Oxytocin modulates the temporal dynamics of resting EEG networks
Journal article
Schiller, Bastian, Koenig, Thomas and Heinrichs, Markus. (2019). Oxytocin modulates the temporal dynamics of resting EEG networks. Scientific Reports. 2019, p. 13418. https://doi.org/10.1038/s41598-019-49636-6
Authors | Schiller, Bastian, Koenig, Thomas and Heinrichs, Markus |
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Abstract | Oxytocin is a key modulator of social interaction, but we possess little knowledge of its underlying effects on neuropsychological processes. We used a spatio-temporal EEG microstates analysis to reveal oxytocin’s effects on the temporal dynamics of intrinsically generated activity in neural networks. Given oxytocin’s known anxiolytic effects, we hypothesized that it increases the temporal stability of the four archetypal EEG resting networks. Eighty-six male participants had received oxytocin or placebo intranasally before we recorded their resting EEG. As hypothesized, oxytocin globally increased the average duration of the four archetypal resting networks and specifically decreased the occurrence and coverage of an autonomic processing-related network to benefit greater coverage of an attention-related network. Moreover, these neurophysiological changes were more pronounced in participants with high anxiety levels and strong subjectively experienced effects of the oxytocin administration. In sum, our study shows that oxytocin reduces rapid switching among neural resting networks by increasing their temporal stability. Specifically, it seems to reduce the brain’s need for preparing the internally-oriented processing of autonomic information, thus enabling the externally-oriented processing of social information. Changes in the temporal dynamics of resting networks might underlie oxytocin’s anxiolytic effects - potentially informing innovative psychobiological treatment strategies. |
Year | 2019 |
Journal | Scientific Reports |
Journal citation | 2019, p. 13418 |
Publisher | NLM (Medline) |
ISSN | 2045-2322 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41598-019-49636-6 |
Scopus EID | 2-s2.0-85072706244 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-9 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 26 Sep 2019 |
Publication process dates | |
Accepted | 29 Aug 2019 |
Deposited | 03 Jun 2021 |
https://acuresearchbank.acu.edu.au/item/8w26y/oxytocin-modulates-the-temporal-dynamics-of-resting-eeg-networks
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Publisher's version
OA_Schiller_2019_Oxytocin_modulates_the_temporal_dynamics_of.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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