Mapping structural connectivity using diffusion MRI : Challenges and opportunities
Journal article
Yeh, Chun-Hung, Jones, Derek K., Liang, Xiaoyun, Descoteaux, Maxime and Connelly, Alan. (2021). Mapping structural connectivity using diffusion MRI : Challenges and opportunities. Journal of Magnetic Resonance Imaging. 53(6), pp. 1666-1682. https://doi.org/10.1002/jmri.27188
Authors | Yeh, Chun-Hung, Jones, Derek K., Liang, Xiaoyun, Descoteaux, Maxime and Connelly, Alan |
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Abstract | Diffusion MRI-based tractography is the most commonly-used technique when inferring the structural brain connectome, i.e., the comprehensive map of the connections in the brain. The utility of graph theory—a powerful mathematical approach for modeling complex network systems—for analyzing tractography-based connectomes brings important opportunities to interrogate connectome data, providing novel insights into the connectivity patterns and topological characteristics of brain structural networks. When applying this framework, however, there are challenges, particularly regarding methodological and biological plausibility. This article describes the challenges surrounding quantitative tractography and potential solutions. In addition, challenges related to the calculation of global network metrics based on graph theory are discussed.Evidence Level: 5Technical Efficacy: Stage 1 |
Keywords | diffusion MRI; tractography; structural connectome; connectomics; graph theoretical analysis; network metrics |
Year | 2021 |
Journal | Journal of Magnetic Resonance Imaging |
Journal citation | 53 (6), pp. 1666-1682 |
Publisher | John Wiley & Sons, Inc. |
ISSN | 1053-1807 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/jmri.27188 |
Scopus EID | 2-s2.0-85086736432 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1666-1682 |
Funder | National Health and Medical Research Council (NHMRC) |
Australian Research Council (ARC) | |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 17 Jun 2020 |
Publication process dates | |
Accepted | 21 Apr 2020 |
Deposited | 20 Aug 2021 |
https://acuresearchbank.acu.edu.au/item/8w9yw/mapping-structural-connectivity-using-diffusion-mri-challenges-and-opportunities
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