Associations between flavonoid intakes and gut microbiota in a group of adults with cystic fibrosis

Journal article


Li, Li and Somerset, Shawn. (2018). Associations between flavonoid intakes and gut microbiota in a group of adults with cystic fibrosis. Nutrients. 10(9), p. Article: 1264. https://doi.org/10.3390/nu10091264
AuthorsLi, Li and Somerset, Shawn
Abstract

Dietary flavonoid intakes can influence gut microbiota (GM), which in turn can affect immune function and host metabolism, both vital considerations in cystic fibrosis (CF) management. In CF, GM may be altered and link to CF respiratory events. This study explored the relationship between flavonoid intakes and GM in free-living adults with CF. Associations between the overall GM variations (unweighted and weighted UniFrac distances between pyrosequencing results of bacterial 16-ss rDNA from frozen faecal samples of sixteen CF adults) and standardised dietary flavonoid intakes (a validated flavonoid-specific food frequency questionnaire) were analysed using adonis tests. Flavonoid intakes that were significant at a false discovery rate (FDR) < 0.3 were subjected to Spearman correlation tests with standardised bacterial relative abundances (FDR < 0.3). Gallocatechin intakes (p = 0.047, q = 0.285) were associated with unweighted UniFrac distances. Intakes of apigenin (p = 0.028, q = 0.227) and kaempferol (p = 0.029, q = 0.227), and % flavonoid intake as flavones (p = 0.013, q = 0.227) and flavonols (p = 0.016, q = 0.227) (both excluding contribution of tea) were associated with weighted UniFrac distances. Among these, gallocatechin correlated with the genus Actinomyces and family Actinomycetaceae (Actinobacteria). Gallocatechin correlated negatively with class Coriobacteriia (Actinobacteria). Intakes of some flavonoids may be associated with GM variations with potential consequences for metabolism, immune function, and inflammation, which are important in CF lung disease and co-morbidity management.

Keywordsflavonoids; cystic fibrosis; gut microbiota; inflammation
Year2018
JournalNutrients
Journal citation10 (9), p. Article: 1264
PublisherMDPI AG
ISSN2072-6643
Digital Object Identifier (DOI)https://doi.org/10.3390/nu10091264
Scopus EID2-s2.0-85053086063
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-13
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online07 Sep 2018
Publication process dates
Accepted03 Sep 2018
Deposited27 Oct 2021
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