Aerobic exercise-induced changes in cardiorespiratory fitness in breast cancer patients receiving chemotherapy : A systematic review and meta-analysis

Journal article


Maginador, Guilherme, Lixandrão, Manoel E., Bortolozo, Henrique I., Vechin, Felipe C., Sarian, Luís O., Derchain, Sophie, Telles, Guilherme D., Zopf, Eva, Ugrinowitsch, Carlos and Conceição, Miguel S.. (2020). Aerobic exercise-induced changes in cardiorespiratory fitness in breast cancer patients receiving chemotherapy : A systematic review and meta-analysis. Cancers. 12(8), p. 2240. https://doi.org/10.3390/cancers12082240
AuthorsMaginador, Guilherme, Lixandrão, Manoel E., Bortolozo, Henrique I., Vechin, Felipe C., Sarian, Luís O., Derchain, Sophie, Telles, Guilherme D., Zopf, Eva, Ugrinowitsch, Carlos and Conceição, Miguel S.
Abstract

While performing aerobic exercise during chemotherapy has been proven feasible and safe, the efficacy of aerobic training on cardiorespiratory fitness (CRF) in women with breast cancer undergoing chemotherapy has not yet been systematically assessed. Therefore, the objective of this work was to determine (a) the efficacy of aerobic training to improve CRF; (b) the role of aerobic training intensity (moderate or vigorous) on CRF response; (c) the effect of the aerobic training mode (continuous or interval) on changes in CRF in women with breast cancer (BC) receiving chemotherapy. A systematic review and meta-analysis were conducted as per PRISMA guidelines, and randomized controlled trials comparing usual care (UC) and aerobic training in women with BC undergoing chemotherapy were eligible. The results suggest that increases in CRF are favored by (a) aerobic training when compared to usual care; (b) vigorous-intensity aerobic exercise (64–90% of maximal oxygen uptake, VO2max) when compared to moderate-intensity aerobic exercise (46–63% of VO2max); and (c) both continuous and interval aerobic training are effective at increasing the VO2max. Aerobic training improves CRF in women with BC undergoing chemotherapy. Notably, training intensity significantly impacts the VO2max response. Where appropriate, vigorous intensity aerobic training should be considered for women with BC receiving chemotherapy.

Keywordsaerobic fitness; breast cancer; exercise rehabilitation; VO2max
Year2020
JournalCancers
Journal citation12 (8), p. 2240
PublisherMDPI AG
ISSN2072-6694
Digital Object Identifier (DOI)https://doi.org/10.3390/cancers12082240
Scopus EID2-s2.0-85089372774
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-14
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online11 Aug 2020
Publication process dates
Accepted30 Jul 2020
Deposited25 Aug 2021
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