Modeling and remodeling : The cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy
Book chapter
Seeman, Ego. (2019). Modeling and remodeling : The cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy. In In Bilezikian, John P., Martin, T. John, Clemens, Thomas L. and Rosen, Clifford J. (Ed.). Principles of bone biology ; volume 1 pp. 245-274 Academic Press. https://doi.org/10.1016/B978-0-12-814841-9.00011-7
Authors | Seeman, Ego |
---|---|
Editors | Bilezikian, John P., Martin, T. John, Clemens, Thomas L. and Rosen, Clifford J. |
Abstract | Bone modeling and remodeling assemble bone's structure during growth. Abnormalities in this cellular machinery appear around midlife and cause microstructural deterioration and bone fragility. For over 60 years, the gain and loss of bone strength have been inferred by measuring bone mineral density (BMD). This is an insensitive surrogate of bone fragility caused by microstructural deterioration, because microstructural deterioration compromises strength disproportionate to the bone loss producing it and the modest deficits in BMD found in most patients with fragility fractures. Quantification of microstructure is now available, but whether these measurements improve the detection of individuals at risk for fracture and improve treatment efficacy is unknown. Antiresorptive agents slow remodeling and microstructural deterioration. Anabolic agents may reconstruct bone, but available therapy produces mainly remodeling-based bone formation, which is limited for a range of reasons. Whether modeling-based bone formation or combined therapy offers better anti-fracture efficacy is unknown. |
Keywords | aging; anabolics; antiresorptives; bone; fragility; growth; modeling; remodeling; strength |
Page range | 245-274 |
Year | 2019 |
Book title | Principles of bone biology ; volume 1 |
Publisher | Academic Press |
Place of publication | London, United Kingdom |
San Diego, CA | |
Cambridge, MA | |
Oxford, United Kingdom | |
ISBN | 9780128148419 |
9780128199329 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/B978-0-12-814841-9.00011-7 |
Scopus EID | 2-s2.0-85083233435 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 23 Aug 2019 |
Publication process dates | |
Deposited | 21 Jun 2022 |
https://acuresearchbank.acu.edu.au/item/8xz02/modeling-and-remodeling-the-cellular-machinery-responsible-for-bone-s-material-and-structural-strength-during-growth-aging-and-drug-therapy
Restricted files
Publisher's version
60
total views0
total downloads0
views this month0
downloads this month