Effects of exercise on sexual dysfunction in patients with prostate cancer - A systematic review

Journal article


Reimer, Nadine, Zopf, Eva Maria, Böwe, Rebecca and Baumann, Freerk Theeagnus. (2021). Effects of exercise on sexual dysfunction in patients with prostate cancer - A systematic review. Journal of Sexual Medicine. 18(11), pp. 1899-1914. https://doi.org/10.1016/j.jsxm.2021.09.001
AuthorsReimer, Nadine, Zopf, Eva Maria, Böwe, Rebecca and Baumann, Freerk Theeagnus
Abstract

Background
Emerging evidence suggests that exercise interventions may improve sexual dysfunction, one of the most common and distressing long-term adverse effects of cancer treatment.

Aim
The aim of this systematic review is to provide an overview of the effects of exercise on sexual dysfunction in prostate cancer patients.

Methods
A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. The systematic literature search was performed on 13th July 2021 using CINAHL, Cochrane Central Register of Controlled Trials, Embase, Medline and Web of Science. Studies were included if they were randomized controlled trials (RCTs) assessing sexual function in prostate cancer patients conducting an exercise intervention alone or in combination with other supportive interventions. The methodological quality was assessed using the Physiotherapy Education Database Score and Jadad scale. Outcomes were reported as between-group differences. Intragroup differences were also reported if significant.

Outcomes
Positive intervention effects on sexual function were primarily observed in patients following prostatectomy and undergoing anti-hormone treatment and for pelvic floor muscle exercises as well as aerobic and resistance exercise.

Results
22 RCTs (n = 1.752 patients) met the eligibility criteria, conducting either an exercise-only intervention (n = 10), a multimodal (exercise plus other supportive therapy) intervention (n = 4), or pelvic floor muscle exercises (n = 8). 6 RCTs assessed sexual dysfunction as a primary endpoint and 8 RCTs used dedicated assessment methods. 9 of the 22 RCTs found significant between-group differences in favor of the intervention group.

Clinical Implications
The multifaceted etiology of sexual dysfunction provides a strong rationale to further investigate the effects of exercise on sexual dysfunction in prostate cancer patients and also to consider a multidisciplinary approach.

Strengths and Limitations
A strength is the comprehensive literature search to identify RCTs involving different exercise interventions and a wide range of sexual function assessments. Further, this is the first systematic review on this topic. The main limitations include the difficulty to compare studies due to the heterogeneity of exercise interventions and low questionnaire completion rates in some studies.

Conclusion
Preliminary data from a small number of studies suggest that certain exercise interventions may improve sexual dysfunction in prostate cancer patients, however further trials involving sexual dyfunction as a primary outcome and more comprehensive assessment tools are needed to confirm the rehabilitative and preventive effects of exercise on sexual dysfunction in prostate cancer patients.

Keywordsprostate cancer; sexual dysfunction; erectile dysfunction; exercise; pelvic floor muscle exercises
Year2021
JournalJournal of Sexual Medicine
Journal citation18 (11), pp. 1899-1914
PublisherElsevier Inc.
ISSN1743-6095
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jsxm.2021.09.001
Scopus EID2-s2.0-85117212278
Research or scholarlyResearch
Page range1899-1914
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online13 Oct 2021
Publication process dates
Accepted02 Sep 2021
Deposited12 Jan 2022
Permalink -

https://acuresearchbank.acu.edu.au/item/8x44q/effects-of-exercise-on-sexual-dysfunction-in-patients-with-prostate-cancer-a-systematic-review

Restricted files

Publisher's version

  • 1
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Supervised pelvic floor muscle exercise is more effective than unsupervised pelvic floor muscle exercise at improving urinary incontinence in prostate cancer patients following radical prostatectomy – a systematic review and meta-analysis
Baumann, Freerk T., Reimer, Nadine, Gockeln, Theresa, Reike, Alexandra, Hallek, Michael, Ricci, Christian, Zopf, Eva M., Schmid, Daniela, Taaffe, Dennis, Newton, Robert U., Galvao, Daniel A. and Leitzmann, Michael. (2021). Supervised pelvic floor muscle exercise is more effective than unsupervised pelvic floor muscle exercise at improving urinary incontinence in prostate cancer patients following radical prostatectomy – a systematic review and meta-analysis. Disability and Rehabilitation. pp. 1-12. https://doi.org/10.1080/09638288.2021.1937717
Quality of life and symptom burden improve in patients attending a multidisciplinary clinical service for cancer cachexia : A retrospective observational review
Bland, Kelcey A., Harrison, Meg, Harrison, Meg, Zopf, Eva M., Sousa, Mariana S., Currow, David C., Ely, Matthew, Agar, Meera, Butcher, Belinda E., Vaughan, Vanessa, Dowd, Anna and Martin, Peter. (2021). Quality of life and symptom burden improve in patients attending a multidisciplinary clinical service for cancer cachexia : A retrospective observational review. Journal of Pain and Symptom Management. 62(3), pp. e164-e176. https://doi.org/10.1016/j.jpainsymman.2021.02.034
Exercise interventions for people diagnosed with cancer : A systematic review of implementation outcomes
Czosnek, Louise, Richards, Justin, Zopf, Eva, Cormie, Prue, Rosenbaum, Simon and Rankin, Nicole M.. (2021). Exercise interventions for people diagnosed with cancer : A systematic review of implementation outcomes. BMC Cancer. 21, p. Article 643. https://doi.org/10.1186/s12885-021-08196-7
Patients and carers' perspectives of participating in a pilot tailored exercise program during chemoradiotherapy for high grade glioma : A qualitative study
Halkett, Georgia K. B., Cormie, Prue, McGough, Shirley, Zopf, Eva M., Galvao, Daniel A., Newton, Robert U. and Nowak, Anna K.. (2021). Patients and carers' perspectives of participating in a pilot tailored exercise program during chemoradiotherapy for high grade glioma : A qualitative study. European Journal of Cancer Care. 30(5), p. Article: e13453. https://doi.org/10.1111/ecc.13453
The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : A systematic review and meta-analysis
Bigaran, Ashley, Zopf, Eva, Gardner, Jason, La Gerche, Andre, Murphy, Declan G., Howden, Erin J., Baker, Michael K. and Cormie, Prue. (2021). The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : A systematic review and meta-analysis. Prostate Cancer and Prostatic Diseases. 24(1), pp. 35-48. https://doi.org/10.1038/s41391-020-00273-5
Aerobic exercise-induced changes in cardiorespiratory fitness in breast cancer patients receiving chemotherapy : A systematic review and meta-analysis
Maginador, Guilherme, Lixandrão, Manoel E., Bortolozo, Henrique I., Vechin, Felipe C., Sarian, Luís O., Derchain, Sophie, Telles, Guilherme D., Zopf, Eva, Ugrinowitsch, Carlos and Conceição, Miguel S.. (2020). Aerobic exercise-induced changes in cardiorespiratory fitness in breast cancer patients receiving chemotherapy : A systematic review and meta-analysis. Cancers. 12(8), p. 2240. https://doi.org/10.3390/cancers12082240
Prognostic markers of overall survival in cancer patients attending a cachexia support service : An evaluation of clinically assessed physical function, malnutrition and inflammatory status
Bland, Kelcey A., Zopf, Eva M., Harrison, Meg, Ely, Matthew, Cormie, Prue, Liu, E., Dowd, Anna and Martin, Peter. (2020). Prognostic markers of overall survival in cancer patients attending a cachexia support service : An evaluation of clinically assessed physical function, malnutrition and inflammatory status. Nutrition and Cancer. 73(8), pp. 1400-1410. https://doi.org/10.1080/01635581.2020.1800765
Implementing Exercise in Healthcare Settings: The Potential of Implementation Science
Louise Czosnek, Nicole Rankin, Eva Zopf, Justin Richards, Simon Rosenbaum and Prue Cormie. (2020). Implementing Exercise in Healthcare Settings: The Potential of Implementation Science. Sports Medicine. 50, pp. 1-14. https://doi.org/10.1007/s40279-019-01228-0
Exercise medicine for the management of androgen deprivation therapy-related side effects in prostate cancer
Cormie, Prue and Zopf, Eva M.. (2020). Exercise medicine for the management of androgen deprivation therapy-related side effects in prostate cancer. Urologic Oncology. 38(2), pp. 62 - 70. https://doi.org/10.1016/j.urolonc.2018.10.008
Health benefits, safety and cost of physical activity interventions for mental health conditions: A meta-review to inform translation efforts
Czosnek, Louise, Lederman, Oscar, Cormie, Prue, Zopf, Eva M., Stubbs, Brendon and Rosenbaum, Simon. (2019). Health benefits, safety and cost of physical activity interventions for mental health conditions: A meta-review to inform translation efforts. Mental Health and Physical Activity. 16, pp. 140 - 151. https://doi.org/10.1016/j.mhpa.2018.11.001
Effects of KYUSHO JITSU on physical activity-levels and quality of life in breast cancer patients
Strunk, Maximilian A., Zopf, Eva, Steck, Jule, Hamacher, Stefanie, Hallek, Michael and Baumann, Freerk T.. (2018). Effects of KYUSHO JITSU on physical activity-levels and quality of life in breast cancer patients. In Vivo: international journal of experimental and clinical pathophysiology and drug research. 32(4), pp. 819 - 824. https://doi.org/10.21873/invivo.11313
Sustainable impact of an individualized exercise program on physical activity level and fatigue syndrome on breast cancer patients in two German rehabilitation centers
Baumann, Freerk T., Bieck, Oliver, Oberste, Max, Kuhn, Rafaela, Schmitt, Joachim, Wentrock, Steffen, Zopf, Eva, Bloch, Wilhelm, Schüle, Klaus and Reuss-Borst, Monika. (2017). Sustainable impact of an individualized exercise program on physical activity level and fatigue syndrome on breast cancer patients in two German rehabilitation centers. Supportive Care in Cancer. 25(4), pp. 1047 - 1054. https://doi.org/10.1007/s00520-016-3490-x
The impact of exercise on cancer mortality, recurrence, and treatment-related adverse effects
Cormie, Prue, Zopf, Eva, Zhang, Xiaochen and Schmitz, Kathryn H.. (2017). The impact of exercise on cancer mortality, recurrence, and treatment-related adverse effects. Epidemiologic Reviews. 39(1), pp. 71 - 92. https://doi.org/10.1093/epirev/mxx007
Associations between aerobic exercise levels and physical and mental health outcomes in men with bone metastatic prostate cancer: A cross-sectional investigation
Zopf, Eva M., Newton, Robert, Taaffe, Dennis R., Spry, Nigel A., Cormie, Prue, Joseph, David, Chambers, Suzanne, Baumann, Freerk T., Bloch, W. and Galvao, Daniel. (2017). Associations between aerobic exercise levels and physical and mental health outcomes in men with bone metastatic prostate cancer: A cross-sectional investigation. European Journal of Cancer Care. 26(6), pp. 1 - 7. https://doi.org/10.1111/ecc.12575
Impact of physical inactivity on the multifactorial process of developing cancer-related cognitive impairments
Pesendorfer, L. M., Zimmer, Philipp, Galvao, Daniel, Zopf, Eva M., Bloch, Wilhelm and Baumann, Freerk T.. (2016). Impact of physical inactivity on the multifactorial process of developing cancer-related cognitive impairments. Journal of Cancer Science and Therapy (online). 8(8), pp. 222 - 227. https://doi.org/10.4172/1948-5956.1000417
Exercise-induced natural killer cell activation is driven by epigenetic modifications
Zimmer, Philipp, Bloch, Wilhelm, Schenk, Alexander, Zopf, Eva M., Hildebrandt, U., Streckmann, F., Beulertz, J., Koliamitra, C., Schollmayer, Friederike and Baumann, F.. (2015). Exercise-induced natural killer cell activation is driven by epigenetic modifications. International Journal of Sports Medicine. 36(6), pp. 510 - 515. https://doi.org/10.1055/s-0034-1398531
Recommendations for assessment methods for exercise trials with cancer patients
Scharhag-Rosenberger, F., Becker, T., Streckmann, F., Schmidt, K., Berling, A., Bernardi, A., Engeroff, T., Exner, A. K., Gutekunst, K., Hofmeister, D., Jensen, W., Kähnert, H., Kneis, S., Limbach, M., Mau-Möller, A., Röcker, K., Schmidt, M. E., Schmidt, T., Stöckel, T., ... Karen, Steindorf. (2014). Recommendations for assessment methods for exercise trials with cancer patients. Deutsche Zeitschrift fur Sportmedizin. 65(11), pp. 304 - 313. https://doi.org/10.5960/dzsm.2014.148
Physical activity and exercise recommendations for cancer patients during rehabilitation
Zopf, Eva M., Baumann, Freerk T. and Pfeifer, K.. (2014). Physical activity and exercise recommendations for cancer patients during rehabilitation. Rehabilitation (Germany). 53(1), pp. 2 - 7. https://doi.org/10.1055/s-0033-1334916
Feasibility of an isometric maximal voluntary contraction test in hematological cancer patients during thrombocytopenia
Zimmer, Philipp, Baumann, Freerk T., Ebel, Janis, Zopf, Eva Maria, Bloch, Wilhelm and Elter, Thomas. (2013). Feasibility of an isometric maximal voluntary contraction test in hematological cancer patients during thrombocytopenia. Journal of Sports Medicine. 2013(Article ID 470489), pp. 1-6. https://doi.org/10.1155/2013/470489
Clinical exercise interventions in prostate cancer patients-a systematic review of randomized controlled trials
Baumann, Freerk T., Zopf, Eva M. and Bloch, Wilhelm. (2012). Clinical exercise interventions in prostate cancer patients-a systematic review of randomized controlled trials. Supportive Care in Cancer. 20(2), pp. 221 - 233. https://doi.org/10.1007/s00520-011-1271-0
Implementation and scientific evaluation of rehabilitative sports groups for prostate cancer patients: Study protocol of the ProRehab Study
Zopf, Eva M., Braun, Moritz, Machtens, Stefan, Zumbé, Jürgen, Bloch, Wilhelm and Baumann, Freerk T.. (2012). Implementation and scientific evaluation of rehabilitative sports groups for prostate cancer patients: Study protocol of the ProRehab Study. BMC Cancer. 12(312), pp. 1 - 7. https://doi.org/10.1186/1471-2407-12-312
Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: Benefits of a moderate exercise intervention
Baumann, Freerk T., Zopf, Eva M., Nykamp, Eike, Kraut, Ludwig, Schüle, Klaus, Elter, Thomas, Fauser, Axel A. and Bloch, Wilhelm. (2011). Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: Benefits of a moderate exercise intervention. European Journal of Haematology. 87(2), pp. 148 - 156. https://doi.org/10.1111/j.1600-0609.2011.01640.x