Neuroanatomical alterations in people with high and low cannabis dependence

Journal article


Lorenzetti, Valentina, Chye, Yann, Suo, Chao, Walterfang, Mark, Lubman, Dan I., Takagi, Michael, Whittle, Sarah, Verdejo-Garcia, Antonio, Cousijn, Janna, Pantelis, Christos, Seal, Marc, Fornito, Alex, Yücel, Murat and Solowij, Nadia. (2020). Neuroanatomical alterations in people with high and low cannabis dependence. Australian and New Zealand Journal of Psychiatry. 54(1), pp. 68-75. https://doi.org/10.1177/0004867419859077
AuthorsLorenzetti, Valentina, Chye, Yann, Suo, Chao, Walterfang, Mark, Lubman, Dan I., Takagi, Michael, Whittle, Sarah, Verdejo-Garcia, Antonio, Cousijn, Janna, Pantelis, Christos, Seal, Marc, Fornito, Alex, Yücel, Murat and Solowij, Nadia
Abstract

Objectives:
We aimed to investigate whether severity of cannabis dependence is associated with the neuroanatomy of key brain regions of the stress and reward brain circuits.

Methods:
To examine dependence-specific regional brain alterations, we compared the volumes of regions relevant to reward and stress, between high-dependence cannabis users (CD+, n = 25), low-dependence cannabis users (CD−, n = 20) and controls (n = 37).

Results:
Compared to CD− and/or controls, the CD+ group had lower cerebellar white matter and hippocampal volumes, and deflation of the right hippocampus head and tail.

Conclusion:
These findings provide initial support for neuroadaptations involving stress and reward circuits that are specific to high-dependence cannabis users.

Keywordscannabis; dependence; neuroanatomy; magnetic resonance imaging; hippocampus; caudate; pituitary gland; cerebellum
Year2020
JournalAustralian and New Zealand Journal of Psychiatry
Journal citation54 (1), pp. 68-75
PublisherSage Publications Ltd.
ISSN0004-8674
Digital Object Identifier (DOI)https://doi.org/10.1177/0004867419859077
Scopus EID2-s2.0-85069451602
Research or scholarlyResearch
FunderNational Health and Medical Research Council
Publisher's version
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All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online12 Jul 2019
Publication process dates
Deposited25 Aug 2021
Grant IDNHMRC/459111
NHMRC/1125504
NHMRC/1105825
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The neural cascade of olfactory processing: A combined fMRI-EEG study
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Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes
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Alteration to hippocampal shape in cannabis users with and without schizophrenia
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