The role of traffic-related air pollution on neurodegenerative diseases in older people : An epidemiological perspective

Journal article


Tham, Rachel and Schikowski, Tamara. (2021). The role of traffic-related air pollution on neurodegenerative diseases in older people : An epidemiological perspective. Journal of Alzheimer's Disease. 79(3), pp. 949-959. https://doi.org/10.3233/JAD-200813
AuthorsTham, Rachel and Schikowski, Tamara
Abstract

Traffic-related air pollution is ubiquitous and almost impossible to avoid. It is important to understand the role that traffic-related air pollution may play in neurodegenerative diseases, such as dementia, Alzheimer’s disease, and Parkinson’s disease, particularly among older populations and at-risk groups. There is a growing interest in this area among the environmental epidemiology literature and the body of evidence identifying this role is emerging and strengthening. This review focuses on the principal components of traffic-related air pollutants (particulate matter and nitrogen oxides) and the epidemiological evidence of their contribution to common neurodegenerative diseases. All studies reported are currently observational in nature and there are mixed findings depending on the study design, assessment of traffic-related air pollutant levels, assessment of the neurodegenerative disease outcome, time period of assessment, and the role of confounding environmental factors and at-risk genetic characteristics. All current studies have been conducted in income-rich countries where traffic-related air pollution levels are relatively low. Additional longer-term studies are needed to confirm the levels of risk, consider other contributing environmental factors and to be conducted in settings where air pollution exposures are higher and at-risk populations reside and work. Better understanding of these relationships will help inform the development of preventive measures and reduce chronic cognitive and physical health burdens (cost, quality of life) at personal and societal levels.

Keywordsair pollution; Alzheimer’s disease; dementia; mild cognitive impairment; Parkinson’s disease
Year2021
JournalJournal of Alzheimer's Disease
Journal citation79 (3), pp. 949-959
PublisherIOS Press
ISSN1387-2877
Digital Object Identifier (DOI)https://doi.org/10.3233/JAD-200813
PubMed ID33361591
Scopus EID2-s2.0-85100582682
Research or scholarlyResearch
Page range949-959
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online02 Feb 2021
Publication process dates
Accepted16 Nov 2020
Deposited11 Nov 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8x072/the-role-of-traffic-related-air-pollution-on-neurodegenerative-diseases-in-older-people-an-epidemiological-perspective

Restricted files

Publisher's version

  • 118
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Improving traffic-related air pollution estimates by modelling minor road traffic volumes
Alvarado-Molina, Miguel, Curto, Ariadna, Wheeler, Amanda J., Tham, Rachel, Cerin, Ester, Nieuwenhuijsen, Mark, Vermeulen, Roel and Donaire Gonzalez, David. (2023). Improving traffic-related air pollution estimates by modelling minor road traffic volumes. Environmental Pollution. 338, p. Article 122657. https://doi.org/10.1016/j.envpol.2023.122657
Urban neighbourhood environments, cardiometabolic health and cognitive function : A national cross-sectional study of middle-aged and older adults in Australia
Cerin, Ester, Barnett, Anthony, Shaw, Jonathan E., Martino, Erika, Knibbs, Luke D., Tham, Rachel, Wheeler, Amanda J. and Anstey, Kaarin J.. (2022). Urban neighbourhood environments, cardiometabolic health and cognitive function : A national cross-sectional study of middle-aged and older adults in Australia. Toxics. 10(1), p. Article 23. https://doi.org/10.3390/toxics10010023
Associations between traffic-related air pollution and cognitive function in Australian urban settings : The moderating role of diabetes status
Tham, Rachel, Wheeler, Amanda J., Carver, Alison, Dunstan, David, Donaire-Gonzalez, David, Anstey, Kaarin J., Shaw, Jonathan E., Magliano, Dianna J., Martino, Erika, Barnett, Anthony and Cerin, Ester. (2022). Associations between traffic-related air pollution and cognitive function in Australian urban settings : The moderating role of diabetes status. Toxics. 10(6), p. Article 289. https://doi.org/10.3390/toxics10060289
Vegetation and vehicle emissions around primary schools across urban Australia : Associations with academic performance
Carver, Alison, Alvarado Molina, Miguel, Claesen, Joep L. A., Klabbers, Gonnie, Donaire Gonzalez, David, Tham, Rachel, Cerin, Ester, Nieuwenhuijsen, Mark and Wheeler, Amanda J.. (2022). Vegetation and vehicle emissions around primary schools across urban Australia : Associations with academic performance. Environmental Research. 212(Part B), p. Article 113256. https://doi.org/10.1016/j.envres.2022.113256
Differences in psychosocial distress among rural and metropolitan health care workers during the COVID-19 pandemic
Tham, Rachel, Pascoe, Amy, Willis, Karen, Kay, Margaret and Smallwood, Natasha. (2022). Differences in psychosocial distress among rural and metropolitan health care workers during the COVID-19 pandemic. Australian Journal of Rural Health. 30(5), pp. 683-696. https://doi.org/10.1111/ajr.12873
Outdoor particulate matter exposure and upper respiratory tract infections in children and adolescents : A systematic review and meta-analysis
Ziou, Myriam, Tham, Rachel, Wheeler, Amanda J., Zosky, Graeme R., Stephens, Nicola and Johnston, Fay H.. (2022). Outdoor particulate matter exposure and upper respiratory tract infections in children and adolescents : A systematic review and meta-analysis. Environmental Research. 210, p. Article 112969. https://doi.org/10.1016/j.envres.2022.112969
From urban neighbourhood environments to cognitive health : A cross-sectional analysis of the role of physical activity and sedentary behaviours
Cerin, Ester, Barnett, Anthony, Shaw, Jonathan E., Martino, Erika, Knibbs, Luke D., Tham, Rachel, Wheeler, Amanda J. and Anstey, Kaarin J.. (2021). From urban neighbourhood environments to cognitive health : A cross-sectional analysis of the role of physical activity and sedentary behaviours. BMC Public Health. 21(1), p. Article 2320. https://doi.org/10.1186/s12889-021-12375-3
Parental preconception exposures to outdoor neighbourhood environments and adverse birth outcomes : A protocol for a scoping review and evidence map
Mavoa, Suzanne, Keevers, Daniel, Kane, Stefan C., Wake, Melissa, Tham, Rachel, Lycett, Kate, Wong, Yen Ting and Chong, Katherine. (2021). Parental preconception exposures to outdoor neighbourhood environments and adverse birth outcomes : A protocol for a scoping review and evidence map. International Journal of Environmental Research and Public Health. 18(17), pp. 1-10. https://doi.org/10.3390/ijerph18178943
The impact of traffic-related air pollution on child and adolescent academic performance : A systematic review
Stenson, Chloe, Wheeler, Amanda J., Carver, Alison, Donaire-Gonzalez, David, Alvarado-Molina, Miguel, Nieuwenhuijsen, Mark and Tham, Rachel. (2021). The impact of traffic-related air pollution on child and adolescent academic performance : A systematic review. Environment International. 155, p. Article 106696. https://doi.org/10.1016/j.envint.2021.106696
A systematic review of the evidence of outdoor air pollution on asthma hospital visits in children and adolescents in South Asia - a call for data
Malamardi, Sowmya, Lambert, Katrina A., Batra, Mehak, Tham, Rachel, Padukudru Anand, Mahesh and Erbas, Bircan. (2021). A systematic review of the evidence of outdoor air pollution on asthma hospital visits in children and adolescents in South Asia - a call for data. Wellcome Open Research. 16, p. Article: 174. https://doi.org/10.12688/wellcomeopenres.16991.1
Development of measures of perceived neighborhood environmental attributed influencing, and perceived barriers to engagement in, healthy behaviors for older Chinese immigrants to Australia
Cerin, Ester, Yin, Shiyuan, Choi, Wing K., Ngan, Winsfred, Tham, Rachel and Barnett, Anthony. (2021). Development of measures of perceived neighborhood environmental attributed influencing, and perceived barriers to engagement in, healthy behaviors for older Chinese immigrants to Australia. International Journal of Environmental Research and Public Health. 18(9), pp. 1-27. https://doi.org/10.3390/ijerph18094531
Is short-term exposure to grass pollen adversely associated with lung function and airway inflammation in the community?
Idrose, Nur Sabrina, Tham, Rachel C. A., Lodge, Caroline J., Lowe, Adrian J., Bui, Dinh, Perret, Jennifer L., Vicendese, Don, Newbigin, Edward J., Tang, Mimi L. K., Aldakheel, Fahad M., Waidyatillake, Nilakshi T., Douglass, Jo A., Abramson, Michael J., Walters, Eugene Haydn, Erbas, Bircan and Dharmage, Shyamali C.. (2021). Is short-term exposure to grass pollen adversely associated with lung function and airway inflammation in the community? Allergy. 76(4), pp. 1136-1146. https://doi.org/10.1111/all.14566
Associations of traffic-related air pollution and greenery with academic outcomes among primary schoolchildren
Wheeler, A., Donaire Gonzalez, D., Alvarado Molina, M., Tham, R., Nieuwenhuijsen, M. and Carver, A.. (2021). Associations of traffic-related air pollution and greenery with academic outcomes among primary schoolchildren. Environmental Research. 35(7), p. 111325. https://doi.org/10.1016/j.envres.2021.111325
Principles for setting air quality guidelines to protect human health in Australia
Zosky, Graeme R., Vander Hoorn, Stephen, Abramson, Michael J., Dwyer, Sophie, Green, Donna, Heyworth, Jane, Jalaludin, Bin B., McCrindle-Fuchs, Jennifer, Tham, Rachel and Marks, Guy B.. (2021). Principles for setting air quality guidelines to protect human health in Australia. Medical Journal of Australia. 214(6), pp. 254-256. https://doi.org/10.5694/mja2.50964
Pattern and causes of oral and maxillofacial injuries presented to a tertiary care public dental hospital in strictly imposed COVID-19 lockdown scenario
Surendra, Gayan, Perera, Irosha, Ranasinghe, Anura, Kumarapeli, Vindya, Tham, Rachel and Wickramaratne, Pujitha. (2021). Pattern and causes of oral and maxillofacial injuries presented to a tertiary care public dental hospital in strictly imposed COVID-19 lockdown scenario. Oral. 1(1), pp. 3-14. https://doi.org/10.3390/oral1010002
Rural health systems : Spotlight on equity and access
Ward, Bernadette and Tham, Rachel. (2020). Rural health systems : Spotlight on equity and access. In In Willis, Eileen, Reynolds, Louise and Rudge, Trudy (Ed.). Understanding the Australian health care system pp. 136-154 Elsevier Australia.
Scoping review to understand the potential for public health impacts of transitioning to lower carbon emission technologies and policies
Tham, Rachel, Morgan, Geoff, Dharmage, Shyamali, Marks, Guy and Cowie, Christine. (2020). Scoping review to understand the potential for public health impacts of transitioning to lower carbon emission technologies and policies. Environmental Research Communications. 2(6), pp. 1-35. https://doi.org/10.1088/2515-7620/ab9526
International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health
Ester Cerin, Anthony Barnett, Basile Chaix, Mark Nieuwenhuijsen, Karen Caeyenberghs, Bin Jalaludin, Takemi Sugiyama, James Sallis, Nicola T. Lautenschlager, Michael Y Ni, Govinda Poudel, David Donaire Gonzalez, Rachel Tham, Amanda Wheeler, Luke Knibbs, Linwei Tian, Kai Chan, David Dunstan, Alison Carver and Kaarin Anstey. (2020). International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health. BMJ Open. 10(3), pp. 1-15. https://doi.org/10.1136/bmjopen-2019-036607
Outdoor fungal spores and acute respiratory effects in vulnerable individuals
Tham, Rachel, Erbas, Bircan, Dharmage, Shyamali Chandrika, Tang, Mimi L. K., Aldakheel, Fahad, Lodge, Caroline J., Thomas, Paul S., Taylor, Philip E., Abramson, Michael J. and Lowe, Adrian J.. (2019). Outdoor fungal spores and acute respiratory effects in vulnerable individuals. Environmental Research. 178, pp. 1 - 9. https://doi.org/10.1016/j.envres.2019.108675
Association between fire smoke fine particulate matter and asthma-related outcomes: Systematic review and meat-analysis
Arriagada, Nicolas Borchers, Horsley, Joshua A., Palmer, Andrew J., Morgan, Geoffrey G., Tham, Rachel and Johnston, Fay H.. (2019). Association between fire smoke fine particulate matter and asthma-related outcomes: Systematic review and meat-analysis. Environmental Research. 179, pp. 1 - 11. https://doi.org/10.1016/j.envres.2019.108777
High ambient levels of grass, weed and other pollen are associated with asthma admissions in children and adolescents: A large 5-year case-crossover study
Shrestha, Som K., Katelaris, C. H., Dharmage, S. C., Burton, Pamela, Vicendese, Don, Tham, Rachel, Abramson, Michael J. and Erbas, B.. (2018). High ambient levels of grass, weed and other pollen are associated with asthma admissions in children and adolescents: A large 5-year case-crossover study. Clinical and Experimental Allergy. 48(11), pp. 1421 - 1428. https://doi.org/10.1111/cea.13225
Outdoor pollen is a trigger of child and adolescent asthma emergency department presentations: A systematic review and meta-analysis
Erbas, Bircan, Jazayeri, Mitra, Lambert, Katrina A., Katelaris, Constance H., Prendergast, Luke A., Tham, Rachel, Parrodi, M.J., Davies, Janet M., Newbigin, Ed J., Abramson, Michael J. and Charmage, Shyamali C.. (2018). Outdoor pollen is a trigger of child and adolescent asthma emergency department presentations: A systematic review and meta-analysis. Allergy. 73(8), pp. 1632 - 1641. https://doi.org/10.1111/all.13407
Air pollution and otitis media in children: A systematic review of literature
Bowatte, Gayan, Tham, Rachel, Perret, Jennifer L., Bloom, Michael S., Dong, Guanghui, Waidyatillake, Nilakshi, Bui, Dinh, Morgan, Geoffrey G., Jalaludin, Bin, Lodge, Caroline J. and Dharmage, Shyamali C.. (2018). Air pollution and otitis media in children: A systematic review of literature. International Journal of Environmental Research and Public Health. 15(2), pp. 1 - 19. https://doi.org/10.3390/ijerph15020257
Greenspace and atopic sensitization in children and adolescents: A systematic review
Lambert, Katrina A., Bowatte, Gayan, Tham, Rachel, Lodge, Caroline J., Prendergast, Luke A., Heinrich, Joachim, Abramson, Michael J., Dharmage, Shyamali C. and Erbas, Bircan. (2018). Greenspace and atopic sensitization in children and adolescents: A systematic review. International Journal of Environmental Research and Public Health. 15(11), pp. 1 - 12. https://doi.org/10.3390/ijerph15112539
Associations between outdoor fungal spores and childhood and adolescent asthma hospitalizations
Tham, Rachel, Vicendese, Don, Dharmage, S. C., Hyndman, Rob J., Newbigin, E., Lewis, Emma, O'Sullivan, Molly, Lowe, Adrian J., Taylor, Philip, Bardin, Philip, Tang, Mimi L. K., Abramson, Michael J. and Erbas, B.. (2017). Associations between outdoor fungal spores and childhood and adolescent asthma hospitalizations. Journal of Allergy and Clinical Immunology. 139(4), pp. 1140 - 1147. https://doi.org/10.1016/j.jaci.2016.06.046
Effect of season of birth on cord blood IgE and IgE at birth: a systematic review and meta-analysis
Susanto, Nugrobo Harry, Vicendese, Don, Salim, Agus, Lowe, Adrian J., Dharmage, S. C., Tham, Rachel, Lodge, Caroline, Garden, Frances L., Allen, Katie, Svanes, Cecilie, Heinrich, Joachim, Abramson, Michael J. and Erbas, B.. (2017). Effect of season of birth on cord blood IgE and IgE at birth: a systematic review and meta-analysis. Environmental Research. 157, pp. 198 - 205. https://doi.org/10.1016/j.envres.2017.05.026
Residential greenness and allergic respiratory diseases in children and adolescents - a systematic review and meta-analysis
Lambert, K. A., Bowatte, G., Tham, Rachel, Lodge, C., Prendergast, L., Heinrich, J., Abramson, Michael J., Dharmage, S. C. and Erbas, B.. (2017). Residential greenness and allergic respiratory diseases in children and adolescents - a systematic review and meta-analysis. Environmental Research. 159, pp. 212 - 221. https://doi.org/10.1016/j.envres.2017.08.002
The role of outdoor fungi on asthma hospital admissions in children and adolescents: a 5-year time stratified case-crossover analysis
Tham, Rachel, Katelaris, Constance H., Vicendese, Don, Dharmage, Shyamali C., Lowe, Adrian J., Bowatte, Gayan, Taylor, Philip, Burton, Pamela, Abramson, Michael J. and Erbas, B.. (2017). The role of outdoor fungi on asthma hospital admissions in children and adolescents: a 5-year time stratified case-crossover analysis. Environmental Research. 154, pp. 42 - 49. https://doi.org/10.1016/j.envres.2016.12.016
The quality of cardiovascular disease prevention in rural primary care
Allenby, Ann, Kinsman, Leigh, Tham, Rachel, Symons, Julie, Jones, Mike and Campbell, Stephen. (2016). The quality of cardiovascular disease prevention in rural primary care. Australian Journal of Rural Health. 24(2), pp. 92 - 98. https://doi.org/10.1111/ajr.12224
Prevention of cardiovascular disease in rural Australian primary care: an exploratory study of the perspectives of clinicians and high-risk men
Kinsman, Leigh, Tham, Rachel, Symons, Julie, Jones, Mike, Campbell, Stephen and Allenby, Ann. (2016). Prevention of cardiovascular disease in rural Australian primary care: an exploratory study of the perspectives of clinicians and high-risk men. Australian Journal of Primary Health. 22(6), pp. 510 - 516. https://doi.org/10.1071/PY15091
Oral health-related knowledge, attitudes and self-efficacy of Australian rural older adults
Marino, Rodrigo Jose, Hopcraft, Matthew, Ghanim, Aghareed, Tham, Rachel, Khew, Chee-Wah and Stevenson, Christine. (2016). Oral health-related knowledge, attitudes and self-efficacy of Australian rural older adults. Gerodontology: an international journal. 33(4), pp. 530 - 538. https://doi.org/10.1111/ger.12202
Breastfeeding and the risk of dental caries: a systematic review and meta-analysis
Tham, Rachel, Bowatte, G., Dharmage, S. C., Tan, D. J., Lau, M. X.Z., Dai, Xiaochen, Allen, K J. and Lodge, C. J.. (2015). Breastfeeding and the risk of dental caries: a systematic review and meta-analysis. Acta Paediatrica. 104(467), pp. 62 - 84. https://doi.org/10.1111/apa.13118
Breastfeeding and asthma and allergies: A systematic review and meta-analysis
Lodge, Caroline J., Tan, D. J., Lau, M. X. Z., Dai, Xiaochen, Tham, Rachel, Lowe, Adrian J., Bowatte, Gayan, Allen, K. J. and Dharmage, Shyamali Chandrika. (2015). Breastfeeding and asthma and allergies: A systematic review and meta-analysis. Acta Paediatrica. 104(467), pp. 38 - 53. https://doi.org/10.1111/apa.13132
Breastfeeding and childhood acute otitis media: A systematic review and meta-analysis
Bowatte, G., Tham, R., Allen, K. J., Tan, D. J., Lau, M. X. Z., Dai, X. and Lodge, C. J.. (2015). Breastfeeding and childhood acute otitis media: A systematic review and meta-analysis. Acta Paediatrica. 104(467), pp. 85 - 95. https://doi.org/10.1111/apa.13151
Reporting dental trauma and its inclusion in an injury surveillance system in Victoria, Australia
Dang, K. M., Day, P. F., Calache, H., Tham, R. and Parashos, P.. (2015). Reporting dental trauma and its inclusion in an injury surveillance system in Victoria, Australia. Australian Dental Journal. 60(1), pp. 88 - 95. https://doi.org/10.1111/adj.12273
Investing in longitudinal studies of primary healthcare: what can we learn about service performance, sustainability and quality?
Ward, Bernadette M., Buykx, P. F., Tham, Rachel, Kinsman, Leigh and Humphreys, John S.. (2014). Investing in longitudinal studies of primary healthcare: what can we learn about service performance, sustainability and quality? Rural and Remote Health. 14(4), pp. 1 - 6.
Staff perceptions of primary healthcare service change: Influences on staff satisfaction
Tham, Rachel, Buykx, Penny, Kinsman, Leigh, Ward, Bernadette, Humphreys, John S., Asaid, Adel, Tuohey, Kathy and Jenner, Rohan. (2014). Staff perceptions of primary healthcare service change: Influences on staff satisfaction. Australian Health Review. 38(5), pp. 580 - 583. https://doi.org/10.1071/AH14015
Outdoor fungi and child asthma health service attendances
Tham, Rachel, Dharmage, Shyamali C., Taylor, Philip E., Katelaris, Constance H., Vicendese, Don, Abramson, Michael J. and Erbas, Bircan. (2014). Outdoor fungi and child asthma health service attendances. Pediatric Allergy and Immunology. 25(5), pp. 439 - 449. https://doi.org/10.1111/pai.12257
Pattern and factors associated with utilization of dental services among older adults in rural Victoria
Mariño, Rodrigo Jose, Khan, A. R., Tham, Rachel, Khew, Chee-Wah and Stevenson, Christine. (2014). Pattern and factors associated with utilization of dental services among older adults in rural Victoria. Australian Dental Journal. 59(4), pp. 504 - 510. https://doi.org/10.1111/adj.12216
Oral healthcare issues in rural residential aged care services in Victoria, Australia
Tham, Rachel and Hardy, Susan. (2013). Oral healthcare issues in rural residential aged care services in Victoria, Australia. Gerodontology. 30(2), pp. 126-132. https://doi.org/10.1111/j.1741-2358.2012.00652.x
The role of seasonal grass pollen on childhood asthma emergency department presentations
Erbas, B., Akram, M., Dharmage, S. C., Tham, R., Dennekamp, M., Newbigin, E., Taylor, P., Tang, M. L. K. and Abramson, M. J.. (2012). The role of seasonal grass pollen on childhood asthma emergency department presentations. Clinical and Experimental Allergy. 42(5), pp. 799 - 805. https://doi.org/10.1111/j.1365-2222.2012.03995.x
Study protocol : Evaluating the impact of a rural Australian primary health care service on rural health
Tham, Rachel, Humphreys, John S., Kinsman, Leigh, Buykx, Penny, Asaid, Adel and Tuohey, Kathy. (2011). Study protocol : Evaluating the impact of a rural Australian primary health care service on rural health. BMC Health Services Research. 11(1), pp. 1-6. https://doi.org/10.1186/1472-6963-11-52