Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals
Journal article
Alemany, Silvia, Crous-Bou, Marta, Vilor-Tejedor, Natalia, Milà-Alomà, Marta, Suárez-Calvet, Marc, Salvadó, Gemma, Cirach, Marta, Arenaza-Urquijo, Eider M., Sánchez-Benavides, Gonzalo, Grau-Rivera, Oriol, Minguillon, Carolina, Fauria, Karine, Kollmorgen, Gwendlyn, Gispert, Juan Domingo, Gascón, Mireia, Nieuwenhuijsen, Mark, Zetterberg, Henrik, Blennow, Kaj, Sunyer, Jordi and Molinuevo, José. (2021). Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals. Environment International. 157, p. Article 106864. https://doi.org/10.1016/j.envint.2021.106864
Authors | Alemany, Silvia, Crous-Bou, Marta, Vilor-Tejedor, Natalia, Milà-Alomà, Marta, Suárez-Calvet, Marc, Salvadó, Gemma, Cirach, Marta, Arenaza-Urquijo, Eider M., Sánchez-Benavides, Gonzalo, Grau-Rivera, Oriol, Minguillon, Carolina, Fauria, Karine, Kollmorgen, Gwendlyn, Gispert, Juan Domingo, Gascón, Mireia, Nieuwenhuijsen, Mark, Zetterberg, Henrik, Blennow, Kaj, Sunyer, Jordi and Molinuevo, José |
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Abstract | Background Participants and methods The sample included 156 cognitively unimpaired adults aged 57 years (61 at biomarkers assessment) with increased risk of AD from the ALFA + Study. We examined CSF levels of Aβ42, Aβ40, p-Tau, t-Tau, neurofilament light (NfL) and cerebral amyloid load (Centiloid). A Land Use Regression model from 2009 was used to estimate residential exposure to air pollutants including nitrogen dioxide (NO2,) and particulate matter (PM2.5, PM2.5 abs, PM10). This model was considered a surrogate of long-term exposure until time of data collection in 2013–2014. Participants have resided in the same residence for at least the previous 3 years. Multiple linear regression models were used to estimate associations between air pollutants and biomarkers. The effect modification by CSF Aβ status and APOE-ε4 carriership was also assessed. Results Conclusion |
Keywords | nitrogen dioxide; particulate matter; neurodegeneration; AD biomarkers; Amyloid-β; APOE |
Year | 2021 |
Journal | Environment International |
Journal citation | 157, p. Article 106864 |
Publisher | Elsevier Ltd |
ISSN | 0160-4120 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.envint.2021.106864 |
Scopus EID | 2-s2.0-85115022185 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-9 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 16 Sep 2021 |
Publication process dates | |
Accepted | 02 Sep 2021 |
Deposited | 22 Dec 2021 |
https://acuresearchbank.acu.edu.au/item/8x3yw/associations-between-air-pollution-and-biomarkers-of-alzheimer-s-disease-in-cognitively-unimpaired-individuals
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Publisher's version
OA_Alemany_2021_Associations_between_air_pollution_and_biomarkers.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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