Simulated microgravity disturbs iron metabolism and distribution in humans : Lessons from dry immersion, an innovative ground-based human model

Journal article


Nay, Kévin, Koechlin-Ramonatxo, Christelle, Rochdi, Sarah, Island, Marie-Laure, Orfila, Luz, Treffel, Loïc, Bareille, Marie-Pierre, Beck, Arnaud, Gauquelin-Koch, Guillemette, Ropert, Martine, Loréal, Olivier and Derbré, Frédéric. (2020). Simulated microgravity disturbs iron metabolism and distribution in humans : Lessons from dry immersion, an innovative ground-based human model. The FASEB Journal. 34(11), pp. 14920-14929. https://doi.org/10.1096/fj.202001199RR
AuthorsNay, Kévin, Koechlin-Ramonatxo, Christelle, Rochdi, Sarah, Island, Marie-Laure, Orfila, Luz, Treffel, Loïc, Bareille, Marie-Pierre, Beck, Arnaud, Gauquelin-Koch, Guillemette, Ropert, Martine, Loréal, Olivier and Derbré, Frédéric
Abstract

The objective of the present study was to determine the effects of dry immersion, an innovative ground-based human model of simulated microgravity and extreme physical inactivity, on iron homeostasis and distribution. Twenty young healthy men were recruited and submitted to 5 days of dry immersion (DI). Fasting blood samples and MRI were performed before and after DI exposure to assess iron status, as well as hematological responses. DI increased spleen iron concentrations (SIC), whereas hepatic iron store (HIC) was not affected. Spleen iron sequestration could be due to the concomitant increase in serum hepcidin levels (P < .001). Increased serum unconjugated bilirubin, as well as the rise of serum myoglobin levels support that DI may promote hemolysis and myolysis. These phenomena could contribute to the concomitant increase of serum iron and transferrin saturation levels (P < .001). As HIC remained unchanged, increased serum hepcidin levels could be due both to higher transferrin saturation level, and to low-grade pro-inflammatory as suggested by the significant rise of serum ferritin and haptoglobin levels after DI (P = .003 and P = .003, respectively). These observations highlight the need for better assessment of iron metabolism in bedridden patients, and an optimization of the diet currently proposed to astronauts.

Keywordsbedrest; erythropoiesis; iron misdistribution; muscle atrophy; spaceflight
Year2020
JournalThe FASEB Journal
Journal citation34 (11), pp. 14920-14929
PublisherJohn Wiley & Sons, Inc.
ISSN0892-6638
Digital Object Identifier (DOI)https://doi.org/10.1096/fj.202001199RR
Scopus EID2-s2.0-85090776813
Research or scholarlyResearch
Page range14920-14929
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online12 Sep 2020
Publication process dates
Accepted25 Aug 2020
Deposited11 Jun 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8w3qy/simulated-microgravity-disturbs-iron-metabolism-and-distribution-in-humans-lessons-from-dry-immersion-an-innovative-ground-based-human-model

Restricted files

Publisher's version

  • 68
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

SGC-CAMKK2-1 : A chemical probe for CAMKK2
Wells, Carrow, Liang, Yi, Pulliam, Thomas L., Lin, Chenchu, Awad, Dominik, Eduful, Benjamin, O’Byrne, Sean, Hossain, Mohammad Anwar, Catta-Preta, Carolina Moura Costa, Ramos, Priscila Zonzini, Gileadi, Opher, Gileadi, Carina, Couñago, Rafael M., Stork, Brittany, Langendorf, Christopher G., Nay, Kevin, Oakhill, Jonathan S., Mukherjee, Debarati, Racioppi, Luigi, ... Drewry, David H.. (2023). SGC-CAMKK2-1 : A chemical probe for CAMKK2. Cells. 12(2), p. Article 287. https://doi.org/10.3390/cells12020287
Oxidative and glycolytic skeletal muscles deploy protective mechanisms to avoid atrophy under pathophysiological iron overload
Martin, David, Nay, Kévin, Robin, François, Rebillard, Amélie, Orfila, Luz, Martin, Brice, Leroyer, Patricia, Guggenbuhl, Pascal, Dufresne, Suzanne, Noirez, Philippe, Ropert, Martine, Loréal, Olivier and Derbré, Frédéric. (2022). Oxidative and glycolytic skeletal muscles deploy protective mechanisms to avoid atrophy under pathophysiological iron overload. Journal of Cachexia, Sarcopenia and Muscle. 13(2), pp. 1250-1261. https://doi.org/10.1002/jcsm.12897
Molecular mechanisms underlying the beneficial effects of exercise on brain function and neurological disorders
Nay, Kévin, Smiles, William J., Kaiser, Jacqueline, McAloon, Luke M., Loh, Kim, Galic, Sandra, Oakhill, Jonathan S., Gundlach, Andrew L. and Scott, John W.. (2021). Molecular mechanisms underlying the beneficial effects of exercise on brain function and neurological disorders. International Journal of Molecular Sciences. 22, p. Article 4052. https://doi.org/10.3390/ijms22084052
Does physical inactivity induce significant changes in human gut microbiota? New answers using the dry immersion hypoactivity model
Jollet, Maxence, Nay, Kevin, Chopard, Angele, Bareille, Marie-Pierre, Beck, Arnaud, Ollendorff, Vincent, Vernus, Barbara, Bonnieu, Anne, Mariadassou, Mahendra, Rué, Olivier, Derbré, Frédéric, Goustard, Bénédicte and Koechlin-Ramonatxo, Christelle. (2021). Does physical inactivity induce significant changes in human gut microbiota? New answers using the dry immersion hypoactivity model. Nutrients. 13(11), p. Article 3865. https://doi.org/10.3390/nu13113865
Hinge binder scaffold hopping identifies potent calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) inhibitor chemotypes
Eduful, Benjamin J., O'Byrne, Sean N., Temme, Louisa, Asquith, Christopher R. M., Liang, Yi, Picado, Alfredo, Pilotte, Joseph R., Hossain, Mohammad Anwar, Wells, Carrow I., Zuercher, William J., Catta-Preta, Carolina M.C, Ramos, Priscila, de S. Santiago, André, Counago, Rafael M., Langendorf, Christopher G., Nay, Kevin, Oakhill, Jonathan S., Pulliam, Thomas L., Lin, Chenchu, ... Drewry, David H.. (2021). Hinge binder scaffold hopping identifies potent calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) inhibitor chemotypes. Journal of Medicinal Chemistry. 64(15), pp. 10849-10877. https://doi.org/10.1021/acs.jmedchem.0c02274
Intermittent reloading does not prevent reduction in iron availability and hepcidin upregulation caused by hindlimb unloading
Nay, Kévin, Martin, David, Orfila, Luz, Saligaut, Dany, Martin, Brice, Horeau, Mathieu, Cavey, Thibaut, Kenawi, Moussa, Island, Marie-Laure, Ropert, Martine, Loréal, Olivier, Koechlin-Ramonatxo, Christelle and Derbré, Frédéric. (2021). Intermittent reloading does not prevent reduction in iron availability and hepcidin upregulation caused by hindlimb unloading. Experimental Physiology. 106(1), pp. 28-36. https://doi.org/10.1113/EP088339
Gut bacteria are critical for optimal muscle function: A potential link with glucose homeostasis
Nay, Kevin, Jollet, Maxence, Goustard, Benedicte, Baati, Narjes, Vernus, Barbara, Pontones, Maria, Lefeuvre-Orfila, Luz, Bendavid, Claude, Rué, Olivier, Mariadassou, Mahendra, Bonnieu, Anne, Ollendorff, Vincent, Lepage, Patricia, Derbré, Frédéric and Koechlin-Ramonatxo, Christelle. (2019). Gut bacteria are critical for optimal muscle function: A potential link with glucose homeostasis. American Journal of Physiology - Endocrinology and Metabolism. 317(1), pp. 158 - 171. https://doi.org/10.1152/ajpendo.00521.2018
Skeletal muscle ceramides do not contribute to physical-inactivity-induced insulin resistance
Appriou, Zéphyra, Nay, Kevin, Pierre, Nicolas, Saligaut, Dany, Lefeuvre-Orfila, Luz, Martin, Brice, Cavey, Thibault, Ropert, Martine, Loréal, Olivier, Rannou-Bekono, Françoise and Derbré, Frédéric. (2019). Skeletal muscle ceramides do not contribute to physical-inactivity-induced insulin resistance. Applied Physiology, Nutrition and Metabolism. 44(11), pp. 1180 - 1188. https://doi.org/10.1139/apnm-2018-0850
Ceruloplasmin deficiency does not induce macrophagic iron overload: Lessons from a new rat model of hereditary aceruloplasminemia
Kenawi, Moussa, Rouger, Emmanuel, Island, Marie-Laure, Leroyer, Patricia, Robin, François, Rémy, Séverine, Tesson, Laurent, Anegon, Ignacio, Nay, Kevin, Derbré, Frédéric, Brissot, Pierre, Ropert, Martine, Cavey, Thibault and Loréal, Olivier. (2019). Ceruloplasmin deficiency does not induce macrophagic iron overload: Lessons from a new rat model of hereditary aceruloplasminemia. The FASEB Journal. 33(12), pp. 13492 - 13502. https://doi.org/10.1096/fj.201901106R
Mitochondrial MDM2 regulates respiratory complex i activity independently of p53
Arena, Giuseppe, Cissé, Madi Yann, Pyrdziak, Samuel, Chatre, Laurent, Riscal, Romain, Fuentes, Maryse, Arnold, Jamie Jon, Kastner, Markus, Gayte, Laurie, Bertrand-Gaday, Christelle, Nay, Kevin, Angebault-Prouteau, Claire, Murray, Kerren, Chabi, Beatrice, Koechlin-Ramonatxo, Christelle, Orsetti, Béatrice, Vincent, Charles, Casas, François, Marine, Jean-Christophe, ... Le Cam, Laurent. (2018). Mitochondrial MDM2 regulates respiratory complex i activity independently of p53. Molecular Cell. 69(4), pp. 594 - 609. https://doi.org/10.1016/j.molcel.2018.01.023