Prostate cancer and asbestos : A systematic review and meta-analysis
Dutheil, Frédéric, Zaragoza-Civale, Laetitia, Pereira, Bruno, Mermillod, Martial, Baker, Julien S., Schmidt, Jeannot, Moustafa, Fares and Navel, Valentin. (2020). Prostate cancer and asbestos : A systematic review and meta-analysis. The Permanente Journal. 24, pp. 1-10. https://doi.org/10.7812/TPP/19.086
|Authors||Dutheil, Frédéric, Zaragoza-Civale, Laetitia, Pereira, Bruno, Mermillod, Martial, Baker, Julien S., Schmidt, Jeannot, Moustafa, Fares and Navel, Valentin|
Introduction: Asbestos-related diseases and cancers represent a major public health concern.
Objective: To conduct a systematic review and meta-analysis to demonstrate that asbestos exposure increases the risk of prostate cancer.
Methods: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched using the keywords (prostate cancer OR prostatic neoplasm) AND (asbestos* OR crocidolite* OR chrysotile* OR amphibole* OR amosite*). To be included, articles needed to describe our primary outcome: Risk of prostate cancer after any asbestos exposure.
Results: We included 33 studies with 15,687 cases of prostate cancer among 723,566 individuals. Asbestos exposure increased the risk of prostate cancer (effect size = 1.10, 95% confidence interval [CI] = 1.05-1.15). When we considered mode of absorption, respiratory inhalation increased the risk of prostate cancer (1.10, 95% CI = 1.05-1.14). Both environmental and occupational exposure increased the risk of prostate cancer (1.25, 95% CI = 1.01-1.48; and 1.07, 1.04-1.10, respectively). For type of fibers, the amosite group had an increased risk of prostate cancer (1.12, 95% CI = 1.05-1.19), and there were no significant results for the chrysotile/crocidolite group. The risk was higher in Europe (1.12, 95% CI = 1.05-1.19), without significant results in other continents.
Discussion: Asbestos exposure seems to increase prostate cancer risk. The main mechanism of absorption was respiratory. Both environmental and occupational asbestos exposure were linked to increased risk of prostate cancer.
Conclusion: Patients who were exposed to asbestos should possibly be encouraged to complete more frequent prostate cancer screening.
|Keywords||amosite; asbestos; chrysolite; crocidolite; environmental asbestos exposure; occupational asbestos exposure; prostate cancer; work asbestos exposure|
|Journal||The Permanente Journal|
|Journal citation||24, pp. 1-10|
|Digital Object Identifier (DOI)||https://doi.org/10.7812/TPP/19.086|
|Research or scholarly||Research|
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|Deposited||13 Jul 2021|
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