The variability of MR axon radii estimates in the human white matter
Journal article
Veraart, Jelle, Raven, Erika P., Edwards, Luke J., Weiskopf, Nikolaus and Jones, Derek K.. (2021). The variability of MR axon radii estimates in the human white matter. Human Brain Mapping. 42(7), pp. 2201-2213. https://doi.org/10.1002/hbm.25359
Authors | Veraart, Jelle, Raven, Erika P., Edwards, Luke J., Weiskopf, Nikolaus and Jones, Derek K. |
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Abstract | The noninvasive quantification of axonal morphology is an exciting avenue for gaining understanding of the function and structure of the central nervous system. Accurate non-invasive mapping of micron-sized axon radii using commonly applied neuroimaging techniques, that is, diffusion-weighted MRI, has been bolstered by recent hardware developments, specifically MR gradient design. Here the whole brain characterization of the effective MR axon radius is presented and the inter- and intra-scanner test–retest repeatability and reproducibility are evaluated to promote the further development of the effective MR axon radius as a neuroimaging biomarker. A coefficient-of-variability of approximately 10% in the voxelwise estimation of the effective MR radius is observed in the test–retest analysis, but it is shown that the performance can be improved fourfold using a customized along-tract analysis. |
Keywords | axon diameter; diffusion MRI; reproducibility; variability |
Year | 2021 |
Journal | Human Brain Mapping |
Journal citation | 42 (7), pp. 2201-2213 |
Publisher | John Wiley & Sons |
ISSN | 1065-9471 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/hbm.25359 |
Scopus EID | 2-s2.0-85101002395 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 2201-2213 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 12 Feb 2021 |
Publication process dates | |
Accepted | 21 Jan 2021 |
Deposited | 06 Aug 2021 |
https://acuresearchbank.acu.edu.au/item/8w775/the-variability-of-mr-axon-radii-estimates-in-the-human-white-matter
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Publisher's version
OA_Veraart_2021_The_variability_of_MR_axon_radii.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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