RSPO3 is important for trabecular bone and fracture risk in mice and humans

Journal article

Nilsson, Karin H., Henning, Petra, El Shahawy, Maha, Nethander, Maria, Andersen, Thomas, Ejersted, Charlotte, Wu, Jianyao, Gustafsson, Karin, Koskela, Antti, Tuukkanen, Juha, Souza, Pedro, Tuckermann, Jan, Lorentzon, Karl Mattias, Ruud, Linda, Lehtimaki, Terho, Tobias, Jon, Zhou, Sirui, Lerner, Ulf H., Richards, J. Brent, ... Ohlsson, Claes. (2021). RSPO3 is important for trabecular bone and fracture risk in mice and humans. Nature Communications. 12(1), p. Article: 4923. https://doi.org/10.1038/s41467-021-25124-2
AuthorsNilsson, Karin H., Henning, Petra, El Shahawy, Maha, Nethander, Maria, Andersen, Thomas, Ejersted, Charlotte, Wu, Jianyao, Gustafsson, Karin, Koskela, Antti, Tuukkanen, Juha, Souza, Pedro, Tuckermann, Jan, Lorentzon, Karl Mattias, Ruud, Linda, Lehtimaki, Terho, Tobias, Jon, Zhou, Sirui, Lerner, Ulf H., Richards, J. Brent, Moverare-Skrtic, Sofia and Ohlsson, Claes
Abstract

With increasing age of the population, countries across the globe are facing a substantial increase in osteoporotic fractures. Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here we show that the fracture reducing allele at the RSPO3 locus associate with increased RSPO3 expression both at the mRNA and protein levels, increased trabecular bone mineral density and reduced risk mainly of distal forearm fractures in humans. We also demonstrate that RSPO3 is expressed in osteoprogenitor cells and osteoblasts and that osteoblast-derived RSPO3 is the principal source of RSPO3 in bone and an important regulator of vertebral trabecular bone mass and bone strength in adult mice. Mechanistic studies revealed that RSPO3 in a cell-autonomous manner increases osteoblast proliferation and differentiation. In conclusion, RSPO3 regulates vertebral trabecular bone mass and bone strength in mice and fracture risk in humans.

Year2021
JournalNature Communications
Journal citation12 (1), p. Article: 4923
PublisherNature Publishing Group
ISSN2041-1723
Digital Object Identifier (DOI)https://doi.org/10.1038/s41467-021-25124-2
PubMed IDPMC8363747
Scopus EID2-s2.0-8511271444
PubMed Central ID34389713
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-18
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online13 Aug 2021
Publication process dates
Accepted19 Jul 2021
Deposited19 Nov 2021
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Svensson, J., Ohlsson, C., Karlsson, M. K., Lorentzon, M., Lewerin, C. and Mellstrom, D.. (2021). Subclinical hyperthyroidism is associated with increased risk of vertebral fractures in older men. Osteoporosis International. 32, pp. 2257-2265. https://doi.org/10.1007/s00198-021-05964-w
FRAX-based intervention thresholds for osteoporosis treatment in Ukraine
Povoroznyuk, Vladyslav, Grygorieva, Nataliia, Johansson, Helena, Lorentzon, Mattias, Harvey, Nicholas C., McCloskey, Eugene V., Musienko, Anna, Liu, Enwu, Kanis, John A., Zaverukha, Nataliia and Ivanyk, Oksana. (2021). FRAX-based intervention thresholds for osteoporosis treatment in Ukraine. Journal of Osteoporosis. 2021, p. Article 2043479. https://doi.org/10.1155/2021/2043479
An assessment of intervention thresholds for very high fracture risk applied to the NOGG guidelines : A report for the National Osteoporosis Guideline Group (NOGG)
Kanis, J. A., Johansson, H., Harvey, N. C., Lorentzon, M., Liu, E., Vandenput, L. and McCloskey, E. V.. (2021). An assessment of intervention thresholds for very high fracture risk applied to the NOGG guidelines : A report for the National Osteoporosis Guideline Group (NOGG). Osteoporosis International. 32, pp. 1951-1960. https://doi.org/10.1007/s00198-021-05942-2
The challenge of applying digital image processing software on intraoral radiographs for osteoporosis risk assessment
Gullberg, Joanna, Al-Okshi, Ayman, Homar Asan, Dalia, Zainea, Anita, Sundh, Daniel, Lorentzon, Mattias and Lindh, Christina. (2021). The challenge of applying digital image processing software on intraoral radiographs for osteoporosis risk assessment. Dentomaxillofacial Radiology. 50, p. Article 20210175. https://doi.org/10.1259/dmfr.20210175
The effect on subsequent fracture risk of age, sex, and prior fracture site by recency of prior fracture
Kanis, J. A., Johansson, H., Harvey, N. C., Gudnason, V., Sigurdsson, G., Siggeirsdottir, K., Lorentzon, M., Liu, E., Vandenput, L. and McCloskey, E. V.. (2021). The effect on subsequent fracture risk of age, sex, and prior fracture site by recency of prior fracture. Osteoporosis International. 32(8), pp. 1547-1555. https://doi.org/10.1007/s00198-020-05803-4
Metabolic alterations in older women with low bone mineral density supplemented with lactobacillus reuteri
Li, Peishun, Sundh, Daniel, Ji, Boyang, Lappa, Dimitra, Ye, Lingqun, Nielsen, Jens and Lorentzon, Mattias. (2021). Metabolic alterations in older women with low bone mineral density supplemented with lactobacillus reuteri. JBMR Plus. 5(4), p. e10478. https://doi.org/10.1002/jbm4.10478
High platelet count is associated with low bone mineral density : The MrOS Sweden cohort
Kristjansdottir, H. L., Mellström, D., Johansson, P., Karlsson, M., Vandenput, L., Lorentzon, M., Herlitz, H., Ohlsson, C., Lerner, U. H. and Lewerin, C.. (2021). High platelet count is associated with low bone mineral density : The MrOS Sweden cohort. Osteoporosis International. 32, pp. 865-871. https://doi.org/10.1007/s00198-020-05766-6
Romosozumab efficacy on fracture outcomes is greater in patients at high baseline fracture risk : A post hoc analysis of the first year of the frame study
McCloskey, E. V., Johansson, H., Harvey, N. C., Lorentzon, K., Shi, Y. and Kanis, J. A.. (2021). Romosozumab efficacy on fracture outcomes is greater in patients at high baseline fracture risk : A post hoc analysis of the first year of the frame study. Osteoporosis International. 32(8), pp. 1601-1608. https://doi.org/10.1007/s00198-020-05815-0
Intermediate monocytes correlate with CXCR3+ Th17 cells but not with bone characteristics in untreated early rheumatoid arthritis
Drevinge, Christina, Scheffler, Julia M., Koro-Arvidsson, Catalin, Sundh, Daniel, Carlsten, Hans, Gjertsson, Inger, Lindholm, Catharina, Lorentzon, Mattias, Rudin, Anna, Ekwall, Anna-Karin Hultgård and Islander, Ulrika. (2021). Intermediate monocytes correlate with CXCR3+ Th17 cells but not with bone characteristics in untreated early rheumatoid arthritis. PLoS ONE. 16(3), p. e0249205. https://doi.org/10.1371/journal.pone.0249205
FRAX-based fracture probabilities in South Africa
Johansson, Helena, Dela, Sapna S., Cassim, Bilkish, Paruk, Farhanah, Brown, Susan L., Conradie, Magda, Harvey, Nicholas C., Jordaan, Johannes D., Kalla, Asgar A., Liu, Enwu, Lorentzon, Mattias, Lukhele, Mkhululi, McCloskey, Eugene V., Mohamed, Ozayr, Chutterpaul, Pariva, Vandenput, Liesbeth and Kanis, John A.. (2021). FRAX-based fracture probabilities in South Africa. Archives of Osteoporosis. 16(1), p. 51. https://doi.org/10.1007/s11657-021-00905-w
Cost-effectiveness of romosozumab for the treatment of postmenopausal women with severe osteoporosis at high risk of fracture in Sweden
Söreskog, E., Lindberg, I., Kanis, J. A., Åkesson, K. E., Willems, D., Lorentzon, M., Ström, O., Berling, P. and Borgström, F.. (2021). Cost-effectiveness of romosozumab for the treatment of postmenopausal women with severe osteoporosis at high risk of fracture in Sweden. Osteoporosis International. 32, pp. 585-594. https://doi.org/10.1007/s00198-020-05780-8
A surrogate FRAX model for Pakistan
Naureen, G., Johansson, H., Iqbal, R., Jafri, L., Khan, A. H., Umer, M., Liu, E., Vandenput, L., Lorentzon, M., Harvey, N. C., McCloskey, E. V. and Kanis, J. A.. (2021). A surrogate FRAX model for Pakistan. Archives of Osteoporosis. 16, p. 34. https://doi.org/10.1007/s11657-021-00894-w
The use of 2-, 5-, and 10-year probabilities to characterize fracture risk after a recent sentinel fracture
Kanis, J. A., Johansson, H., Harvey, N. C., Gudnason, V., Sigurdsson, G., Siggeirsdottir, K., Lorentzon, M., Liu, E., Vandenput, L., Leslie, W. D. and McCloskey, E. V.. (2021). The use of 2-, 5-, and 10-year probabilities to characterize fracture risk after a recent sentinel fracture. Osteoporosis International. 32(1), pp. 47-54. https://doi.org/10.1007/s00198-020-05700-w
The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density
Larsson, B. A. M., Johansson, L., Johansson, H., Axelsson, K. F., Harvey, N., Vandenput, L., Magnusson, P., McCloskey, E., Liu, E., Kanis, J. A., Sundh, D. and Lorentzon, M.. (2021). The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density. Osteoporosis International. 32(1), pp. 75-84. https://doi.org/10.1007/s00198-020-05681-w
Low-level cadmium exposure is associated with decreased cortical thickness, cortical area and trabecular bone volume fraction in elderly men : The MrOS Sweden study
Wallin, Maria, Barregard, Lars, Sallsten, Gerd, Lundh, Thomas, Sundh, Daniel, Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2021). Low-level cadmium exposure is associated with decreased cortical thickness, cortical area and trabecular bone volume fraction in elderly men : The MrOS Sweden study. Bone. 143, p. 115768. https://doi.org/10.1016/j.bone.2020.115768
Combining fracture outcomes in phase 3 trials of osteoporosis : An analysis of the effects of denosumab in postmenopausal women
Kanis, J. A., Harvey, N. C., Lorentzon, M., Liu, E., Vandenput, L., McCloskey, E. V. and Johansson, H.. (2021). Combining fracture outcomes in phase 3 trials of osteoporosis : An analysis of the effects of denosumab in postmenopausal women. Osteoporosis International. 32(1), pp. 165-171. https://doi.org/10.1007/s00198-020-05699-0
Incidence of myocardial infarction and associated mortality varies by latitude and season : Findings from a Swedish Registry Study
Harvey, Nicholas C., Lorentzon, Mattias, Kanis, John A., McCloskey, Eugene and Johansson, Helena. (2020). Incidence of myocardial infarction and associated mortality varies by latitude and season : Findings from a Swedish Registry Study. Journal of Public Health. 42(4), pp. e440-e448. https://doi.org/10.1093/pubmed/fdz131
Grade 1 vertebral fractures identified by densitometric lateral spine imaging predict incident major osteoporotic fracture independently of clinical risk factors and bone mineral density in older women
Johansson, Lisa, Sundh, Daniel, Magnusson, Per, Rukmangatharajan, Komagal, Mellström, Dan, Nilsson, Anna G. and Lorentzon, Mattias. (2020). Grade 1 vertebral fractures identified by densitometric lateral spine imaging predict incident major osteoporotic fracture independently of clinical risk factors and bone mineral density in older women. Journal of Bone and Mineral Research. 35(10), pp. 1942-1951. https://doi.org/10.1002/jbmr.4108
Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures
Kanis, J. A., Johansson, H., Harvey, N. C., Gudnason, V., Sigurdsson, G., Siggeirsdottir, K., Lorentzon, M., Liu, E., Vandenput, L. and McCloskey, E. V.. (2020). Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures. Osteoporosis International. 31(10), pp. 1817-1828. https://doi.org/10.1007/s00198-020-05517-7
FRAX and ethnicity
Kanis, J. A., Cooper, C., Dawson-Hughes, B., Harvey, N. C., Johansson, H., Lorentzon, M., McCloskey, E. V., Reginster, J. Y., Rizzoli, R. and International Osteoporosis Foundation. (2020). FRAX and ethnicity. Osteoporosis International. 31(11), pp. 2063-2067. https://doi.org/10.1007/s00198-020-05631-6
Risk for hip fracture before and after total knee replacement in Sweden
Vala, C. H., Kärrholm, J., Kanis, J. A., Johansson, H., Sten, S., Sundh, V., Karlsson, M., Lorentzon, M. and Mellström, D.. (2020). Risk for hip fracture before and after total knee replacement in Sweden. Osteoporosis International. 31(5), pp. 887-895. https://doi.org/10.1007/s00198-019-05241-x
The Importance and Possible Clinical Impact of Measuring Trabecular and Cortical Bone Microstructure to Improve Fracture Risk Prediction
Mattias Lorentzon. (2020). The Importance and Possible Clinical Impact of Measuring Trabecular and Cortical Bone Microstructure to Improve Fracture Risk Prediction. Journal of Bone and Mineral Research. 35(5), pp. 831-832. https://doi.org/10.1002/jbmr.3940
Secondary fracture prevention : Consensus clinical recommendations from a multistakeholder coalition
Conley, Robert B., Adib, Gemma, Adler, Robert A., Åkesson, Kristina E., Alexander, Ivy M., Amenta, Kelly C., Blank, Robert D., Brox, William Timothy, Carmody, Emily E., Chapman-Novakofski, Karen, Clarke, Bart L., Cody, Kathleen M., Cooper, Cyrus, Crandall, Carolyn J., Dirschl, Douglas R., Eagen, Thomas J., Elderkin, Ann L., Fujita, Masaki, Greenspan, Susan L., ... Kiel, Douglas P.. (2020). Secondary fracture prevention : Consensus clinical recommendations from a multistakeholder coalition. Journal of Bone and Mineral Research. 35(1), pp. 36-52. https://doi.org/10.1002/jbmr.3877
Increased risk for hip fracture after death of a spouse - further support for bereavement frailty?
Vala, C. H., Lorentzon, M., Sundh, V., Johansson, H., Lewerin, C., Sten, S., Karlsson, M., Ohlsson, C., Johansson, B., Kanis, J. A. and Mellström, D.. (2020). Increased risk for hip fracture after death of a spouse - further support for bereavement frailty? Osteoporosis International. 31, pp. 485-492. https://doi.org/10.1007/s00198-019-05242-w
Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures
John Kanis, Nicholas C. Harvey, Eugene McCloskey, Olivier Bruyere, N. Veronese, Mattias Lorentzon, C. Cooper, Rene Rizzoli, G. Adib, Nasser M. Al-Daghri, C. Campusano, Manju Chandran, Bess Dawson-Hughes, M. K. Javaid, F. Jiwa, Helena Johansson, J K Lee, Enwu Liu, D Messina, ... Jean Yves Reginster. (2020). Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures. Osteoporosis International. 31, pp. 1-12. https://doi.org/10.1007/s00198-019-05176-3
Fragility fractures in Europe : Burden, management and opportunities 
Borgström, Fredrik, Karlsson, Linda, Ortsäter, Gustav, Norton, Nicolas, Halbout, Philippe, Cooper, Cyrus, Lorentzon, Mattias, McCloskey, Eugene V., Harvey, Nicholas C., Javaid, Muhamamd K., Kanis, John A. and International Osteoporosis Foundation. (2020). Fragility fractures in Europe : Burden, management and opportunities . Archives of Osteoporosis. 15(59), pp. 1-21. https://doi.org/10.1007/s11657-020-0706-y
Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model
Issayeva, S., Lesnyak, O., Zakroyeva, A., Issayeva, B., Dilmanova, D., Johansson, H., Liu, E., Lorentzon, M., Harvey, N. C., McCloskey, E. and Kanis, J. A.. (2020). Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model. Archives of Osteoporosis. 15, pp. 1-8. https://doi.org/10.1007/s11657-020-0701-3
A surrogate FRAX model for the Kyrgyz Republic
Lesnyak, O., Zakroyeva, A., Lobanchenko, O., Johansson, H., Liu, E., Lorentzon, M., Harvey, N. C., McCloskey, E. and Kanis, J. A.. (2020). A surrogate FRAX model for the Kyrgyz Republic. Archives of Osteoporosis. 15, pp. 1-5. https://doi.org/10.1007/s11657-020-00743-2
Epidemiology of hip fractures in Bulgaria: Development of a country-specific FRAX model
Kirilova, E., Johansson, H., Kirilov, N., Vladeva, S., Petranova, T., Kolarov, Z., Liu, E., Lorentzon, M., Vandenput, L., Harvey, N. C., McCloskey, E. and Kanis, John A.. (2020). Epidemiology of hip fractures in Bulgaria: Development of a country-specific FRAX model. Archives of Osteoporosis. 15(28), pp. 1 - 7. https://doi.org/10.1007/s11657-020-0710-2
Association between recurrent fracture risk and implementation of fracture liaison services in four Swedish hospitals : A cohort study
Axelsson, Kristian F., Johansson, Helena, Lundh, Dan, Möller, Michael and Lorentzon, Mattias. (2020). Association between recurrent fracture risk and implementation of fracture liaison services in four Swedish hospitals : A cohort study. The Lancet Diabetes & Endocrinology. 35(7), pp. 1216-1223. https://doi.org/10.1002/jbmr.3990
A decade of FRAX: How has it changed the management of osteoporosis?
Kanis, John A., Harvey, Nicholas C., Johansson, Helena, Liu, Enwu, Vandenput, Liesbeth, Lorentzon, Mattias, Leslie, William D. and McCloskey, Eugene V.. (2020). A decade of FRAX: How has it changed the management of osteoporosis? Aging Clinical and Experimental Research. 32(2), pp. 187 - 196. https://doi.org/10.1007/s40520-019-01432-y
Use of age-dependent FRAX-based intervention thresholds for Singapore
Kanis, John A., Chandran, Manju, Chionh, Siok Bee, Ganeson, Ganga, Harvey, Nicholas C., Koh, Woon-Puay, Kwok, Timothy, Lau, Tang Ching, Liu, Enwu, Lorentzon, Mattias, McCloskey, Eugene V., Tan, Kelvin Bryan, Vandenput, Liesbeth and Johansson, Helena. (2020). Use of age-dependent FRAX-based intervention thresholds for Singapore. Archives of Osteoporosis. 15, pp. 1 - 10. https://doi.org/10.1007/s11657-020-00782-9
Physical function tests predict incident falls: A prospective study of 2969 men in the Swedish Osteoporotic Fractures in Men study
Coster, Marcus E., Karlsson, Magnus, Ohlsson, Claes, Mellstrom, Dan, Lorentzon, Mattias, Ribom, Eva and Rosengren, Bjorn. (2020). Physical function tests predict incident falls: A prospective study of 2969 men in the Swedish Osteoporotic Fractures in Men study. Scandinavian Journal of Public Health. 48(4), pp. 436 - 441. https://doi.org/10.1177/1403494818801628
BMD-related genetic risk scores predict site-specific fractures as well as trabecular and cortical bone microstructure
Nethander, Maria, Pettersson-Kymmer, Ulrika, Vandenput, Liesbeth, Lorentzon, Mattias, Karlsson, Magnus, Mellström, Dan and Ohlsson, Claes. (2020). BMD-related genetic risk scores predict site-specific fractures as well as trabecular and cortical bone microstructure. The Journal of Clinical Endocrinology and Metabolism. 105(4), pp. e1344-e1357. https://doi.org/10.1210/clinem/dgaa082
High plasma erythropoietin predicts incident fractures in elderly men with normal renal function: The MrOS Sweden cohort
Kristjansdottir, Hallgerdur Lind, Lewerin, Catharina, Lerner, Ulf H., Herlitz, Hans, Johansson, Peter, Johansson, Helena, Karlsson, Magnus, Lorentzon, Mattias, Ohlsson, Claes, Ljunggren, Östen and Mellstrom, Dan. (2020). High plasma erythropoietin predicts incident fractures in elderly men with normal renal function: The MrOS Sweden cohort. Journal of Bone and Mineral Research. 35(2), pp. 298 - 305. https://doi.org/10.1002/jbmr.3900
Disentangling the genetics of lean mass
Karasik, David, Zillikens, M. Carola, Hsu, Yi Hsiang, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Barroso, Inês, Bennett, David A., Bertram, Lars, Bochud, Murielle, Borecki, Ingrid, Broer, Linda, Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos-Obando, Natalia, Cauley, Jane, Cawthon, Peggy M, Chambers, John, ... Ohlsson, Claes. (2019). Disentangling the genetics of lean mass. American Journal of Clinical Nutrition. 109(2), pp. 276-278. https://doi.org/10.1093/ajcn/nqy272
Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC) : A prospective study
Samelson, Elizabeth J., Broe, Kerry E., Xu, Hanfei, Yang, Laiji, Boyd, Steven, Biver, Emmanuel, Szulc, Pawel, Adachi, Jonathan, Amin, Shreyasee, Atkinson, Elizabeth, Berger, Claudie, Burt, Lauren, Chapurlat, Roland, Chevalley, Thierry, Ferrari, Serge, Goltzman, David, Hanley, David A., Hannan, Marian T., Khosla, Sundeep, ... Bouxsein, Mary L.. (2019). Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC) : A prospective study. The Lancet Diabetes & Endocrinology. 7(1), pp. 34-43. https://doi.org/10.1016/S2213-8587(18)30308-5
Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis
Mattias Lorentzon, Jaime Branco, Maria Luisa Brandi, Olivier Bruyere, Roland D Chapurlat, Cyrus Cooper, Bernard Cortet, Aldolfo Diez-Perez, Serge L Ferrari, Andrea Ildiko Gasparik, Markus Herrmann, N. R. Jorgensen, John Kanis, Jean-Marc Kaufman, A. Laslop, Medea Locquet, Radmila Matijevic, Eugene McCloskey, Salvatore Minisola, ... Etienne Cavalier. (2019). Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis. Advances in Therapy. 36(10), pp. 2811-2824. https://doi.org/10.1007/s12325-019-01063-9
Treating osteoporosis to prevent fractures: Current concepts and future developments
Lorentzon, Mattias. (2019). Treating osteoporosis to prevent fractures: Current concepts and future developments. Journal of Internal Medicine. 285(4), pp. 381 - 394. https://doi.org/10.1111/joim.12873
Mendelian randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures
Zheng, Jie, Maerz, Winfried, Gergei, Ingrid, Kleber, Marcus E., Drechsler, Christiane, Wanner, Christoph, Brandenburg, Vincent, Reppe, Sjur, Gautvik, Kaare M., Medina-Gomez, Carolina, Shevroja, Enisa, Gilly, Arthur, Park, Young-Chan, Dedoussis, George, Zeggini, Eleftheria, Lorentzon, Mattias, Henning, Petra, Lerner, Ulf H., Nilsson, Karin H., ... Tobias, Jonathan H.. (2019). Mendelian randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures. Journal of Bone and Mineral Research. 34(10), pp. 1824 - 1836. https://doi.org/10.1002/jbmr.3803
Extensive undertreatment of osteoporosis in older Swedish women
Lorentzon, Mattias, Nilsson, A. G., Johansson, Helena, Kanis, John A., Mellström, Dan and Sundh, D.. (2019). Extensive undertreatment of osteoporosis in older Swedish women. Osteoporosis International. 30(6), pp. 1297 - 1305. https://doi.org/10.1007/s00198-019-04872-4
Appendicular lean mass and fracture risk assessment: Implications for FRAX(R) and sarcopenia
Harvey, Nicholas C., Kanis, John A., Liu, Enwu, Johansson, Helena, Lorentzon, Mattias and McCloskey, Eugene. (2019). Appendicular lean mass and fracture risk assessment: Implications for FRAX(R) and sarcopenia. Osteoporosis International. 30(3), pp. 537 - 539. https://doi.org/10.1007/s00198-019-04904-z
Temporal changes in access to FRAX in Thailand between 2010 and 2018
Chotiyarnwong, Pojchong, Harvey, Nicholas C., Johansson, Helena, Liu, Enwu, Lorentzon, Mattias, Kanis, John A. and McCloskey, Eugene V.. (2019). Temporal changes in access to FRAX in Thailand between 2010 and 2018. Archives of Osteoporosis. 14(1), pp. 1 - 7. https://doi.org/10.1007/s11657-019-0613-2
Patients with prostate cancer and androgen deprivation therapy have increased risk of fractures—a study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO)
Wallander, M., Axelsson, K. F., Lundh, D. and Lorentzon, Mattias. (2019). Patients with prostate cancer and androgen deprivation therapy have increased risk of fractures—a study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO). Osteoporosis International. 30(1), pp. 115 - 125. https://doi.org/10.1007/s00198-018-4722-3
Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture
Johansson, L., Svensson, H. K., Karlsson, J., Olsson, L. E., Mellström, Dan, Lorentzon, Mattias and Sundh, D.. (2019). Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture. Osteoporosis International. 30, pp. 1961 - 1971. https://doi.org/10.1007/s00198-019-05044-0
Meta-analysis of genomewide association studies reveals genetic variants for hip bone geometry
Hsu, Yi-Hsiang, Estrada, Karol, Evangelou, Evangelos, Ackert-Bicknell, Cheryl, Åkesson, Kristina, Beck, Thomas, Brown, Suzanne J., Capellini, Terence, Carbone, Laura, Cauley, Jane, Cheung, Ching-Lung, Cummings, Steven R., Czerwinski, Stefan, Demissie, Serkalem, Econs, Michael J., Evans, Daniel S., Farber, Charles, Gautvik, Kaare M., Harris, Tamara, ... Karasik, David. (2019). Meta-analysis of genomewide association studies reveals genetic variants for hip bone geometry. Journal of Bone and Mineral Research. 34(7), pp. 1284 - 1296. https://doi.org/10.1002/jbmr.3698
FRAX-based intervention and assessment thresholds for osteoporosis in Iran
Khashayar, P., Keshtkar, A., Ostovar, A., Larijani, B., Johansson, H., Harvey, N. C., Lorentzon, M., McCloskey, E. and Kanis, John A.. (2019). FRAX-based intervention and assessment thresholds for osteoporosis in Iran. Osteoporosis International. 30, pp. 2225-2230. https://doi.org/10.1007/s00198-019-05078-4
Association between cortical bone microstructure and statin use in older women
Larsson, Berit A. M., Sundh, Daniel, Mellström, Dan, Axelsson, Kristian F., Nilsson, Anna G. and Lorentzon, Mattias. (2019). Association between cortical bone microstructure and statin use in older women. The Journal of Clinical Endocrinology and Metabolism. 104(2), pp. 250 - 257. https://doi.org/10.1210/jc.2018-02054
Genome analyses of > 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders
Vaez, Ahmad, Võsa, Urmo, Stathopoulou, Maria G., de Vries, Paul S., Prins, Bram P., Van der Most, Peter J., Tanaka, Toshiko, Naderi, Elnaz, Rose, Lynda M., Wu, Ying, Karlsson, Robert, Barbalic, Maja, Lin, Honghuang, Pool, René, Zhu, Gu, Macé, Aurélien, Sidore, Carlo, Trompet, Stella, Mangino, Massimo, ... Alizadeh, Behrooz Z.. (2018). Genome analyses of > 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders. American Journal of Human Genetics. 103(5), pp. 691-706. https://doi.org/10.1016/j.ajhg.2018.09.009
Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study
Trajanoska, Katerina, Morris, John A., Oei, Ling, Zheng, Hou-Feng, Evans, David M., Kiel, Douglas P., Ohlsson, Claes, Richards, J. Brent, Rivadeneira, Fernando, on behalf of the GEFOS/GENOMOS consortium and the 23andMe research team*, Lorentzon, Mattias and Vandenput, Liesbeth. (2018). Assessment of the genetic and clinical determinants of fracture risk: Genome wide association and mendelian randomisation study. BMJ. 362, p. Article k3225. https://doi.org/10.1136/bmj.k3225
High serum serotonin predicts increased risk for hip fracture and nonvertebral osteoporotic fractures: The MrOS Sweden Study
Kristjansdottir, Hallgerdur Lind, Lewerin, C., Lerner, Ulf H., Waern, Ewa, Johansson, Helena, Sundh, Daniel, Karlsson, Magnus, Cummings, Steven R., Zetterberg, Henrik, Lorentzon, Mattias, Ohlsson, Claes and Mellstrom, Dan. (2018). High serum serotonin predicts increased risk for hip fracture and nonvertebral osteoporotic fractures: The MrOS Sweden Study. Journal of Bone and Mineral Research. 33(9), pp. 1560 - 1567. https://doi.org/10.1002/jbmr.3443
High-impact mechanical loading increases bone material strength in postmenopausal women—a 3-month intervention study
Sundh, Daniel, Nilsson, Martin, Zoulakis, Michail, Pasco, Courtney, Yilmaz, Melis, Kazakia, Galateia J., Hellgren, Martin and Lorentzon, Mattias. (2018). High-impact mechanical loading increases bone material strength in postmenopausal women—a 3-month intervention study. Journal of Bone and Mineral Research. 33(7), pp. 1242 - 1251. https://doi.org/10.1002/jbmr.3431
Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: A randomized, placebo-controlled, double-blind, clinical trial
Nilsson, A. G., Sundh, D., Bäckhed, F. and Lorentzon, Mattias. (2018). Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: A randomized, placebo-controlled, double-blind, clinical trial. Journal of Internal Medicine. 284(3), pp. 307 - 317. https://doi.org/10.1111/joim.12805
Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects
Medina-Gómez, Carolina, Kemp, John P., Trajanoska, Katerina, Luan, Jian'an, Chesi, Alessandra, Ahluwalia, Tarunveer S., Mook-Kanamori, Dennis O., Ham, Annelies C., Hartwig, Fernando P., Evans, Daniel S., Joro, Raimo, Nedeljkovic, Ivana, Zheng, Hou-Feng, Zhu, Kun, Atalay, Mustafa, Liu, Ching-Ti, Nethander, Maria, Broer, Linda, Porleifsson, Gudmar, ... Rivadeneira, Fernando. (2018). Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects. American Journal of Human Genetics. 102(1), pp. 88 - 102. https://doi.org/10.1016/j.ajhg.2017.12.005
Low risk for hip fracture and high risk for hip arthroplasty due to osteoarthritis among Swedish farmers
Johansson, Helena, Vala, C. H., Oden, Anders, Lorentzon, Mattias, McCloskey, Eugene, Kanis, John, Harvey, Nicholas C., Ohlsson, Claes, Lohmander, L. S., Karrholm, J. and Mellstrom, D.. (2018). Low risk for hip fracture and high risk for hip arthroplasty due to osteoarthritis among Swedish farmers. Osteoporosis International. 29(3), pp. 741 - 749. https://doi.org/10.1007/s00198-017-4355-y
The prevalence of vertebral fractures is associated with reduced hip bone density and inferior peripheral appendicular volumetric bone density and structure in older women
Johansson, Lisa, Sundh, Daniel, Zoulakis, Michael, Rudäng, Robert, Darelid, Anna, Brisby, Helena, Nilsson, Anna G., Mellström, Dan and Lorentzon, Mattias. (2018). The prevalence of vertebral fractures is associated with reduced hip bone density and inferior peripheral appendicular volumetric bone density and structure in older women. Journal of Bone and Mineral Research. 33(2), pp. 250 - 260. https://doi.org/10.1002/jbmr.3297
Vertebral fractures and their association with health-related quality of life, back pain and physical function in older women
Johansson, Lisa, Sundh, Daniel, Nilsson, Dan, Mellström, Dan and Lorentzon, Mattias. (2018). Vertebral fractures and their association with health-related quality of life, back pain and physical function in older women. Osteoporosis International. 29(1), pp. 89 - 99. https://doi.org/10.1007/s00198-017-4296-5
Fracture risk after gastric bypass surgery: A retrospective cohort study
Axelsson, Kristian F., Werling, Malin, Eliasson, Björn, Szabo, Eva, Näslund, Ingmar, Wedel, Hans, Lundh, Dan and Lorentzon, Mattias. (2018). Fracture risk after gastric bypass surgery: A retrospective cohort study. Journal of Bone and Mineral Research. 33(12), pp. 2122 - 2131. https://doi.org/10.1002/jbmr.3553
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Jiang, Xia, O'Reilly, Paul F., Aschard, Hugues, Hsu, Yi-Hsiang, Richards, J. Brent, Dupuis, Josée, Ingelsson, Erik, Karasik, David, Pilz, Stefan, Berry, Diane, Kestenbaum, Bryan, Zheng, Jusheng, Luan, Jianan, Sofianopoulou, Eleni, Streeten, Elizabeth A., Albanes, Demetrius, Lutsey, Pamela L., Yao, Lu, Tang, Weihong, ... Lorentzon, Mattias. (2018). Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature Communications. 9(1), p. 260. https://doi.org/10.1038/s41467-017-02662-2
Genetic determinants of circulating estrogen levels and evidence of a causal effect of estradiol on bone density in men
Eriksson, Anna L., Perry, John R. B., Coviello, Andreas D., Delgado, Graciela E., Ferrucci, Luigi, Hoffman, Andrew R., Huhtaniemi, Ilpo T., Ikram, M. Arfan, Karlsson, Magnus K., Kleber, Marcus E., Laughlin, Gail A., Liu, Yongmei, Lorentzon, Mattias, Lunetta, Kathryn L., Mellström, Dan, Murabito, Joanne M., Murray, Anna, Nethander, Maria, Nielson, Carrie M., ... Ohlsson, Claes. (2018). Genetic determinants of circulating estrogen levels and evidence of a causal effect of estradiol on bone density in men. The Journal of Clinical Endocrinology and Metabolism. 103(3), pp. 991 - 1004. https://doi.org/10.1210/jc.2017-02060
Normal bone microstructure and density but worse physical function in older women treated with selective serotonin reuptake inhibitors, a cross-sectional population-based study
Larsson, Berit A. M., Mellström, Dan, Johansson, Lisa, Nilsson, Anna G., Lorentzon, Mattias and Sundh, Daniel. (2018). Normal bone microstructure and density but worse physical function in older women treated with selective serotonin reuptake inhibitors, a cross-sectional population-based study. Calcified Tissue International. 103(3), pp. 278 - 288. https://doi.org/10.1007/s00223-018-0427-z
The limited clinical utility of testosterone, estradiol, and sex hormone binding globulin measurements in the prediction of fracture risk and bone loss in older men
Orwoll, Eric S., Lapidus, Jodi, Wang, Patty Y., Vandenput, Liesbeth, Hoffman, Andrew, Fink, Howard A., Laughlin, Gail A., Nethander, Maria, Ljunggren, Östen, Kindmark, Andreas, Lorentzon, Mattias, Karlsson, Magnus K., Mellström, Dan, Kwok, Anthony, Khosla, Sundeep, Kwok, Timothy and Ohlsson, Claes. (2017). The limited clinical utility of testosterone, estradiol, and sex hormone binding globulin measurements in the prediction of fracture risk and bone loss in older men. Journal of Bone and Mineral Research. 32(3), pp. 633-640. https://doi.org/10.1002/jbmr.3021
Risk factors for low back pain and sciatica in elderly men--the MrOS Sweden study
Kherad, Mehrsa, Rosengren, Björn E., Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattias, Ljunggren, Östen and Karlsson, Magnus K.. (2017). Risk factors for low back pain and sciatica in elderly men--the MrOS Sweden study. Age and Ageing. 46(1), pp. 64 - 71. https://doi.org/10.1093/ageing/afw152
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Graff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, bin Qi, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, ... Lorentzon, Mattias. (2017). Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. PLoS Genetics. 13(4), pp. 1 - 26. https://doi.org/10.1371/journal.pgen.1006528
Cortical bone area predicts incident fractures independently of areal bone mineral density in older men
Ohlsson, Claes, Sundh, Daniel, Wallerek, Andreas, Nilson, Martin, Karlsson, Magnus, Johansson, Helena, Mellstrom, Dan and Lorentzon, Mattias. (2017). Cortical bone area predicts incident fractures independently of areal bone mineral density in older men. The Journal of Clinical Endocrinology and Metabolism. 102(2), pp. 516 - 524. https://doi.org/10.1210/jc.2016-3177
Association between alendronate use and hip fracture risk in older patients using oral prednisolone
Axelsson, Kristian F., Nilsson, Anna G., Wedel, Hans, Lundh, Dan and Lorentzon, Mattias. (2017). Association between alendronate use and hip fracture risk in older patients using oral prednisolone. JAMA: Journal of the American Medical Association. 318(2), pp. 146 - 155. https://doi.org/10.1001/jama.2017.8040
Hip fracture risk and safety with alendronate treatment in the oldest-old
Axelsson, K. F., Wallander, M., Johansson, Helena, Lundh, D. and Lorentzon, Mattias. (2017). Hip fracture risk and safety with alendronate treatment in the oldest-old. Journal of Internal Medicine. 282(6), pp. 546 - 559. https://doi.org/10.1111/joim.12678
Type 2 diabetes and risk of hip fractures and non-skeletal fall injuries in the elderly: A study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO)
Wallander, Märit, Axelsson, Kristian F., Nilsson, Anna G., Lundh, Dan and Lorentzon, Mattias. (2017). Type 2 diabetes and risk of hip fractures and non-skeletal fall injuries in the elderly: A study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO). Journal of Bone and Mineral Research. 32(3), pp. 449 - 460. https://doi.org/10.1002/jbmr.3002
Increased risk of hip fracture among spouses-evidence of a homogamy effect
Vala, C. H., Oden, Anders, Lorentzon, Mattias, Sundh, V., Johansson, Helena, Karlsson, Magnus, Rosengren, Björn E., Ohlsson, Claes, Johansson, B., Kanis, John and Mellström, Dan. (2017). Increased risk of hip fracture among spouses-evidence of a homogamy effect. Osteoporosis International. 28(1), pp. 95 - 102. https://doi.org/10.1007/s00198-016-3738-9
Bone traits seem to develop also during the third decade in life—normative cross-sectional data on 1083 men aged 18–28 years
Lindgren, Erik, Karlsson, Magnus K., Lorentzon, Mattias and Rosengren, Björn E.. (2017). Bone traits seem to develop also during the third decade in life—normative cross-sectional data on 1083 men aged 18–28 years. Journal of Clinical Densitometry. 20(1), pp. 32 - 43. https://doi.org/10.1016/j.jocd.2016.07.002
Low testosterone, but not estradiol, is associated with incident falls in older men: The international MrOS study
Vandenput, Liesbeth, Mellström, Dan, Laughlin, Gail A., Cawthon, Peggy M., Cauley, Jane A., Hoffman, Andrew R., Karlsson, Magnus K., Rosengren, Björn E., Ljunggren, Östen, Nethander, Maria, Eriksson, Anna L., Lorentzon, Mattias, Leung, Jason, Kwok, Timothy, Orwoll, Eric S. and Ohlsson, Claes. (2017). Low testosterone, but not estradiol, is associated with incident falls in older men: The international MrOS study. Journal of Bone and Mineral Research. 32(6), pp. 1174 - 1181. https://doi.org/10.1002/jbmr.3088
Increased cortical porosity in women with hip fracture
Sundh, Daniel, Nilsson, A. G., Nilsson, Martin, Johansson, L., Mellström, Dan and Lorentzon, Mattias. (2017). Increased cortical porosity in women with hip fracture. Journal of Internal Medicine. 281(5), pp. 496 - 506. https://doi.org/10.1111/joim.12587
Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study
Lewerin, Catharina, Ljunggren, Östen, Nilsson-Ehle, Herman, Karlsson, Magnus K., Herlitz, Hans, Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2017). Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study. Bone. 98, pp. 1 - 8. https://doi.org/10.1016/j.bone.2017.02.005
Low-frequency synonymous coding variation in CYP2R1 has large effects on vitamin d levels and risk of multiple sclerosis
Manousaki, Despoina, Dudding, Tom, Haworth, Simon, Hsu, Yi-Hsiang, Liu, Chiang-Ti, Medina-Gómez, Carolina, Voortman, Trudy, van der Velde, Nathalie, Melhus, Håkan, Robinson-Cohen, Cassianne, Cousminer, Diana L., Nethander, Maria, Vandenput, Liesbeth, Noordam, Raymond, Forgetta, Vincenzo, Greenwood, Celia M. T., Biggs, Mary L., Psaty, Bruce M., Rotter, Jerome I., ... Richards, J. Brent. (2017). Low-frequency synonymous coding variation in CYP2R1 has large effects on vitamin d levels and risk of multiple sclerosis. American Journal of Human Genetics. 101(2), pp. 227 - 238. https://doi.org/10.1016/j.ajhg.2017.06.014
Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: A population-based study
Nilsson, Anna G., Sundh, Daniel, Johansson, Lisa, Nilsson, Martin, Mellström, Dan, Rudäng, Robert, Zoulakis, Michail, Wallander, Märit, Darelid, Anna and Lorentzon, Mattias. (2017). Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: A population-based study. Journal of Bone and Mineral Research. 32(5), pp. 1062 - 1071. https://doi.org/10.1002/jbmr.3057
Bone mass development from childhood into young adulthood in patients with childhood-onset inflammatory bowel disease
Sigurdsson, Gudmundur Vignir, Schmidt, Susanne, Mellström, Dan, Ohlsson, Claes, Kindblom, Jenny M., Lorentzon, Mattias and Saalman, Robert. (2017). Bone mass development from childhood into young adulthood in patients with childhood-onset inflammatory bowel disease. Inflammatory Bowel Diseases. 23(12), pp. 2215 - 2226. https://doi.org/10.1097/MIB.0000000000001277
Genetic variants associated with circulating parathyroid hormone
Robinson-Cohen, Cassianne, Lutsey, Pamela L., Kleber, Marcus E., Nielson, Carrie M., Mitchell, Braxton D., Bis, Joshua C., Eny, Karen M., Portas, Laura, Eriksson, Joel, Lorentzon, Mattias, Koller, Daniel L., Milaneschi, Yuri, Teumer, Alexander, Pilz, Stefan, Nethander, Maria, Selvin, Elizabeth, Tang, Weihong, Weng, Lu-Chen, Wong, Hoi Suen, ... Kestenbaum, Bryan. (2017). Genetic variants associated with circulating parathyroid hormone. Journal of the American Society of Nephrology. 28(5), pp. 1553 - 1565. https://doi.org/10.1681/ASN.2016010069
Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
Eriksson, Joel, Haring, Robin, Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik, Hansen, Torben, Mellström, Dan, Pedersen, Oluf, Nauck, Matthias, Lorentzon, Mattias, Husemoen, Lise Lotte Nystrup, Völzke, Henry, Karlsson, Magnus, Baumeister, Sebastian E., Linneberg, Allan and Ohlsson, Claes. (2017). Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PLoS ONE. 12(4), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0176277
Romosozumab or alendronate for fracture prevention in women with osteoporosis
Saag, Kenneth G., Petersen, Jeffrey, Brandi, Maria Luisa, Karaplis, Andrew C., Lorentzon, Mattias, Thomas, Thierry A., Maddox, Judy, Fan, Michelle, Meisner, Paul D. and Grauer, Andreas. (2017). Romosozumab or alendronate for fracture prevention in women with osteoporosis. New England Journal of Medicine. 377(15), pp. 1417 - 1427. https://doi.org/10.1056/NEJMoa1708322
Low serum DHEAS predicts increased fracture risk in older men: The MrOS Sweden study
Ohlsson, Claes, Nethander, Maria, Kindmark, Andreas, Ljunggren, Östen, Lorentzon, Mattias, Rosengren, Björn E., Karlsson, Magnus K., Mellström, Dan and Vandenput, Liesbeth. (2017). Low serum DHEAS predicts increased fracture risk in older men: The MrOS Sweden study. Journal of Bone and Mineral Research. 32(8), pp. 1607 - 1614. https://doi.org/10.1002/jbmr.3123
Current physical activity is independently associated with cortical bone size and bone strength in elderly Swedish women
Nilsson, Martin, Sundh, Daniel, Mellström, Dan and Lorentzon, Mattias. (2017). Current physical activity is independently associated with cortical bone size and bone strength in elderly Swedish women. Journal of Bone and Mineral Research. 32(3), pp. 473 - 485. https://doi.org/10.1002/jbmr.3006
Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study
Deminger, Anna, Klingberg, Eva, Lorentzon, Mattias, Geijer, Mats, Göthlin, Jan, Hedberg, Martin, Rehnberg, Eva, Carlsten, Hans, Jacobsson, Lennart T. and Forsblad-d'Elia, Helena. (2017). Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study. Arthritis Research and Therapy. 19(1), pp. 1 - 12. https://doi.org/10.1186/s13075-017-1480-0
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin L., Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y., Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zoltán, Xue, Luting, ... Lorentzon, Mattias. (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications. 8(1), pp. 1 - 19. https://doi.org/10.1038/ncomms14977
Characteristics of prevalent vertebral fractures predict new fractures in elderly men
Karlsson, Magnus K., Kherad, Mehrsa, Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias, Mellström, Dan and Rosengren, Björn E.. (2016). Characteristics of prevalent vertebral fractures predict new fractures in elderly men. Journal of Bone and Joint Surgery: American Volume. 98(5), pp. 379 - 385. https://doi.org/10.2106/JBJS.15.00328
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried, Janina S., Jeff, Janina, Chu, Audrey Y., Bragg-Gresham, Jennifer L., van Dongen, Jenny, Huffman, Jennifer E., Ahluwalia, Tarunveer S., Cadby, Gemma, Eklund, Niina, Eriksson, Joel, Esko, Tõnu, Feitosa, Mary F., Goel, Anuj, Gorski, Mathias, Hayward, Caroline, Heard-Costa, Nancy L., Jackson, Anne U., Jokinen, Eero, Kanoni, Stavroula, ... Loos, Ruth J. F.. (2016). A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications. 7(1), pp. 1 - 11. https://doi.org/10.1038/ncomms13357
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits
Teumer, Alexander, Qi, bin Qi, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja I., Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock, Stephen J., Chen, Ming-Huei, Chen, Tai C., Chen, Yii-Der, Chung, Jonathan, Del Greco Miglianico, Fabiola, Eriksson, Joel, Ferrucci, Luigi, ... Lorentzon, Mattias. (2016). Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 15(5), pp. 811 - 824. https://doi.org/10.1111/acel.12490
Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women
Brembeck, Peter, Winkvist, Anna, Ohlsson, Claes, Lorentzon, Mattias and Augustin, Hanna. (2016). Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women. The British Journal of Nutrition. 116(10), pp. 1736 - 1744. https://doi.org/10.1017/S0007114516003998
Fall risk assessment predicts fall-related injury, hip fracture, and head injury in older adults
Nilsson, , Eriksson, Joel, Larsson, Berit A. M., Odén, Anders, Johansson, Helena and Lorentzon, Mattias. (2016). Fall risk assessment predicts fall-related injury, hip fracture, and head injury in older adults. Journal of the American Geriatrics Society. 64(11), pp. 2242 - 2250. https://doi.org/10.1111/jgs.14439
Bone material strength is associated with areal BMD but not with prevalent fractures in older women
Rudäng, R., Zoulakis, M., Sundh, D., Brisby, H., Diez-Perez, Aldolfo, Johansson, L., Mellström, Dan, Darelid, A. and Lorentzon, Mattias. (2016). Bone material strength is associated with areal BMD but not with prevalent fractures in older women. Osteoporosis International. 27(4), pp. 1585 - 1592. https://doi.org/10.1007/s00198-015-3419-0
High serum SHBG predicts incident vertebral fractures in elderly men
Vandenput, Liesbeth, Mellström, Dan, Kindmark, Andreas, Johansson, Helena, Lorentzon, Mattias, Leung, Jason, Redlund-Johnell, Inga, Rosengren, Björn E., Karlsson, Magnus K., Wang, Yi-Xiang, Kwok, Timothy and Ohlsson, Claes. (2016). High serum SHBG predicts incident vertebral fractures in elderly men. Journal of Bone and Mineral Research. 31(3), pp. 683 - 689. https://doi.org/10.1002/jbmr.2718
Effectiveness of a minimal resource fracture liaison service
Axelsson, K. F., Jacobsson, R., Lund, D. and Lorentzon, Mattias. (2016). Effectiveness of a minimal resource fracture liaison service. Osteoporosis International. 27(11), pp. 3165 - 3175. https://doi.org/10.1007/s00198-016-3643-2
High plasma osteocalcin is associated with low blood haemoglobin in elderly men: The MrOS Sweden Study
Lewerin, C., Johansson, Helena, Karlsson, Magnus K., Lorentzon, Mattias, Lerner, Ulf H., Kindblom, J. M., Ohlsson, Claes, Smith, Ulf and Mellström, Dan. (2016). High plasma osteocalcin is associated with low blood haemoglobin in elderly men: The MrOS Sweden Study. Journal of Internal Medicine. 280(4), pp. 398 - 406. https://doi.org/10.1111/joim.12505
Low serum vitamin D is associated with higher cortical porosity in elderly men
Sundh, D., Mellström, Dan, Ljunggren, Östen, Karlsson, Magnus K., Ohlsson, Claes, Nilsson, M., Nilsson, A. G. and Lorentzon, Mattias. (2016). Low serum vitamin D is associated with higher cortical porosity in elderly men. Journal of Internal Medicine. 280(5), pp. 496 - 508. https://doi.org/10.1111/joim.12514
A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX
McCloskey, Eugene, Oden, Anders, Harvey, Nicholas C., Leslie, William, Hans, D., Johansson, Helena, Barkmann, Reinhard, Boutroy, Stephanie, Brown, J. P., Chapurlat, Roland D., Elders, Petra J. M., Fujita, Yuki, Glüer, Claus C., Goltzman, David, Iki, Masayuki, Karlsson, M. K., Kindmark, Andreas, Kotowicz, Mark, Kurumatani, Norio, ... Kanis, John A.. (2016). A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. Journal of Bone and Mineral Research. 31(5), pp. 940 - 948. https://doi.org/10.1002/jbmr.2734
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpeläinen, Tuomas O., Martin Carli, Jayne F., Skowronski, Alicja A., Sun, Qi, Kriebel, Jennifer, Feitosa, Mary F., Hedman, Åsa K., Drong, Alexander W., Hayes, James E., Zhao, Jinghua H., Pers, Tune H., Schick, Ursula M., Grarup, Niels, Kutalik, Zoltán, Trompet, Stella, Mangino, Massimo, Kristiansson, Kati, Beekman, Marian, Lyytikäinen, Leo-Pekka, ... Lorentzon, Mattias. (2016). Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nature Communications. 7(1), pp. 1 - 14. https://doi.org/10.1038/ncomms10494
A high amount of local adipose tissue Is associated with high cortical porosity and low bone material strength in older women
Sundh, Daniel, Rudäng, Robert, Zoulakis, Michail, Nilsson, Anna G., Darelid, Anna and Lorentzon, Mattias. (2016). A high amount of local adipose tissue Is associated with high cortical porosity and low bone material strength in older women. Journal of Bone and Mineral Research. 31(4), pp. 749 - 757. https://doi.org/10.1002/jbmr.2747
Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: The MrOS Sweden study
Wallin, Maria, Barregard, Lars, Sallsten, Gerd, Lundh, Thomas, Karlsson, Magnus K., Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2016). Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: The MrOS Sweden study. Journal of Bone and Mineral Research. 31(4), pp. 732 - 741. https://doi.org/10.1002/jbmr.2743
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study
Winkler, T.W., Justice, A.E., Graff, M., Barata, Llilda, Feitosa, M.F., Chu, Su, Czajkowski, Jacek, Esko, T., Fall, T., Kilpeläinen, T.O., Lu, Yingchang, Mägi, R., Mihailov, E., Lorentzon, Karl Mattias, Vandenput, Liesbeth and et. al.. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study. PLoS Genetics. 11(10), pp. 1-42. https://doi.org/10.1371/journal.pgen.1005378
Osteoporosis: The evolution of a diagnosis
Lorentzon, Mattias and Cummings, Steven R.. (2015). Osteoporosis: The evolution of a diagnosis. Journal of Internal Medicine. 277(6), pp. 650 - 661. https://doi.org/10.1111/joim.12369
New genetic loci link adipose and insulin biology to body fat distribution
Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., ... Lorentzon, Mattias. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature. 518, pp. 187 - 196. https://doi.org/10.1038/nature14132
Lower urinary symptoms are associated with low levels of serum serotonin, high levels of adinopectin and fasting glucose, and benign prostatic enlargement
Haghsheno, Mohammad-Ali, Mellstrom, Dan, Peeker, Ralph, Hammarsten, Jan, Lorentzon, Mattias, Sundh, Valter, Karlsson, Magnus, Ohlsson, Claes and Damber, Jan-Erik. (2015). Lower urinary symptoms are associated with low levels of serum serotonin, high levels of adinopectin and fasting glucose, and benign prostatic enlargement. Scandinavian Journal of Urology. 49(2), pp. 155 - 161. https://doi.org/10.3109/21681805.2014.936495
The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis
Kherad, M., Mellström, Dan, Rosengren, Björn E., Hasserius, R., Nilsson, J.-Å., Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias and Karlsson, Magnus K.. (2015). The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis. The Bone and Joint Journal. 97-B(8), pp. 1106 - 1110. https://doi.org/10.1302/0301-620X.97B8.35032
Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum
Brembeck, P., Lorentzon, Mattias, Ohlsson, Claes, Winkvist, A. and Augustin, H.. (2015). Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum. The Journal of Clinical Endocrinology and Metabolism. 100(2), pp. 535 - 543. https://doi.org/10.1210/jc.2014-2825
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Cornelis, Marilyn C., Byrne, Enda M., Esko, Tonu, Nalls, Michael A., Ganna, Andrea, Paynter, Nina, Monda, Keri L., Amin, Najaf, Fischer, Krista, Renstrom, Frida, Ngwa, Julius S., Huikari, Ville, Cavadino, Alana, Nolte, Ilja M., Teumer, Alexander, Yu, Kai, Marques-Vidal, Pedro Manuel, Rawal, Rajesh, Manichaikul, Ani, ... UK Brain Expression Consortium (UKBEC). (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry. 20(5), pp. 647-656. https://doi.org/10.1038/mp.2014.107
Low clinical relevance of a prevalent vertebral fracture in elderly men - the MrOs Sweden study
Kherad, Mehrsa, Rosengren, Björn E., Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias, Mellström, Dan and Karlsson, Magnus K.. (2015). Low clinical relevance of a prevalent vertebral fracture in elderly men - the MrOs Sweden study. The Spine Journal. 15(2), pp. 281 - 289. https://doi.org/10.1016/j.spinee.2014.09.016
Increased cortical porosity in older men with fracture
Sundh, Daniel, Mellström, Dan, Nilsson, Martin, Karlsson, Magnus, Ohlsson, Claes and Lorentzon, Mattias. (2015). Increased cortical porosity in older men with fracture. Journal of Bone and Mineral Research. 30(9), pp. 1692 - 1700. https://doi.org/10.1002/jbmr.2509
Bone turnover markers predict bone mass development in young adult men: A five-year longitudinal study
Darelid, Anna, Nilsson, Martin, Kindblom, Jenny M., Mellström, Dan, Ohlsson, Claes and Lorentzon, Mattias. (2015). Bone turnover markers predict bone mass development in young adult men: A five-year longitudinal study. The Journal of Clinical Endocrinology and Metabolism. 100(4), pp. 1460 - 1468. https://doi.org/10.1210/jc.2014-3947
High serum adiponectin is associated with low blood haemoglobin in elderly men: The Swedish MrOS study
Lewerin, C., Johansson, Helena, Lerner, Ulf H., Karlsson, Magnus K., Lorentzon, Mattias, Barrett-Connor, Elizabeth, Smith, Ulf, Ohlsson, Claes and Mellström, Dan. (2015). High serum adiponectin is associated with low blood haemoglobin in elderly men: The Swedish MrOS study. Journal of Internal Medicine. 278(1), pp. 68 - 76. https://doi.org/10.1111/joim.12340
Is the Swedish FRAX model appropriate for Swedish immigrants?
Johansson, Helena, Oden, Anders, Lorentzon, Mattias, McCloskey, Eugene V., Kanis, John A., Harvey, Nicholas C., Karlsson, M. K. and Mellström, Dan. (2015). Is the Swedish FRAX model appropriate for Swedish immigrants? Osteoporosis International. 26(11), pp. 2617 - 2622. https://doi.org/10.1007/s00198-015-3180-4
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index
Hoggart, Clive J., Venturini, Giulia, Mangino, Massimo, Gomez, Felicia, Ascari, Giulia, Zhao, Jing Hua, Teumer, Alexander, Winkler, Thomas W., Tšernikova, Natalia, Luan, Jian'an, Mihailov, Evelin, Ehret, Georg B., Zhang, Weihua, Lamparter, David, Esko, Tõnu, Macé, Aurelien, Rüeger, Sina, Bochud, Pierre-Yves, Barcella, Matteo, ... Lorentzon, Mattias*. (2014). Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. PLoS Genetics. 10(7), p. e1004508. https://doi.org/10.1371/journal.pgen.1004508
Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study
Vimaleswaran, Karani S., Cavadino, Alana, Berry, Diane J., Jorde, Rolf, Dieffenbach, Aida Karina, Lu, Chen, Alves, Alexessander Couto, Heerspink, Hiddo J. Lambers, Tikkanen, Emmi, Eriksson, Joel, Wong, Andrew, Mangino, Massimo, Jablonski, Kathleen A., Nolte, Ilja M., Houston, Denise K., Ahluwalia, Tarunveer Singh, van der Most, Peter J., Pasko, Dorota, Zgaga, Lina, ... Hyppönen, Elina. (2014). Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study. The Lancet Diabetes & Endocrinology. 2(9), pp. 719 - 729. https://doi.org/10.1016/S2213-8587(14)70113-5
Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men
Nilsson, Martin, Sundh, Daniel, Ohlsson, Claes, Karlsson, Magnus, Mellström, Dan and Lorentzon, Mattias. (2014). Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men. Journal of Bone and Mineral Research. 29(8), pp. 1795 - 1804. https://doi.org/10.1002/jbmr.2212
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, Andrew R., Esko, Tonu, Yang, Jian, Vedantam, Sailaya, Pers, Tune H., Gustafsson, Stefan, Chu, Audrey Y., Estrada, Karol, Luan, Jian'an, Kutalik, Zoltán, Amin, Najaf, Buchkovich, Martin L., Croteau-Chonka, Damien C., Day, Felix R., Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U., ... Lorentzon, Mattias. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46(11), pp. 1173 - 1186. https://doi.org/10.1038/ng.3097
Serum estradiol levels are inversely associated with cortical porosity in older men
Vandenput, Liesbeth, Lorentzon, Mattias, Sundh, Daniel, Nilsson, Maria E., Karlsson, Magnus K., Mellström, Dan and Ohlsson, Claes. (2014). Serum estradiol levels are inversely associated with cortical porosity in older men. The Journal of Clinical Endocrinology and Metabolism. 99(7), pp. E1322 - E1326. https://doi.org/10.1210/jc.2014-1319
International and ethnic variability of falls in older men
Karlsson, Magnus L., Ribom, Eva L., Nilsson, J.-Å., Karlsson, Caroline, Cöster, Maria, Vonschewelov, Thord, Mallmin, Hans, Ljunggren, Östen, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattias, Leung, Ping C., Lau, Edith, Cauley, Jane A., Barrett-Connor, Elizabeth, Stefanick, Marcia L., Orwoll, Eric and Rosengren, Björn E.. (2014). International and ethnic variability of falls in older men. Scandinavian Journal of Public Health. 42(2), pp. 194 - 200. https://doi.org/10.1177/1403494813510789
Serum estradiol associates with blood hemoglobin in elderly men: The MrOS Sweden study
Lewerin, Catharina, Nilsson-Ehle, Herman, Jacobsson, Stefan, Johansson, Helena, Sundh, Valter, Karlsson, Magnus K., Lorentzon, Mattias, Barrett-Connor, Elizabeth, Vandenput, Liesbeth, Ohlsson, Claes and Mellström, Dan. (2014). Serum estradiol associates with blood hemoglobin in elderly men: The MrOS Sweden study. The Journal of Clinical Endocrinology and Metabolism. 99(7), pp. 2549 - 2556. https://doi.org/10.1210/jc.2013-4111
Low holotranscobalamin and cobalamins predict incident fractures in elderly men: The MrOS Sweden
Lewerin, C. Lewerin, Nilsson-Ehle, H., Jacobsson, S., Johansson, Helena, Sundh, V., Karlsson, Magnus, Ljunggren, Östen, Lorentzon, Mattias, Kanis, John A., Lerner, Ulf H., Cummings, Steven R., Ohlsson, Claes and Mellström, Dan. (2014). Low holotranscobalamin and cobalamins predict incident fractures in elderly men: The MrOS Sweden. Osteoporosis International. 25(1), pp. 131 - 140. https://doi.org/10.1007/s00198-013-2527-y
A 6-year exercise program improves skeletal traits without affecting fracture risk: A prospective controlled study in 2621 children
Detter, Fredrik, Rosengren, Björn E., Dencker, Magnus, Lorentzon, Mattias, Nilsson, Jan‐Åke and Karlsson, Magnus K.. (2014). A 6-year exercise program improves skeletal traits without affecting fracture risk: A prospective controlled study in 2621 children. Journal of Bone and Mineral Research. 29(6), pp. 1325 - 1336. https://doi.org/10.1002/jbmr.2168
Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT
Kemp, John P., Sayers, Adrian, Paternoster, Lavinia, Evans, David M., Deere, Kevin, St. Pourcain, Beate, Timpson, Nicholas J., Ring, Susan M., Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo-Pekka, Smith, George Davey, Fraser, William D., ... Tobias, Jon H.. (2014). Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT. Journal of Bone and Mineral Research. 29(4), pp. 1015 - 1024. https://doi.org/10.1002/jbmr.2093
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels
Kwan, Johnny S. H., Hsu, Yi-Hsiang, Cheung, Ching-Lung, Dupuis, Josée, Saint-Pierre, Aude, Eriksson, Joel, Handelman, Samuel K., Aragaki, Aaron K., Karasik, David, Pramstaller, Peter P., Kooperberg, Charles, Lacroix, Andrea Z., Larson, Martin G., Lau, Kam-Shing, Lorentzon, Mattias, Pichler, Irene, Sham, Pak Chung, Taliun, Daniel, Vandenput, Liesbeth, ... Kung, Annie Wai Chee. (2014). Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. Human Molecular Genetics. 23(24), pp. 6684 - 6693. https://doi.org/10.1093/hmg/ddu386
Meta-analysis of gene-level associations for rare variants based on single-variant statistics
Hu, Yi-Juan, Berndt, Sonja, Gustafsson, Stefan, Ganna, Andrea, Hirschhorn, Joel, North, Kari, Ingelsson, Erik, Lin, Dan-Yu, Lorentzon, Karl Mattias and al, et. (2013). Meta-analysis of gene-level associations for rare variants based on single-variant statistics. American Journal of Human Genetics. 93(2), pp. 236-248. https://doi.org/10.1016/j.ajhg.2013.06.011
Causal relationship between obesity and vitamin d status : Bi-directional mendelian randomization analysis of multiple cohorts
Vimaleswaran, Karani, Berry, Diane, Lu, Chen, Tikkanen, E., Pilz, Stefan, Hiraki, Linda, Cooper, Jason, Dastani, Zari, Li, Rui, Houston, Denise, Wood, Andrew, Michaelsson, Karl, Vandenput, Liesbeth, Lorentzon, Karl Mattias, Zgaga, Lina, Yerges-Armstrong, Laura, McCarthy, Mark I., Dupuis, Josee, Kaakinen, Marika, ... al, et. (2013). Causal relationship between obesity and vitamin d status : Bi-directional mendelian randomization analysis of multiple cohorts. PLoS Medicine. 10(2), pp. 1-13. https://doi.org/10.1371/journal.pmed.1001383
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
Randall, J., Winkler, T.W., Kutalik, Z., Berndt, S.I., Jackson, Anne, Monda, K.L., Kilpelainen, Tuomas, Esko, Tonu, Magi, Reedik, Li, Shengxu, Workalemahu, T., Feitosa, Mary, Croteau-Chonka, D.C., Lorentzon, Karl Mattias, Day, Felix, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Locke, A.E., ... al, et. (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genetics. 9(6), pp. 1-19. https://doi.org/10.1371/journal.pgen.1003500
X-ray-verified fractures are associated with finite element analysis-derived bone strength and trabecular microstructure in young adult men
Rudäng, Robert, Darelid, Anna, Nilsson, Martin, Mellström, Dan, Ohlsson, Claes and Lorentzon, Mattias. (2013). X-ray-verified fractures are associated with finite element analysis-derived bone strength and trabecular microstructure in young adult men. Journal of Bone and Mineral Research. 28(11), pp. 2305-2316. https://doi.org/10.1002/jbmr.1974
Sport-specific association between exercise loading and the density, geometry, and microstructure of weight-bearing bone in young adult men
Nilsson, M., Ohlsson, C., Mellström, D. and Lorentzon, M.. (2013). Sport-specific association between exercise loading and the density, geometry, and microstructure of weight-bearing bone in young adult men. Osteoporosis International. 24(5), pp. 1613-1622. https://doi.org/10.1007/s00198-012-2142-3
Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density of forearm
Zheng, Hou-Feng, Duncan, Emma L., Yerges-Armstrong, Laura M., Eriksson, Joel, Bergström, Ulrica, Leo, Paul J., Leslie, William D., Goltzman, David, Blangero, John, Hanley, David A., Carless, Melanie A., Streeten, Elizabeth A., Lorentzon, Mattias, Brown, Matthew A., Spector, Tim D., Pettersson-Kymmer, Ulrika, Ohlsson, Claes, Mitchell, Braxton D. and Richards, J. Brent. (2013). Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density of forearm. Journal of Medical Genetics. 50(7), pp. 473-478. https://doi.org/10.1136/jmedgenet-2012-101287
Low 25-OH vitamin d is associated with benign prostatic hyperplasia
Haghsheno, Mohammad-Ali, Mellström, Dan, Behre, Carl-Johan, Damber, Jan-Erik, Johansson, Helena, Karlsson, Magnus, Lorentzon, Mattias, Peeker, Ralph, Barret-Connor, Elisabet, Waern, Ewa, Sundh, Valter, Ohlsson, Claes and Hammarsten, Jan. (2013). Low 25-OH vitamin d is associated with benign prostatic hyperplasia. 190(2), pp. 608-614. https://doi.org/10.1016/j.juro.2013.01.104
Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes
Klingberg, Eva, Lorentzon, Mattias, Göthlin, Jan, Mellström, Dan, Geijer, Mats, Ohlsson, Claes, Atkinson, Elizabeth J., Khosla, Sundeep, Carlsten, Hans and Forsblad-d’Elia, Helena. (2013). Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes. Arthritis Research and Therapy. 15, pp. 1-11. https://doi.org/10.1186/ar4368
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure
Paternoster, Lavinia, Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo-Pekka, Mellström, Dan, Karlsson, Magnus, Ljunggren, Östen, Grundberg, Elin, Kemp, John P., Sayers, Adrian, Nethander, Maria, Evans, David M., Vandenput, Liesbeth, ... Ohlsson, Claes. (2013). Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genetics. 9(2), pp. 1 - 15. https://doi.org/10.1371/journal.pgen.1003247
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt, Sonja I., Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jianan, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., ... Lorentzon, Mattias. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics. 45, pp. 501 - 512. https://doi.org/10.1038/ng.2606
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
Hoed, Marcel den, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J.J.M., Peal, David S., Evans, David M., Nolte, Ilja M., Segrè, Ayellet V., Hólm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, ... Lorentzon, Mattias. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics. 45(6), pp. 621 - 631. https://doi.org/10.1038/ng.2610
Assessment of gene-by-sex interaction effect on bone mineral density
Liu, Ching-Ti, Estrada, Karol, Yerges-Armstrong, Laura, Amin, Najaf, Evangelou, Evangelos, Li, Guo, Minster, Ryan L., Carless, Melanie, Kammerer, Candace M., Oei, Ling, Zhou, Yanhua, Alonso, Nerea, Vandenput, Liesbeth, Lorentzon, Karl Mattias, Dailiana, Zoe, Eriksson, Joel, Garcia-Giralt, Natalia, Giroux, Sylvie, Husted, Lise Bjerre, ... al, et. (2012). Assessment of gene-by-sex interaction effect on bone mineral density. Journal of Bone and Mineral Research. 27(10), pp. 2051-2064. https://doi.org/10.1002/jbmr.1679
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation
Coviello, A.D., Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimaki, Terho, Keildson, S., Lunetta, Kathryn, He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N. Charlotte, Vandenput, Liesbeth, Lorentzon, Karl Mattias and et. al.. (2012). A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genetics. 8(7), pp. 1-12. https://doi.org/10.1371/journal.pgen.1002805
Vertebral fractures in ankylosing spondylitis are associated with lower bone mineral density in both central and peripheral skeleton
Klingberg, Eva, Geijer, Mats, Göthlin, Jan, Mellström, Dan, Lorentzon, Mattias, Hilme, Elisabet, Hedberg, Martin, Carlsten, Hans and Forsblad-d'Elia, Helena. (2012). Vertebral fractures in ankylosing spondylitis are associated with lower bone mineral density in both central and peripheral skeleton. The Journal of Rheumatology. 39(10), pp. 1987-1995. https://doi.org/10.3899/jrheum.120316
Smoking is associated with impaired bone mass development in young adult men : A 5-year longitudinal study
Rudäng, Robert, Darelid, Anna, Nilsson, Martin, Nilsson, Staffan, Mellström, Dan, Ohlsson, Claes and Lorentzon, Mattias. (2012). Smoking is associated with impaired bone mass development in young adult men : A 5-year longitudinal study. Journal of Bone and Mineral Research. 27(10), pp. 2189-2197. https://doi.org/10.1002/jbmr.1674
Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment
Klingberg, Eva, Lorentzon, Mattias, Mellström, Dan, Geijer, Mats, Göthlin, Jan, Hilme, Elisabet, Hedberg, Martin, Carlsten, Hans and Forsblad-d'Elia, Helena. (2012). Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment. Arthritis Research and Therapy. 14(3), pp. 1-12. https://doi.org/10.1186/ar3833
Inferior physical performance tests in 10,998 men in the MrOS study is associated with recurrent falls
Karlsson, Magnus K., Ribom, Eva, Nilsson, Jan-Åke, Ljunggren, Östen, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattiaz, Mallmin, Hans, Stefanick, Marcia, Lapidus, Jodi, Leung, Ping Chung, Kwok, Anthony, Barrett-Connor, Elizabeth, Orwoll, Eric and Rosengren, Björn E.. (2012). Inferior physical performance tests in 10,998 men in the MrOS study is associated with recurrent falls. Age and Ageing. 41(6), pp. 740-746. https://doi.org/10.1093/ageing/afs104
Inferior physical performance test results of 10,998 men in the MrOS Study is associated with high fracture risk
Rosengren, Björn E., Ribom, Eva L., Nilsson, Jan-Åke, Mallmin, Hans, Ljunggren, Östen, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattias, Stefanick, Marcia, Lapidus, Jodi, Leung, Ping Chung, Kwok, Anthony, Barrett-Connor, Elizabeth, Orwoll, Eric and Karlsson, Magnus K.. (2012). Inferior physical performance test results of 10,998 men in the MrOS Study is associated with high fracture risk. Age and Ageing. 41(3), pp. 339-344. https://doi.org/10.1093/ageing/afs010
Increased physical activity is associated with enhanced development of peak bone mass in men : A five-year longitudinal study
Nilsson, Martin, Ohlsson, Claes, Odén, Anders, Mellström, Dan and Lorentzon, Mattias. (2012). Increased physical activity is associated with enhanced development of peak bone mass in men : A five-year longitudinal study. Journal of Bone and Mineral Research. 27(5), pp. 1206-1214. https://doi.org/10.1002/jbmr.1549
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Estrada, Karol, Styrkarsdottir, Unnur, Evangelou, Evangelos, Hsu, Yi-Hsiang, Duncan, Emma L., Ntzani, Evangelia E., Oei, Ling, Albagha, Omar M. E., Amin, Najaf, Kemp, John P., Koller, Daniel L., Li, Guo, Liu, Ching-Ti, Minster, Ryan L., Moayyeri, Alireza, Vandenput, Liesbeth, Willner, Dana, Xiao, Su-Mei, Yerges-Armstrong, Laura M., ... Rivadeneira, Fernando. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics. 44(5), pp. 491-503. https://doi.org/10.1038/ng.2249
Catch up in bone acquisition in young adult men with late normal puberty
Darelid, Anna, Ohlsson, Claes, Nilsson, Martin, Kindblom, Jenny M., Dan Mellström and Lorentzon, Mattias. (2012). Catch up in bone acquisition in young adult men with late normal puberty. Journal of Bone and Mineral Research. 27(10), pp. 2198-2207. https://doi.org/10.1002/jbmr.1675
Age at adiposity rebound is associated with fat mass in young adult males - The GOOD Study
Ohlsson, Claes, Lorentzon, Mattias, Norjavaara, Ensio and Kindblom, Jenny M.. (2012). Age at adiposity rebound is associated with fat mass in young adult males - The GOOD Study. PLoS ONE. 7(11), pp. 1-8. https://doi.org/10.1371/journal.pone.0049404
Advancing maternal age is associated with lower bone mineral density in young adult male offspring
Rudäng, R., Mellström, D., Clark, E., Ohlsson, C. and Lorentzon, M.. (2012). Advancing maternal age is associated with lower bone mineral density in young adult male offspring. Osteoporosis International. 23, pp. 475-482. https://doi.org/10.1007/s00198-011-1558-5
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
Zheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimäki, Terho, Bergström, Ulrica, Kähönen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lehtimäki, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, ... Lorentzon, Mattias. (2012). WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genetics. 8(7), pp. 1 - 13. https://doi.org/10.1371/journal.pgen.1002745
Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden
Johansson, Helena Johansson, Oden, Anders, Kanis, John A., McCloskey, Eugene, Lorentzon, Mattias, Ljunggren, Östen, Karlsson, Magnus, Thorsby, P. M., Tivesten, A., Barrett-Connor, Elizabeth, Ohlsson, Claes and Mellström, Dan. (2012). Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden. Osteoporosis International. 23(3), pp. 991 - 999. https://doi.org/10.1007/s00198-011-1809-5
High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden
Johansson, Helena, Oden, Anders, Lerner, Ulf H., Jutberger, Hans, Lorentzon, Mattias, Barrett-Connor, Elizabeth, Karlsson, Magnus, Ljunggren, Östen, Smith, Ulf, McCloskey, Eugene, Kanis, John A., Ohlsson, Claes and Mellstrom, Dan. (2012). High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden. Journal of Bone and Mineral Research. 27(6), pp. 1390 - 1396. https://doi.org/10.1002/jbmr.1591
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
Medina-Gomez, Carolina, Kemp, John P., Estrada, Karol, Eriksson, Joel, Liu, Jeff, Reppe, Sjur, Evans, David M., Heppe, Denise H. M., Vandenput, Liesbeth, Herrera, Lizbeth, Ring, Susan M., Kruithof, Claudia J., Timpson, Nicholas J., Zillikens, M. Carola, Olstad, Ole K., Zheng, Hou-Feng, Richards, J. Brent, St. Pourcain, Beate, Hofman, Albert, ... Rivadeneira, Fernando. (2012). Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genetics. 8(7), pp. 1 - 14. https://doi.org/10.1371/journal.pgen.1002718
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
Strawbridge, Rona, Dupuis, Josee, Prokopenko, I., Barker, Adam, Ahlqvist, Emma, Rybin, Denis, Petrie, John, Travers, M.E., Bouatia-Naji, N., Dimas, Antigone, Nica, Alexandra, Wheeler, Eleanor, Chen, Han, Voight, Benjamin, Taneera, Jalal, Lorentzon, K. and et. al.. (2011). Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes. 60(10), pp. 2624-2634. https://doi.org/10.2337/db11-0415
Pubertal timing predicts leg length and childhood body mass index predicts sitting height in young adult men
Lorentzon, Mattias, Norjavaara, Ensio and Kindblom, Jenny M.. (2011). Pubertal timing predicts leg length and childhood body mass index predicts sitting height in young adult men. 158(3), pp. 452-457. https://doi.org/10.1016/j.jpeds.2010.09.009
Cortical consolidation due to increased mineralization and endosteal contraction in young adult men : A five-year longitudinal study
Ohlsson, Claes, Darelid, Anna, Nilsson, Martin, Melin, Johanna, Mellström, Dan and Lorentzon, Mattias. (2011). Cortical consolidation due to increased mineralization and endosteal contraction in young adult men : A five-year longitudinal study. The Journal of Clinical Endocrinology and Metabolism. 96(7), pp. 2262-2269. https://doi.org/10.1210/jc.2010-2751
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
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Genetic determinants of serum testosterone concentrations in men
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