Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits

Journal article


Parkes, Linden, Tiego, Jeggan, Aquino, Kevin, Braganza, Leah, Chamberlain, Samuel R., Fontenelle, Leonardo F., Harrison, Ben J., Lorenzetti, Valentina, Paton, Bryan, Razi, Adeel, Fornito, Alex and Yücel, Murat. (2019) Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits. NeuroImage. 202, p. 116070. https://doi.org/10.1016/j.neuroimage.2019.116070
AuthorsParkes, Linden, Tiego, Jeggan, Aquino, Kevin, Braganza, Leah, Chamberlain, Samuel R., Fontenelle, Leonardo F., Harrison, Ben J., Lorenzetti, Valentina, Paton, Bryan, Razi, Adeel, Fornito, Alex and Yücel, Murat
Abstract

Individual differences in impulsivity and compulsivity is thought to underlie vulnerability to a broad range of disorders and are closely tied to cortical-striatal-thalamic-cortical function. However, whether impulsivity and compulsivity in clinical disorders is continuous with the healthy population and explains cortical-striatal-thalamic-cortical dysfunction across different disorders remains unclear. Here, we characterized the relationship between cortical-striatal-thalamic-cortical effective connectivity, estimated using dynamic causal modelling of resting-state functional magnetic resonance imaging data, and dimensional phenotypes of impulsivity and compulsivity in two symptomatically distinct but phenotypically related disorders, obsessive-compulsive disorder and gambling disorder. 487 online participants provided data for modelling of dimensional phenotypes. These data were combined with 34 obsessive-compulsive disorder patients, 22 gambling disorder patients, and 39 healthy controls, who underwent functional magnetic resonance imaging. Three core dimensions were identified: disinhibition, impulsivity, and compulsivity. Patients’ scores on these dimensions were continuously distributed with the healthy participants, supporting a continuum model of psychopathology. Across all participants, higher disinhibition correlated with lower bottom-up connectivity in the dorsal circuit and greater bottom-up connectivity in the ventral circuit, and higher compulsivity correlated with lower bottom-up connectivity in the dorsal circuit. In patients, higher clinical severity was also linked to lower bottom-up connectivity in the dorsal circuit, but these findings were independent of phenotypic variation, demonstrating convergence towards behaviourally and clinically relevant changes in brain dynamics. Effective connectivity did not differ as a function of traditional diagnostic labels and only weak associations were observed for functional connectivity measures. Together, our results demonstrate that cortical-striatal-thalamic-cortical dysfunction across obsessive-compulsive disorder and gambling disorder may be better characterized by dimensional phenotypes than diagnostic comparisons, supporting investigation of quantitative liability phenotypes.

Keywordsimpulsivity; compulsivity; disinhibition; OCD; GD; DCM
Year2019
JournalNeuroImage
Journal citation202, p. 116070
PublisherElsevier BV
ISSN1053-8119
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neuroimage.2019.116070
Scopus EID2-s2.0-85070696222
Research or scholarlyResearch
Page range1-10
FunderAustralian Research Council
Publisher's version
License
All rights reserved
File Access Level
Controlled
Publication process dates
Deposited09 Jun 2021
ARC Funded ResearchThis output has been funded, wholly or partially, under the Australian Research Council Act 2001
Grant IDARC/DE170100128
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