Relating exercise-induced desaturation and gas-exchange in pulmonary artery hypertension

Journal article


Balmain, Bryce N., Seale, Helen, Harris, Julie, Hall, Kathleen, Lin, Aaron C. W., Sabapathy, Surendran and Morris, Norman R.. (2019) Relating exercise-induced desaturation and gas-exchange in pulmonary artery hypertension. Respiratory Physiology & Neurobiology. 259, pp. 58-62. https://doi.org/10.1016/j.resp.2018.07.008
AuthorsBalmain, Bryce N., Seale, Helen, Harris, Julie, Hall, Kathleen, Lin, Aaron C. W., Sabapathy, Surendran and Morris, Norman R.
Abstract

We measured pulmonary gas exchange during six minute walk test (6MWT) in patients with idiopathic (IPAH) and congenital heart disease-related pulmonary hypertension (CHDPH), and determined the relationship between the degree of desaturation and changes in minute ventilation to carbon dioxide production and end-tidal partial pressure for carbon dioxide (PetCO2) in both groups. Fifty-two patients (IPAH, n = 28; CHDPH, n = 24) completed 6MWT with simultaneous pulmonary gas exchange. Whilst no significant difference in six minute walk distance was observed between groups (IPAH: 529 ± 89; CHDPH: 476 ± 119 m, p = 0.10), oxygen uptake, carbon dioxide production, and minute ventilation were higher in IPAH than CHDPH (p < 0.01). In addition, CHDPH desaturated to a greater extent than IPAH with a lower post-6MWT SPO2 (IPAH: 92.3 ± 7.9; CHDPH: 73.3 ± 14.9%, p < 0.01). The change in SpO2 correlated to the change in (r=−0.44, p = 0.02) and PetCO2 (r = 0.49, p < 0.01) for CHDPH, but not IPAH. The exercise-induced hypoxic stimulus during 6MWT in CHDPH may be associated with an enhanced ventilatory response.

Keywordspulmonary rehabilitation; pulmonary circulation; rare lung diseases; respiratory structure/function; ventilation
Year2019
JournalRespiratory Physiology & Neurobiology
Journal citation259, pp. 58-62
PublisherElsevier BV
ISSN1569-9048
Digital Object Identifier (DOI)https://doi.org/10.1016/j.resp.2018.07.008
Scopus EID2-s2.0-85050808080
Research or scholarlyResearch
Page range58-62
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online23 Jul 2018
Publication process dates
Accepted23 Jul 2018
Deposited04 Jun 2021
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