The ENIGMA-Epilepsy working group : Mapping disease from large data sets
Journal article
Sisodiya, Sanjay M., Whelan, Christopher D., Hatton, Sean N., Huynh, Khoa, Altmann, Andre, Ryten, Mina, Vezzani, Annamaria, Caligiuri, Maria Eugenia, Labate, Angelo, Gambardella, Antonio, Ives-Deliperi, Victoria, Meletti, Stefano, Munsell, Brent C., Bonilha, Leonardo, Tondelli, Manuela, Rebsamen, Michael, Rummel, Christian, Vaudano, Anna Elisabetta, Wiest, Roland, ... Enigma Consortium Epilepsy Working Group. (2022). The ENIGMA-Epilepsy working group : Mapping disease from large data sets. Human Brain Mapping. 43(1), pp. 113-128. https://doi.org/10.1002/hbm.25037
Authors | Sisodiya, Sanjay M., Whelan, Christopher D., Hatton, Sean N., Huynh, Khoa, Altmann, Andre, Ryten, Mina, Vezzani, Annamaria, Caligiuri, Maria Eugenia, Labate, Angelo, Gambardella, Antonio, Ives-Deliperi, Victoria, Meletti, Stefano, Munsell, Brent C., Bonilha, Leonardo, Tondelli, Manuela, Rebsamen, Michael, Rummel, Christian, Vaudano, Anna Elisabetta, Wiest, Roland, Balachandra, Akshara R., Bargallo, Núria, Bartolini, Emanuele, Bernasconi, Andrea, Bernasconi, Neda, Bernhardt, Boris, Caldairou, Benoit, Carr, Sarah J. A., Cavalleri, Gianpiero L., Cendes, Fernando, Concha, Luis, Desmond, Patricia M., Domin, Martin, Duncan, John S., Focke, Niels K., Guerrini, Renzo, Hamandi, Khalid, Jackson, Graeme D., Jahanshad, Neda, Kälviäinen, Reetta, Keller, Simon S., Kochunov, Peter, Kowalczyk, Magdalena A., Kreilkamp, Barbara A. K., Kwan, Patrick, Lariviere, Sara, Lenge, Matteo, Lopez, Seymour M., Martin, Pascal, Mascalchi, Mario, Moreira, José C. V., Morita-Sherman, Marcia E., Pardoe, Heath R., Pariente, Jose C., Kotikalapudi, Raviteja, Rocha, Cristiane S., Rodríguez-Cruces, Raúl, Seeck, Margitta, Semmelroch, Mira K. H. G., Sinclair, Benjamin, Soltanian-Zadeh, Hamid, Stein, Dan J., Striano, Pasquale, Taylor, Peter N., Thomas, Rhys H., Thomopoulos, Sophia I., Velakoulis, Dennis, Vivash, Lucy, Weber, Bernd, Yasuda, Clarissa Lin, Zhang, Junsong, Thompson, Paul M., McDonald, Carrie R. and Enigma Consortium Epilepsy Working Group |
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Abstract | Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller-scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well-established by the ENIGMA Consortium, ENIGMA-Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event-based modeling analysis. We explore age of onset- and duration-related features, as well as phenomena-specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA-Epilepsy. |
Keywords | covariance; deep learning; DTI; event-based modeling; gene expression; genetics; imaging; MRI; quantitative; rsfMRI |
Year | 2022 |
Journal | Human Brain Mapping |
Journal citation | 43 (1), pp. 113-128 |
Publisher | Wiley-Blackwell |
ISSN | 1097-0193 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/hbm.25037 |
PubMed ID | 32468614 |
PubMed Central ID | PMC8675408 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 113-128 |
Funder | National Health and Medical Research Council (NHMRC) |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 29 May 2020 |
Publication process dates | |
Accepted | 03 May 2020 |
Deposited | 09 Mar 2022 |
Grant ID | NHMRC/1091593 |
NHMRC/1081151 |
https://acuresearchbank.acu.edu.au/item/8x7ww/the-enigma-epilepsy-working-group-mapping-disease-from-large-data-sets
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Publisher's version
OA_Sisodiya_2022_The_ENIGMA-Epilepsy_working_group_mapping.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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