Test-retest reliability of homeostatic plasticity in the human primary motor cortex
Journal article
Thapa, Tribikram and Schabrun, Siobhan M.. (2018). Test-retest reliability of homeostatic plasticity in the human primary motor cortex. Neural Plasticity. 2018, p. Article 6207508. https://doi.org/10.1155/2018/6207508
Authors | Thapa, Tribikram and Schabrun, Siobhan M. |
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Abstract | Homeostatic plasticity regulates synaptic activity by preventing uncontrolled increases (long-term potentiation) or decreases (long-term depression) in synaptic efficacy. Homeostatic plasticity can be induced and assessed in the human primary motor cortex (M1) using noninvasive brain stimulation. However, the reliability of this methodology has not been investigated. Here, we examined the test-retest reliability of homeostatic plasticity induced and assessed in M1 using noninvasive brain stimulation in ten, right-handed, healthy volunteers on days 0, 2, 7, and 14. Homeostatic plasticity was induced in the left M1 using two blocks of anodal transcranial direct current stimulation (tDCS) applied for 7 min and 5 min, separated by a 3 min interval. To assess homeostatic plasticity, 15 motor-evoked potentials to single-pulse transcranial magnetic stimulation were recorded at baseline, between the two blocks of anodal tDCS, and at 0 min, 10 min, and 20 min follow-up. Test-retest reliability was evaluated using intraclass correlation coefficients (ICCs). Moderate-to-good test-retest reliability was observed for the M1 homeostatic plasticity response at all follow-up time points (0 min, 10 min, and 20 min, ICC range: 0.43–0.67) at intervals up to 2 weeks. The greatest reliability was observed when the homeostatic response was assessed at 10 min follow-up (). These data suggest that M1 homeostatic plasticity can be reliably induced and assessed in healthy individuals using two blocks of anodal tDCS at intervals of 48 hours, 7 days, and 2 weeks. |
Year | 2018 |
Journal | Neural Plasticity |
Journal citation | 2018, p. Article 6207508 |
Publisher | Hindawi Limited |
ISSN | 2090-5904 |
Digital Object Identifier (DOI) | https://doi.org/10.1155/2018/6207508 |
PubMed ID | 29983706 |
Scopus EID | 2-s2.0-85054998687 |
PubMed Central ID | PMC6015686 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-9 |
Funder | National Health and Medical Research Council (NHMRC) |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 10 Jun 2018 |
Publication process dates | |
Accepted | 26 Apr 2018 |
Deposited | 19 Aug 2022 |
Grant ID | 1105040 |
https://acuresearchbank.acu.edu.au/item/8y228/test-retest-reliability-of-homeostatic-plasticity-in-the-human-primary-motor-cortex
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Publisher's version
OA_Thapa_2018_Test_retest_reliability_of_homeostatic_plasticity.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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