Relating exercise-induced desaturation and gas-exchange in pulmonary artery hypertension

Journal article

Balmain, Bryce N., Seale, Helen, Harris, Julie, Hall, Kathleen, Lin, Aaron C. W., Sabapathy, Surendran and Morris, Norman R.. (2019). Relating exercise-induced desaturation and gas-exchange in pulmonary artery hypertension. Respiratory Physiology & Neurobiology. 259, pp. 58-62. https://doi.org/10.1016/j.resp.2018.07.008
AuthorsBalmain, Bryce N., Seale, Helen, Harris, Julie, Hall, Kathleen, Lin, Aaron C. W., Sabapathy, Surendran and Morris, Norman R.
Abstract

We measured pulmonary gas exchange during six minute walk test (6MWT) in patients with idiopathic (IPAH) and congenital heart disease-related pulmonary hypertension (CHDPH), and determined the relationship between the degree of desaturation and changes in minute ventilation to carbon dioxide production and end-tidal partial pressure for carbon dioxide (PetCO2) in both groups. Fifty-two patients (IPAH, n = 28; CHDPH, n = 24) completed 6MWT with simultaneous pulmonary gas exchange. Whilst no significant difference in six minute walk distance was observed between groups (IPAH: 529 ± 89; CHDPH: 476 ± 119 m, p = 0.10), oxygen uptake, carbon dioxide production, and minute ventilation were higher in IPAH than CHDPH (p < 0.01). In addition, CHDPH desaturated to a greater extent than IPAH with a lower post-6MWT SPO2 (IPAH: 92.3 ± 7.9; CHDPH: 73.3 ± 14.9%, p < 0.01). The change in SpO2 correlated to the change in (r=−0.44, p = 0.02) and PetCO2 (r = 0.49, p < 0.01) for CHDPH, but not IPAH. The exercise-induced hypoxic stimulus during 6MWT in CHDPH may be associated with an enhanced ventilatory response.

Keywordspulmonary rehabilitation; pulmonary circulation; rare lung diseases; respiratory structure/function; ventilation
Year2019
JournalRespiratory Physiology & Neurobiology
Journal citation259, pp. 58-62
PublisherElsevier B.V.
ISSN1569-9048
Digital Object Identifier (DOI)https://doi.org/10.1016/j.resp.2018.07.008
Scopus EID2-s2.0-85050808080
Research or scholarlyResearch
Page range58-62
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online23 Jul 2018
Publication process dates
Accepted23 Jul 2018
Deposited04 Jun 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8w294/relating-exercise-induced-desaturation-and-gas-exchange-in-pulmonary-artery-hypertension

Log in to edit

Restricted files

Publisher's version

  • 81
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Physiotherapist perspectives of airway clearance techniques in bronchiectasis
Franks, Lisa J., Walsh, James R., Hall, Kathleen, Adsett, Julie A. and Morris, Norman R.. (2023). Physiotherapist perspectives of airway clearance techniques in bronchiectasis. Physiotherapy Theory and Practice. 39(4), pp. 785-793. https://doi.org/10.1080/09593985.2022.2028326
Evaluation of the inclusion of an allied health assistant within an adult cystic fibrosis centre : Their role, scope of practice, and impact on physiotherapy services
Hall, Kathleen. (2022). Evaluation of the inclusion of an allied health assistant within an adult cystic fibrosis centre : Their role, scope of practice, and impact on physiotherapy services [PhD Thesis]. Australian Catholic University https://doi.org/10.26199/acu.90096
Patient perspectives of airway clearance techniques in bronchiectasis
Franks, Lisa J., Walsh, James R., Hall, Kathleen, Adsett, Julie A. and Morris, Norman R.. (2022). Patient perspectives of airway clearance techniques in bronchiectasis. Physiotherapy Theory and Practice. pp. 1-11. https://doi.org/10.1080/09593985.2022.2126741
Benchmarking service provision, scope of practice, and skill mix for physiotherapists in adult cystic fibrosis care delivery
Hall, Kathleen, Maxwell, Lyndal, Cobb, Robyn, Chambers, Rebecca, Roll, Mark, Bell, Scott C. and Kuys, Suzanne. (2022). Benchmarking service provision, scope of practice, and skill mix for physiotherapists in adult cystic fibrosis care delivery. Physiotherapy Theory and Practice. 38(4), pp. 572-578. https://doi.org/10.1080/09593985.2020.1777606
Physiotherapy service provision in a specialist adult cystic fibrosis service : A pre-post design study with the inclusion of an allied health assistant
Hall, Kathleen, Maxwell, Lyndal, Cobb, Robyn, Steele, Michael, Chambers, Rebecca, Roll, Mark, Bell, Scott Cameron and Kuys, Suzanne. (2021). Physiotherapy service provision in a specialist adult cystic fibrosis service : A pre-post design study with the inclusion of an allied health assistant. Chronic Respiratory Disease. 18, pp. 1-10. https://doi.org/10.1177/14799731211017895
Measuring airway clearance outcomes in bronchiectasis : A review
Franks, Lisa J., Walsh, James R., Hall, Kathleen and Morris, Norman R.. (2020). Measuring airway clearance outcomes in bronchiectasis : A review. European Respiratory Review. 29(156), p. 190161. https://doi.org/10.1183/16000617.0161-2019
Exercise is commonly used as a substitute for traditional airway clearance techniques by adults with cystic fibrosis in Australia : A survey
Ward, Nathan, Stiller, Kathy, Holland, Anne E., Australian Cystic Fibrosis Exercise Survey group and Hall, Kathleen. (2019). Exercise is commonly used as a substitute for traditional airway clearance techniques by adults with cystic fibrosis in Australia : A survey. Journal of Physiotherapy. 65(1), pp. 43-50. https://doi.org/10.1016/j.jphys.2018.11.006
Comparing the performance characteristics of different positive expiratory pressure devices
Franks, Lisa J., Walsh, James R., Hall, Kathleen, Jacuinde, Guillermo, Yerkovich, Stephanie and Morris, Norman R.. (2019). Comparing the performance characteristics of different positive expiratory pressure devices. Respiratory Care. 64(4), pp. 434-444. https://doi.org/10.4187/respcare.06410
Gas exchange responses during 6-min walk test in patients with pulmonary arterial hypertension
Morris, Norman R., Seale, Helen, Harris, Julie, Hall, Kathleen, Lin, Aaron C. W. and Kermeen, Fiona. (2017). Gas exchange responses during 6-min walk test in patients with pulmonary arterial hypertension. Respirology. 22(1), pp. 165 - 171. https://doi.org/10.1111/resp.12868
Physiotherapy for cystic fibrosis in Australia and New Zealand: A clinical practice guideline
Button, Brenda M., Wilson, Christine, Dentice, Ruth, Cox, Narelle S., Middleton, Anna, Tannenbaum, Esta, Bishop, Jennifer, Cobb, Robyn, Burton, Kate, Wood, Michelle, Moran, Fiona, Black, Ryan, Bowen, Summar, Day, Rosemary, Depiazzi, Julie, Doiron, Katherine, Doumit, Michael, Dwyer, Tiffany, Elliot, Alison, ... Holland, Anne E.. (2016). Physiotherapy for cystic fibrosis in Australia and New Zealand: A clinical practice guideline. Respirology. 21(4), pp. 656 - 667. https://doi.org/10.1111/resp.12764
The challenge of establishing, growing and sustaining a large biobank. A personal perspective
McQueen, M. J., Keys, J. L., Bamford, K. and Hall, Kathleen. (2014). The challenge of establishing, growing and sustaining a large biobank. A personal perspective. Clinical Biochemistry. 47(4 - 5), pp. 239 - 244. https://doi.org/10.1016/j.clinbiochem.2013.11.017
Gaming console exercise and cycle or treadmill exercise provide similar cardiovascular demand in adults with cystic fibrosis : A randomised cross-over trial
Kuys, Suzanne, Hall, Kathleen, Peasey, Maureen, Wood, Michelle, Cobb, Robyn and Bell, Scott. (2011). Gaming console exercise and cycle or treadmill exercise provide similar cardiovascular demand in adults with cystic fibrosis : A randomised cross-over trial. Journal of Physiotherapy. 57(1), pp. 35 - 40. https://doi.org/10.1016/S1836-9553(11)70005-4