Sex-specific differences in percutaneous coronary intervention outcomes after a cardiac event : A cohort study examining the role of depression, worry and autonomic function

Journal article

O'Neil, Adrienne, Scovelle, Anna J., Thomas, Emma, Russell, Josephine D., Taylor, C. Barr, Hare, David L., Toukhsati, Samia, Oldroyd, John, Rangani, W. P. Thanuja, Dheerasinghe, D. S. Anoja F. and Oldenburg, Brian. (2020). Sex-specific differences in percutaneous coronary intervention outcomes after a cardiac event : A cohort study examining the role of depression, worry and autonomic function. Heart, Lung and Circulation. 29(10), pp. 1449-1458. https://doi.org/10.1016/j.hlc.2020.03.001
AuthorsO'Neil, Adrienne, Scovelle, Anna J., Thomas, Emma, Russell, Josephine D., Taylor, C. Barr, Hare, David L., Toukhsati, Samia, Oldroyd, John, Rangani, W. P. Thanuja, Dheerasinghe, D. S. Anoja F. and Oldenburg, Brian
Abstract

Background
To determine whether differential all-cause hospital readmission exists for men and women 2 years after percutaneous coronary intervention (PCI) treatment for acute coronary syndrome (ACS), and to identify potential autonomic and psychological pathways contributing to this association.

Methods
Four hundred and sixteen (416) patients admitted with ACS were recruited from coronary care wards. Participants attended the study centre at one (T0) and 12 (T1) months following discharge. Heart rate variability (HRV) was used to assess autonomic functioning measured via a three-lead electrocardiogram. Psychological variables of interest (pathological worry, depression and phobic anxiety) were measured using validated self-report questionnaires. Percutaneous coronary intervention treatment data were collected from hospital records. The primary outcome was 2-year all-cause hospital readmission (yes/no). Logistic regression modelling using both complete case analysis and multiple imputation analysis was applied.

Results
Men who received PCI had a significant reduction in the odds of being rehospitalised over the following 2 years, relative to women who did not (OR=0.45, 95% CI=0.20, 0.98). No other group benefited to this extent. Adjustment for age, ACS severity and Very Low Frequency (VLF) Power appeared to strengthen the association in both the complete case analysis and multiple imputation analysis models. The inclusion of depression and worry also marginally explained these associations in the multiple imputation analysis model.

Conclusions
Men who receive PCI after ACS were less likely to be readmitted to hospital over the following 2 years than their female counterparts. The small sample size of women and observational study design limit interpretation of the findings. However, heart rate variability, specifically VLF power, requires further investigation as a driver of such sex-specific outcomes.

Keywordsacute coronary syndrome; percutaneous coronary intervention; psychophysiology; depression; heart rate variability
Year2020
JournalHeart, Lung and Circulation
Journal citation29 (10), pp. 1449-1458
PublisherElsevier Ltd
ISSN1443-9506
Digital Object Identifier (DOI)https://doi.org/10.1016/j.hlc.2020.03.001
Scopus EID2-s2.0-85084473039
Research or scholarlyResearch
Page range1449-1458
FunderNational Health and Medical Research Council (NHMRC)
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online20 Mar 2020
Publication process dates
Accepted04 Mar 2020
Deposited14 Jul 2021
Grant IDNHMRC/1021294
NHMRC/1113920
Permalink -

https://acuresearchbank.acu.edu.au/item/8w5x3/sex-specific-differences-in-percutaneous-coronary-intervention-outcomes-after-a-cardiac-event-a-cohort-study-examining-the-role-of-depression-worry-and-autonomic-function

Log in to edit

Restricted files

Publisher's version

  • 43
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Resting heart rate and heart rate variability in the year following acute coronary syndrome : How do women fare?
Scovelle, Anna J., Oldenburg, Brian, Taylor, C. Barr, Hare, David L., Thomas, Emma E., Toukhsati, Samia R., Oldroyd, John, Russell, Josephine D. and O’Neil, Adrienne. (2021). Resting heart rate and heart rate variability in the year following acute coronary syndrome : How do women fare? Heart, Lung and Circulation. 30(1), pp. 128-134. https://doi.org/10.1016/j.hlc.2020.06.019
The use of journal clubs to teach evidence-based medicine to health professionals : A systematic review and meta-analysis
Ilic, Dragan, de Voogt, Annelies and Oldroyd, John. (2020). The use of journal clubs to teach evidence-based medicine to health professionals : A systematic review and meta-analysis. Journal of Evidence-Based Medicine. 13(1), pp. 42-56. https://doi.org/10.1111/jebm.12370
The relationship between phobic anxiety and 2-year readmission after acute coronary syndrome : What is the role of heart rate variability?
O'Neil, Adrienne, Taylor, C. Barr, Hare, David L., Thomas, Emma, Toukhsati, Samia R., Oldroyd, John, Scovelle, Anna J. and Oldenburg, Brian. (2019). The relationship between phobic anxiety and 2-year readmission after acute coronary syndrome : What is the role of heart rate variability? Journal of Affective Disorders. 247, pp. 73-80. https://doi.org/10.1016/j.jad.2018.12.078
Prevalence of symptomatic pelvic floor disorders in community-dwelling women in low and middle-income countries : A systematic review and meta-analysis
Islam, Rakibul M., Oldroyd, John, Rana, Juwel, Romero, Lorena and Karim, Md Nazmul. (2019). Prevalence of symptomatic pelvic floor disorders in community-dwelling women in low and middle-income countries : A systematic review and meta-analysis. International Urogynecology Journal and Pelvic Floor Dysfunction. 30(12), pp. 2001-2011. https://doi.org/10.1007/s00192-019-03992-z
Evaluating the impact of 2006 Australasian Clinical Practice Guidelines for nutrition in children with cystic fibrosis in Australia
Rasa Ruseckaite, Natalie Pekin, Susannah King, Erin Carr, Susannah Ahern, John Oldroyd, Arul Earnest, Claire Wainwright and David Armstrong. (2018). Evaluating the impact of 2006 Australasian Clinical Practice Guidelines for nutrition in children with cystic fibrosis in Australia. Respiratory Medicine. 142, pp. 7-14. https://doi.org/10.1016/j.rmed.2018.07.007
A group-based lifestyle intervention for diabetes prevention in low- and middle-income country: Implementation evaluation of the Kerala Diabetes Prevention Program
Aziz, Zahra, Mathews, Elezebeth, Absetz, Pilvikki, Sathish, Thirunavukkarasu, Oldroyd, John, Balachandran, Sajitha, Shetty, Suman S., Thankappan, K. R. and Oldenburg, Brian. (2018). A group-based lifestyle intervention for diabetes prevention in low- and middle-income country: Implementation evaluation of the Kerala Diabetes Prevention Program. Implementation Science. 13(1), pp. 1 - 14. https://doi.org/10.1186/s13012-018-0791-0
Systematic review and meta-analysis of prevalence of, and risk factors for, pelvic floor disorders in community-dwelling women in low and middle-income countries : A protocol study
Islam, Rakibul M., Oldroyd, John, Karim, Md Nazmul, Hossain, Sultana Monira, Md Emdadul Hoque, Dewan, Romero, Lorena and Fisher, Jane. (2017). Systematic review and meta-analysis of prevalence of, and risk factors for, pelvic floor disorders in community-dwelling women in low and middle-income countries : A protocol study. BMJ Open. 7(6), p. e015626. https://doi.org/10.1136/bmjopen-2016-015626
Descriptive characteristics and in-hospital mortality of critically bleeding patients requiring massive transfusion: Results from the Australian and New Zealand Massive Transfusion Registry
Ruseckaite, Rasa, McQuilten, Z. K., Oldroyd, John C., Richter, T. H., Cameron, Peter A., Isbister, J. P. and Wood, E. M.. (2017). Descriptive characteristics and in-hospital mortality of critically bleeding patients requiring massive transfusion: Results from the Australian and New Zealand Massive Transfusion Registry. Vox Sanguinis. 112(3), pp. 240 - 248. https://doi.org/10.1111/vox.12487
Barriers to cervical cancer and breast cancer screening uptake in low-income and middle-income countries: A systematic review
Islam, Rakibul M., Billah, Baki, Hossain, Md Nassif and Oldroyd, John. (2017). Barriers to cervical cancer and breast cancer screening uptake in low-income and middle-income countries: A systematic review. Asian Pacific Journal of Cancer Prevention. 18(7), pp. 1751 - 1763. https://doi.org/10.22034/APJCP.2017.18.7.1751
Program evaluation of the inner south community health oral health program for priority populations
Oldroyd, John C., White, Sue, Stephens, Mary, Neil, Andrew A. and Nanayakkara, Vajira. (2017). Program evaluation of the inner south community health oral health program for priority populations. Journal of Health Care for the Poor and Underserved. 28(3), pp. 1222 - 1239. https://doi.org/10.1353/hpu.2017.0107
Prevalence of, and risk factors for, symptomatic pelvic organ prolapse in Rural Bangladesh: A cross-sectional survey study
Akter, Farjana, Gartoulla, Pragya, Oldroyd, John and Islam, Rakibul M.. (2016). Prevalence of, and risk factors for, symptomatic pelvic organ prolapse in Rural Bangladesh: A cross-sectional survey study. International Urogynecology Journal. 27(11), pp. 1753 - 1759. https://doi.org/10.1007/s00192-016-3038-0
Improving outcomes for hospital patients with critical bleeding requiring massive transfusion: The Australian and New Zealand Massive Transfusion Registry study methodology
Oldroyd, John C., Venardos, K. M., Aoki, N. J., Zatta, A. J., McQuilten, Z. K., Phillips, L. E., Andrianopoulos, Nick, Cooper, D. J., Cameron, Peter A., Isbister, J. P. and Wood, E. M.. (2016). Improving outcomes for hospital patients with critical bleeding requiring massive transfusion: The Australian and New Zealand Massive Transfusion Registry study methodology. BMC Research Notes. 9(1), pp. 1 - 10. https://doi.org/10.1186/s13104-016-2261-6
The impact of intensive care in a private hospital on patients aged 80 and over: Health-related quality of life, functional status and burden versus benefit
Levinson, Michele, Mills, A., Oldroyd, John, Gellie, A., Barrett, J., Staples, Margaret and Stephenson, G.. (2016). The impact of intensive care in a private hospital on patients aged 80 and over: Health-related quality of life, functional status and burden versus benefit. Internal Medicine Journal. 46(6), pp. 694 - 702. https://doi.org/10.1111/imj.13079
A systematic review of real-world diabetes prevention programs: Learnings from the last 15 years
Aziz, Zahra, Absetz, Pilvikki, Oldroyd, John, Pronk, Nicolaas P. and Oldenburg, Brian. (2015). A systematic review of real-world diabetes prevention programs: Learnings from the last 15 years. Implementation Science. 10(1), pp. 1 - 17. https://doi.org/10.1186/s13012-015-0354-6
Circulating insulin-like growth factor-binding protein 3 levels, independent of insulin-like growth factor 1, associate with truncal fat and systolic blood pressure in South Asian and white European preschool children
Leena Patel, Andrew Whatmore, Jill Davies, Narinder Bansal, Avni Vyas, Isla Gemmell, John Oldroyd, John Kennedy Cruickshank and Peter Clayton. (2014). Circulating insulin-like growth factor-binding protein 3 levels, independent of insulin-like growth factor 1, associate with truncal fat and systolic blood pressure in South Asian and white European preschool children. Hormone Research in Paediatrics: from developmental endocrinology to clinical research. 81(2), pp. 109-117. https://doi.org/10.1159/000355824
Closing the gap in maternal and child health: A qualitative study examining health needs of migrant mothers in Dandenong, Victoria, Australia
Renzaho, Andre M. N. and Oldroyd, John C.. (2014). Closing the gap in maternal and child health: A qualitative study examining health needs of migrant mothers in Dandenong, Victoria, Australia. Maternal and Child Health Journal. 18(6), pp. 1391 - 1402. https://doi.org/10.1007/s10995-013-1378-7
A focus group study investigating medical decision making in octogenarians of high socioeconomic status with successful outcomes following cardiac surgery
Oldroyd, John C., Levinson, Michele R., Stephenson, Gemma, Rouse, Alice and Leeuwrik, Tina. (2014). A focus group study investigating medical decision making in octogenarians of high socioeconomic status with successful outcomes following cardiac surgery. Australasian Journal on Ageing. 33(3), pp. 174 - 179. https://doi.org/10.1111/ajag.12022