Current perspectives on the role of very-low-energy diets in the treatment of obesity and type 2 diabetes in youth

Journal article


Gow, Megan L., Pham-Short, Anna, Jebeile, Hiba, Varley, Benjamin and Craig, Maria E.. (2021). Current perspectives on the role of very-low-energy diets in the treatment of obesity and type 2 diabetes in youth. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 14, pp. 215-225. https://doi.org/10.2147/DMSO.S238419
AuthorsGow, Megan L., Pham-Short, Anna, Jebeile, Hiba, Varley, Benjamin and Craig, Maria E.
Abstract

In both developed and developing countries, pediatric obesity and type 2 diabetes are an increasing public health concern: globally 5.6% of girls and 7.8% of boys aged ≥ 5 years have obesity. The incidence of type 2 diabetes has increased in youth in recent decades and disproportionately affects those from ethnic/racial minority groups and disadvantaged backgrounds. For the treatment of both conditions, conventional lifestyle intervention is frequently ineffective, access to bariatric surgery is very limited and many young people are unsuitable or unwilling to undergo surgery. A very-low-energy diet (VLED) provides a viable alternative and may be effective for weight reduction and improved glycemic control in youth, based on one systematic review. In particular, in the treatment of type 2 diabetes, a chart review and a pilot study both demonstrated that a VLED can reduce the requirement for medications, including insulin, and lead to the remission of diabetes. However, long-term follow-up and safety data remain limited and therefore a VLED is inconsistently recommended by clinical practice guidelines for the treatment of pediatric obesity and type 2 diabetes. In clinical practice, VLED use in children and adolescents is uniquely challenging due to intolerance of expected side effects, difficulty adhering to the highly restrictive diet and difficulty with behaviour change within the current social context and environment. Ultimately, more research, including larger, longer-term trials with comprehensive safety monitoring are required to strengthen the evidence base. This would inform clinical practice guidelines, which may facilitate more widespread utilization of VLED programs in the management of obesity and type 2 diabetes in youth.

Keywordspediatrics; obesity; type 2 diabetes; very-low-energy diet; youth
Year2021
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Journal citation14, pp. 215-225
PublisherDove Medical Press Ltd.
ISSN1178-7007
Digital Object Identifier (DOI)https://doi.org/10.2147/DMSO.S238419
Scopus EID2-s2.0-85099915777
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range215-225
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online06 Jan 2021
Publication process dates
Deposited14 Oct 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8wx00/current-perspectives-on-the-role-of-very-low-energy-diets-in-the-treatment-of-obesity-and-type-2-diabetes-in-youth

Download files


Publisher's version
OA_Gow_2021_Current_perspectives_on_the_role_of.pdf
License: CC BY-NC 4.0
File access level: Open

  • 2
    total views
  • 2
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Revisiting poststroke upper limb stratification : Resilience in a larger cohort
Varley, Benjamin J., Shiner, Christine T., Johnson, Liam, McNulty, Penelope A. and Thompson Butel, A.. (2021). Revisiting poststroke upper limb stratification : Resilience in a larger cohort. Neurorehabilitation and Neural Repair. 35(3), pp. 280-289. https://doi.org/10.1177/1545968321992048
A low-carbohydrate ketogenic diet reduces body mass without compromising performance in powerlifting and Olympic weightlifting athletes
Greene, David A., Varley, Benjamin J., Hartwig, Timothy B., Chapman, Phillip and Rigney, Michael. (2018). A low-carbohydrate ketogenic diet reduces body mass without compromising performance in powerlifting and Olympic weightlifting athletes. The Journal of Strength and Conditioning Research. 32(12), pp. 3373 - 3382. https://doi.org/10.1519/JSC.0000000000002904
Assessment of body composition in junior representative and first grade rugby league players using dual x-ray absorptiometry
David Greene, Benjamin Varley, Craig Duncan and Tim Gabbett. (2017). Assessment of body composition in junior representative and first grade rugby league players using dual x-ray absorptiometry. Science and Medicine in Football. 1(3), pp. 197-202. https://doi.org/10.1080/24733938.2017.1331043