The impact of intrathecal baclofen therapy on health-related quality of life for children with marked hypertonia

Journal article

Stewart, Kirsty, Copeland, Lisa and Lewis, Jennifer. (2020). The impact of intrathecal baclofen therapy on health-related quality of life for children with marked hypertonia. Developmental Neurorehabilitation. 23(8), pp. 542-547. https://doi.org/10.1080/17518423.2020.1753841
AuthorsStewart, Kirsty, Copeland, Lisa and Lewis, Jennifer
Abstract

Purpose: To investigate the effects of intrathecal baclofen therapy (ITB) on health-related quality of life for children with cerebral palsy and neurological conditions.

Method: This study is part of a longitudinal, multicentre audit. The primary outcome measure, the Caregiver Priorities and Child Health Index of Life with Disabilities, was completed at baseline, 6 and 12 months post ITB implant.

Results: Forty subjects with cerebral palsy and other neurological conditions demonstrated significant improvement in aspects of health-related quality of life following ITB therapy, mean change 42.3 (SD 14.9) at baseline to 53.3 (SD 14.7) at 12 months (p< .001).

Conclusion: Evidence to demonstrate the utility of ITB in pediatric populations beyond spasticity and dystonia reduction is limited. Our findings suggest that ITB improves aspects of quality of life, comfort, and ease of caregiving in children with cerebral palsy and other neurological conditions.

Keywordsintrathecal baclofen; cerebral palsy; spasticity; dystonia; quality of life
Year2020
JournalDevelopmental Neurorehabilitation
Journal citation23 (8), pp. 542-547
PublisherTaylor & Francis
ISSN1751-8423
Digital Object Identifier (DOI)https://doi.org/10.1080/17518423.2020.1753841
Scopus EID2-s2.0-85084255200
Research or scholarlyResearch
Page range542-547
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online27 Apr 2020
Publication process dates
Accepted02 Apr 2020
Deposited15 Jun 2021
Supplemental file
License
All rights reserved
File Access Level
Controlled
Additional information

Authored on behalf of the Australian Paediatric ITB Research Group.

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