidt, Gunther, Wippich, Werner, Ehlert, Ulrike and Hellhammer, Dirk H.. (2004). Selective amnesic effects of oxytocin on human memory. Physiology & Behavior. 83(1 SPEC. ISS.), pp. 31 - 38. https://doi.org/10.1016/j.physbeh.2004.07.020
Acute stress impairs recognition for positive words - Association with stress-induced cortisol secretion
Domes, Gregor, Heinrichs, Markus, Rimmele, Ulrike, Reichwald, U. and Hautzinger, M.. (2004). Acute stress impairs recognition for positive words - Association with stress-induced cortisol secretion. Stress: the International Journal on the Biology of Stress. 7(3), pp. 173 - 181. https://doi.org/10.1080/10253890412331273213
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Heinrichs, Markus, Baumgartner, Thomas, Kirschbaum, Clemens and Ehlert, Ulrike. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry. 54(12), pp. 1389 - 1398. https://doi.org/10.1016/S0006-3223(03)00465-7
Lactation and stress: Protective effects of breast-feeding in humans
Heinrichs, Markus, Neumann, Inga D. and Ehlert, Ulrike. (2002). Lactation and stress: Protective effects of breast-feeding in humans. Stress: the International Journal on the Biology of Stress. 5(3), pp. 195 - 203. https://doi.org/10.1080/1025389021000010530
Hypothalamic-pituitary-adrenal axis reactivity to psychological stress and memory in middle-aged women: High responders exhibit enhanced declarative memory performance
Domes, Gregor, Heinrichs, Markus, Reichwald, U. and Hautzinger, M.. (2002). Hypothalamic-pituitary-adrenal axis reactivity to psychological stress and memory in middle-aged women: High responders exhibit enhanced declarative memory performance. Psychoneuroendocrinology. 27(7), pp. 843 - 853. https://doi.org/10.1016/S0306-4530(01)00085-3
Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women
Heinrichs, Markus, Meinlschmidt, Gunther, Neumann, Inga D., Wagner, Sabine, Kirschbaum, Clemens, Ehlert, Ulrike and Hellhammer, Dirk H.. (2001). Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women. The Journal of Clinical Endocrinology and Metabolism. 86(10), pp. 4798 - 4804. https://doi.org/10.1210/jc.86.10.4798
Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: The role of the hypothalamus-pituitary-adrenal axis
Ehlert, Ulrike, Gaab, Jens and Heinrichs, Markus. (2001). Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: The role of the hypothalamus-pituitary-adrenal axis. Biological Psychology. 57(43891), pp. 141 - 152. https://doi.org/10.1016/S0301-0511(01)00092-8
Social desirability scores are associated with higher morning cortisol levels in firefighters
Brody, Stuart, Wagner, D., Heinrichs, Markus, James, Alma, Hellhammer, Dirk H. and Ehlert, Ulrike. (2000). Social desirability scores are associated with higher morning cortisol levels in firefighters. Journal of Psychosomatic Research. 49(4), pp. 227 - 228. https://doi.org/10.1016/S0022-3999(00)00169-0
Psychobiological aspects of posttraumatic stress disorder
Ehlert, Ulrike, Wagner, D., Heinrichs, Markus and Heim, Christine. (1999). Psychobiological aspects of posttraumatic stress disorder. Der Nervenarzt: Monatsschrift fuer alle Gebiete nervenaerztlicher Forschung und Praxis. 70(9), pp. 773 - 779. https://doi.org/10.1007/s001150050511
Prevalence of symptoms of posttraumatic stress disorder in German professional firefighters
Wagner, D., Heinrichs, Markus and Ehlert, Ulrike. (1998). Prevalence of symptoms of posttraumatic stress disorder in German professional firefighters. American Journal of Psychiatry. 155(12), pp. 1727 - 1732. https://doi.org/10.1176/ajp.155.12.1727