The acute and non-acute effects of cannabis on reward processing : A systematic review
Journal article
Skumlien, Martine, Langley, Christelle, Lawn, Will, Voon, Valerie, Curran, H. Valerie, Roiser, Jonathan P. and Sahakian, Barbara J.. (2021). The acute and non-acute effects of cannabis on reward processing : A systematic review. Neuroscience and Biobehavioral Reviews. 130, pp. 512-528. https://doi.org/10.1016/j.neubiorev.2021.09.008
Authors | Skumlien, Martine, Langley, Christelle, Lawn, Will, Voon, Valerie, Curran, H. Valerie, Roiser, Jonathan P. and Sahakian, Barbara J. |
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Abstract | Cannabis use has historically been thought to cause amotivation, but the relationship between cannabis and apathy, anhedonia, and reward processing remains poorly characterised. In this systematic review, we evaluated whether cannabis exposure acutely and/or non-acutely was associated with altered reward processing using questionnaire, behavioural, or functional neuroimaging measures. Questionnaire studies demonstrated greater anhedonia in adolescent cannabis users, and some indication of greater apathy in young adult cannabis users. Behavioural studies yielded some evidence of reduced reward learning in adolescent cannabis users, though there were too few studies in this category for reliable conclusions. Finally, longitudinal and acute functional neuroimaging studies showed an association between cannabis and blunted neural responses to reward, which did not emerge consistently in cross-sectional studies. The current results suggest that cannabis use is associated with specific impairments in reward and motivation. Future large-scale, longitudinal studies which use multiple behavioural and neuroimaging measures of reward processing may further clarify the impact of cannabis use on motivational and reward processes, and neural networks. |
Keywords | cannabis use; THC; reward processing; anhedonia; apathy; motivation; MID task |
Year | 2021 |
Journal | Neuroscience and Biobehavioral Reviews |
Journal citation | 130, pp. 512-528 |
Publisher | Elsevier Ltd |
ISSN | 0149-7634 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.neubiorev.2021.09.008 |
Scopus EID | 2-s2.0-85115358648 |
Research or scholarly | Research |
Page range | 512-528 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 09 Sep 2021 |
Publication process dates | |
Accepted | 05 Sep 2021 |
Deposited | 18 Mar 2022 |
https://acuresearchbank.acu.edu.au/item/8x906/the-acute-and-non-acute-effects-of-cannabis-on-reward-processing-a-systematic-review
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