The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius : A post-hoc HR-pQCT study

Journal article

Hu, Yizhong, Chines, Arkadi, Shi, Yifei, Seeman, Ego and Guo, X. Edward. (2022). The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius : A post-hoc HR-pQCT study. Bone. 154, p. 116187. https://doi.org/10.1016/j.bone.2021.116187

Publication dates
Authors	Hu, Yizhong, Chines, Arkadi, Shi, Yifei, Seeman, Ego and Guo, X. Edward
Abstract	Background Age-related trabecular microstructural deterioration and conversion from plate-like trabeculae to rod-like trabeculae occur because of unbalanced rapid remodeling. As denosumab achieves greater remodeling suppression and lower cortical porosity than alendronate, we hypothesized that denosumab might also preserve trabecular plate microstructure, bone stiffness and strength more effectively than alendronate. Methods In this post hoc analysis of a phase 2 study, postmenopausal women randomized to placebo (P, n = 74), denosumab (D, n = 72), or alendronate (A, n = 68). HR-pQCT scans of the distal radius and tibia were performed at baseline and Month-12 (M12). Trabecular compartment was subjected to Individual Trabecula Segmentation while finite element analysis was performed to estimate stiffness and strength. Percent change from baseline at M12 of each parameter was compared between patient groups. Results At the distal tibia, in the placebo group, plate surface area (pTb.S, −1.3%) decreased while rod bone volume fraction (rBV/TV, +4.5%) and number (rTb.N, +2.1%) increased. These changes were prevented by denosumab but persisted despite alendronate therapy (pTb.S: −1.7%; rBV/TV: +6.9%; rTb.N: +3.0%). Both treatments improved whole bone stiffness (D: +3.1%; A: +1.8%) and failure load (D: +3.0%; A: +2.2%); improvements using denosumab was significant compared to placebo (stiffness: p = 0.004; failure load: p = 0.003). At the distal radius, denosumab increased total trabecular bone volume fraction (BV/TV, +3.4%) and whole bone failure load (+4.0%), significantly different from placebo (BV/TV: p = 0.044; failure load: p = 0.046). Significantly different effects of either drug on plate and rod microstructure were not detected. Conclusions Denosumab preserved trabecular plate microstructure. Alendronate did not. However, estimated strength did not differ between denosumab and alendronate treated groups.
Keywords	osteoporosis; antiresorptives; bone QCT/microCT; matrix mineralization; microstructure; individual trabecula segmentation
Year	2022
Journal	Bone
Journal citation	154, p. 116187
Publisher	Elsevier Inc.
ISSN	8756-3282
Digital Object Identifier (DOI)	https://doi.org/10.1016/j.bone.2021.116187
PubMed ID	34530172
Scopus EID	2-s2.0-85115331192
Research or scholarly	Research
Page range	1-8
Publisher's version	License All rights reserved File Access Level Controlled
Output status	Published
Online	14 Sep 2021
Publication process dates
Accepted	09 Sep 2021
Deposited	16 Dec 2021

Permalink -

https://acuresearchbank.acu.edu.au/item/8x336/the-effect-of-denosumab-and-alendronate-on-trabecular-plate-and-rod-microstructure-at-the-distal-tibia-and-radius-a-post-hoc-hr-pqct-study

Restricted files

Publisher's version

(1 files)

86
total views
0
total downloads
0
views this month
0
downloads this month

These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Bone Remodeling and Modeling : Cellular Targets for Antiresorptive and Anabolic Treatments, Including Approaches Through the Parathyroid Hormone (PTH)/PTH-Related Protein Pathway

Martin, T. John and Seeman, Ego. (2023). Bone Remodeling and Modeling : Cellular Targets for Antiresorptive and Anabolic Treatments, Including Approaches Through the Parathyroid Hormone (PTH)/PTH-Related Protein Pathway. Neurospine. 20(4), pp. 1097-1109. https://doi.org/10.14245/ns.2346966.483

Bone microarchitecture and estimated failure load are deteriorated whether patients with chronic kidney disease have normal bone mineral density, osteopenia or osteoporosis

Ghasem-Zadeh, Ali, Bui, Minh, Seeman, Ego, Boyd, Steven K., Iuliano, Sandra, Jaipurwala, Rizwan, Mount, Peter F., Toussaint, Nigel D. and Chiang, Cherie. (2022). Bone microarchitecture and estimated failure load are deteriorated whether patients with chronic kidney disease have normal bone mineral density, osteopenia or osteoporosis. Bone. 154, p. Article 116260. https://doi.org/10.1016/j.bone.2021.116260

Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults : Analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)

Talevski, J, Sanders, K. M., Watts, J. J., Nicholson, G. C., Seeman, E., Iuliano, S., Prince, R., March, L., Winzenberg, T., Duque, G., Ebeling, P. R., Borgström, F., Kanis, J. A., Stuart, A. L., Beauchamp, A. and Brennan-Olsen, S. L.. (2022). Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults : Analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 33(1), pp. 67-75. https://doi.org/10.1007/s00198-021-06058-3

Bilateral atypical femoral fractures during denosumab therapy in a patient with adult-onset hypophosphatasia

Warren, Annabelle M., Ebeling, Peter R., Grill, Vivian, Seeman, Ego and Sztal-Mazer, Shoshana. (2021). Bilateral atypical femoral fractures during denosumab therapy in a patient with adult-onset hypophosphatasia. Endocrinology, Diabetes & Metabolism. 2021(1), pp. 1-5. https://doi.org/10.1530/EDM-21-0096

Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R

Martin, T. John, Sims, Natalie A. and Seeman, Ego. (2021). Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R. Endocrine Reviews. 42(4), pp. 383-406. https://doi.org/10.1210/endrev/bnab005

Recovery of quality of life is associated with lower mortality 5-year post-fracture : the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)

Talevski, Jason, Sanders, Kerrie M., Vogrin, Sara, Duque, Gustavo, Beauchamp, Alison, Seeman, Ego, Iuliano, Sandra, Svedbom, Axel, Borgström, Fredrik, Kanis, John A., Stuart, Amanda L. and Brennan-Olsen, Sharon L.. (2021). Recovery of quality of life is associated with lower mortality 5-year post-fracture : the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Archives of Osteoporosis. 16, p. Article 112. https://doi.org/10.1007/s11657-021-00981-y

Heterogeneity in microstructural deterioration following spinal cord injury

Ghasem-Zadeh, Ali, Galea, Mary P., Nunn, Andrew, Panisset, Maya, Wang, Xiao-Fang, Iuliano, Sandra, Boyd, Steven K., Forwood, Mark R. and Seeman, Ego. (2021). Heterogeneity in microstructural deterioration following spinal cord injury. Bone. 142, p. 115778. https://doi.org/10.1016/j.bone.2020.115778

High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures

Zendeli, Afrodite, Bui, Minh, Fischer, Lukas, Ghasem-Zadeh, Ali, Schima, Wolfgang and Seeman, Ego. (2021). High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures. Journal of Clinical Sleep Medicine. 10(5), pp. 1-10. https://doi.org/10.3390/jcm10051123

Cost-effectiveness of treatment of women aged 70 years and older with both osteopenia and microstructural deterioration

Liew, Danny, Chapurlat, R. D., Sornay-Rendu, E., Lespessailles, Eric, Peng, Yu and Seeman, Ego. (2021). Cost-effectiveness of treatment of women aged 70 years and older with both osteopenia and microstructural deterioration. Bone. 142, p. 115682. https://doi.org/10.1016/j.bone.2020.115682

Reduced bone modeling and unbalanced bone remodeling : Targets for antiresorptive and anabolic therapy

Ramchand, Sabashini and Seeman, Ego. (2020). Reduced bone modeling and unbalanced bone remodeling : Targets for antiresorptive and anabolic therapy. In In Stern, Paula H. (Ed.). Bone regulators and osteoporosis therapy pp. 423-450 Springer Nature Switzerland AG. https://doi.org/10.1007/164_2020_354

Differing effects of zoledronic acid on bone microarchitecture and bone mineral density in men receiving androgen deprivation therapy : A randomized controlled trial

Cheung, Ada S., Hoermann, Rudolf, Ghasem-Zadeh, Ali, Tinson, Alistair J., Ly, Vivian, Milevski, Stefan V., Joon, Daryl Lim, Zajac, Jeffrey D., Seeman, Ego and Grossmann, Mathis. (2020). Differing effects of zoledronic acid on bone microarchitecture and bone mineral density in men receiving androgen deprivation therapy : A randomized controlled trial. Journal of Bone and Mineral Research. 35(10), pp. 1871-1880. https://doi.org/10.1002/jbmr.4106

Deterioration of cortical and trabecular microstructure identifies women with osteopenia or normal bone mineral density at imminent and long-term risk for fragility fracture : A prospective study

Chapurlat, Roland, Bui, Minh, Sornay-Rendu, Elisabeth, Zebaze, Roger, Delmas, Pierre D., Liew, Danny, Lespessailles, Eric and Seeman, Ego. (2020). Deterioration of cortical and trabecular microstructure identifies women with osteopenia or normal bone mineral density at imminent and long-term risk for fragility fracture : A prospective study. Journal of Bone and Mineral Research. 35(6), pp. 833-844. https://doi.org/10.1002/jbmr.3924

Osteocalcin and its forms across the lifespan in adult men

Smith, Cassandra, Voisin, Sarah, Al Saedi, Ahmed, Phu, Steven, Brennan-Speranza, Tara C., Parker, Lewan, Eynon, Nir, Hiam, Danielle S., Yan, Xu, Scott, David, Blekkenhorst, Lauren C., Lewis, Joshua R., Seeman, Ego, Byrnes, Elizabeth, Flicker, Leon, Duque, Gustavo, Yeap, Bu B. and Levinger, Itamar. (2020). Osteocalcin and its forms across the lifespan in adult men. Bone. 130, pp. 1 - 6. https://doi.org/10.1016/j.bone.2019.115085

Modeling and remodeling : The cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy

Seeman, Ego. (2019). Modeling and remodeling : The cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy. In In Bilezikian, John P., Martin, T. John, Clemens, Thomas L. and Rosen, Clifford J. (Ed.). Principles of bone biology ; volume 1 pp. 245-274 Academic Press. https://doi.org/10.1016/B978-0-12-814841-9.00011-7

The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017

Tatangelo, Gemma, Watts, Jennifer J., Lim, Karen, Connaughton, Catherine, Abimanyi-Ochom, Julie, Borgström, Fredrik, Nicholson, Geoff C., Shore-Lorenti, Catherine, Stuart, Amanda L., Iuliano-Burns, Sandra, Seeman, Ego, Prince, Richard L., March, Lyn, Cross, Marita, Winzenberg, Tania, Laslett, Laura L., Duque, Gustavo, Ebeling, Peter R. and Sanders, Kerrie M.. (2019). The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017. Journal of Bone and Mineral Research. 34(4), pp. 616 - 625. https://doi.org/10.1002/jbmr.3640

Skeletal growth: A major determinant of bone's structural diversity in women and men

Seeman, Ego. (2019). Skeletal growth: A major determinant of bone's structural diversity in women and men. In In J. P. Bilezikian (Ed.). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism pp. 123 - 130 Wiley-Blackwell. https://doi.org/10.1002/9781119266594.ch16

Fat from dairy foods and 'meat' consumed within recommended levels is associated with favourable serum cholesterol levels in institutionalised older adults

Liu, Yusi, Poon, Shirley, Seeman, Ego, Hare, David L., Bui, Minh Q. and Iuliano, Sandra. (2019). Fat from dairy foods and 'meat' consumed within recommended levels is associated with favourable serum cholesterol levels in institutionalised older adults. Journal of Nutritional Science. 8(e10), pp. 1 - 8. https://doi.org/10.1017/jns.2019.5

Dimorphism in axial and appendicular dimensions, cortical and trabecular microstructure and matrix mineral density in Chinese and Caucasian women

Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Zhou, Bin, Guo, X. Edward, Zhang, Zhendong and Seeman, Ego. (2019). Dimorphism in axial and appendicular dimensions, cortical and trabecular microstructure and matrix mineral density in Chinese and Caucasian women. Bone. 128, pp. 1 - 7. https://doi.org/10.1016/j.bone.2019.115039

Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls

Zebaze, Roger M., Osima, Marit, Bui, Minh Q., Lukic, Marko, Wang, Xiaofang, Ghasem-Zadeh, Ali, Eriksen, Erik F., Vais, Angela, Shore-Lorenti, Catherine, Ebeling, Peter R., Seeman, Ego and Bjørnerem, Ashild. (2019). Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls. Journal of Bone and Mineral Research. 34(8), pp. 1451 - 1460. https://doi.org/10.1002/jbmr.3721

Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration

Zebaze, Roger M., Atkinson, Elizabeth J., Peng, Yu, Bui, Minh, Ghasem-Zadeh, Ali, Khosla, Sundeep and Seeman, Ego. (2019). Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration. JBMR Plus. 3(4), pp. 1 - 7. https://doi.org/10.1002/jbm4.10078

Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin

Parker, Lewan, Lin, Xuzhu, Garnham, Andrew, McConell, Glenn, Stepto, Nigel K., Hare, David L., Byrnes, Elizabeth, Ebeling, Peter R., Seeman, Ego, Brennan-Speranza, Tara C. and Levinger, Itamar. (2019). Glucocorticoid-induced insulin resistance in men is associated with suppressed undercarboxylated osteocalcin. Journal of Bone and Mineral Research. 34(1), pp. 49-58. https://doi.org/10.1002/jbmr.3574

Menopause and age-related bone loss

Isales, Carlos M. and Seeman, Ego. (2019). Menopause and age-related bone loss. In In J. P. Bilezikian (Ed.). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism pp. 155 - 161 Wiley-Blackwell. https://doi.org/10.1002/9781119266594.ch21

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility

Seeman, Ego and Martin, T. J.. (2019). Antiresorptive and anabolic agents in the prevention and reversal of bone fragility. Nature Reviews Rheumatology. 15(4), pp. 225 - 236. https://doi.org/10.1038/s41584-019-0172-3

The influence of cortical porosity on the strength of bone during growth and advancing age

Ramchand, S. K. and Seeman, Ego. (2018). The influence of cortical porosity on the strength of bone during growth and advancing age. Current Osteoporosis Reports. 16(5), pp. 561 - 572. https://doi.org/10.1007/s11914-018-0478-0

Mechanical loading of the femoral neck in human locomotion

Kersh, M. E., Martelli, Saulo, Zebaze, Roger M., Seeman, Ego and Pandy, Marcus. (2018). Mechanical loading of the femoral neck in human locomotion. Journal of Bone and Mineral Research. 33(11), pp. 1999 - 2006. https://doi.org/10.1002/jbmr.3529

Sexual dimorphism in cortical and trabecular bone microstructure appears during puberty in chinese children

Cheuk, Ka Yee, Wang, Xiao-Fang, Wang, Ji, Zhang, Zhendong, Yu, Fiona Wai Ping, Tam, Elisa Man Shan, Hung, Vivian Wing Yin, Lee, Wayne Yuk Wai, Ghasem-Zadeh, Ali, Zebaze, Roger, Zhu, Tracy Y., Guo, X. Edward, Cheng, Jack Chun Yiu, Lam, Tsz Ping and Seeman, Ego. (2018). Sexual dimorphism in cortical and trabecular bone microstructure appears during puberty in chinese children. Journal of Bone and Mineral Research. 33(11), pp. 1948 - 1955. https://doi.org/10.1002/jbmr.3551

Cortical matrix mineral density measured noninvasively in pre- and postmenopausal women and a woman with vitamin d–dependent rickets

Chiang, Cherie Y., Zebaze, Roger, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Zajac, Jeffrey D. and Seeman, Ego. (2018). Cortical matrix mineral density measured noninvasively in pre- and postmenopausal women and a woman with vitamin d–dependent rickets. Journal of Bone and Mineral Research. 33(7), pp. 1312 - 1317. https://doi.org/10.1002/jbmr.3415

Systemic mastocytosis identified in two women developing fragility fractures during lactation

Zhu, J. J., Mahendran, D., Lee, M.H., Seah, J., Fourlanos, S., Varadarajan, S., Ghasem-Zadeh, Ali, MacIsaac, Richard and Seeman, Ego. (2018). Systemic mastocytosis identified in two women developing fragility fractures during lactation. Osteoporosis International. 29(7), pp. 1671 - 1674. https://doi.org/10.1007/s00198-018-4498-5

The material and structural basis of the growth-related gain and age-related loss of bone strength

Seeman, Ego. (2018). The material and structural basis of the growth-related gain and age-related loss of bone strength. In In N. C. Harvey and C. Cooper (Ed.). Osteoporosis: A Lifecourse Epidemiology Approach to Skeletal Health pp. 105 - 122 CRC Press. https://doi.org/10.1201/9781351234627-9

An even distribution of protein intake daily promotes protein adequacy but does not influence nutritional status in institutionalized elderly

Tieland, Michael, Beelen, Janne, Laan, Anna C. M., Poon, Shirley, de Groot, Lisette C. P. G. M., Seeman, Ego, Wang, Xiaofang and Iuliano, Sandra. (2018). An even distribution of protein intake daily promotes protein adequacy but does not influence nutritional status in institutionalized elderly. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 19(1), pp. 33 - 39. https://doi.org/10.1016/j.jamda.2017.07.007

The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study

Leslie, William D., Seeman, Ego, Morin, Suzanne N., Lix, Lisa and Majumdar, S. R.. (2018). The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study. Bone. 114, pp. 298 - 303. https://doi.org/10.1016/j.bone.2018.07.004

Advances and unmet needs in the therapeutics of bone fragility

Ramchand, S. K. and Seeman, Ego. (2018). Advances and unmet needs in the therapeutics of bone fragility. Frontiers in Endocrinology. 9, pp. 1 - 10. https://doi.org/10.3389/fendo.2018.00505

Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity

Bjørnerem, Ashild, Wang, Xiaofang, Bui, Q. M., Ghasem-Zadeh, Ali, Hopper, John, Zebaze, Roger M. and Seeman, Ego. (2018). Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity. Journal of Bone and Mineral Research. 33(4), pp. 598 - 605. https://doi.org/10.1002/jbmr.3333

Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide

Zebaze, Roger, Takao-Kawabata, Ryoko, Peng, Yu, Zadeh, Ali Ghasem, Hirano, Kyoko, Yamane, Hiroshi, Takakura, Aya, Isogai, Yukihiro, Ishizuya, Toshinori and Seeman, Ego. (2017). Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide. Bone. 99, pp. 80 - 84. https://doi.org/10.1016/j.bone.2017.03.042

Dairy food supplementation may reduce malnutrition risk in institutionalised elderly

Iuliano, Sandra, Poon, Shirley, Wang, Xiaofang, Bui, Minh and Seeman, Ego. (2017). Dairy food supplementation may reduce malnutrition risk in institutionalised elderly. British Journal of Nutrition. 117(1), pp. 142 - 147. https://doi.org/10.1017/S000711451600461X

Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease

Seeman, Ego. (2017). Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease. Nephrology. 22(Suppl 2), pp. 34 - 35. https://doi.org/10.1111/nep.13024

Serum 25-hydroxyvitamin d insufficiency in search of a bone disease

Shah, Sonali, Chiang, Cherie, Sikaris, Ken, Lu, Zhong, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Serum 25-hydroxyvitamin d insufficiency in search of a bone disease. The Journal of Clinical Endocrinology and Metabolism. 102(7), pp. 2321 - 2328. https://doi.org/10.1210/jc.2016-3189

Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding

Bjørnerem, Åshild, Ghasem-Zadeh, Ali, Wang, Xiaofang, Bui, Minh, Walker, Susan P., Zebaze, Roger and Seeman, Ego. (2017). Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding. Journal of Bone and Mineral Research. 32(4), pp. 681 - 687. https://doi.org/10.1002/jbmr.3018

Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure

Ramchand, Sabashini K., Seeman, Ego, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Francis, Prudence A., Ponnusamy, Evangeline J., Bardin, Michele S., Bui, Minh, Zebaze, Roger, Zajac, Jeffrey D. and Grossmann, Mathis. (2017). Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure. Bone. 103, pp. 131 - 135. https://doi.org/10.1016/j.bone.2017.06.024

Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions

Ghasem-Zadeh, Ali, Burghardt, Andrew, Wang, Xiao-Fang, Iuliano, Sandra, Bonaretti, Serena, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions. Bone. 101, pp. 206 - 213. https://doi.org/10.1016/j.bone.2017.05.010

Abaloparatide is an anabolic, but does it spare resorption?

Martin, T. John and Seeman, Ego. (2017). Abaloparatide is an anabolic, but does it spare resorption? Journal of Bone and Mineral Research. 32(1), pp. 11 - 16. https://doi.org/10.1001/jama.2016.11136

Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age

Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age. Journal of Clinical Densitometry. 20(1), pp. 5 - 7. https://doi.org/10.1016/j.jocd.2016.08.006

A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol

Levinger, Itamar, Brennan-Speranza, Tara C., Stepto, Nigel K., Jerums, George, Parker, Lewan, McConell, Glenn K., Anderson, Mitchell, Garnham, Andrew, Hare, David L., Ebeling, Peter R. and Seeman, Ego. (2016). A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol. JMIR Research Protocols. 5(2), pp. 1 - 7. https://doi.org/10.2196/resprot.5119

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy

Barker, Anna L., McNeil, John J., Seeman, Ego, Ward, Stephanie A., Sanders, Kerrie M., Khosla, Sundeep, Cumming, Robert G., Pasco, Julie A., Bohensky, Megan A., Ebeling, Peter E., Woods, Robyn L., Lockery, Jessica E., Wolfe, Rory, Talevski, Jason and ASPREE Investigator Group. (2016). A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy. Injury Prevention. 22(4), pp. 297-301. https://doi.org/10.1136/injuryprev-2015-041655

Glucose-loading reduces bone remodeling in women and osteoblast function in vitro

Levinger, Itamar, Seeman, Ego, Jerums, George, McConell, Glenn K., Rybchyn, Mark S., Cassar, Samantha, Byrnes, Elizabeth, Selig, Steve, Mason, Rebecca S., Ebeling, Peter R. and Brennan-Speranza, Tara C.. (2016). Glucose-loading reduces bone remodeling in women and osteoblast function in vitro. Physiological Reports. 4(3), pp. 1 - 10. https://doi.org/10.14814/phy2.12700

Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report

Ramchand, S. K., Chiang, C. Y., Zebaze, R. M. and Seeman, Ego. (2016). Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report. Osteoporosis International. 27(2), pp. 821 - 825. https://doi.org/10.1007/s00198-015-3354-0

The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo

Levinger, Itamar, Lin, X, Zhang, X., Brennan-Speranza, T C., Volpato, B, Hayes, A., Jeru, G, Seeman, Ego and Mcconell, Glenn K.. (2016). The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo. Osteoporosis International. 27(2), pp. 653 - 663. https://doi.org/10.1007/s00198-015-3273-0

Challenges in the acquisition and analysis of bone microstructure during growth

Seeman, Ego and Ghasem-Zadeh, Ali. (2016). Challenges in the acquisition and analysis of bone microstructure during growth. Journal of Bone and Mineral Research. 31(12), pp. 2239 - 2241. https://doi.org/10.1002/jbmr.3015

Bone remodeling markers: So easy to measure, so difficult to interpret

Seeman, E. and Nguyen, T. V.. (2016). Bone remodeling markers: So easy to measure, so difficult to interpret. Osteoporosis International. 27, pp. 33 - 35. https://doi.org/10.1007/s00198-015-3374-9

Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis

Zebaze, Roger M., Libanati, Cesar, McClung, Michael R., Zanchetta, Jose Ruben, Kendler, David L., Høiseth, Arne, Wang, Andrea, Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis. Journal of Bone and Mineral Research. 31(10), pp. 1827 - 1834. https://doi.org/10.1002/jbmr.2855

Osteoporosis: Treat or let die twice more likely

Nguyen, Tuan V. and Seeman, Ego. (2015). Osteoporosis: Treat or let die twice more likely. Journal of Bone and Mineral Research. 30(9), pp. 1551 - 1552. https://doi.org/10.1002/jbmr.2601/pdf

Cortical bone: A challenging geography

Zebaze, Roger and Seeman, Ego. (2015). Cortical bone: A challenging geography. Journal of Bone and Mineral Research. 30(1), pp. 24 - 29. https://doi.org/10.1002/jbmr.2419

Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft

Perilli, Egon, Bala, Yohann, Zebaze, Roger M., Reynolds, Karen J. and Seeman, Ego. (2015). Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft. Calcified Tissue International. 97(4), pp. 327 - 335. https://doi.org/10.1007/s00223-015-0014-5

Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)

Abimanyi-Ochom, J., Watts, Jennifer, Borgstrom, F., Nicholson, Geoffrey, Shore-Lorenti, Catherine, Stuart, Amanda, Zhang, Y., Luliano, S., Seeman, Ego, Prince, Richard, March, Lyn, Winzenberg, T., Laslett, Laura, Duque, Gustavo, Ebeling, P. and Sanders, K. M.. (2015). Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 26(6), pp. 1781 - 1790. https://doi.org/10.1007/s00198-015-3088-z

Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study

Bjornerem, Ashild, Bui, Q Minh, Wang, Xiaofang, Ghasem-Zadeh, Ali, Hopper, John L., Zebaze, Roger M. and Seeman, Ego. (2015). Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study. Journal of Bone and Mineral Research. 30(3), pp. 516 - 524. https://doi.org/10.1002/jbmr.2365

Bones material constituents and their contribution to bone strength in health, disease, and treatment

Bala, Y. and Seeman, Ego. (2015). Bones material constituents and their contribution to bone strength in health, disease, and treatment. Calcified Tissue International. 97(3), pp. 308 - 326. https://doi.org/10.1007/s00223-015-9971-y

A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015

Manolagas, Stavros C., Compston, Juliet, Rao, Sudhaker and Seeman, Ego. (2015). A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015. Journal of Bone and Mineral Research. 30(8), pp. 1349 - 1355. https://doi.org/10.1002/jbmr.2576

Co-administration of antiresorptive and anabolic agents: A missed opportunity

Seeman, Ego and Martin, T. John. (2015). Co-administration of antiresorptive and anabolic agents: A missed opportunity. Journal of Bone and Mineral Research. 30(5), pp. 753 - 764. https://doi.org/10.1002/jbmr.2496

The ABC of writing a grant proposal

Seeman, Ego. (2015). The ABC of writing a grant proposal. Osteoporosis International. 26(6), pp. 1665 - 1666. https://doi.org/10.1007/s00198-015-3085-2

Growth and age-related abnormalities in cortical structure and fracture risk

Seeman, Ego. (2015). Growth and age-related abnormalities in cortical structure and fracture risk. Endocrinology and Metabolism. 30(4), pp. 419 - 428. https://doi.org/10.3803/EnM.2015.30.4.419

High-resolution in vivo imaging of bone and joints: a window to microarchitecture

Geusens, P., Geusens, P., Chapurlat, Roland D., Chapurlat, Roland D., Schett, G., Ghasem-Zadeh, Ali, Ghasem-Zadeh, Ali, Seeman, Ego, De Jong, J. and Van Den Bergh, J.. (2014). High-resolution in vivo imaging of bone and joints: a window to microarchitecture. Nature Reviews Rheumatology. 10(5), pp. 304 - 313. https://doi.org/10.1038/nrrheum.2014.23

A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images

Zebaze, Roger M., Ghasem-Zadeh, Ali, Mbala, A. and Seeman, Ego. (2013). A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images. Bone. 54(1), pp. 8 - 20. https://doi.org/10.1016/j.bone.2013.01.007

Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy

Chiang, Cherie Ying, Zebaze, Roger M.D., Ghasem-Zadeh, Ali, Iuliano-Burns, Sandra, Hardidge, Andrew and Seeman, Ego. (2013). Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy. Bone. 52(1), pp. 360 - 365. https://doi.org/10.1016/j.bone.2012.10.006

Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial

Wustrack, R., Seeman, Ego, Bucci-Rechtweg, C. and Burch, S.. (2012). Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial. Osteoporosis International. 23(1), pp. 53 - 58. https://doi.org/10.1007/s00198-011-1664-4

The effect of acute exercise on undercarboxylated osteocalcin in obese men

Levinger, Itamar, Zebaze, Roger M., Jeru, G., Hare, David L., Selig, Steve and Seeman, Ego. (2011). The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporosis International. 22(5), pp. 1621 - 1626. https://doi.org/10.1007/s00198-010-1370-7

The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius : A post-hoc HR-pQCT study

Restricted files

Publisher's version

86

0

0

0

Export as

Related outputs