Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and exercise

Journal article


Mallard, Alistair R., Spathis, Jemima and Coombes, Jeff S. (2020). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and exercise. Free Radical Biology & Medicine. 160, pp. 471-479. https://doi.org/10.1016/j.freeradbiomed.2020.08.024
AuthorsMallard, Alistair R., Spathis, Jemima and Coombes, Jeff S
Abstract

Chronic metabolic health diseases are increasing worldwide placing strain on healthcare systems and importantly, impacting individuals’ quality of life. It is well established that many chronic diseases are associated with inflammation and oxidative stress. Exercise is a known strategy to manage and treat inflammation in animals and humans. Understanding the mechanisms which cause acute and chronic changes to systems via various exercise protocols may provide insights into how we can better clinically manage patients with inflammatory and oxidative stress associated diseases. Nrf2 is a basic leucine transcription factor which regulates the expression of antioxidant proteins to protect against damage caused by electrophilic or oxidative stress. The aim of this narrative review is to provide an overview of the literature which has investigated the relationship between acute and chronic exercise training and Nrf2 protein, mRNA and Nrf2-ARE binding activity. This narrative review presents analysis of twenty-nine articles presenting studies using animals and humans. Findings from animal models suggest that exercise increases all molecular aspects of the Nrf2-ARE pathway in all tissues studied. It was noted that there seems to be an age-related decline in Nrf2 protein upregulation with exercise training. In humans, however, there is a lack of evidence to support this claim.

Keywordsexercise; resistance exercise; redox control; antioxidant; review; Nrf2; nuclear factor (erythroid-derived 2)-like 2; (Nrf2)
Year2020
JournalFree Radical Biology & Medicine
Journal citation160, pp. 471-479
PublisherElsevier Inc.
ISSN0891-5849
Digital Object Identifier (DOI)https://doi.org/10.1016/j.freeradbiomed.2020.08.024
Scopus EID2-s2.0-85090348320
Research or scholarlyResearch
Page range471-479
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online29 Aug 2020
Publication process dates
Accepted24 Aug 2020
Deposited17 Aug 2021
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