Relating exercise-induced desaturation and gas-exchange in pulmonary artery hypertension
Journal article
Balmain, Bryce N., Seale, Helen, Harris, Julie, Hall, Kathleen, Lin, Aaron C. W., Sabapathy, Surendran and Morris, Norman R.. (2019). Relating exercise-induced desaturation and gas-exchange in pulmonary artery hypertension. Respiratory Physiology & Neurobiology. 259, pp. 58-62. https://doi.org/10.1016/j.resp.2018.07.008
Authors | Balmain, Bryce N., Seale, Helen, Harris, Julie, Hall, Kathleen, Lin, Aaron C. W., Sabapathy, Surendran and Morris, Norman R. |
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Abstract | We measured pulmonary gas exchange during six minute walk test (6MWT) in patients with idiopathic (IPAH) and congenital heart disease-related pulmonary hypertension (CHDPH), and determined the relationship between the degree of desaturation and changes in minute ventilation to carbon dioxide production and end-tidal partial pressure for carbon dioxide (PetCO2) in both groups. Fifty-two patients (IPAH, n = 28; CHDPH, n = 24) completed 6MWT with simultaneous pulmonary gas exchange. Whilst no significant difference in six minute walk distance was observed between groups (IPAH: 529 ± 89; CHDPH: 476 ± 119 m, p = 0.10), oxygen uptake, carbon dioxide production, and minute ventilation were higher in IPAH than CHDPH (p < 0.01). In addition, CHDPH desaturated to a greater extent than IPAH with a lower post-6MWT SPO2 (IPAH: 92.3 ± 7.9; CHDPH: 73.3 ± 14.9%, p < 0.01). The change in SpO2 correlated to the change in (r=−0.44, p = 0.02) and PetCO2 (r = 0.49, p < 0.01) for CHDPH, but not IPAH. The exercise-induced hypoxic stimulus during 6MWT in CHDPH may be associated with an enhanced ventilatory response. |
Keywords | pulmonary rehabilitation; pulmonary circulation; rare lung diseases; respiratory structure/function; ventilation |
Year | 2019 |
Journal | Respiratory Physiology & Neurobiology |
Journal citation | 259, pp. 58-62 |
Publisher | Elsevier B.V. |
ISSN | 1569-9048 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.resp.2018.07.008 |
Scopus EID | 2-s2.0-85050808080 |
Research or scholarly | Research |
Page range | 58-62 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 23 Jul 2018 |
Publication process dates | |
Accepted | 23 Jul 2018 |
Deposited | 04 Jun 2021 |
https://acuresearchbank.acu.edu.au/item/8w294/relating-exercise-induced-desaturation-and-gas-exchange-in-pulmonary-artery-hypertension
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