Hitting the sweet spot : A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Journal article


Johnson, Joel B., Mani, Janice S., Broszczak, Daniel, Prasad, Shirtika S., Ekanayake, Charitha P., Strappe, Padraig, Valeris, Peter and Naiker, Mani. (2021). Hitting the sweet spot : A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants. Phytotherapy Research. 35(7), pp. 3484-3508. https://doi.org/10.1002/ptr.7042
AuthorsJohnson, Joel B., Mani, Janice S., Broszczak, Daniel, Prasad, Shirtika S., Ekanayake, Charitha P., Strappe, Padraig, Valeris, Peter and Naiker, Mani
Abstract

Phenolic acid and flavonoid glycosides form a varied class of naturally occurring compounds, characterised by high polarity—resulting from the glycone moiety—and the presence of multiple phenol functionalities, which often leads to strong antioxidant activity. Phenolic glycosides, and in particular flavonoid glycosides, may possess strong bioactive properties with broad spectrum activity. This systematic literature review provides a detailed overview of 28 studies examining the biological activity of phenolic and flavonoid glycosides from plant sources, highlighting the potential of these compounds as therapeutic agents. The activity of glycosides depends upon the biological activity type, identity of the aglycone and the identity and specific location of the glycone moiety. From studies reporting the activity of both glycosides and their respective aglycones, phenolic glycosides appear to generally be a storage/reserve pool of precursors of more bioactive compounds. The glycosylated compounds are likely to be more bioavailable compared to their aglycone forms, due to the presence of the sugar moieties. Hydrolysis of the glycoside in the in vivo environment would release the free aglycone, potentiating their biological activity. However, further high-quality studies are needed to firmly establish the clinical efficacy of glycosides from many of the plant species studied.

Keywordsbioactive compounds; flavonoids; glycosides; phenolics
Year2021
JournalPhytotherapy Research
Journal citation35 (7), pp. 3484-3508
PublisherJohn Wiley & Sons Ltd
ISSN0951-418X
Digital Object Identifier (DOI)https://doi.org/10.1002/ptr.7042
Scopus EID2-s2.0-85101114392
Research or scholarlyResearch
Page range3484-3508
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online21 Feb 2021
Publication process dates
Accepted25 Jan 2021
Deposited08 Aug 2021
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