New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology
Journal article
Rosdah, Ayeshah A., Smiles, William J., Oakhill, Jonathan S., Scott, John W., Langendorf, Christopher G., Delbridge, Lea M. D., Holien, Jessica K. and Lim, Shiang Y.. (2020). New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology. Pharmacology and Therapeutics. 213, p. Article 107594. https://doi.org/10.1016/j.pharmthera.2020.107594
Authors | Rosdah, Ayeshah A., Smiles, William J., Oakhill, Jonathan S., Scott, John W., Langendorf, Christopher G., Delbridge, Lea M. D., Holien, Jessica K. and Lim, Shiang Y. |
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Abstract | Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochondrial fusion and fission is required to maintain cellular health under different physiological conditions. Mutation and dysregulation of Drp1, the major driver of mitochondrial fission, has been associated with various neurological, oncological and cardiovascular disorders. Moreover, when subjected to pathological insults, mitochondria often undergo excessive fission, generating fragmented and dysfunctional mitochondria leading to cell death. Therefore, manipulating mitochondrial fission by targeting Drp1 has been an appealing therapeutic approach for cytoprotection. However, studies have been inconsistent. Studies employing Drp1 constructs representing alternate Drp1 isoforms, have demonstrated differing impacts of these isoforms on mitochondrial fission and cell death. Furthermore, there are distinct expression patterns of Drp1 isoforms in different tissues, suggesting idiosyncratic engagement in specific cellular functions. In this review, we will discuss these inherent variations among human Drp1 isoforms and how they could affect Drp1-mediated mitochondrial fission and cell death. |
Keywords | Drp1; isoforms; mitochondrial morphology; mitochondrial function; cell survival |
Year | 2020 |
Journal | Pharmacology and Therapeutics |
Journal citation | 213, p. Article 107594 |
Publisher | Elsevier Inc. |
ISSN | 0163-7258 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.pharmthera.2020.107594 |
Scopus EID | 2-s2.0-85085874585 |
Research or scholarly | Research |
Page range | 1-16 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 29 May 2020 |
Publication process dates | |
Deposited | 14 Mar 2022 |
https://acuresearchbank.acu.edu.au/item/8x8q3/new-perspectives-on-the-role-of-drp1-isoforms-in-regulating-mitochondrial-pathophysiology
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