Adolescent-onset depression : Are obesity and inflammation developmental mechanisms or outcomes?

Journal article


Byrne, Michelle L., O’Brien-Simpson, Neil M., Mitchell, Sarah A. and Allen, Nicholas B.. (2015). Adolescent-onset depression : Are obesity and inflammation developmental mechanisms or outcomes? Child Psychiatry and Human Development. 46(6), pp. 839-850. https://doi.org/10.1007/s10578-014-0524-9
AuthorsByrne, Michelle L., O’Brien-Simpson, Neil M., Mitchell, Sarah A. and Allen, Nicholas B.
Abstract

Depression often has its first onset during adolescence and is associated with obesity. Furthermore, inflammatory processes have been implicated in both depression and obesity, although research amongst adolescents is limited. This review explores associations between depression and obesity, depression and inflammation, and obesity and inflammation from a developmental perspective. The temporal relations between these factors are examined to explore whether obesity and elevated inflammation act as either risk factors for, or outcomes of, adolescent-onset depression. Sex differences in these processes are also summarized. We propose a model whereby increases in sex hormones during puberty increase risk for depression for females, which can lead to obesity, which in turn increases levels of inflammation. Importantly, this model suggests that inflammation and obesity are outcomes of adolescent depression, rather than initial contributing causes. Further research on biological and psychosocial effects of sex hormones is needed, as is longitudinal research with children and adolescents.

Keywordsadolescent depression; obesity; inflammation; puberty; sex differences
Year2015
JournalChild Psychiatry and Human Development
Journal citation46 (6), pp. 839-850
PublisherSpringer
ISSN0009-398X
Digital Object Identifier (DOI)https://doi.org/10.1007/s10578-014-0524-9
Scopus EID2-s2.0-84945488629
Research or scholarlyResearch
Page range839-850
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online10 Feb 2015
Publication process dates
Deposited20 Oct 2021
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