Abnormalities in orbitofrontal cortex gyrification and mental health outcomes in adolescents born extremely preterm and/or at an extremely low birth weight

Journal article


Ganella, Eleni P., Burnett, Alice, Cheong, Jeanie, Thompson, Deanne, Roberts, Gehan, Wood, Stephen, Lee, Katherine, Duff, Julianne, Anderson, Peter J., Pantelis, Christos, Doyle, Lex W., Bartholomeusz, Cali and on behalf of the Victorian Infant Collaborative Study, Group. (2015). Abnormalities in orbitofrontal cortex gyrification and mental health outcomes in adolescents born extremely preterm and/or at an extremely low birth weight. Human Brain Mapping. 36(3), pp. 1138-1150.
AuthorsGanella, Eleni P., Burnett, Alice, Cheong, Jeanie, Thompson, Deanne, Roberts, Gehan, Wood, Stephen, Lee, Katherine, Duff, Julianne, Anderson, Peter J., Pantelis, Christos, Doyle, Lex W., Bartholomeusz, Cali and on behalf of the Victorian Infant Collaborative Study, Group
Abstract

Extremely preterm (EP, <28 weeks) and/or extremely low birth weight (ELBW, <1000 g) infants are at high risk of aberrant neurodevelopment. Sulcogyral folding patterns of the orbitofrontal cortex (OFC) are determined during the third trimester, however little is known about OFC patterning in EP/ELBW cohorts, for whom this gestational period is disturbed. This study investigated whether the distribution of OFC pattern types and frequency of intermediate and/or posterior orbital sulci (IOS/POS) differed between EP/ELBW and control adolescents. This study also investigated whether OFC pattern type was associated with mental illness or executive function outcome in adolescence. Magnetic resonance images of 194 EP/ELBW and 147 full term (>37 completed weeks) and/or normal birth weight (>2500 g) adolescents were acquired, from which the OFC pattern of each hemisphere was classified as Type I, II, or III. Compared with controls, more EP/ELBW adolescents possessed a Type II in the left hemisphere (P = 0.019). The EP/ELBW group had fewer IOS (P = 0.024) and more POS (P = 0.021) in the left hemisphere compared with controls. OFC pattern type was not associated with mental illness, however in terms of executive functioning, Type III in the left hemisphere was associated with better parent-reported metacognition scores overall (P = 0.008) and better self-reported behavioral regulation scores in the control group (P = 0.001) compared with Type I. We show, for the first time that EP/ELBW birth is associated with changes in orbitofrontal development, and that specific patterns of OFC folding are associated with executive function at age 18 years in both EP/ELBW and control subjects. Hum Brain Mapp 36:1138–1150, 2015. © 2014 Wiley Periodicals, Inc.

Keywordsorbitofrontal cortex; extremely preterm; extremely low birth weight; sulcogyral folding patterns; mental illness; executive function
Year2015
JournalHuman Brain Mapping
Journal citation36 (3), pp. 1138-1150
PublisherJohn Wiley & Sons, Ltd
ISSN1065-9471
Scopus EID2-s2.0-84922776908
Research or scholarlyResearch
Page range1138-1150
FunderNational Health and Medical Research Council (NHMRC)
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online19 Nov 2014
Publication process dates
Accepted10 Nov 2014
Deposited27 Jul 2021
Grant IDNHMRC/491246
NHMRC/546519
NHMRC/1053787
NHMRC/1012236
NHMRC/628371
NHMRC/628386
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https://acuresearchbank.acu.edu.au/item/8w6qw/abnormalities-in-orbitofrontal-cortex-gyrification-and-mental-health-outcomes-in-adolescents-born-extremely-preterm-and-or-at-an-extremely-low-birth-weight

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