Natural product-derived phytochemicals as potential agents against coronaviruses : A review

Journal article


Mani, Janice S., Johnson, Joel B., Steel, Jason C., Broszczak, Daniel A., Neilsen, Paul M., Walsh, Kerry B. and Naiker, Mani. (2020). Natural product-derived phytochemicals as potential agents against coronaviruses : A review. Virus Research. 284, p. 197989. https://doi.org/10.1016/j.virusres.2020.197989
AuthorsMani, Janice S., Johnson, Joel B., Steel, Jason C., Broszczak, Daniel A., Neilsen, Paul M., Walsh, Kerry B. and Naiker, Mani
Abstract

Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents for many coronavirus strains. Naturally existing compounds provide a wealth of chemical diversity, including antiviral activity, and thus may have utility as therapeutic agents against coronaviral infections. The PubMed database was searched for papers including the keywords coronavirus, SARS or MERS, as well as traditional medicine, herbal, remedy or plants, with 55 primary research articles identified. The overwhelming majority of publications focussed on polar compounds. Compounds that show promise for the inhibition of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, saikosaponin B2, quercetin, myricetin, caffeic acid, psoralidin, isobavachalcone, and lectins such as griffithsin. Other compounds such as lycorine may be suitable if a therapeutic level of antiviral activity can be achieved without exceeding toxic plasma concentrations. It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.

KeywordsCoronaviridae; Severe acute respiratory syndrome (SARS); Middle East respiratory syndrome (MERS); traditional medicine; COVID-19; SARS-CoV-2
Year2020
JournalVirus Research
Journal citation284, p. 197989
PublisherElsevier BV
ISSN0168-1702
Digital Object Identifier (DOI)https://doi.org/10.1016/j.virusres.2020.197989
Scopus EID2-s2.0-85084236371
Research or scholarlyResearch
Page range1-16
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online30 Apr 2020
Publication process dates
Accepted24 Apr 2020
Deposited26 Aug 2021
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