Hitting the sweet spot : A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants
Journal article
Johnson, Joel B., Mani, Janice S., Broszczak, Daniel, Prasad, Shirtika S., Ekanayake, Charitha P., Strappe, Padraig, Valeris, Peter and Naiker, Mani. (2021). Hitting the sweet spot : A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants. Phytotherapy Research. 35(7), pp. 3484-3508. https://doi.org/10.1002/ptr.7042
Authors | Johnson, Joel B., Mani, Janice S., Broszczak, Daniel, Prasad, Shirtika S., Ekanayake, Charitha P., Strappe, Padraig, Valeris, Peter and Naiker, Mani |
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Abstract | Phenolic acid and flavonoid glycosides form a varied class of naturally occurring compounds, characterised by high polarity—resulting from the glycone moiety—and the presence of multiple phenol functionalities, which often leads to strong antioxidant activity. Phenolic glycosides, and in particular flavonoid glycosides, may possess strong bioactive properties with broad spectrum activity. This systematic literature review provides a detailed overview of 28 studies examining the biological activity of phenolic and flavonoid glycosides from plant sources, highlighting the potential of these compounds as therapeutic agents. The activity of glycosides depends upon the biological activity type, identity of the aglycone and the identity and specific location of the glycone moiety. From studies reporting the activity of both glycosides and their respective aglycones, phenolic glycosides appear to generally be a storage/reserve pool of precursors of more bioactive compounds. The glycosylated compounds are likely to be more bioavailable compared to their aglycone forms, due to the presence of the sugar moieties. Hydrolysis of the glycoside in the in vivo environment would release the free aglycone, potentiating their biological activity. However, further high-quality studies are needed to firmly establish the clinical efficacy of glycosides from many of the plant species studied. |
Keywords | bioactive compounds; flavonoids; glycosides; phenolics |
Year | 2021 |
Journal | Phytotherapy Research |
Journal citation | 35 (7), pp. 3484-3508 |
Publisher | John Wiley & Sons Ltd |
ISSN | 0951-418X |
Digital Object Identifier (DOI) | https://doi.org/10.1002/ptr.7042 |
Scopus EID | 2-s2.0-85101114392 |
Research or scholarly | Research |
Page range | 3484-3508 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 21 Feb 2021 |
Publication process dates | |
Accepted | 25 Jan 2021 |
Deposited | 08 Aug 2021 |
https://acuresearchbank.acu.edu.au/item/8w8y8/hitting-the-sweet-spot-a-systematic-review-of-the-bioactivity-and-health-benefits-of-phenolic-glycosides-from-medicinally-used-plants
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