The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling : A narrative review
Journal article
Holwerda, Andrew M. and van Loon, Luc J. C.. (2022). The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling : A narrative review. Nutrition Reviews. 80(6), pp. 1497-1514. https://doi.org/10.1093/nutrit/nuab083
Authors | Holwerda, Andrew M. and van Loon, Luc J. C. |
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Abstract | Collagen is the central structural component of extracellular connective tissue, which provides elastic qualities to tissues. For skeletal muscle, extracellular connective tissue transmits contractile force to the tendons and bones. Connective tissue proteins are in a constant state of remodeling and have been shown to express a high level of plasticity. Dietary-protein ingestion increases muscle protein synthesis rates. High-quality, rapidly digestible proteins are generally considered the preferred protein source to maximally stimulate myofibrillar (contractile) protein synthesis rates. In contrast, recent evidence demonstrates that protein ingestion does not increase muscle connective tissue protein synthesis. The absence of an increase in muscle connective tissue protein synthesis after protein ingestion may be explained by insufficient provision of glycine and/or proline. Dietary collagen contains large amounts of glycine and proline and, therefore, has been proposed to provide the precursors required to facilitate connective tissue protein synthesis. This literature review provides a comprehensive evaluation of the current knowledge on the proposed benefits of dietary collagen consumption to stimulate connective tissue remodeling to improve health and functional performance. |
Keywords | collagen; hydrolysate; muscle; peptides; protein |
Year | 2022 |
Journal | Nutrition Reviews |
Journal citation | 80 (6), pp. 1497-1514 |
Publisher | Oxford University Press |
ISSN | 0029-6643 |
Digital Object Identifier (DOI) | https://doi.org/10.1093/nutrit/nuab083 |
PubMed ID | 34605901 |
Scopus EID | 2-s2.0-85128755705 |
PubMed Central ID | PMC9086765 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1497-1514 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 04 Oct 2021 |
Publication process dates | |
Deposited | 08 Apr 2022 |
https://acuresearchbank.acu.edu.au/item/8xqy6/the-impact-of-collagen-protein-ingestion-on-musculoskeletal-connective-tissue-remodeling-a-narrative-review
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Publisher's version
OA_Holwerda_2022_The_impact_of_collagen_protein_ingestion.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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