Brief report : Passive mechanical properties of gastrocnemius in multiple sclerosis and ankle contracture

Journal article


Hoang, Phu D., Psarakis, Michael, Kwah, Li Khim, Clarke, Jillian L., Gandevia, Simon C. and Diong, Joanna. (2021). Brief report : Passive mechanical properties of gastrocnemius in multiple sclerosis and ankle contracture. Clinical Biomechanics. 84, p. Article 105338. https://doi.org/10.1016/j.clinbiomech.2021.105338
AuthorsHoang, Phu D., Psarakis, Michael, Kwah, Li Khim, Clarke, Jillian L., Gandevia, Simon C. and Diong, Joanna
Abstract

Background
Ankle contracture is common in people with multiple sclerosis (MS) but the mechanisms of contracture are not clear. This study aimed to identify the mechanisms of contracture in MS by comparing passive muscle length and stiffness at known tension, separated into contributions by muscle fascicles and tendons, between people with MS who had contracture and healthy people.

Methods
Passive length-tension curves of the gastrocnemius muscle-tendon unit were derived from passive ankle torque and angle using a published biomechanical method. Ultrasound images of medial gastrocnemius muscle fascicles were used to partition length-tension curves into fascicle and tendon components. Lengths and stiffness of the muscle-tendon unit, muscle fascicles and tendons were compared between groups with linear regression.

Findings
Data were obtained from 15 participants with MS who had contracture [age 53 (12) years, mean (SD)] and 25 healthy participants [48 (20) years]. Participants with MS had clinically significant ankle contracture, and had shorter fascicles at slack length (between-groups mean difference −0.8 cm, 95% CI −1.2 to −0.4 cm, p < 0.001) and at 100 N (−0.7 cm, 95% CI −1.3 to −0.1 cm, p = 0.02) compared to healthy participants. There were no differences between groups in all other outcomes.

Interpretation
Tension-referenced comparisons of passive muscle length and stiffness show that people with MS who had contracture had shorter fascicles at low and high tension compared to healthy people, but there were no changes to the muscle-tendon unit or tendon. Further studies are needed to identify the causes and mechanisms of contracture in neurological conditions.

Keywordsankle; range of motion; muscle tendon unit; slack length; ultrasound; muscle fascicles; contracture
Year2021
JournalClinical Biomechanics
Journal citation84, p. Article 105338
PublisherElsevier Ltd
ISSN0268-0033
Digital Object Identifier (DOI)https://doi.org/10.1016/j.clinbiomech.2021.105338
Scopus EID2-s2.0-85105006311
Research or scholarlyResearch
Page range1-5
FunderAustralian Research Council (ARC)
National Health and Medical Research Council (NHMRC)
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online23 Mar 2021
Publication process dates
Accepted19 Mar 2021
Deposited09 Nov 2021
ARC Funded ResearchThis output has been funded, wholly or partially, under the Australian Research Council Act 2001
Permalink -

https://acuresearchbank.acu.edu.au/item/8x05q/brief-report-passive-mechanical-properties-of-gastrocnemius-in-multiple-sclerosis-and-ankle-contracture

Restricted files

Publisher's version

  • 30
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Safety, feasibility, and efficacy of an eccentric exercise intervention in people with multiple sclerosis with ankle contractures
Psarakis, Michael, Lord, Stephen R. and Hoang, Phu D.. (2021). Safety, feasibility, and efficacy of an eccentric exercise intervention in people with multiple sclerosis with ankle contractures. International Journal of MS Care. 23(1), pp. 31-36. https://doi.org/10.7224/1537-2073.2019-022
Ankle contractures in people with multiple sclerosis : Implications, measurement and treatment
Psarakis, Michael. (2020). Ankle contractures in people with multiple sclerosis : Implications, measurement and treatment [PhD Thesis]. Australian Catholic University School of Behavioural and Health Sciences https://doi.org/10.26199/acu.8vywz
Quality of clinical practice guidelines for management of limb amputations : A systematic review
Kwah, Li Khim, Green, Jordan, Butler, Jane and Lam, Lawrence. (2019). Quality of clinical practice guidelines for management of limb amputations : A systematic review. Physical Therapy. 99(5), pp. 577-590. https://doi.org/10.1093/ptj/pzz006
The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue : A single centre experience
Lin, Sophia D., Butler, Jane E., Boswell-Ruys, Claire L., Phu, Hoang, Jarvis, Tom, Gandevia, Simon C. and McCaughey, Euan J.. (2019). The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue : A single centre experience. PLoS ONE. 14(9), p. e0222731. https://doi.org/10.1371/journal.pone.0222731
Cold Water Ingestion Improves Exercise Tolerance of Heat-Sensitive People with MS
Georgia K. Chaseling, Davide Filingeri, Michael Barnett, Phu Hoang, Scott L. Davis and Ollie Jay. (2018). Cold Water Ingestion Improves Exercise Tolerance of Heat-Sensitive People with MS. Medicine and Science in Sports and Exercise. 50(4), pp. 643-649. https://doi.org/10.1249/MSS.0000000000001496
Between session reliability of heel-to-toe progression measurements in the stance phase of gait
Vanessa Ade, Dale Schalkwijk, Michael Psarakis, Michael D. Laporte, Timothy J. Faras, Remi Sandoval, Fadi Najjar and Peter Stubbs. (2018). Between session reliability of heel-to-toe progression measurements in the stance phase of gait. PLoS ONE. 13(7), pp. 1-6. https://doi.org/10.1371/journal.pone.0200436
Relationship between physiological and perceived fall risk in people with multiple sclerosis: Implications for assessment and management
Gunn, Hilary, Cameron, Michelle, Hoang, Phu, Lord, Stephen R., Shaw, Steve and Freeman, Jennifer. (2018). Relationship between physiological and perceived fall risk in people with multiple sclerosis: Implications for assessment and management. Archives of Physical Medicine and Rehabilitation. 99(10), pp. 2022 - 2029. https://doi.org/10.1016/j.apmr.2018.03.019
Wearable technology reveals gait compensations, unstable walking patterns and fatigue in people with multiple sclerosis
Psarakis, Michael, Greene, David A., Cole, Michael H., Lord, Stephen R., Hoang, Phu and Brodie, Matthew A. D.. (2018). Wearable technology reveals gait compensations, unstable walking patterns and fatigue in people with multiple sclerosis. Physiological Measurement. 39(7), pp. 1 - 13. https://doi.org/10.1088/1361-6579/aac0a3
Afferent thermosensory function in relapsing–remitting multiple sclerosis following exercise-induced increases in body temperature
Filingeri, Davide, Chaseling, Georgia K., Hoang, Phu, Barnett, Michael, Davis, Scott L. and Jay, Ollie. (2017). Afferent thermosensory function in relapsing–remitting multiple sclerosis following exercise-induced increases in body temperature. Experimental Physiology. 102(8), pp. 887 - 893. https://doi.org/10.1113/EP086320
Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis
Psarakis, Michael, Greene, David, Moresi, Mark, Baker, Michael, Stubbs, Peter, Brodie, Matthew, Lord, Stephen and Hoang, Phu. (2017). Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis. Clinical Biomechanics. 49, pp. 96-100. https://doi.org/10.1016/j.clinbiomech.2017.08.012
A simple test of choice stepping reaction time for assessing fall risk in people with multiple sclerosis
Tijsma, Mylou, Vister, Eva, Hoang, Phu and Lord, Stephen R.. (2017). A simple test of choice stepping reaction time for assessing fall risk in people with multiple sclerosis. Disability and Rehabilitation. 39(6), pp. 601 - 607. https://doi.org/10.3109/09638288.2016.1148784
Effects of a home-based step training programme on balance, stepping, cognition and functional performance in people with multiple sclerosis - A randomized controlled trial
Hoang, Phu, Schoene, Daniel, Gandevia, Simon C., Smith, Stuart T. and Lord, Stephen R.. (2016). Effects of a home-based step training programme on balance, stepping, cognition and functional performance in people with multiple sclerosis - A randomized controlled trial. Multiple Sclerosis Journal. 22(1), pp. 94 - 103. https://doi.org/10.1177/1352458515579442
Gyroscopic corrections improve wearable sensor data prior to measuring dynamic sway in the gait of people with Multiple Sclerosis
Brodie, Matthew A. D., Psarakis, Michael and Hoang, Phu. (2016). Gyroscopic corrections improve wearable sensor data prior to measuring dynamic sway in the gait of people with Multiple Sclerosis. Computer Methods in Biomechanics and Biomedical Engineering. 19(12), pp. 1339 - 1346. https://doi.org/10.1080/10255842.2016.1140747
Medications are associated with falls in people with multiple sclerosis - A Prospective Cohort study
Cameron, Michelle H., Karstens, Lisa, Hoang, Phu, Bourdette, Dennis and Lord, Stephen R.. (2015). Medications are associated with falls in people with multiple sclerosis - A Prospective Cohort study. International Journal of MS Care. 17(5), pp. 207 - 214. https://doi.org/10.7224/1537-2073.2014-076
Falls in people with MS - An individual data meta-analysis from studies from Australia, Sweden, United Kingdom and the United States
Nilsagård, Ylva E., Gunn, Hilary, Freeman, Jennifer, Hoang, Phu, Lord, Stephen R., Mazumder, Rajarshi and Cameron, Michelle. (2015). Falls in people with MS - An individual data meta-analysis from studies from Australia, Sweden, United Kingdom and the United States. Multiple Sclerosis Journal. 21(1), pp. 92 - 100. https://doi.org/10.1177/1352458514538884
Neuromuscular electrical stimulation cycling exercise for persons with advanced multiple sclerosis
Fornusek, Ché and Hoang, Phu. (2014). Neuromuscular electrical stimulation cycling exercise for persons with advanced multiple sclerosis. Journal of Rehabilitation Medicine. 46(7), pp. 698 - 702. https://doi.org/10.2340/16501977-1792
Models containing age and NIHSS predict recovery of ambulation and upper limb function six months after stroke : an observational study
Kwah, Li Khim, Harvey, Lisa A., Diong, Joanna and Herbert, Robert D.. (2013). Models containing age and NIHSS predict recovery of ambulation and upper limb function six months after stroke : an observational study. Journal of Physiotherapy. 59(3), pp. 189 - 197. https://doi.org/10.1016/S1836-9553(13)70183-8
Reliability and validity of ultrasound measurements of muscle fascicle length and pennation in humans : A systematic review
Kwah, Li, Pinto, Rafael, Diong, Joanna and Herbert, Robert. (2013). Reliability and validity of ultrasound measurements of muscle fascicle length and pennation in humans : A systematic review. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.01430.2011
Reliability and validity of ultrasound measurements of muscle fascicle length and pennation in humans : a systematic review
Kwah, Li Khim, Harvey, Lisa A., Diong, Joanna and Herbert, Robert D.. (2013). Reliability and validity of ultrasound measurements of muscle fascicle length and pennation in humans : a systematic review. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.01430.2011
Mechanisms of increased passive compliance of hamstring muscle-tendon units after spinal cord injury
Diong, Joanna, Herbert, Robert, Kwah, Li, Clark, Jillian and Harvey, Lisa A.. (2012). Mechanisms of increased passive compliance of hamstring muscle-tendon units after spinal cord injury. Clinical Biomechanics. 27(9), pp. 893 - 898. https://doi.org/10.1016/j.clinbiomech.2012.07.003
Incidence and predictors of contracture after spinal cord injurya prospective cohort study
Diong, Joanna, Harvey, Lisa A., Kwah, Li Khim, Eyles, J., Ling, M. J., Ben, M. and Herbert, Robert Dale. (2012). Incidence and predictors of contracture after spinal cord injurya prospective cohort study. Spinal Cord. 50(8), pp. 579 - 584. https://doi.org/10.1038/sc.2012.25
Passive mechanical properties of the gastrocnemius after spinal cord injury
Diong, Joanna, Herbert, Robert, Harvey, Lisa, Kwah, Li, Clark, Jillian, Hoang, Phu, Martin, Josh, Clarke, E, Bilston, L and Gandevia, S. (2012). Passive mechanical properties of the gastrocnemius after spinal cord injury. Muscle & Nerve. 46(2), pp. 237 - 245. https://doi.org/10.1002/mus.23356
In vivo passive mechanical behaviour of muscle fascicles and tendons in human gastrocnemius muscle-tendon units
Herbert, Robert, Clarke, Jane, Kwah, Li, Diong, Joanna, Martin, Josh, Clarke, E, Bilston, L and Gandevia, S. (2011). In vivo passive mechanical behaviour of muscle fascicles and tendons in human gastrocnemius muscle-tendon units. The Journal of Physiology. 589(21), pp. 5257 - 5267. https://doi.org/10.1113/jphysiol.2011.212175