Cerebral peak alpha frequency reflects average pain severity in a human model of sustained, musculoskeletal pain

Journal article


Furman, Andrew J., Thapa Rana, Tribikram, Summers, Simon J., Cavaleri, Rocco, Fogarty, Jack S., Steiner, Genevieve Z., Schabrun, Siobhan M. and Seminowicz, David A.. (2019). Cerebral peak alpha frequency reflects average pain severity in a human model of sustained, musculoskeletal pain. Journal of Neurophysiology. 122(4), pp. 1784-1793. https://doi.org/10.1152/jn.00279.2019
AuthorsFurman, Andrew J., Thapa Rana, Tribikram, Summers, Simon J., Cavaleri, Rocco, Fogarty, Jack S., Steiner, Genevieve Z., Schabrun, Siobhan M. and Seminowicz, David A.
Abstract

Heightened pain sensitivity, the amount of pain experienced in response to a noxious event, is a known risk factor for development of chronic pain. We have previously reported that pain-free, sensorimotor peak alpha frequency (PAF) is a reliable biomarker of pain sensitivity for thermal, prolonged pains lasting tens of minutes. To test whether PAF can provide information about pain sensitivity occurring over clinically relevant timescales (i.e., weeks), EEG was recorded before and while participants experienced a long-lasting pain model, repeated intramuscular injection of nerve growth factor (NGF), that produces progressively developing muscle pain for up to 21 days. We demonstrate that pain-free, sensorimotor PAF is negatively correlated with NGF pain sensitivity; increasingly slower PAF is associated with increasingly greater pain sensitivity. Furthermore, PAF remained stable following NGF injection, indicating that the presence of NGF pain for multiple weeks is not sufficient to induce the PAF slowing reported in chronic pain. In total, our results demonstrate that slower pain-free, sensorimotor PAF is associated with heightened sensitivity to a long-lasting musculoskeletal pain and also suggest that the apparent slowing of PAF in chronic pain may reflect predisease pain sensitivity.

Keywordsbiomarker; EEG; nerve growth factor; pain sensitivity
Year2019
JournalJournal of Neurophysiology
Journal citation122 (4), pp. 1784-1793
PublisherAmerican Physiological Society
ISSN0022-3077
Digital Object Identifier (DOI)https://doi.org/10.1152/jn.00279.2019
Scopus EID2-s2.0-85073305358
Research or scholarlyResearch
Page range1784-1793
FunderNational Health and Medical Research Council
Australian Research Council
National Center for Complementary and Integrative Health
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online16 Oct 2019
Publication process dates
Accepted07 Aug 2019
Deposited23 Aug 2022
ARC Funded ResearchThis output has been funded, wholly or partially, under the Australian Research Council Act 2001
Grant ID1105040
1102532
R01AT007176
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