Photobiomodulation of the microbiome : Implications for metabolic and inflammatory diseases

Journal article


Bicknell, Brian, Liebert, Ann, Johnstone, Daniel and Kiat, Hosen. (2019). Photobiomodulation of the microbiome : Implications for metabolic and inflammatory diseases. Lasers in Medical Science. 34(2), pp. 317-327. https://doi.org/10.1007/s10103-018-2594-6
AuthorsBicknell, Brian, Liebert, Ann, Johnstone, Daniel and Kiat, Hosen
Abstract

The human microbiome is intimately associated with human health, with a role in obesity, metabolic diseases such as type 2 diabetes, and divergent diseases such as cardiovascular and neurodegenerative diseases. The microbiome can be changed by diet, probiotics, and faecal transplants, which has flow-on effects to health outcomes. Photobiomodulation has a therapeutic effect on inflammation and neurological disorders (amongst others) and has been reported to influence metabolic disorders and obesity. The aim of this study was to examine the possibility that PBM could influence the microbiome of mice. Mice had their abdomen irradiated with red (660 nm) or infrared (808 nm) low-level laser, either as single or multiple doses, over a 2-week period. Genomic DNA extracted from faecal pellets was pyrosequenced for the 16S rRNA gene. There was a significant (p < 0.05) difference in microbial diversity between PBM- and sham-treated mice. One genus of bacterium (Allobaculum) significantly increased (p < 0.001) after infrared (but not red light) PBM by day 14. Despite being a preliminary trial with small experimental numbers, we have demonstrated for the first time that PBM can alter microbiome diversity in healthy mice and increase numbers of Allobaculum, a bacterium associated with a healthy microbiome. This change is most probably a result of PBMt affecting the host, which in turn influenced the microbiome. If this is confirmed in humans, the possibility exists for PBMt to be used as an adjunct therapy in treatment of obesity and other lifestyle-related disorders, as well as cardiovascular and neurodegenerative diseases. The clinical implications of altering the microbiome using PBM warrants further investigation.

Keywordsphotobiomodulation; microbiome; allobaculum; infrared laser
Year2019
JournalLasers in Medical Science
Journal citation34 (2), pp. 317-327
PublisherSpringer London
ISSN0268-8921
Digital Object Identifier (DOI)https://doi.org/10.1007/s10103-018-2594-6
Scopus EID2-s2.0-85051679125
Research or scholarlyResearch
Page range317-327
FunderNational Health and Medical Research Council (NHMRC)
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online03 Aug 2018
Publication process dates
Accepted16 Jul 2018
Deposited17 May 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8w122/photobiomodulation-of-the-microbiome-implications-for-metabolic-and-inflammatory-diseases

Restricted files

Publisher's version

  • 98
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

The effect of photobiomodulation on the brain during wakefulness and sleep
Moro, Cecile, Valverde, Audrey, Dole, Marjorie, Hoh Kam, Jaimie, Hamilton, Catherine, Liebert, Ann, Bicknell, Brian, Benabid, Alim-Louis, Magistretti, Pierre and Mitrofanis, John. (2022). The effect of photobiomodulation on the brain during wakefulness and sleep. Frontiers in Neuroscience. 16, p. Article 942536. https://doi.org/10.3389/fnins.2022.942536
A potential role for photobiomodulation therapy in disease treatment and prevention in the era of COVID-19
Liebert, Ann, Bicknell, Brian, Markman, Wayne and Kiat, Hosen. (2020). A potential role for photobiomodulation therapy in disease treatment and prevention in the era of COVID-19. Aging and Disease. 11(6), pp. 1352-1362. https://doi.org/10.14336/AD.2020.0901
"Photobiomics" : Can Light, Including Photobiomodulation, Alter the Microbiome?
Liebert, Ann, Bicknell, Brian, Johnstone, Daniel, Gordon, Luke C., Kiat, Hosen and Hamblin, Michael R.. (2019). "Photobiomics" : Can Light, Including Photobiomodulation, Alter the Microbiome? Photobiomodulation, Photomedicine, and Laser Surgery. 37(11), pp. 681-693. https://doi.org/10.1089/photob.2019.4628
A Role for Photobiomodulation in the Prevention of Myocardial Ischemic Reperfusion Injury: A Systematic Review and Potential Molecular Mechanisms
Ann Liebert, Andrew Krause, Neil Goonetilleke, Brian Bicknell and Hosen Kiat. (2017). A Role for Photobiomodulation in the Prevention of Myocardial Ischemic Reperfusion Injury: A Systematic Review and Potential Molecular Mechanisms. Scientific Reports. 7(1), pp. 1-13. https://doi.org/10.1038/srep42386
Protein conformational modulation by photons : A mechanism for laser treatment effects
Liebert, Ann, Bicknell, Brian and Adams, Roger. (2014). Protein conformational modulation by photons : A mechanism for laser treatment effects. Medical Hypotheses. 82(3), pp. 275 - 281. https://doi.org/10.1016/j.mehy.2013.12.009
Prion protein signalling in the nervous system: A review and perspective
Liebert, Ann, Bicknell, Brian and Adams, Roger. (2014). Prion protein signalling in the nervous system: A review and perspective. Signal Transduction Insights. 3(32), pp. 11 - 32. https://doi.org/10.4137/STI.S12319
Quantification of the absorption of low-level 904nm super pulsed laser light as a function of skin colour
Liebert, Ann, Waddington, Gordon, Bicknell, Brian, Chow, R. and Adams, Roger. (2013). Quantification of the absorption of low-level 904nm super pulsed laser light as a function of skin colour. In E-L Laasko and C Young (Ed.). 10th World Association for Laser Therapy Congress WALT. Italy: Medimond. pp. 11 - 16
Mosquito Consumption by Insectivorous Bats : Does size matter?
Gonsalves, Leroy, Bicknell, Brian, Law, Bradley, Webb, Cameron and Monamy, Vaughan. (2013). Mosquito Consumption by Insectivorous Bats : Does size matter? PLoS ONE. https://doi.org/10.1371/journal.pone.0077183
The role of channelopathies in pain and the implications for laser treatment
Liebert, Ann and Bicknell, Brian. (2013). The role of channelopathies in pain and the implications for laser treatment. In E-L Laasko and C Young (Ed.). 9th World Association for Laser Therapy Congress WALT. Italy: Medimond. pp. 33 - 40