No benefit of flat head positioning in early moderate–severe acute ischaemic stroke : A HeadPoST study subgroup analysis
Brunser, Alejandro M., Ouyang, Menglu, Arima, Hisatomi, Lavados, Pablo M., Robinson, Thompson, Muñoz-Venturelli, Paula, Olavarría, Verónica V., Billot, Laurent, Hackett, Marre L., Song, Lili, Middleton, Sandy, Pontes-Neto, Octavio, Lee, Tsong-Hai, Watkins, Caroline and Anderson, Craig S.. (2020) No benefit of flat head positioning in early moderate–severe acute ischaemic stroke : A HeadPoST study subgroup analysis. Stroke and Vascular Neurology. 5(4), pp. 406-409. https://doi.org/10.1136/svn-2020-000387
|Authors||Brunser, Alejandro M., Ouyang, Menglu, Arima, Hisatomi, Lavados, Pablo M., Robinson, Thompson, Muñoz-Venturelli, Paula, Olavarría, Verónica V., Billot, Laurent, Hackett, Marre L., Song, Lili, Middleton, Sandy, Pontes-Neto, Octavio, Lee, Tsong-Hai, Watkins, Caroline and Anderson, Craig S.|
Background: Although the Head Positioning in acute Stroke Trial (HeadPoST) showed no effect of the flat head position (FP; vs sitting up head position (SUP)) on functional outcome, we hypothesised that it could still offer benefits if commenced early in those with acute ischaemic stroke (AIS) of at least moderate severity.
Methods: Subgroup analysis of HeadPoST in participants with National Institutes of Health Stroke Scale (NIHSS) scores ≥7, ≥10 and ≥14, randomised to FP or SUP <4.5 hours of AIS onset on functional outcomes defined by a shift in scores on the modified Rankin scale (mRS) and death/disability (mRS scores 3–6), and any cardiovascular serious adverse event. Logistic regression analyses were undertaken adjusted for study design and baseline risk factors.
Results: There was no significant differential treatment effect in patient subgroups defined by increasing baseline NIHSS scores: adjusted OR and 95% CI for ordinal shift and binary (3–6) mRS scores: for NIHSS ≥7 (n=867) 0.92 (0.67 to 1.25) and 0.74 (0.52 to 1.04); NIHSS ≥ 10 (n=606) 0.80 (0.58 to 1.10) and 0.77 (0.49 to 1.19); NIHSS ≥14 (n=378) 0.82 (0.54 to 1.24) and 1.22 (0.69 to 2.14).
Conclusions: Early FP had no significant effect in patients with moderate–severe AIS.
Trial registration number: NCT02162017.
|Journal||Stroke and Vascular Neurology|
|Journal citation||5 (4), pp. 406-409|
|Publisher||BMJ Publishing Group Limited|
|Digital Object Identifier (DOI)||https://doi.org/10.1136/svn-2020-000387|
|Open access||Published as ‘gold’ (paid) open access|
|Research or scholarly||Research|
File Access Level
|Online||25 Jun 2020|
|Publication process dates|
|Accepted||28 May 2020|
|Deposited||03 Jun 2021|
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