The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane
Journal article
Austin, Christopher J. D., Kahlert, Jan, Issa, Fatiah, Reed, John H., Smith, Jason R., Ioppolo, Joseph A., Ong, Jennifer A., Jamie, Joanne F., Hibbs, David and Rendina, Louis M.. (2014). The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane. Dalton Transactions. 43(28), pp. 10719-10724. https://doi.org/10.1039/c4dt00444b
Authors | Austin, Christopher J. D., Kahlert, Jan, Issa, Fatiah, Reed, John H., Smith, Jason R., Ioppolo, Joseph A., Ong, Jennifer A., Jamie, Joanne F., Hibbs, David and Rendina, Louis M. |
---|---|
Abstract | Indoleamine-2,3-dioxygenase-1 (IDO1) is a critical immunoregulatory enzyme responsible for the metabolism of tryptophan during inflammation and disease. Based upon a pyranonaphthoquinone framework, the first examples of indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing a carborane cage are reported. The novel closo-1,2-carboranyl-N-pyranonaphthoquinone derivatives display low μM binding affinity for the human recombinant enzyme, with IC50 values ranging from 0.78 to 1.77 μM. |
Year | 2014 |
Journal | Dalton Transactions |
Journal citation | 43 (28), pp. 10719-10724 |
Publisher | Royal Society of Chemistry |
ISSN | 1477-9226 |
Digital Object Identifier (DOI) | https://doi.org/10.1039/c4dt00444b |
Scopus EID | 2-s2.0-84903464291 |
Open access | Published as green open access |
Research or scholarly | Research |
Page range | 10719-10724 |
Author's accepted manuscript | License All rights reserved File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 22 Apr 2014 |
Publication process dates | |
Accepted | 03 Apr 2014 |
Deposited | 28 Oct 2021 |
Permalink -
https://acuresearchbank.acu.edu.au/item/8wxz7/the-first-indoleamine-2-3-dioxygenase-1-ido1-inhibitors-containing-carborane
Download files
Author's accepted manuscript
AM_Austin_2014_The_first_indoleamine_23_dioxygenase_1.pdf | |
License: All rights reserved | |
File access level: Open |
Restricted files
Publisher's version
(1 files)
65
total views29
total downloads0
views this month0
downloads this month