Prostate cancer and asbestos : A systematic review and meta-analysis
Journal article
Dutheil, Frédéric, Zaragoza-Civale, Laetitia, Pereira, Bruno, Mermillod, Martial, Baker, Julien S., Schmidt, Jeannot, Moustafa, Fares and Navel, Valentin. (2020). Prostate cancer and asbestos : A systematic review and meta-analysis. The Permanente Journal. 24, pp. 1-10. https://doi.org/10.7812/TPP/19.086
Authors | Dutheil, Frédéric, Zaragoza-Civale, Laetitia, Pereira, Bruno, Mermillod, Martial, Baker, Julien S., Schmidt, Jeannot, Moustafa, Fares and Navel, Valentin |
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Abstract | Introduction: Asbestos-related diseases and cancers represent a major public health concern. Objective: To conduct a systematic review and meta-analysis to demonstrate that asbestos exposure increases the risk of prostate cancer. Methods: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched using the keywords (prostate cancer OR prostatic neoplasm) AND (asbestos* OR crocidolite* OR chrysotile* OR amphibole* OR amosite*). To be included, articles needed to describe our primary outcome: Risk of prostate cancer after any asbestos exposure. Results: We included 33 studies with 15,687 cases of prostate cancer among 723,566 individuals. Asbestos exposure increased the risk of prostate cancer (effect size = 1.10, 95% confidence interval [CI] = 1.05-1.15). When we considered mode of absorption, respiratory inhalation increased the risk of prostate cancer (1.10, 95% CI = 1.05-1.14). Both environmental and occupational exposure increased the risk of prostate cancer (1.25, 95% CI = 1.01-1.48; and 1.07, 1.04-1.10, respectively). For type of fibers, the amosite group had an increased risk of prostate cancer (1.12, 95% CI = 1.05-1.19), and there were no significant results for the chrysotile/crocidolite group. The risk was higher in Europe (1.12, 95% CI = 1.05-1.19), without significant results in other continents. Discussion: Asbestos exposure seems to increase prostate cancer risk. The main mechanism of absorption was respiratory. Both environmental and occupational asbestos exposure were linked to increased risk of prostate cancer. Conclusion: Patients who were exposed to asbestos should possibly be encouraged to complete more frequent prostate cancer screening. |
Keywords | amosite; asbestos; chrysolite; crocidolite; environmental asbestos exposure; occupational asbestos exposure; prostate cancer; work asbestos exposure |
Year | 2020 |
Journal | The Permanente Journal |
Journal citation | 24, pp. 1-10 |
Publisher | NLM (Medline) |
ISSN | 1552-5775 |
Digital Object Identifier (DOI) | https://doi.org/10.7812/TPP/19.086 |
Scopus EID | 2-s2.0-85080029394 |
Research or scholarly | Research |
Page range | 1-10 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication process dates | |
Deposited | 13 Jul 2021 |
https://acuresearchbank.acu.edu.au/item/8w5w1/prostate-cancer-and-asbestos-a-systematic-review-and-meta-analysis
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