Diet and biomarkers of Alzheimer's disease : A systematic review and meta-analysis
Journal article
Hill, Edward, Goodwill, Alicia M., Gorelik, Alexandra and Szoeke, Cassandra. (2019). Diet and biomarkers of Alzheimer's disease : A systematic review and meta-analysis. Neurobiology of Aging. 76, pp. 45-52. https://doi.org/10.1016/j.neurobiolaging.2018.12.008
Authors | Hill, Edward, Goodwill, Alicia M., Gorelik, Alexandra and Szoeke, Cassandra |
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Abstract | Alzheimer's disease (AD) risk increases with age and lacks efficacious pharmacological options. Summaries of the existing evidence reveal an association between Mediterranean-style diet adherence and reduced AD incidence; however, no review has investigated this relationship with respect to the hallmark AD biomarkers (tau and beta-amyloid) that manifest decades before clinical symptomatology. MEDLINE, PubMed, PsycINFO, Google Scholar, and SCOPUS databases were systematically searched to identify peer-reviewed articles investigating diet and AD biomarkers in the last 2 decades. Two thousand seven hundred twenty-six records were extracted, quality assessed, and double-blind screened by 2 authors. Fifteen studies met the inclusion criteria and 13 studies found a significant relationship. Of these, 4 studies found a high-glycemic load was related to an increase in AD biomarker burden; 6 found adherence to a Mediterranean or “AD-protective” dietary pattern conferred a reduction in AD biomarker burden. Meta-analysis revealed a small but significant effect of diet on AD biomarkers (β = 0.11 [95% CI 0.04–0.17], p = 0.002). This systematic review supports the notion that diet and nutrition display potential for nonpharmacological AD prevention. |
Keywords | Alzheimer’s disease; biomarkers; Tau; beta-amyloid; diet; nutrition |
Year | 2019 |
Journal | Neurobiology of Aging |
Journal citation | 76, pp. 45-52 |
Publisher | Elsevier Inc. |
ISSN | 0197-4580 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.neurobiolaging.2018.12.008 |
Scopus EID | 2-s2.0-85060203136 |
Research or scholarly | Research |
Page range | 45-52 |
Funder | National Health and Medical Research Council (NHMRC) |
Publication process dates | |
Deposited | 14 May 2021 |
Grant ID | NHMRC/547600 |
NHMRC/1032350 | |
NHMRC/1062133 |
https://acuresearchbank.acu.edu.au/item/8w0x1/diet-and-biomarkers-of-alzheimer-s-disease-a-systematic-review-and-meta-analysis
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