Highly increased risk of fracture in patients with myeloproliferative neoplasm
Journal article
Johansson, Peter, Kristjansdottir, Hallgerdur Lind, Johansson, Helena, Jakir, Ana, Mellström, Dan and Lewerin, Cataharina. (2021). Highly increased risk of fracture in patients with myeloproliferative neoplasm. Leukemia and Lymphoma. 62(1), pp. 211-217. https://doi.org/10.1080/10428194.2020.1817437
Authors | Johansson, Peter, Kristjansdottir, Hallgerdur Lind, Johansson, Helena, Jakir, Ana, Mellström, Dan and Lewerin, Cataharina |
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Abstract | The risk for hip and vertebral fracture was determined in 10,752 patients diagnosed with myeloproliferative neoplasms (MPN) in Sweden 1995–2015. The mean follow-up time were 6.34 years. Five percent developed hip fracture and 1.3% a vertebral fracture. There was a significant increased risk for fracture among the MPN patients compared with the Swedish population. The ratio of observed (obs) and expected (exp) number of hip fracture in all MPN patients, polycythemia vera (PV), essential thrombocythemia and MPN undetermined (MPNu) was 1.20 (95% confidence interval (CI): 1.10–1.31), 1.37 (95% CI: 1.19–1.58), 1.02 (95% CI: 0.87–1.19), and 1.28 (95% CI: 1.07–1.52), respectively. Corresponding figures for vertebral fractures were 1.94 (95% CI: 1.64–2.29), 2.09 (95% CI: 1.56–2.75), 1.50 (95% CI: 1.06–2.07) and 2.47 (95% CI: 1.77–3.35), respectively. Patients with MPN had an increased risk of hip and vertebral fracture, especially patients with PV and MPNu in comparison with the entire Swedish population. |
Keywords | myeloproliferative disorders; polycythemia vera; essential; thrombocythemia; fracture |
Year | 2021 |
Journal | Leukemia and Lymphoma |
Journal citation | 62 (1), pp. 211-217 |
Publisher | Taylor & Francis |
ISSN | 1042-8194 |
Digital Object Identifier (DOI) | https://doi.org/10.1080/10428194.2020.1817437 |
Scopus EID | 2-s2.0-85090458040 |
Research or scholarly | Research |
Page range | 211-217 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 10 Sep 2020 |
Publication process dates | |
Accepted | 22 Aug 2020 |
Deposited | 28 Jun 2021 |
https://acuresearchbank.acu.edu.au/item/8w466/highly-increased-risk-of-fracture-in-patients-with-myeloproliferative-neoplasm
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