Frailty and the risk of all-cause mortality and hospitalization in chronic heart failure: a meta-analysis
Journal article
Uchmanowicz, Izabella, Lee, Christopher S., Vitale, Cristiana, Manulik, Stanisław, Denfeld, Quin E., Uchmanowicz, Bartosz, Rosińczuk, Joanna, Drozd, Marcin, Jaroch, Joanna and Jankowska, Ewa A.. (2020). Frailty and the risk of all-cause mortality and hospitalization in chronic heart failure: a meta-analysis. ESC Heart Failure. 7(6), pp. 3427-3437. https://doi.org/10.1002/ehf2.12827
Authors | Uchmanowicz, Izabella, Lee, Christopher S., Vitale, Cristiana, Manulik, Stanisław, Denfeld, Quin E., Uchmanowicz, Bartosz, Rosińczuk, Joanna, Drozd, Marcin, Jaroch, Joanna and Jankowska, Ewa A. |
---|---|
Abstract | To estimate the risk of all-cause mortality and hospitalization in frail patients with chronic heart failure (HF), a systematic search and meta-analysis was carried out to identify all prospective cohort studies conducted among adults with HF where frailty was quantified and related to the primary endpoints of all-cause mortality and/or hospitalization. Twenty-nine studies reporting the link between frailty and all-cause mortality in 18 757 patients were available for the meta-analysis, along with 11 studies, with 13 525 patients, reporting the association between frailty and hospitalization. Frailty was a predictor of all-cause mortality and hospitalization with summary hazard ratios (HRs) of 1.48 [95% confidence interval (CI): 1.31–1.65, P < 0.001] and 1.40 (95% CI: 1.27–1.54, P < 0.001), respectively. Summary HRs for all-cause mortality among frail inpatients undergoing ventricular assist device implantation, inpatients hospitalized for HF, and outpatients were 1.46 (95% CI: 1.18–1.73, P < 0.001), 1.58 (95% CI: 0.94–2.22, P = not significant), and 1.53 (95% CI: 1.28–1.78, P < 0.001), respectively. Summary HRs for all-cause mortality and frailty based on Fried's phenotype were 1.48 (95% CI: 1.03–1.93, P < 0.001) and 1.42 (95% CI: 1.05–1.79, P < 0.001) for inpatients and outpatients, respectively, and based on other frailty measures were 1.42 (95% CI: 1.12–1.72, P < 0.001) and 1.60 (95% CI: 1.43–1.77, P < 0.001) for inpatients and outpatients, respectively. Across clinical contexts, frailty in chronic HF is associated with an average of 48% and 40% increase in the hazard of all-cause mortality and hospitalization, respectively. The relationship between frailty and all-cause mortality is similar across clinical settings and comparing measurement using Fried's phenotype or other measures. |
Keywords | heart failure; frailty; fried’s phenotype; mortality; hospitalization; meta-analysis |
Year | 2020 |
Journal | ESC Heart Failure |
Journal citation | 7 (6), pp. 3427-3437 |
Publisher | John Wiley & Sons |
ISSN | 2055-5822 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/ehf2.12827 |
Scopus EID | 2-s2.0-85091169297 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 3427-3437 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 21 Sep 2020 |
Publication process dates | |
Accepted | 21 May 2020 |
Deposited | 25 Aug 2021 |
https://acuresearchbank.acu.edu.au/item/8wq52/frailty-and-the-risk-of-all-cause-mortality-and-hospitalization-in-chronic-heart-failure-a-meta-analysis
Download files
Publisher's version
OA_Uchmanowicz_2020_Frailty_and_the_risk_of_all.pdf | |
License: CC BY-NC 4.0 | |
File access level: Open |
98
total views56
total downloads2
views this month0
downloads this month