High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures
Journal article
Zendeli, Afrodite, Bui, Minh, Fischer, Lukas, Ghasem-Zadeh, Ali, Schima, Wolfgang and Seeman, Ego. (2021). High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures. Journal of Clinical Sleep Medicine. 10(5), pp. 1-10. https://doi.org/10.3390/jcm10051123
Authors | Zendeli, Afrodite, Bui, Minh, Fischer, Lukas, Ghasem-Zadeh, Ali, Schima, Wolfgang and Seeman, Ego |
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Abstract | To determine whether stress fractures are associated with bone microstructural deterioration we quantified distal radial and the unfractured distal tibia using high resolution peripheral quantitative computed tomography in 26 cases with lower limb stress fractures (15 males, 11 females; mean age 37.1 ± 3.1 years) and 62 age-matched healthy controls (24 males, 38 females; mean age 35.0 ± 1.6 years). Relative to controls, in men, at the distal radius, cases had smaller cortical cross sectional area (CSA) (p = 0.012), higher porosity of the outer transitional zone (OTZ) (p = 0.006), inner transitional zone (ITZ) (p = 0.043) and the compact-appearing cortex (CC) (p = 0.023) while trabecular vBMD was lower (p = 0.002). At the distal tibia, cases also had a smaller cortical CSA (p = 0.008). Cortical porosity was not higher, but trabecular vBMD was lower (p = 0.001). Relative to controls, in women, cases had higher distal radial porosity of the OTZ (p = 0.028), ITZ (p = 0.030) not CC (p = 0.054). Trabecular vBMD was lower (p = 0.041). Distal tibial porosity was higher in the OTZ (p = 0.035), ITZ (p = 0.009), not CC. Stress fractures are associated with compromised cortical and trabecular microstructure. |
Keywords | bone microstructural deterioration; cortical porosity; high resolution peripheral quantitative computed tomography; stress fracture |
Year | 2021 |
Journal | Journal of Clinical Sleep Medicine |
Journal citation | 10 (5), pp. 1-10 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI AG) |
ISSN | 2077-0383 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/jcm10051123 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-10 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 08 Mar 2021 |
Publication process dates | |
Accepted | 01 Mar 2021 |
Deposited | 06 Jul 2021 |
https://acuresearchbank.acu.edu.au/item/8w515/high-cortico-trabecular-transitional-zone-porosity-and-reduced-trabecular-density-in-men-and-women-with-stress-fractures
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Publisher's version
OA_Zendeli_2021_High_cortico_trabecular_transitional_zone_porosity.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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