Pathways to functional outcomes in schizophrenia spectrum disorders : Meta-analysis of social cognitive and neurocognitive predictors
Journal article
Halverson, Tate F., Orleans-Pobee, Maku, Merritt, Carrington, Sheeran, Paschal, Fett, Anne-Kathrin and Penn, David L.. (2019). Pathways to functional outcomes in schizophrenia spectrum disorders : Meta-analysis of social cognitive and neurocognitive predictors. Neuroscience and Biobehavioral Reviews. 105, pp. 212-219. https://doi.org/10.1016/j.neubiorev.2019.07.020
Authors | Halverson, Tate F., Orleans-Pobee, Maku, Merritt, Carrington, Sheeran, Paschal, Fett, Anne-Kathrin and Penn, David L. |
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Abstract | The current meta-analysis explored relationships between functional outcomes in schizophrenia spectrum disorders and different domains of neurocognition and social cognition. Literature searches were conducted in PsycINFO, PubMed, and ProQuest to identify articles reporting correlations between cognition domains and functional outcomes. Of 1361 articles identified, 166 met all inclusion criteria (12,868 participants; 518 correlations). Fifty-three random-effects meta-analyses yielded mean correlation estimates for relationships between neurocognition and social cognition and functional outcomes. Overall, associations between social cognition and neurocognition, and functional outcomes demonstrated significant small-to-medium effect sizes. Social cognition explained more unique variance in functioning than neurocognition (7.3% vs. 4.4%; 9.2% total average variance). Social cognition also mediated the relationship between neurocognition and functional outcomes. A significant proportion of the variance in the relationships between cognition and functional outcomes remained unexplained. These findings suggest that integrated interventions targeting both neurocognition and social cognition may optimally improve functional outcomes. Standardized measurement of cognition and functioning, longitudinal studies, and tests of additional moderators (e.g., first episode samples) in future research were identified as important future directions. |
Keywords | schizophrenia; psychosis; functional outcome; community functioning; quality of life; social cognition; neurocognition |
Year | 2019 |
Journal | Neuroscience and Biobehavioral Reviews |
Journal citation | 105, pp. 212-219 |
Publisher | Elsevier Ltd |
ISSN | 0149-7634 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.neubiorev.2019.07.020 |
Scopus EID | 2-s2.0-85070797445 |
Research or scholarly | Research |
Page range | 212-219 |
Author's accepted manuscript | License File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 12 Aug 2019 |
Publication process dates | |
Accepted | 28 Jul 2019 |
Deposited | 03 Jun 2021 |
https://acuresearchbank.acu.edu.au/item/8w279/pathways-to-functional-outcomes-in-schizophrenia-spectrum-disorders-meta-analysis-of-social-cognitive-and-neurocognitive-predictors
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Author's accepted manuscript
AM_Halverson_2019_Pathways_to_functional_outcomes_in_schizophrenia.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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