Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes
Journal article
Dunstan, D., Homer, A., Wheeler, M. and Maniar, N.. (2021). Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes. American Journal of Physiology: Heart and Circulatory Physiology. 320(1), pp. H393-H403. https://doi.org/10.1152/ajpheart.00422.2020
Authors | Dunstan, D., Homer, A., Wheeler, M. and Maniar, N. |
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Abstract | In healthy and overweight/obese adults, interrupting prolonged sitting with activity bouts mitigates impairment in vascular function. However, it is unknown whether these benefits extend to those with type 2 diabetes (T2D), nor whether an optimal frequency of activity interruptions exist. We examined the acute effects on vascular function in T2D of interrupting prolonged sitting with simple resistance activities (SRA) at different frequencies. In a randomized crossover trial, 24 adults with T2D (35−70 yr) completed three 7-h conditions: 1) uninterrupted sitting (SIT), 2) sitting with 3-min bouts of SRA every 30 min (SRA3), and 3) sitting with 6 min bouts of SRA every 60 min (SRA6). Femoral artery flow-mediated dilation (FMD), resting shear rate, blood flow, and endothelin-1 were measured at 0, 1, 3.5, 4.5, and 6.5–7 h. Mean femoral artery FMD over 7 h was significantly higher in SRA3 (4.1 ± 0.3%) compared with SIT (3.7 ± 0.3%, P = 0.04) but not in SRA6. Mean resting femoral shear rate over 7 h was increased significantly for SRA3 (45.3 ± 4.1/s, P < 0.001) and SRA6 (46.2 ± 4.1/s, P < 0.001) relative to SIT (33.1 ± 4.1/s). Endothelin-1 concentrations were not statistically different between conditions. Interrupting sitting with activity breaks every 30 min, but not 60 min, significantly increased mean femoral artery FMD over 7 h, relative to SIT. Our findings suggest that more frequent and shorter breaks may be more beneficial than longer, less frequent breaks for vascular health in those with T2D. |
Keywords | arteries; blood flow; sedentary behavior |
Year | 2021 |
Journal | American Journal of Physiology: Heart and Circulatory Physiology |
Journal citation | 320 (1), pp. H393-H403 |
Publisher | American Physiological Society |
ISSN | 0363-6135 |
Digital Object Identifier (DOI) | https://doi.org/10.1152/ajpheart.00422.2020 |
Scopus EID | 2-s2.0-85100069847 |
Research or scholarly | Research |
Page range | H393-H403 |
Funder | National Health and Medical Research Council (NHMRC) |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 15 Jan 2021 |
01 Jan 2021 | |
Publication process dates | |
Accepted | 28 Oct 2020 |
Deposited | 23 Jun 2021 |
Grant ID | NMHRC/1057608 |
https://acuresearchbank.acu.edu.au/item/8w43y/acute-effects-of-interrupting-prolonged-sitting-on-vascular-function-in-type-2-diabetes
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