Metabolomics and lipidomics : Expanding the molecular landscape of exercise biology
Journal article
Belhaj, Mehdi R., Lawler, Nathan G. and Hoffman, Nolan J.. (2021). Metabolomics and lipidomics : Expanding the molecular landscape of exercise biology. Metabolites. 11(151), p. Article 151. https://doi.org/10.3390/metabo11030151
Authors | Belhaj, Mehdi R., Lawler, Nathan G. and Hoffman, Nolan J. |
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Abstract | Dynamic changes in circulating and tissue metabolites and lipids occur in response to exercise-induced cellular and whole-body energy demands to maintain metabolic homeostasis. The metabolome and lipidome in a given biological system provides a molecular snapshot of these rapid and complex metabolic perturbations. The application of metabolomics and lipidomics to map the metabolic responses to an acute bout of aerobic/endurance or resistance exercise has dramatically expanded over the past decade thanks to major analytical advancements, with most exercise-related studies to date focused on analyzing human biofluids and tissues. Experimental and analytical considerations, as well as complementary studies using animal model systems, are warranted to help overcome challenges associated with large human interindividual variability and decipher the breadth of molecular mechanisms underlying the metabolic health-promoting effects of exercise. In this review, we provide a guide for exercise researchers regarding analytical techniques and experimental workflows commonly used in metabolomics and lipidomics. Furthermore, we discuss advancements in human and mammalian exercise research utilizing metabolomic and lipidomic approaches in the last decade, as well as highlight key technical considerations and remaining knowledge gaps to continue expanding the molecular landscape of exercise biology. |
Keywords | exercise; metabolism; omics; metabolomics; metabolome; lipidomics; lipidome; mass spectrometry; nuclear magnetic resonance |
Year | 2021 |
Journal | Metabolites |
Journal citation | 11 (151), p. Article 151 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI AG) |
ISSN | 2218-1989 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/metabo11030151 |
PubMed ID | 33799958 |
Scopus EID | 2-s2.0-85103051402 |
PubMed Central ID | PMC8001908 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-34 |
Funder | Australian Catholic University (ACU) |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 07 Mar 2021 |
Publication process dates | |
Accepted | 05 Mar 2021 |
Deposited | 04 Apr 2022 |
https://acuresearchbank.acu.edu.au/item/8xq1w/metabolomics-and-lipidomics-expanding-the-molecular-landscape-of-exercise-biology
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Publisher's version
OA_Belhaj_2021_Metabolomics_and_lipidomics_expanding_the_molecular.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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