Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation

Journal article

Balcells, Eva, Gimeno-Santos, Elena, de Batlle, Jordi, Ramon, Maria Antonia, Rodríguez, Esther, Benet, Marta, Farrero, Eva, Ferrer, Antoni, Guerra, Stefano, Ferrer, Jaume, Sauleda, Jaume, Barberà, Joan A., Agustí, Àlvar, Rodriguez-Roisin, Robert, Gea, Joaquim, Antó, Josep M., Garcia-Aymerich, Judith, the, P. A. C. Copd Study Group and Donaire Gonzalez, David. (2015). Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation. BMC Pulmonary Medicine. 15(1), p. Article 4. https://doi.org/10.1186/1471-2466-15-4
AuthorsBalcells, Eva, Gimeno-Santos, Elena, de Batlle, Jordi, Ramon, Maria Antonia, Rodríguez, Esther, Benet, Marta, Farrero, Eva, Ferrer, Antoni, Guerra, Stefano, Ferrer, Jaume, Sauleda, Jaume, Barberà, Joan A., Agustí, Àlvar, Rodriguez-Roisin, Robert, Gea, Joaquim, Antó, Josep M., Garcia-Aymerich, Judith, the, P. A. C. Copd Study Group and Donaire Gonzalez, David
Abstract

Background
Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD.

Methods
The PAC-COPD cohort included 342 COPD patients hospitalised for the first time for an exacerbation of COPD (2004–2006). Patients were extensively characterised using sociodemographic, clinical and functional variables, and the cohort was followed-up through 2008. We defined “undiagnosed COPD” by the absence of any self-reported respiratory disease and regular use of any pharmacological respiratory treatment.

Results
Undiagnosed COPD was present in 34% of patients. They were younger (mean age 66 vs. 68 years, p = 0.03), reported fewer symptoms (mMRC dyspnoea score, 2.1 vs. 2.6, p < 0.01), and had a better health status (SGRQ total score, 29 vs. 40, p < 0.01), milder airflow limitation (FEV1% ref., 59% vs. 49%, p < 0.01), and fewer comorbidities (two or more, 40% vs. 56%, p < 0.01) when compared with patients with an established COPD diagnosis. Three months after hospital discharge, 16% of the undiagnosed COPD patients had stopped smoking (vs. 5%, p = 0.019). During follow-up, annual hospitalisation rates were lower in undiagnosed COPD patients (0.14 vs. 0.25, p < 0.01); however, this difference disappeared after adjustment for severity. Mortality was similar in both groups.

Conclusions
Undiagnosed COPD patients have less severe disease and lower risk of re-hospitalisation when compared with hospitalised patients with known COPD.

Keywordspulmonary disease; chronic obstructive; hospitalisation; cohort studies; epidemiology; health services
Year2015
JournalBMC Pulmonary Medicine
Journal citation15 (1), p. Article 4
PublisherBiomed Central Ltd
ISSN1471-2466
Digital Object Identifier (DOI)https://doi.org/10.1186/1471-2466-15-4
Scopus EID2-s2.0-84925234718
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-9
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online17 Jan 2015
Publication process dates
Accepted08 Jan 2015
Deposited09 Sep 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8wvz8/characterisation-and-prognosis-of-undiagnosed-chronic-obstructive-pulmonary-disease-patients-at-their-first-hospitalisation

Log in to edit

Download files

Publisher's version
OA_Balcells_2015_Characterisation_and_prognosis_of_undiagnosed_chronic.pdf
License: CC BY 4.0
File access level: Open

  • 93
    total views
  • 35
    total downloads
  • 2
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Improving traffic-related air pollution estimates by modelling minor road traffic volumes
Alvarado-Molina, Miguel, Curto, Ariadna, Wheeler, Amanda J., Tham, Rachel, Cerin, Ester, Nieuwenhuijsen, Mark, Vermeulen, Roel and Donaire Gonzalez, David. (2023). Improving traffic-related air pollution estimates by modelling minor road traffic volumes. Environmental Pollution. 338, p. Article 122657. https://doi.org/10.1016/j.envpol.2023.122657
Associations between traffic-related air pollution and cognitive function in Australian urban settings : The moderating role of diabetes status
Tham, Rachel, Wheeler, Amanda J., Carver, Alison, Dunstan, David, Donaire-Gonzalez, David, Anstey, Kaarin J., Shaw, Jonathan E., Magliano, Dianna J., Martino, Erika, Barnett, Anthony and Cerin, Ester. (2022). Associations between traffic-related air pollution and cognitive function in Australian urban settings : The moderating role of diabetes status. Toxics. 10(6), p. Article 289. https://doi.org/10.3390/toxics10060289
Urban environment and health behaviours in children from six European countries
Fernández-Barrés, Sílvia, Robinson, Oliver, Fossati, Serena, Márquez, Sandra, Basagaña, Xavier, de Bont, Jeroen, de Castro, Montserrat, Donaire-Gonzalez, David, Maitre, Léa, Nieuwenhuijsen, Mark, Romaguera, Dora, Urquiza, José, Chatzi, Leda, Iakovides, Minas, Vafeiadi, Marina, Grazuleviciene, Regina, Dedele, Audrius, Andrusaityte, Sandra, Aasvang, Gunn Marit, ... Vrijheid, Martine. (2022). Urban environment and health behaviours in children from six European countries. Environment International. 165, p. Article 107319. https://doi.org/10.1016/j.envint.2022.107319
Vegetation and vehicle emissions around primary schools across urban Australia : Associations with academic performance
Carver, Alison, Alvarado Molina, Miguel, Claesen, Joep L. A., Klabbers, Gonnie, Donaire Gonzalez, David, Tham, Rachel, Cerin, Ester, Nieuwenhuijsen, Mark and Wheeler, Amanda J.. (2022). Vegetation and vehicle emissions around primary schools across urban Australia : Associations with academic performance. Environmental Research. 212(Part B), p. Article 113256. https://doi.org/10.1016/j.envres.2022.113256
The neighbourhood environment and profiles of the metabolic syndrome
Barnett, Anthony, Martino, Erika, Knibbs, Luke, Shaw, Jonathan, Dunstan, David Wayne, Magliano, Dianna, Donaire Gonzalez, David and Cerin, Ester. (2022). The neighbourhood environment and profiles of the metabolic syndrome. Environmental Health: A Global Access Science Source. 21(1), pp. 1-18. https://doi.org/10.1186/s12940-022-00894-4
The impact of traffic-related air pollution on child and adolescent academic performance : A systematic review
Stenson, Chloe, Wheeler, Amanda J., Carver, Alison, Donaire-Gonzalez, David, Alvarado-Molina, Miguel, Nieuwenhuijsen, Mark and Tham, Rachel. (2021). The impact of traffic-related air pollution on child and adolescent academic performance : A systematic review. Environment International. 155, p. Article 106696. https://doi.org/10.1016/j.envint.2021.106696
Early life multiple exposures and child cognitive function : A multi-centric birth cohort study in six European countries
Julvez, Jordi, López-Vicente, Mónica, Warembourg, Charline, Maitre, Lea, Philippat, Claire, Gützkow, Kristine B., Guxens, Monica, Evandt, Jorunn, Andrusaityte, Sandra, Burgaleta, Miguel, Casas, Maribel, Chatzi, Leda, de Castro, Montserrat, Donaire-González, David, Gražulevičienė, Regina, Hernandez-Ferrer, Carles, Heude, Barbara, McEachan, Rosie, Mon-Williams, Mark, ... Vrijheid, Martine. (2021). Early life multiple exposures and child cognitive function : A multi-centric birth cohort study in six European countries. Environmental Pollution. 284, p. 117404. https://doi.org/10.1016/j.envpol.2021.117404
Associations of traffic-related air pollution and greenery with academic outcomes among primary schoolchildren
Wheeler, A., Donaire Gonzalez, D., Alvarado Molina, M., Tham, R., Nieuwenhuijsen, M. and Carver, A.. (2021). Associations of traffic-related air pollution and greenery with academic outcomes among primary schoolchildren. Environmental Research. 35(7), p. 111325. https://doi.org/10.1016/j.envres.2021.111325
Does surrounding greenness moderte the relationship between apparent temperature and physical activity? Findings from the PHENOTYPE project
Ho, Janice Y., Zijlema, Wilma L., Triguero-Mas, Margarita, Donaire-Gonzalez, David, Valentín, Antònia, Ballester, Joan, Chan, Emily Y. Y., Goggins, William B., Mo, Phoenix K. H., Kruize, Hanneke, van den Berg, Magdalena, Gražuleviciene, Regina, Gidlow, Christopher J., Jerrett, Michael, Seto, Edmund Y. W., Barrera-Gómez, Jose and Nieuwenhuijsen, Mark J.. (2021). Does surrounding greenness moderte the relationship between apparent temperature and physical activity? Findings from the PHENOTYPE project. Environmental Research. 197, p. 110992. https://doi.org/10.1016/j.envres.2021.110992
Physical and mental health effects of repeated short walks in a blue space environment : A randomised crossover study
Vert, Cristina, Gascon, Mireia, Ranzani, Otavio, Márquez, Sandra, Triguero-Mas, Margarita, Carrasco-Turigas, Glòria, Arjona, Lourdes, Koch, Sarah, Llopis, Maria, Donaire-Gonzalez, David, Elliott, Lewis R. and Nieuwenhuijsen, Mark. (2020). Physical and mental health effects of repeated short walks in a blue space environment : A randomised crossover study. Environmental Research. 188, pp. 1-15. https://doi.org/10.1016/j.envres.2020.109812
Momentary mood response to natural outdoor environments in four European cities
Kondo, Michelle C., Triguero-Mas, Margarita, Donaire-Gonzalez, David, Seto, Edmund, Valentín, Antònia, Hurst, Gemma, Carrasco-Turigas, Glòria, Masterson, Daniel, Ambròs, Albert, Ellis, Naomi, Swart, Wim, Davis, Nora, Maas, Jolanda, Jerrett, Michael, Gidlow, Christopher J. and Nieuwenhuijsen, Mark J.. (2020). Momentary mood response to natural outdoor environments in four European cities. Environment International. 134, pp. 1-9. https://doi.org/10.1016/j.envint.2019.105237
International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health
Ester Cerin, Anthony Barnett, Basile Chaix, Mark Nieuwenhuijsen, Karen Caeyenberghs, Bin Jalaludin, Takemi Sugiyama, James Sallis, Nicola T. Lautenschlager, Michael Y Ni, Govinda Poudel, David Donaire Gonzalez, Rachel Tham, Amanda Wheeler, Luke Knibbs, Linwei Tian, Kai Chan, David Dunstan, Alison Carver and Kaarin Anstey. (2020). International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health. BMJ Open. 10(3), pp. 1-15. https://doi.org/10.1136/bmjopen-2019-036607
Multiple environmental exposures in early-life and allergy-related outcomes in childhood
Berit Granum, Bente Oftedal, Lydiane Agier, Valerie Siroux, Philippa K Bird, Maribel Casas, Charline Warembourg, John Wright, Leda Chatzi, Montserrat de Castro, David Donaire Gonzalez, Regina Grazuleviciene, Line Smastuen Haug, Léa Maitre, Oliver Robinson, Ibon Tamayo-Uria, Jose Urquiza, Mark Nieuwenhuijsen, Rémy Slama, ... Martine Vrijheid. (2020). Multiple environmental exposures in early-life and allergy-related outcomes in childhood. Environment International. 144, pp. 1-9. https://doi.org/10.1016/j.envint.2020.106038
Early-life environmental exposures and childhood obesity : An exposome-wide approach
Vrijheid, Martine, Fossati, Serena, Maitre, Léa, Márquez, Sandra, Roumeliotaki, Theano, Agier, Lydiane, Andrusaityte, Sandra, Cadiou, Solène, Casas, Maribel, de Castro, Montserrat, Dedele, Audrius, Donaire-Gonzalez, David, Grazuleviciene, Regina, Haug, Line S., McEachan, Rosemary, Meltzer, Helle Margrete, Papadopouplou, Eleni, Robinson, Oliver, Sakhi, Amrit K., ... Chatzi, Leda. (2020). Early-life environmental exposures and childhood obesity : An exposome-wide approach. Environmental Health Perspectives. 128(6), pp. 067009-1 - 067009-14. https://doi.org/10.1289/EHP5975
Agier 2020 Association between the pregnancy exposome and
Agier, Lydiane, Basagaña, Xavier, Hernandez-Ferrer, Carles, Maitre, Léa, Uria, Ibon Tamayo, Urquiza, Jose, Andrusaityte, Sandra, Casas, Maribel, de Castro, Montserrat, Cequier, Enrique, Chatzi, Leda, Donaire-González, David, Giorgis-Allemand, Lise, González, Juan R., Grazuleviciene, Regina, Gützkow, Kristine B., Haug, Line Smastuen, Sakhi, Amrit K., McEachan, Rosemary R. C., ... Slama, Rémy. (2020). Agier 2020 Association between the pregnancy exposome and. International Journal of Epidemiology. 49(2), pp. 572-586. https://doi.org/10.1093/ije/dyaa017
Personal assessment of the external exposome during pregnancy and childhood in Europe
Donaire Gonzalez, David, Curto, Ariadna, Valentin, Antònia, Andrusaityte, Sandra, Basagaña, Xavier, Casas, Maribel, Chatzi, Leda, de Bont, Jeroen, de Castro, Montserrat, Dedele, Audrius, Granum, Berit, Grazuleviciene, Regina, Kampouri, Mariza, Lyon-Caen, Sarah, Manzano-Salgado, Cyntia B., Aasvang, Gunn Marit, McEachan, Rosemary R. C., Meinhard-Kjellstad, Carin Helena, Michalaki, Eirini, ... Vrijheid, Martine. (2019). Personal assessment of the external exposome during pregnancy and childhood in Europe. Environmental Research. 174, pp. 95 - 104. https://doi.org/10.1016/j.envres.2019.04.015
Predictors of personal exposure to black carbon among women in southern semi-rural Mozambique
Curto, Ariadna, Donaire Gonzalez, David, Manaca, Maria N., González, Raquel, Sacoor, Charfudin, Rivas, Ioar, Gascon, Mireia, Wellenius, Gregory A., Querol, Xavier, Sunyer, Jordi, Macete, Eusébio, Menéndez, Clara and Tonne, Cathryn. (2019). Predictors of personal exposure to black carbon among women in southern semi-rural Mozambique. Environment International. 131, pp. 1 - 14. https://doi.org/10.1016/j.envint.2019.104962
ExpoApp: An integrated system to assess multiple personal environmental exposures
Donaire-Gonzalez, David, Valentín, Antònia, van Nunen, Erik, Curto, Ariadna, Rodriguez, Albert, Fernandez-Nieto, Mario, Naccarati, Alessio, Tarallo, Sonia, Tsai, Ming-Yi, Probst-Hensch, Nicole M., Vermeulen, Roel, Hoek, Gerard, Vineis, Paolo, Gulliver, John and Nieuwenhuijsen, Mark J.. (2019). ExpoApp: An integrated system to assess multiple personal environmental exposures. Environment International. 126, pp. 494 - 503. https://doi.org/10.1016/j.envint.2019.02.054
Early life exposome and lung function in children in Europe: An analysis of data from the longitudinal, population-based HELIX cohort
Agier, Lydiane, Basagana, Xavier, Maitre, Lea, Granum, Berit, Bird, Philippa K., Casas, Maribel, Oftedal, Bente, Wright, John, Andrusaityte, Sandra, Castro, Montserrat de, Cequier, Enrique, Chatzi, Leda, Donaire-Gonzalez, David, Grazuleviciene, Regina, Haug, Line Smastuen, Sakhi, Amrit K., Leventakou, Vasiliki, McEachan, Rosemary R. C., Nieuwenhuijsen, Mark, ... Siroux, Valérie. (2019). Early life exposome and lung function in children in Europe: An analysis of data from the longitudinal, population-based HELIX cohort. The Lancet Planetary Health. 3(2), pp. 81 - 92. https://doi.org/10.1016/S2542-5196(19)30010-5
Physical activity is associated with attenuated disease progression in Chronic Obstructive Disease
Demeyer, Heleen, Donaire-Gonzalez, David, Gimeno-Santos, Elena, Ramon, Maria A., de Battle, Jordie, Benet, Marta, Serra, Ignasi, Guerra, Stefano, Farrero, Eva, Rodriguez, Esther, Ferrer, Jaume, Sauleda, Jaume, Monso, Eduard, Gea, Joaquim, Rodriguez-Roisin, Robert, Agusti, Alvar, Antó, Josep M. and Garcia-Aymerich, Judith. (2019). Physical activity is associated with attenuated disease progression in Chronic Obstructive Disease. Medicine and Science in Sports and Exercise. 51(5), pp. 833 - 840. https://doi.org/10.1249/MSS.0000000000001859
Telecommunication devices use, screen time and sleep in adolescents
Cabré-Riera, Alba, Torrent, Maties, Donaire Gonzalez, David, Vrijheid, Martine, Cardis, Elisabeth and Guxens, Mònica. (2019). Telecommunication devices use, screen time and sleep in adolescents. Environmental Research. 171, pp. 341 - 347. https://doi.org/10.1016/j.envres.2018.10.036
Estimated effects of air pollution and space-time-activity on cardiopulmonary outcomes in healthy adults: A repeated measures study
Cole-Hunter, Tom, de Nazelle, Audrey, Donaire-Gonzalez, David, Kubesch, Nadine, Carrasco-Turigas, Glòria, Matt, Florian, Foraster, Maria, Martínez, Tania, Ambros, Albert, Cirach, Marta, Martínez, David, Belmonte, Jordina and Nieuwenhuijsen, Mark. (2018). Estimated effects of air pollution and space-time-activity on cardiopulmonary outcomes in healthy adults: A repeated measures study. Environment International. 111, pp. 247 - 259. https://doi.org/10.1016/j.envint.2017.11.024
Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children
Casas, Maribel, Basagaña, Xavier, Sakhi, Amrit K., Haug, Line Smastuen, Philippat, Claire, Granum, Berit, Manzano-Salgado, Cyntia B., Brochot, Céline, Zeman, Florence, de Bont, Jeroen, Andrusaityte, Sandra, Chatzi, Leda, Donaire-Gonzalez, David, Giorgis-Allemand, Lise, Gonzalez, Juan R., Gracia-Lavedan, Esther, Grazuleviciene, Regina, Kampouri, Mariza, Lyon-Caen, Sarah, ... Vrijheid, Martine. (2018). Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children. Environment International. 121(Pt 1), pp. 561 - 573. https://doi.org/10.1016/j.envint.2018.09.046
Performance of low-cost monitors to assess household air pollution
Curto, A., Donaire-Gonzalez, D., Barrera-Gómez, J., Marshall, J. D., Nieuwenhuijsen, Mark, Wellenius, G. A. and Tonne, C.. (2018). Performance of low-cost monitors to assess household air pollution. Environmental Research. 163, pp. 53 - 63. https://doi.org/10.1016/j.envres.2018.01.024
Land use regression models for the oxidative potential of fine particles (PM2.5) in five European areas
Gulliver, John, Morley, David, Dunster, Chrissi, McCrea, Adrienne, van Nunen, Erik, Tsai, Ming-Yi, Probst-Hensch, Nicole, Eeftens, Marloes, Imboden, Medea, Ducret-Stich, Regina, Naccarati, Alessio, Galassi, Claudia, Ranzi, Andrea, Nieuwenhuijsen, Mark, Curto, A., Donaire-Gonzalez, D., Cirach, Marta, Vermeulen, Roel, Vineis, Paolo, ... Kelly, Frank J.. (2018). Land use regression models for the oxidative potential of fine particles (PM2.5) in five European areas. Environmental Research. 160, pp. 247 - 255. https://doi.org/10.1016/j.envres.2017.10.002
The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model
Ramon, Maria A., Riet, Gerben Ter, Carsin, Anne-Elie, Gimeno-Santos, Elena, Agustí, Alvar, Antó, Josep M., Donaire-Gonzalez, David, Ferrer, Jaume, Rodríguez, Esther, Rodriguez-Roisin, Robert, Puhan, Milo A., Garcia-Aymerich, Judith, PAC-COPD Study Group, and PAC-COPD Study Group. (2018). The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model. European Respiratory Journal. 52(3), pp. 1 - 3. https://doi.org/10.1183/13993003.00079-2018
Validating novel air pollution sensors to improve exposure estimates for epidemiological analyses and citizen science
Jerrett, Michael, Donaire-Gonzalez, D., Popoola, Olalekan, Jones, Rod L., Cohen, Ronald C., Almanza, Estela, de Nazelle, Audrey, Mead, Iq, Carrasco-Turigas, Glòria, Cole-Hunter, Tom, Triguero-Mas, Margarita, Seto, Edmund and Nieuwenhuijsen, Mark. (2017). Validating novel air pollution sensors to improve exposure estimates for epidemiological analyses and citizen science. Environmental Research. 158, pp. 286 - 294. https://doi.org/10.1016/j.envres.2017.04.023
Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity
Spina, Gabriele, Spruit, Martijn A., Alison, Jennifer, Benzo, Roberto P., Calverley, Peter M. A., Clarenbach, Christian F., Costello, Richard W., Donaire-Gonzalez, David, Dürr, Selina, Garcia-Aymerich, Judith, van Gestel, Arnoldus J. R., Gramm, Marco, Hernandes, Nidia A., Hill, Kylie, Hopkinson, Nicholas S., Jarreta, Diana, Kohler, Malcolm, Kirsten, Anne M., Leuppi, Jörg D., ... den Brinker, Albertus C.. (2017). Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity. Thorax. 72(8), pp. 694 - 701. https://doi.org/10.1136/thoraxjnl-2016-208900
Urban and transport planning related exposures and mortality: a health impact assessment for cities
Mueller, Natalie, Rojas-Rueda, David, Basagaña, Xavier, Cirach, Marta, Hunter, Tom Cole, Dadvand, Payam, Donaire-Gonzalez, D., Foraster, Maria, Gascon, Mireia, Martínez, David, Tonne, C., Triguero-Mas, Margarita, Valentín, A. and Nieuwenhuijsen, Mark. (2017). Urban and transport planning related exposures and mortality: a health impact assessment for cities. Environmental Health Perspectives. 125(1), pp. 89 - 96. https://doi.org/10.1289/EHP220
Land use regression models for ultrafine particles in six European areas
van Nunen, Erik, Vermeulen, Roel, Tsai, Ming-Yi, Probst-Hensch, Nicole, Ineichen, Alex, Davey, Mark, Imboden, Medea, Ducret-Stich, Regina, Naccarati, Alessio, Raffaele, Daniela, Ranzi, Andrea, Ivaldi, Cristiana, Galassi, Claudia, Nieuwenhuijsen, Mark, Curto, A., Donaire-Gonzalez, D., Cirach, Marta, Chatzi, Leda, Kampouri, Mariza, ... Gerard,. (2017). Land use regression models for ultrafine particles in six European areas. Environmental Science and Technology. 51(6), pp. 3336 - 3345. https://doi.org/10.1021/acs.est.6b05920
The effect of randomised exposure to different types of natural outdoor environments compared to exposure to an urban environment on people with indications of psychological distress in Catalonia
Triguero-Mas, Margarita, Gidlow, Christopher, Martínez, David, De Bont, Jeroen, Carrasco-Turigas, Glòria, Martinez-Iñiguez, Tania, Hurst, Gemma, Masterson, Daniel, Donaire-Gonzalez, D., Seto, Edmund, Jones, Marc V. and Nieuwenhuijsen, Mark. (2017). The effect of randomised exposure to different types of natural outdoor environments compared to exposure to an urban environment on people with indications of psychological distress in Catalonia. PLoS ONE. 12(3), pp. 1 - 17. https://doi.org/10.1371/journal.pone.0172200
Impact of commuting exposure to traffic-related air pollution on cognitive development in children walking to school
Alvarez-Pedrerol, Mar, Rivas, Ioar, López-Vicente, Monica, Suades-González, Elisabet, Donaire-Gonzalez, D., Cirach, Marta, de Castro, Montserrat, Esnaola, Mikel, Basagaña, Xavier, Dadvand, Payam, Nieuwenhuijsen, Mark and Sunyer, Jordi. (2017). Impact of commuting exposure to traffic-related air pollution on cognitive development in children walking to school. Environmental Pollution. 231, pp. 837 - 844. https://doi.org/10.1016/j.envpol.2017.08.075
Living close to natural outdoor environments inf our European cities: adults' contact with the environments and physical activity
Triguero-Mas, Margarita, Donaire-Gonzalez, David, Seto, Edmund, Valentin, Antonia, Smith, Graham, Martinez, David, Carrasco-Turigas, Gloria, Masterson, Daniel, van den Berg, Magdalena, Ambros, Albert, Martinez-Iniguez, Tania, Dedele, Audrius, Hurst, Gemma, Ellis, Naomi, Grazulevicius, Tomas, Voorsmit, Martin, Cirach, Marta, Cirach-Claveras, Judith, Swart, Wim, ... Mark, . (2017). Living close to natural outdoor environments inf our European cities: adults' contact with the environments and physical activity. International Journal of Environmental Research and Public Health. 14(10), pp. 1 - 21. https://doi.org/10.3390/ijerph14101162
Natural outdoor environments and mental health: stress as a possible mechanism
Triguero-Mas, Margarita, Donaire-Gonzalez, D., Seto, Edmund, Valentín, A., Martínez, David, Smith, Graham, Hurst, Gemma, Carrasco-Turigas, Glòria, Masterson, Daniel, van den Berg, Magdalena, Ambros, Albert, Martinez-Iñiguez, Tania, Dedele, Audrius, Ellis, Naomi, Grazulevicius, Tomas, Voorsmit, Martin, Cirach, Marta, Cirac-Claveras, Judith, Swart, Wim, ... Mark, . (2017). Natural outdoor environments and mental health: stress as a possible mechanism. Environmental Research. 159, pp. 629 - 638. https://doi.org/10.1016/j.envres.2017.08.048
Health impacts related to urban and transport planning: a burden of disease assessment
Mueller, Natalie, Rojas-Rueda, David, Basagaña, Xavier, Cirach, Marta, Cole-Hunter, Tom, Dadvand, Payam, Donaire-Gonzalez, D., Foraster, Maria, Gascon, Mireia, Martínez, David, Tonne, C., Triguero-Mas, Margarita, Valentín, A. and Nieuwenhuijsen, Mark. (2017). Health impacts related to urban and transport planning: a burden of disease assessment. Environment International. 107, pp. 243 - 257. https://doi.org/10.1016/j.envint.2017.07.020
Ultrafine particles and black carbon personal exposures in asthmatic and non-asthmatic children at school age
Pañella, P., Casas, M., Donaire-Gonzalez, D., Garcia-Esteban, R., Robinson, O., Valentín, A., Gulliver, John, Momas, I., Nieuwenhuijsen, Mark, Vrijheid, Martine and Sunyer, Jordi. (2017). Ultrafine particles and black carbon personal exposures in asthmatic and non-asthmatic children at school age. Indoor Air: international journal of indoor air quality and climate. 27(5), pp. 891 - 899. https://doi.org/10.1111/ina.12382
Physical activity patterns and clusters in 1001 patients with COPD
Mesquita, Rafael, Spina, Gabriele, Pitta, Fabio, Donaire-Gonzalez, David, Deering, Brenda M., Patel, Mehul S., Mitchell, Katy E., Alison, Jennifer, van Gestel, Arnoldus J. R., Zogg, Stefanie, Gagnon, Philippe, Abascal-Bolado, Beatriz, Vagaggini, Barbara, Garcia-Aymerich, Judith, Jenkins, Sue C., Romme, Elisabeth A. P. M., Kon, Samantha S. C., Albert, Paul S., Waschki, Benjamin, ... Spruit, Martijn A.. (2017). Physical activity patterns and clusters in 1001 patients with COPD. Chronic Respiratory Disease. 14(3), pp. 256 - 269. https://doi.org/10.1177/1479972316687207
The relationship between bicycle commuting and perceived stress: a cross-sectional study
Avila-Palencia, Ione, de Nazelle, Audrey, Cole-Hunter, Tom, Donaire-Gonzalez, D., Jerrett, Michael, Rodríguez, Daniel A. and Nieuwenhuijsen, Mark. (2017). The relationship between bicycle commuting and perceived stress: a cross-sectional study. BMJ Open. 7(6), pp. 1 - 11. https://doi.org/10.1136/bmjopen-2016-013542
Private and public modes of bicycle commuting: A perspective on attitude and perception
Curto, A., de Nazelle, Audrey, Donaire-Gonzalez, David, Cole-Hunter, Tom, Garcia-Aymerich, J., Martínez, David, Anaya, Esther, Rodríguez, Daniel A., Jerrett, Michael and Nieuwenhuijsen, Mark J.. (2016). Private and public modes of bicycle commuting: A perspective on attitude and perception. European Journal of Public Health. 26(4), pp. 717 - 723. https://doi.org/10.1093/eurpub/ckv235
Acute respiratory response to traffic-related air pollution during physical activity performance
Matt, Florian, Cole-Hunter, Tom, Donaire-Gonzalez, David, Kubesch, Nadine, Martínez, David, Carrasco-Turigas, Glòria and Nieuwenhuijsen, Mark. (2016). Acute respiratory response to traffic-related air pollution during physical activity performance. Environment International. 97, pp. 45 - 55. https://doi.org/10.1016/j.envint.2016.10.011
Spatiotemporally resolved black carbon concentration, schoolchildren's exposure and dose in Barcelona
Rivas, Ioar, Donaire-Gonzalez, David, Bouso, L., Esnaola, Mikel, Pandolfi, M., de Castro, Montserrat, Viana, M., Alvarez-Pedrerol, Mar, Nieuwenhuijsen, Mark J., Alastuey, A., Sunyer, Jordi and Querol, Xavier. (2016). Spatiotemporally resolved black carbon concentration, schoolchildren's exposure and dose in Barcelona. Indoor Air. 26(3), pp. 391 - 402. https://doi.org/10.1111/ina.12214
Short-term planning and policy interventions to promote cycling in urban centers: Findings from a commute mode choice analysis in Barcelona, Spain
Braun, Lindsay M., Rodríguez, Daniel A., Cole-Hunter, Tom, Ambros, Albert, Donaire-Gonzalez, David, Jerrett, Michael, Mendez, Michelle A., Nieuwenhuijsen, Mark J. and de Nazelle, Audrey. (2016). Short-term planning and policy interventions to promote cycling in urban centers: Findings from a commute mode choice analysis in Barcelona, Spain. Transportation Research Part A. 89, pp. 164 - 183. https://doi.org/10.1016/j.tra.2016.05.007
Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD
Ramon, Maria A., Ferrer, Jaume, Gimeno-Santos, Elena, Donaire-Gonzalez, David, Rodríguez, Esther, Balcells, Eva, de Batlle, Jordi, Benet, Marta, Guerra, Stefano, Sauleda, Jaume, Ferrer, Antoni, Farrero, Eva, Gea, Joaquim, Barberà, Joan A., Agustí, Àlvar, Rodriguez-Roisin, Robert, Antó, Josep M. and Garcia-Aymerich, Judith. (2016). Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology. 21(3), pp. 476 - 482. https://doi.org/10.1111/resp.12723
The added benefit of bicycle commuting on the regular amount of physical activity performed
Donaire-Gonzalez, David, de Nazelle, Audrey, Cole-Hunter, Tom, Curto, Ariadna, Rodríguez, Daniel A., Mendez, Michelle A., Garcia-Aymerich, Judith, Basagaña, Xavier, Ambros, Albert, Jerrett, Michael and Nieuwenhuijsen, Mark J.. (2015). The added benefit of bicycle commuting on the regular amount of physical activity performed. American Journal of Preventive Medicine. 49(6), pp. 842 - 849. https://doi.org/10.1016/j.amepre.2015.03.036
Objective correlates and determinants of bicycle commuting propensity in an urban environment
Cole-Hunter, Tom, Donaire-Gonzalez, David, Curto, A., Ambros, Albert, Valentín, Antònia, Garcia-Aymerich, J., Martínez, David, Braun, Lindsay M., Mendez, Michelle, Jerrett, Michael, Rodríguez, Daniel A., de Nazelle, Audrey and Nieuwenhuijsen, Mark J.. (2015). Objective correlates and determinants of bicycle commuting propensity in an urban environment. Transportation Research Part D. 40, pp. 132 - 143. https://doi.org/10.1016/j.trd.2015.07.004
Benefits of physical activity on COPD hospitalisation depend on intensity
Donaire-Gonzalez, David, Gimeno-Santos, Elena, Balcells, Eva, De Batlle, Jordi, Ramon, Maria A., Rodriguez, Esther, Farrero, Eva, Benet, Marta, Guerra, Stefano, Sauleda, Jaume, Ferrer, Antoni, Barberà, Joan A., Rodriguez-Roisin, Robert, Gea, Joaquim, Agusti, Alvar, Antó, Josep M., Garcia-Aymerich, Judith, PAC-COPD Study Group, , Ferrer, Jaume and PAC-COPD Study Group. (2015). Benefits of physical activity on COPD hospitalisation depend on intensity. European Respiratory Journal. 46(5), pp. 1281 - 1289. https://doi.org/10.1183/13993003.01699-2014
Positive health effects of the natural outdoor environment in typical populations in different regions in Europe (PHENOTYPE): A study programme protocol
Nieuwenhuijsen, Mark J., Kruize, Hanneke, Gidlow, Christopher, Andrusaityte, Sandra, Antó, Josep M., Basagaña, Xavier, Cirach, Marta, Dadvand, Payam, Danileviciute, Asta, Donaire-Gonzalez, David, Garcia, Judith, Jerrett, Michael, Jones, Marc V., Julvez, Jordi, van Kempen, Elise, van Kamp, Irene, Maas, Jolanda, Seto, Edmund, Smith, Graham, ... Gražulevičienė, Regina. (2014). Positive health effects of the natural outdoor environment in typical populations in different regions in Europe (PHENOTYPE): A study programme protocol. BMJ Open. 4(4), pp. 1 - 11. https://doi.org/10.1136/bmjopen-2014-004951
Lifetime occupational exposure to dusts, gases and fumes is associated with bronchitis symptoms and higher diffusion capacity in COPD patients
Rodríguez, Esther, Ferrer, Jaume, Zock, Jan-Paul, Serra, Ignasi, Antó, Josep M., De Batlle, Jordi, Kromhout, Hans, Vermeulen, Roel, Donaire-Gonzalez, David, Benet, Marta, Balcells, Eva, Monso, Eduard, Gayete, Angel, Garcia-Aymerich, J., Guerra, Stefano, Gea, Joaquim, Orozco-Levi, Mauricio, Vollmer, Ivan, Barberà, Joan A., ... Belda, José. (2014). Lifetime occupational exposure to dusts, gases and fumes is associated with bronchitis symptoms and higher diffusion capacity in COPD patients. PLoS ONE. 9(2), pp. 1 - 7. https://doi.org/10.1371/journal.pone.0088426
Using personal sensors to assess the exposome and acute health effects
Nieuwenhuijsen, Mark J., Donaire-Gonzalez, David, Foraster, Maria, Martínez, David and Cisneros, Andres. (2014). Using personal sensors to assess the exposome and acute health effects. International Journal of Environmental Research and Public Health. 11(8), pp. 7805 - 7819. https://doi.org/10.3390/ijerph110807805
Physical activity in COPD patients : Patterns and bouts
Donaire-Gonzalez, David, Gimeno-Santos, Elena, Balcells, Eva, Rodríguez, Diego A., Farrero, Eva, de Batlle, Jordi, Benet, Marta, Ferrer, Antoni, Barberà, Joan A., Gea, Joaquim, Rodriguez-Roisin, Robert, Antó, Josep M. and Garcia-Aymerich, Judith. (2013). Physical activity in COPD patients : Patterns and bouts. European Respiratory Journal. 42(4), pp. 993-1002. https://doi.org/10.1183/09031936.00101512
Comparison of physical activity measures using mobile phone-based calfit and actigraph
Donaire-Gonzalez, David, de Nazelle, Audrey, Seto, Edmund, Mendez, Michelle, Nieuwenhuijsen, Mark J. and Jerrett, Michael. (2013). Comparison of physical activity measures using mobile phone-based calfit and actigraph. Journal of Medical Internet Research. 15(6), p. e111. https://doi.org/10.2196/jmir.2470
Improving estimates of air pollution exposure through ubiquitous sensing technologies
de Nazelle, Audrey, Seto, Edmund, Donaire-Gonzalez, David, Mendez, Michelle, Matamala, Jaume, Nieuwenhuijsen, Mark J. and Jerrett, Michael. (2013). Improving estimates of air pollution exposure through ubiquitous sensing technologies. Environmental Pollution. 176, pp. 92 - 99. https://doi.org/10.1016/j.envpol.2012.12.032
Effect of bronchial colonisation on airway and systemic inflammation in stable COPD
Marin, Alicia, Garcia-Aymerich, Judith, Sauleda, Jaume, Belda, Jose, Millares, Laura, García-Núñez, Marian, Serra, Ignasi, Benet, Marta, Agustí, Alvar, Antó, Josep M., Monsó, Eduard, PAC-COPD Study Group and Donaire-Gonzalez, David. (2012). Effect of bronchial colonisation on airway and systemic inflammation in stable COPD. COPD. 9(2), pp. 121-130. https://doi.org/10.3109/15412555.2011.636407
Cured meat consumption increases risk of readmission in COPD patients
Jordi de Batlle, Mendez, Michelle, Romieu, Isabelle, Balcells, Eva, Benet, Marta, Donaire-Gonzalez, David, Ferrer, Jaume J., Orozco-Levi, Mauricio, Antó, Josep M., Garcia-Aymerich, Judith and PAC-COPD Study Group. (2012). Cured meat consumption increases risk of readmission in COPD patients. European Respiratory Journal. 40(3), pp. 555-560. https://doi.org/10.1183/09031936.00116911
Specific IgA and metalloproteinase activity in bronchial secretions from stable chronic obstructive pulmonary disease patients colonized by Haemophilus influenzae
Millares, Laura, Marin, Alicia, Garcia-Aymerich, J., Sauleda, Jaume, Belda, José, Monso, Eduard, Antó, Josep M., Benet, Marta, De Batlle, Jordi, Serra, Ignasi, Donaire Gonzalez, David, Guerra, Stefano, Gea, Joaquim, Balcells, Eva, Gayete, ADavidngel, Orozco-Levi, Mauricio, Vollmer, Ivan, Barberà, Joan A., Gomez, Federico P., ... Pallissa, Esther. (2012). Specific IgA and metalloproteinase activity in bronchial secretions from stable chronic obstructive pulmonary disease patients colonized by Haemophilus influenzae. Respiratory Research. 13(1). https://doi.org/10.1186/1465-9921-13-113
Validation of the Yale Physical Activity Survey in Chronic Obstructive Pulmonary Disease Patients
Donaire-Gonzalez, David, Gimeno-Santos, Elena, Serra, Ignasi, Roca, Josep, Balcells, Eva, Rodríguez, Esther, Farrero, Eva, Antó, Josep M. and Garcia-Aymerich, Judith. (2011). Validation of the Yale Physical Activity Survey in Chronic Obstructive Pulmonary Disease Patients. Archivos de Bronconeumología. 47(11), pp. 552-560.