Cortical thickness and resting-state cardiac function across the lifespan : A cross-sectional pooled mega-analysis
Journal article
Koenig, Julian, Abler, Birgit, Agartz, Ingrid, Åkerstedt, Torbjörn, Andreassen, Ole A., Anthony, Mia, Bär, Karl-Jürgen, Bertsch, Katja, Brown, Rebecca C., Brunner, Romuald, Carnevali, Luca, Critchley, Hugo D., Cullen, Kathryn R., de Geus, Eco J. C., de la Cruz, Feliberto, Dziobek, Isabel, Ferger, Marc D., Fischer, Håkan, Flor, Herta, ... Quintana, Daniel S.. (2021). Cortical thickness and resting-state cardiac function across the lifespan : A cross-sectional pooled mega-analysis. Psychophysiology. 58(7), p. e13688. https://doi.org/10.1111/psyp.13688
Authors | Koenig, Julian, Abler, Birgit, Agartz, Ingrid, Åkerstedt, Torbjörn, Andreassen, Ole A., Anthony, Mia, Bär, Karl-Jürgen, Bertsch, Katja, Brown, Rebecca C., Brunner, Romuald, Carnevali, Luca, Critchley, Hugo D., Cullen, Kathryn R., de Geus, Eco J. C., de la Cruz, Feliberto, Dziobek, Isabel, Ferger, Marc D., Fischer, Håkan, Flor, Herta, Gaebler, Michael, Gianaros, Peter J., Giummarra, Melita J., Greening, Steven G., Guendelman, Simon, Heathers, James A. J., Herpertz, Sabine C., Hu, Mandy X., Jentschke, Sebastian, Kaess, Michael, Kaufmann, Tobias, Klimes-Dougan, Bonnie, Koelsch, Stefan, Krauch, Marlene, Kumral, Deniz, Lamers, Femke, Lee, Tae-Ho, Lekander, Mats, Lin, Feng, Lotze, Martin, Makovac, Elena, Mancini, Matteo, Mancke, Falk, Månsson, Kristoffer N. T., Manuck, Stephen B., Mather, Mara, Meeten, Frances, Min, Jungwon, Mueller, Bryon, Muench, Vera, Nees, Frauke, Nga, Lin, Nilsonne, Gustav, Ordonez Acuna, Daniela, Osnes, Berge, Ottaviani, Cristina, Penninx, Brenda W. J. H., Ponzio, Allison, Poudel, Govinda R., Reinelt, Janis, Ren, Ping, Sakaki, Michiko, Schumann, Andy, Sørensen, Lin, Specht, Karsten, Straub, Joana, Tamm, Sandra, Thai, Michelle, Thayer, Julian F., Ubani, Benjamin, van der Mee, Denise J., van Velzen, Laura S., Ventura-Bort, Carlos, Villringer, Arno, Watson, David R., Wei, Luqing, Wendt, Julia, Schreiner, Melinda Westlund, Westlye, Lars T., Weymar, Mathias, Winkelmann, Tobias, Wu, Guo-Rong, Yoo, Hyun Joo and Quintana, Daniel S. |
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Abstract | Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research. |
Keywords | aging; autonomic nervous system; cortical thickness; heart rate; heart rate variability; sex |
Year | 2021 |
Journal | Psychophysiology |
Journal citation | 58 (7), p. e13688 |
Publisher | Wiley-Blackwell Publishing, Inc. |
ISSN | 0048-5772 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/psyp.13688 |
Scopus EID | 2-s2.0-85092322264 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-16 |
Funder | Australian Research Council (ARC) |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 10 Oct 2020 |
Publication process dates | |
Accepted | 27 Jul 2020 |
Deposited | 09 Aug 2021 |
ARC Funded Research | This output has been funded, wholly or partially, under the Australian Research Council Act 2001 |
Grant ID | ARC/DE170100726 |
https://acuresearchbank.acu.edu.au/item/8w8zv/cortical-thickness-and-resting-state-cardiac-function-across-the-lifespan-a-cross-sectional-pooled-mega-analysis
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Publisher's version
OA_Koenig_2021_Cortical_thickness_and_resting_state_cardiac.pdf | |
License: CC BY-NC 4.0 | |
File access level: Open |
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