Effect of home-based strength training program on IGF-I, IGFBP-1 and IGFBP-3 in obese Latino boys participating in a 16-week randomized controlled trial

Journal article

Kelly, Louise, Holmberg, Patrick M., Schroeder, E. Todd, Loza, Armando, Lin, Xiao, Moody, Alastai, Hughes, Adrienne, Gibson, Ann-Marie and Kirk, Alison. (2019). Effect of home-based strength training program on IGF-I, IGFBP-1 and IGFBP-3 in obese Latino boys participating in a 16-week randomized controlled trial. Journal of Pediatric Endocrinology and Metabolism. 32(10), pp. 1121-1129. https://doi.org/10.1515/jpem-2019-0073
AuthorsKelly, Louise, Holmberg, Patrick M., Schroeder, E. Todd, Loza, Armando, Lin, Xiao, Moody, Alastai, Hughes, Adrienne, Gibson, Ann-Marie and Kirk, Alison
Abstract

Introduction
Growing evidence indicates that circulating concentrations of insulin-like growth factor 1 (IGF-I), along with IGF-I relative to IGF-binding proteins (IGFBP), are associated with an increased risk of cancer. In accord, regular exercise is linked with a lower risk of cancer.

Purpose
To assess the effects of a 16-week home-based strength training (HBST) program on serum IGF-I, IGFBP-1 and IGFBP-3.

Methods
A total of 32 obese Latino adolescent males (aged 14–18 years) were randomized into a twice-weekly HBST (n = 16) or a control group (C, n = 16) for 16 weeks. The following were measured at pre- and post-intervention: IGF-I, IGFBP-1 and IGFBP-3, glucose/insulin indices by oral and/or intravenous (IV) glucose tolerance tests, strength by one-repetition maximum (1RM), dietary intake by 3-d records, body composition by DEXA and physical activity using the Actigraph GT1X. The generalized linear model (GLM) was used to assess differences in changes among outcome measures between the HBST and C groups.

Results
Exercise adherence in the HBST group was 89%. IGF-1 showed a trend for significant within-subject improvements (p = 0.078) but no significant within-subject or between-subject differences for IGFBP-1, IGFBP-3 two-glucose, fasting glucose or 2-h glucose (p > 0.05). There was a significant decrease (p > 0.05) in fasting glucose in the C group (p = 0.02) and also in the intervention group (p = 0.03) between baseline and follow-up testing. A significant difference was also found in the C group for 2-h glucose with an increase at follow-up testing (p = 0.04).

Conclusions
Though not statistically significant (p < 0.05), the results indicated that a 16-week HBST program decreased IGF-I and increased IGFBP-1, along with IGFBP-3, concentrations among overweight/obese Latino boys. However, further studies should consider increasing either the dose or the duration of the intervention to elicit greater improvements in this at-risk pediatric population.

Keywordsexercise; IGF-1; IGFBP-1; IGFBP-3; Latino; obese; pediatric; strength training
Year2019
JournalJournal of Pediatric Endocrinology and Metabolism
Journal citation32 (10), pp. 1121-1129
PublisherDe Gruyter
ISSN0334-018X
Digital Object Identifier (DOI)https://doi.org/10.1515/jpem-2019-0073
Scopus EID2-s2.0-85072665203
Research or scholarlyResearch
Page range1121-1129
FunderNational Cancer Institute (NCI), National Institutes of Health
University of Southern California
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online20 Sep 2019
Publication process dates
Deposited22 Aug 2022
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