Exercise-based interventions to counteract skeletal muscle mass loss in people with cancer : Can we overcome the odds?

Journal article

Bland, Kelcey A., Kouw, Imre W. K., van Loon, Luc J. C., Zopf, Eva M. and Fairman, Ciaran M.. (2022). Exercise-based interventions to counteract skeletal muscle mass loss in people with cancer : Can we overcome the odds? Sports Medicine. 52(5), pp. 1009-1027. https://doi.org/10.1007/s40279-021-01638-z

Publication dates
Authors	Bland, Kelcey A., Kouw, Imre W. K., van Loon, Luc J. C., Zopf, Eva M. and Fairman, Ciaran M.
Abstract	Addressing skeletal muscle mass loss is an important focus in oncology research to improve clinical outcomes, including cancer treatment tolerability and survival. Exercise is likely a necessary component of muscle-mass-preserving interventions for people with cancer. However, randomized controlled trials with exercise that include people with cancer with increased susceptibility to more rapid and severe muscle mass loss are limited. The aim of the current review is to highlight features of cancer-related skeletal muscle mass loss, discuss the impact in patients most at risk, and describe the possible role of exercise as a management strategy. We present current gaps within the exercise oncology literature and offer several recommendations for future studies to support research translation, including (1) utilizing accurate and reliable body composition techniques to assess changes in skeletal muscle mass, (2) incorporating comprehensive assessments of patient health status to allow personalized exercise prescription, (3) coupling exercise with robust nutritional recommendations to maximize the impact on skeletal muscle outcomes, and (4) considering key exercise intervention features that may improve exercise efficacy and adherence. Ultimately, the driving forces behind skeletal muscle mass loss are complex and may impede exercise tolerability and efficacy. Our recommendations are intended to foster the design of high-quality patient-centred research studies to determine whether exercise can counteract muscle mass loss in people with cancer and, as such, improve knowledge on this topic.
Year	2022
Journal	Sports Medicine
Journal citation	52 (5), pp. 1009-1027
Publisher	Adis International Ltd.
ISSN	0112-1642
Digital Object Identifier (DOI)	https://doi.org/10.1007/s40279-021-01638-z
Scopus EID	2-s2.0-85124244663
Page range	1009-1027
Publisher's version	License All rights reserved File Access Level Controlled
Output status	Published
Online	04 Feb 2022
Publication process dates
Accepted	27 Dec 2021
Deposited	12 Oct 2022

Permalink -

https://acuresearchbank.acu.edu.au/item/8y53z/exercise-based-interventions-to-counteract-skeletal-muscle-mass-loss-in-people-with-cancer-can-we-overcome-the-odds

Restricted files

Publisher's version

(1 files)

74
total views
0
total downloads
2
views this month
0
downloads this month

These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

“It gave me a sense of achievement and a sense of purpose” - a qualitative study of patient experiences of a virtually supervised exercise program for adults with advanced cancer and cachexia

Bland, K., France-Ratcliffe, Madeleine, Krishnasamy, Meinir, Nandi, Amruta, Parr, E., Martin, Peter, Cormie, P., Van Loon, Luc J. C. and Zopf, E.. (2024). “It gave me a sense of achievement and a sense of purpose” - a qualitative study of patient experiences of a virtually supervised exercise program for adults with advanced cancer and cachexia. Supportive Care in Cancer. 32(5), pp. 1-11. https://doi.org/10.1007/s00520-024-08526-y

Effects of qigong exercise on physical fitness and patient-reported health outcomes in lung cancer survivors

Xing, Ruirui, Wang, Renwei, Zopf, Eva Maria, Rachele, Jerome, Wang, Zhen, Li, Yuchao and Zhu, Weimo. (2024). Effects of qigong exercise on physical fitness and patient-reported health outcomes in lung cancer survivors. Supportive Care in Cancer. 32(2), pp. 1-11. https://doi.org/10.1007/s00520-023-08296-z

Early detection of brain metastases in a supervised exercise program for patients with advanced breast cancer : A case report

Pelaez, Mireia, Stuiver, Martijn M., Broekman, Marike, Schmitz, Kathryn H., Zopf, Eva M., Clauss, Dorothea, Wengström, Yvonne, Rosenberger, Friederike, Steindorf, Karen, Urruticoechea, Ander and May, Anne M.. (2023). Early detection of brain metastases in a supervised exercise program for patients with advanced breast cancer : A case report. Medicine and Science in Sports and Exercise. 55(10), pp. 1745-1749. https://doi.org/10.1249/MSS.0000000000003213

Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial

Parr, Evelyn B., Kouw, Imre W. K., Wheeler, Michael J., Radford, Bridget E., Hall, Rebecca C., Senden, Joan M., Goessens, Joy P. B., Van Loon, Luc J. C. and Hawley, John A.. (2023). Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial. Obesity. 31(S1), pp. 116-126. https://doi.org/10.1002/oby.23637

Intradialytic protein ingestion and exercise do not compromise uremic toxin removal throughout hemodialysis

Hendriks, Floris K., Kuijpers, Jeffrey H. W., van Kranenburg, Janneau M. X., Senden, Joan M. G., van der Sande, Frank M., Kooman, Jeroen P., Meex, Steven J. R. and van Loon, Luc J. C.. (2023). Intradialytic protein ingestion and exercise do not compromise uremic toxin removal throughout hemodialysis. Journal of Renal Nutrition. 33(2), pp. 376-385. https://doi.org/10.1053/j.jrn.2022.07.006

Restricting sugar or carbohydrate intake does not impact physical activity level or energy intake over 24 h despite changes in substrate use : A randomised crossover study in healthy men and women

Hengist, Aaron, Davies, Russell G., Rogers, Peter J., Brunstrom, Jeff M., van Loon, Luc J. C., Walhin, Jean-Philippe, Thompson, Dylan, Koumanov, Françoise, Betts, James A. and Gonzales, Javier T.. (2023). Restricting sugar or carbohydrate intake does not impact physical activity level or energy intake over 24 h despite changes in substrate use : A randomised crossover study in healthy men and women. European Journal of Nutrition. 62(2), pp. 921-940. https://doi.org/10.1007/s00394-022-03048-x

Implementation of physical activity interventions in a community-based youth mental healthcare service : A case study of context, strategies, and outcomes

Czosnek, Louise, Rosenbaum, Simon, Rankin, Nicole M., Zopf, Eva M., Cormie, Prue, Herbert, Brittany and Richards, Justin. (2023). Implementation of physical activity interventions in a community-based youth mental healthcare service : A case study of context, strategies, and outcomes. Early Intervention in Psychiatry. 17(2), pp. 212-222. https://doi.org/10.1111/eip.13324

Design of a multinational randomized controlled trial to assess the effects of structured and individualized exercise in patients with metastatic breast cancer on fatigue and quality of life : the EFFECT study

Hiensch, Anouk, Monninkhof, Evelyn, Schmidt, Martina, Zopf, Eva Maria, Bolam, Kate, Aaronson, Neil, Belloso, Jon, Bloch, Wilhelm, Clauss, Dorothea, Depenbusch, Johanna, Lachowicz, Milena, Pelaez, Mireia, Rundqvist, Helene, Senkus, Elzbieta, Stuiver, Martijn, Trevaskis, Mark, Urruticoechea, Ander, Rosenberger, Friederike, van der Wall, Elsken, ... May, Anne. (2022). Design of a multinational randomized controlled trial to assess the effects of structured and individualized exercise in patients with metastatic breast cancer on fatigue and quality of life : the EFFECT study. Trials. 23(1), pp. 1-14. https://doi.org/10.1186/s13063-022-06556-7

Perspective : Vegan Diets for Older Adults? A Perspective On the Potential Impact On Muscle Mass and Strength

Domic, Jacinta, Grootswagers, Pol, Van Loon, Lucas and de Groot, Lisette. (2022). Perspective : Vegan Diets for Older Adults? A Perspective On the Potential Impact On Muscle Mass and Strength. Advances in Nutrition. 13(3), pp. 712-725. https://doi.org/10.1093/advances/nmac009

Cheese ingestion increases muscle protein synthesis rates both at rest and during recovery from exercise in healthy, young males : A randomized parallel-group trial

Hermans, Wesley J. H., Fuchs, Cas J., Hendriks, Floris K., Houben, Lisanne H. P., Senden, Joan M., Verdijk, Lex B. and Van Loon, Luc. (2022). Cheese ingestion increases muscle protein synthesis rates both at rest and during recovery from exercise in healthy, young males : A randomized parallel-group trial. The Journal of Nutrition. 152(4), pp. 1022-1030. https://doi.org/10.1093/jn/nxac007

Developing an implementation research logic model : Using a multiple case study design to establish a worked exemplar

Czosnek, Louise, Zopf, Eva M., Cormie, Prue, Rosenbaum, Simon, Richards, Justin and Rankin, Nicole M.. (2022). Developing an implementation research logic model : Using a multiple case study design to establish a worked exemplar. Implementation Science Communications. 3, p. Article 90. https://doi.org/10.1186/s43058-022-00337-8

Muscle protein synthesis after protein administration in critical illness

Chapple, Lee-anne S., Kouw, Imre W. K., Summers, Matthew J., Weinel, Luke M., Gluck, Samuel, Raith, Eamon, Slobodian, Peter, Soenen, Stijn, Deane, Adam M., Van Loon, Luc J. C. and Chapman, Marianne J.. (2022). Muscle protein synthesis after protein administration in critical illness. American Journal of Respiratory and Critical Care Medicine. 206(6), pp. 740-749. https://doi.org/10.1164/rccm.202112-2780OC

Resistance exercise training increases muscle mass and strength in prostate cancer patients on androgen deprivation therapy

Houben, Lisanne H. P., Overkamp, Maarten, van Kraaij, Puck, Trommelen, Jorn, van Roermund, Joep G. H., de Vries, Peter, de Laet, Kevin, van der Meer, Saskia, Mikkelsen, Ulla R., Verdijk, Lex B., van Loon, Luc J. C., Beijer, Sandra and Beelen, Milou. (2022). Resistance exercise training increases muscle mass and strength in prostate cancer patients on androgen deprivation therapy. Medicine and Science in Sports and Exercise. 55(4), pp. 614-624. https://doi.org/10.1249/MSS.0000000000003095

"I want to get myself as fit as I can and not die just yet" - Perceptions of exercise in people with advanced cancer and cachexia : A qualitative study

Bland, Kelcey A., Krishnasamy, Meinir, Parr, Evelyn B., Mulder, Stella, Martin, Peter, van Loon, Luc, Cormie, Prue, Michael, Natasha and Zopf, Eva M.. (2022). "I want to get myself as fit as I can and not die just yet" - Perceptions of exercise in people with advanced cancer and cachexia : A qualitative study. BMC Palliative Care. 21(1), p. Article 75. https://doi.org/10.1186/s12904-022-00948-x

Myofibrillar protein synthesis rate are increased in chronically exercised skeletal muscle despite decreased anabolic signaling

Langer, Henning T., West, Daniel, Senden, Joan, Spuler, Simone, van Loon, Luc J. C. and Baar, Keith. (2022). Myofibrillar protein synthesis rate are increased in chronically exercised skeletal muscle despite decreased anabolic signaling. Scientific Reports. 12(1), p. Article 7553. https://doi.org/10.1038/s41598-022-11621-x

The muscle protein synthetic response to the ingestion of a plant-derived protein blend does not differ from an equivalent amount of milk protein in healthy, young males

Pinckaers, Philippe J. M., Kouw, Imre W. K., Gorissen, Stefan H. M., Houben, Lisanne H. P., Senden, Joan M., Wodzig, Will K. H. W., de Groot, Lisette C. P. G. M., Verdijk, Lex B., Snijders, Tim and van Loon, Luc J. C.. (2022). The muscle protein synthetic response to the ingestion of a plant-derived protein blend does not differ from an equivalent amount of milk protein in healthy, young males. The Journal of Nutrition. 152(12), pp. 2734-2743. https://doi.org/10.1093/jn/nxac222

Relative validity and reliability of isometric lower extremity strength assessment in older adults by using a handheld dynamometer

Grootswagers, Pol, Vaes, Anouk M. M., Hangelbroek, Roland, Tieland, Michael, Van Loon, Lucas J. C. and de Groot, Lisette C. P. G. M.. (2022). Relative validity and reliability of isometric lower extremity strength assessment in older adults by using a handheld dynamometer. Sports Health. 14(6), pp. 899-905. https://doi.org/10.1177/19417381211063847

Ingestion of free amino acids compared with an equivalent amount of intact protein results in more rapid amino acid absorption and greater postprandial plasma amino acid availability without affecting muscle protein synthesis rates in young adults in a double-blind randomized trial

Weijzen, Michelle E. G., van Gassel, Rob J. J., Kouw, Imre W. K., Trommelen, Jorn, Gorissen, Stefan H. M., van Kranenburg, Janneau, Goessens, Joy P. B., van de Poll, Marcel C. G., Verdijk, Lex B. and van Loon, Luc J. C.. (2022). Ingestion of free amino acids compared with an equivalent amount of intact protein results in more rapid amino acid absorption and greater postprandial plasma amino acid availability without affecting muscle protein synthesis rates in young adults in a double-blind randomized trial. The Journal of Nutrition. 152(1), pp. 59-67. https://doi.org/10.1093/jn/nxab305

Effect and feasibility of wearable physical activity trackers and pedometers for increasing physical activity and improving health outcomes in cancer survivors : A systematic review and meta-analysis

Singh, Benjamin, Zopf, Eva M. and Howden, Erin J.. (2022). Effect and feasibility of wearable physical activity trackers and pedometers for increasing physical activity and improving health outcomes in cancer survivors : A systematic review and meta-analysis. Journal of Sport and Health Science. 11(2), pp. 184-193. https://doi.org/10.1016/j.jshs.2021.07.008

Potato protein ingestion increases muscle protein synthesis rates at rest and during recovery from exercise in humans

Pinckaers, Philippe J. M., Hendriks, Floris K., Hermans, Wesley J. H., Goessens, Joy J. B., Senden, Joan M., Van Kranenburg, Janneau M. X., Wodzig, Will K. H. W., Snijders, Tim and van Loon, Luc J. C.. (2022). Potato protein ingestion increases muscle protein synthesis rates at rest and during recovery from exercise in humans. Medicine and Science in Sports and Exercise. 54(9), pp. 1572-1581. https://doi.org/10.1249/MSS.0000000000002937

Twist2-expressing cells reside in human skeletal muscle and are responsive to aging and resistance exercise training

Gaulton, Nick, Wakelin, Griffen, Young, Laura V., Wotherspoon, Scott, Kamal, Michael, Parise, Gianni, Nederveen, Joshua P., Holwerda, Andy, Verdijk, Lex B., van Loon, Luc J. C., Snijders, Tim and Johnston, Adam P.. (2022). Twist2-expressing cells reside in human skeletal muscle and are responsive to aging and resistance exercise training. The FASEB Journal. 36(12), p. Article e22642. https://doi.org/10.1096/fj.202201349RR

Skeletal Muscle Fibre Characteristics of the Lumbar Multifidus Muscle in Patients Undergoing Microdiscectomy for Unilateral Lumbar Disc Herniation

Stevens, S, Agten, A, Snijders, T, Plazier, M, Bamps, S, Assieker, T, Betz, M, Timmermans, A, Van Loon, Lucas and Vandenabeele, F. (2022). Skeletal Muscle Fibre Characteristics of the Lumbar Multifidus Muscle in Patients Undergoing Microdiscectomy for Unilateral Lumbar Disc Herniation. Muscle, Ligaments and Tendons Journal (MLTJ). 12(3), pp. 432-443. https://doi.org/10.32098/mltj.03.2022.19

Dietary nitrate increases submaximal SERCA activity and ADP-transfer to mitochondria in slow-twitch muscle of female mice

Petrick, Heather, Brownell, Stuart, Vachon, Bayley, Brunetta, Henver, Handy, Rachel, Van Loon, Lucas, Murrant, Coral and Holloway, Graham. (2022). Dietary nitrate increases submaximal SERCA activity and ADP-transfer to mitochondria in slow-twitch muscle of female mice. American Journal of Physiology: Endocrinology and Metabolism. 323(2), pp. 1-14. https://doi.org/10.1152/ajpendo.00371.2021

Raw eggs to support post-exercise recovery in healthy young men : Did Rocky get it right or wrong?

Fuchs, Cas J., Hermans, Wesley J. H., Smeets, Joey S. J., Senden, Joan M., van Kranenburg, Janneau, Gorissen, Stefan H. M., Burd, Nicholas A., Verdijk, Lex B. and van Loon, Luc J. C.. (2022). Raw eggs to support post-exercise recovery in healthy young men : Did Rocky get it right or wrong? The Journal of Nutrition. 152, pp. 2376-2386. https://doi.org/10.1093/jn/nxac174

Skeletal muscles of patients infected with SARS-CoV-2 develop severe myofiber damage upon one week of admission on the intensive care unit

Stevens, Sjoerd, Hendrickx, Paul, Snijders, Tim, Lambrichts, Ivo, Stessel, Björn, Dubois, Jasperina, van Loon, Lucas J. C., Vandenabeele, Frank and Agten, Anouk. (2022). Skeletal muscles of patients infected with SARS-CoV-2 develop severe myofiber damage upon one week of admission on the intensive care unit. Applied Sciences. 12(14), p. Article 7310. https://doi.org/10.3390/app12147310

Ingestion of an ample amount of meat substitute based on a lysine-enriched,plant-based protein blend stimulates postprandial muscle proteinsynthesis to a similar extent as an isonitrogenous amount of chickenin healthy, young men

Kouw, Imre W. K., Pinckaers, Philippe J. M., Le Bourgot, Cindy, van Kranenburg, Janneau M. X., Zorenc, Antoine H., de Groot, Lisette C. P. G. M., Verdijk, Lex, Snijders, Tim and van Loon, Luc J. C.. (2022). Ingestion of an ample amount of meat substitute based on a lysine-enriched,plant-based protein blend stimulates postprandial muscle proteinsynthesis to a similar extent as an isonitrogenous amount of chickenin healthy, young men. British Journal of Nutrition. 128, pp. 1955-1965. https://doi.org/10.1017/S0007114521004906

Effects of supervised aerobic exercise on cardiorespiratory fitness and patient-reported health outcomes in colorectal cancer patients undergoing adjuvant chemotherapy — A pilot study

Zopf, Eva M., Schulz, Holger, Poeschko, Jonas, Aschenbroich, Kerstin, Wilhelm, Thomas, Eypasch, Ernst, Kleimann, Elmar, Severin, Kai, Benz, Jutta, Liu, Enwu, Bloch, Wilhelm and Baumann, Freerk T.. (2022). Effects of supervised aerobic exercise on cardiorespiratory fitness and patient-reported health outcomes in colorectal cancer patients undergoing adjuvant chemotherapy — A pilot study. Supportive Care in Cancer. 30(3), pp. 1945-1955. https://doi.org/10.1007/s00520-021-06608-9

Nutritional strategies to attenuate postprandial glycemic response

Pasmans, Kenneth, Meex, Ruth C. R., van Loon, Luc J. C. and Blaak, Ellen E.. (2022). Nutritional strategies to attenuate postprandial glycemic response. Obesity Reviews. 23(9), p. e13486. https://doi.org/10.1111/obr.13486

The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling : A narrative review

Holwerda, Andrew M. and van Loon, Luc J. C.. (2022). The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling : A narrative review. Nutrition Reviews. 80(6), pp. 1497-1514. https://doi.org/10.1093/nutrit/nuab083

Impact of magnesium on bone health in older adults : A systematic review and meta-analysis

Groenendijk, Inge, van Delft, Marieke, Versloot, Pieter, van Loon, Luc J. C. and de Groot, Lisette C. P. G. M.. (2022). Impact of magnesium on bone health in older adults : A systematic review and meta-analysis. Bone. 154, p. Article 116233. https://doi.org/10.1016/j.bone.2021.116233

Supervised pelvic floor muscle exercise is more effective than unsupervised pelvic floor muscle exercise at improving urinary incontinence in prostate cancer patients following radical prostatectomy – a systematic review and meta-analysis

Baumann, Freerk T., Reimer, Nadine, Gockeln, Theresa, Reike, Alexandra, Hallek, Michael, Ricci, Christian, Zopf, Eva M., Schmid, Daniela, Taaffe, Dennis, Newton, Robert U., Galvao, Daniel A. and Leitzmann, Michael. (2022). Supervised pelvic floor muscle exercise is more effective than unsupervised pelvic floor muscle exercise at improving urinary incontinence in prostate cancer patients following radical prostatectomy – a systematic review and meta-analysis. Disability and Rehabilitation. 44(9), p. 5374–5385. https://doi.org/10.1080/09638288.2021.1937717

L-arabinose co-ingestion delays glucose absorption derived from sucrose in healthy men and women : A double-blind, randomized crossover trial

Pasmans, Kenneth, Meex, Ruth C. R., Trommelen, Jorn, Senden, Joan M. G., Vaughan, Elaine E., van Loon, Luc J. C. and Blaak, Ellen E.. (2021). L-arabinose co-ingestion delays glucose absorption derived from sucrose in healthy men and women : A double-blind, randomized crossover trial. British Journal of Nutrition. 128(6), pp. 1072-1081. https://doi.org/10.1017/S0007114521004153

Amino acid removal during hemodialysis can be compensated for by protein ingestion and is not compromised by intradialytic exercise : A randomized controlled crossover trial

Hendriks, Floris K., Smeets, Joey S. J., van Kranenburg, Janneau M. X., Broers, Natascha J. H., van der Sande, Frank M., Verdijk, Lex B., Kooman, Jeroen P. and van Loon, Luc J. C.. (2021). Amino acid removal during hemodialysis can be compensated for by protein ingestion and is not compromised by intradialytic exercise : A randomized controlled crossover trial. American Journal of Clinical Nutrition. 114(6), pp. 2074-2083. https://doi.org/10.1093/ajcn/nqab274

Fragile bones of elite cyclists : To treat or not to treat?

Hilkens, Luuk, Knuiman, Pim, Heijboer, Mathieu, Kempers, Robert, Jeukendrup, Asker E., van Loon, Luc J. C. and van Dijk, Jan-Willem. (2021). Fragile bones of elite cyclists : To treat or not to treat? Journal of Applied Physiology. 131, pp. 26-28. https://doi.org/10.1152/japplphysiol.01034.2020

Gut amino acid absorption in humans : Concepts and relevance for postprandial metabolism

Trommelen, Jorn, Tomé, Daniel and van Loon, Luc J. C.. (2021). Gut amino acid absorption in humans : Concepts and relevance for postprandial metabolism. Clinical Nutrition Open Science. 36, pp. 43-55. https://doi.org/10.1016/j.nutos.2020.12.006

Comprehensive assessment of post-prandial protein handling by the application of intrinsically labelled protein in vivo in human subjects

Trommelen, Jorn, Holwerda, Andrew M., Pinckaers, Philippe J. M. and van Loon, Lucas J. C.. (2021). Comprehensive assessment of post-prandial protein handling by the application of intrinsically labelled protein in vivo in human subjects. Proceedings of the Nutrition Society. 80(2), pp. 221-229. https://doi.org/10.1017/S0029665120008034

Dietary protein interventions to improve nutritional status in end-stage renal disease patients undergoing hemodialysis

Hendriks, Floris K., Kooman, Jeroen P. and van Loon, Luc J. C.. (2021). Dietary protein interventions to improve nutritional status in end-stage renal disease patients undergoing hemodialysis. Current Opinion in Clinical Nutrition and Metabolic Care. 24(1), pp. 79-87. https://doi.org/10.1097/MCO.0000000000000703

A white paper on collagen hydrolyzates and ultrahydrolyzates : Potential supplements to support joint health in osteoarthritis?

Mobasheri, Ali, Mahmoudian, Armaghan, Kalvaityte, Ursule, Uzieliene, Ilona, Larder, Christina E., Iskandar, Michèle M., Kubow, Stan, Hamdan, Paulo Cesar, de Almeida Jr, Cyro Scala, Favazzo, Lacey J., van Loon, Luc J. C., Emans, Pieter J., Plapler, Pérola G. and Zuscik, Michael J.. (2021). A white paper on collagen hydrolyzates and ultrahydrolyzates : Potential supplements to support joint health in osteoarthritis? Current Rheumatology Reports. 23(11), p. Article 78. https://doi.org/10.1007/s11926-021-01042-6

The anabolic response to plant-based protein ingestion

Pinckaers, Philippe J. M., Trommelen, Jorn, Snijders, Tim and van Loon, Luc J. C.. (2021). The anabolic response to plant-based protein ingestion. Sports Medicine. 51(Supplement 1), pp. 59-74. https://doi.org/10.1007/s40279-021-01540-8

Effects of exercise on sexual dysfunction in patients with prostate cancer - A systematic review

Reimer, Nadine, Zopf, Eva Maria, Böwe, Rebecca and Baumann, Freerk Theeagnus. (2021). Effects of exercise on sexual dysfunction in patients with prostate cancer - A systematic review. Journal of Sexual Medicine. 18(11), pp. 1899-1914. https://doi.org/10.1016/j.jsxm.2021.09.001

Hepatic steatosis contributes to the development of muscle atrophy via inter-organ crosstalk

Pasmans, Kenneth, Adriaens, Michiel E., Olinga, Peter, Langen, Ramon, Rensen, Sander S., Schaap, Frank G., Damink, Steven W. M. Olde, Caiment, Florian, van Loon, Luc J. C., Blaak, Ellen E. and Meex, Ruth C. R.. (2021). Hepatic steatosis contributes to the development of muscle atrophy via inter-organ crosstalk. Frontiers in Endocrinology. 12, p. Article 733625. https://doi.org/10.3389/fendo.2021.733625

Acute effects of dietary nitrate on exercise tolerance, muscle oxygenation, and cardiovascular function in patients with peripheral arterial disease

van der Avoort, Cindy M.T., Van Loon, Luc J.C., Verdijk, Lex B., Poyck, Paul P.C., Thijssen, Dick T.J. and Hopman, Maria T.E.. (2021). Acute effects of dietary nitrate on exercise tolerance, muscle oxygenation, and cardiovascular function in patients with peripheral arterial disease. International Journal of Sport Nutrition and Exercise Metabolism. 31(5), pp. 385-396. https://doi.org/10.1123/ijsnem.2021-0054

Quality of life and symptom burden improve in patients attending a multidisciplinary clinical service for cancer cachexia : A retrospective observational review

Bland, Kelcey A., Harrison, Meg, Harrison, Meg, Zopf, Eva M., Sousa, Mariana S., Currow, David C., Ely, Matthew, Agar, Meera, Butcher, Belinda E., Vaughan, Vanessa, Dowd, Anna and Martin, Peter. (2021). Quality of life and symptom burden improve in patients attending a multidisciplinary clinical service for cancer cachexia : A retrospective observational review. Journal of Pain and Symptom Management. 62(3), pp. e164-e176. https://doi.org/10.1016/j.jpainsymman.2021.02.034

Mass spectrometry imaging of L-[ring-13 C6]- labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma

Cao, Jianhua, Balluff, Benjamin, Arts, Martijn, Dubois, Ludwig J., van Loon, Luc J. C., Hackeng, Tilman M., van Eijk, Hans M. H., Eijkel, Gert, Heij, Lara R., Soons, Zita, Olde Damink, Steven W. M. and Heeren, Ron M. A.. (2021). Mass spectrometry imaging of L-[ring-13 C6]- labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma . Cancer & Metabolism. 9, p. Article 26. https://doi.org/10.1186/s40170-021-00262-9

Insects are a viable protein source for human consumption : From insect protein digestion to postprandial muscle protein synthesis in vivo in humans : A double-blind randomized trial

Hermans, Wesley J. H., Senden, Joan M., Churchward-Venne, Tyler A., Paulussen, Kevin J. M., Fuchs, Cas J., Smeets, Joey S. J., van Loon, Joop J. A., Verdijk, Lex B. and van Loon, Luc J. C.. (2021). Insects are a viable protein source for human consumption : From insect protein digestion to postprandial muscle protein synthesis in vivo in humans : A double-blind randomized trial. American Journal of Clinical Nutrition. 114(3), pp. 934-944. https://doi.org/10.1093/ajcn/nqab115

Increasing nitrate-rich vegetable intake lowers ambulatory blood pressure in (pre)hypertensive middle-aged and older adults : A 12-wk randomized controlled trial

van der Avoort, Cindy M. T., ten Haaf, Dominique S. M., Bongers, Coen C. W. G., van Oorschot, Frederieke, Verdijk, Lex B., van Loon, Luc J. C. and Hopman, Maria T. E.. (2021). Increasing nitrate-rich vegetable intake lowers ambulatory blood pressure in (pre)hypertensive middle-aged and older adults : A 12-wk randomized controlled trial. The Journal of Nutrition. 151(9), pp. 2667-2679. https://doi.org/10.1093/jn/nxab157

Exercise interventions for people diagnosed with cancer : A systematic review of implementation outcomes

Czosnek, Louise, Richards, Justin, Zopf, Eva, Cormie, Prue, Rosenbaum, Simon and Rankin, Nicole M.. (2021). Exercise interventions for people diagnosed with cancer : A systematic review of implementation outcomes. BMC Cancer. 21, p. Article 643. https://doi.org/10.1186/s12885-021-08196-7

Patients and carers' perspectives of participating in a pilot tailored exercise program during chemoradiotherapy for high grade glioma : A qualitative study

Halkett, Georgia K. B., Cormie, Prue, McGough, Shirley, Zopf, Eva M., Galvao, Daniel A., Newton, Robert U. and Nowak, Anna K.. (2021). Patients and carers' perspectives of participating in a pilot tailored exercise program during chemoradiotherapy for high grade glioma : A qualitative study. European Journal of Cancer Care. 30(5), p. Article: e13453. https://doi.org/10.1111/ecc.13453

Eat like an athlete : Insights of sports nutrition science to support active aging in healthy older adults

Oikawa, Sara Y., Brisbois, Tristin D., van Loon, Luc J. C. and Rollo, Ian. (2021). Eat like an athlete : Insights of sports nutrition science to support active aging in healthy older adults. GeroScience. 43(5), pp. 2485-2495. https://doi.org/10.1007/s11357-021-00419-w

Undeclared doping substances are highly prevalent in commercial sports nutrition supplements

Duiven, Erik, Luc J.C. van Loon, Spruijt, Laila, Koert, Willem and de Hon, Olivier M.. (2021). Undeclared doping substances are highly prevalent in commercial sports nutrition supplements. Journal of Sports Science and Medicine. 20, pp. 328-338. https://doi.org/10.52082/jssm.2021.328

No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males

Pinckaers, Philippe J. M., Kouw, Imre W. K., Hendriks, Floris K., van Kranenburg, Janneau M. X., de Groot, Lisette C. P. G. M., Verdijk, Lex B., Snijders, Tim and van Loon, Luc J. C.. (2021). No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males. British Journal of Nutrition. 126(12), pp. 1832-1842. https://doi.org/10.1017/S0007114521000635

Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial

Murphy, Caoileann H., Flanagan, Ellen M., De Vito, Giuseppe, Susta, Davide, Mitchelson, Kathleen A. J., de Marco Castro, Elena, Senden, Joan M. G., Goessens, Joy P. B., Mikłosz, Agnieszka, Chabowski, Adrian, Segurado, Ricardo, Corish, Clare A., McCarthy, Sinead N., Egan, Brendan, van Loon, Luc J. C. and Roche, Helen M.. (2021). Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition. 113(6), pp. 1411-1427. https://doi.org/10.1093/ajcn/nqaa449

Daily myofibrillar protein synthesis rates in response to low- And high-frequency resistance exercise training in healthy, young men

Shad, Brandon J., Thompson, Janice L., McKendry, James, Holwerda, Andrew M., Elhassan, Yasir S., Breen, Leigh, van Loon, Luc J. C. and Wallis, Gareth A.. (2021). Daily myofibrillar protein synthesis rates in response to low- And high-frequency resistance exercise training in healthy, young men. International Journal of Sport Nutrition and Exercise Metabolism. 31(3), pp. 209-216. https://doi.org/10.1123/IJSNEM.2020-0274

Basal protein synthesis rates differ between vastus lateralis and rectus abdominis muscle

Smeets, Joey S. J., Horstman, Astrid M. H., van Dijk, David P. J., van Boxtel, Astrid G. M., ter Woorst, Joost F., Damink, Steven W. M. Olde, Schijns, Olaf E. M. G. and van Loon, Luc J. C.. (2021). Basal protein synthesis rates differ between vastus lateralis and rectus abdominis muscle. Journal of Cachexia, Sarcopenia and Muscle. 12(3), pp. 769-778. https://doi.org/10.1002/jcsm.12701

Myonuclear content and domain size in small versus larger muscle fibres in response to 12 weeks of resistance exercise training in older adults

Snijders, Tim, Holwerda, Andy M., van Loon, Luc J. C. and Verdijk, Lex B.. (2021). Myonuclear content and domain size in small versus larger muscle fibres in response to 12 weeks of resistance exercise training in older adults. Acta Physiologica. 231(4), p. e13599. https://doi.org/10.1111/apha.13599

The impact of beetroot juice supplementation on muscular endurance, maximal strength and countermovement jump performance

Jonvik, Kristin L., Hoogervorst, Daan, Peelen, Harmen B., de Niet, Mark, Verdijk, Lex B., van Loon, Luc J. C. and van Dijk, Jan-Willem. (2021). The impact of beetroot juice supplementation on muscular endurance, maximal strength and countermovement jump performance. European Journal of Sport Science. 21(6), pp. 871-878. https://doi.org/10.1080/17461391.2020.1788649

Assessing the whole-body protein synthetic response to feeding in vivo in human subjects

Trommelen, Jorn and Van Loon, Luc J. C.. (2021). Assessing the whole-body protein synthetic response to feeding in vivo in human subjects. Proceedings of the Nutrition Society. 80, pp. 139-147. https://doi.org/10.1017/S0029665120008009

The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : A systematic review and meta-analysis

Bigaran, Ashley, Zopf, Eva, Gardner, Jason, La Gerche, Andre, Murphy, Declan G., Howden, Erin J., Baker, Michael K. and Cormie, Prue. (2021). The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : A systematic review and meta-analysis. Prostate Cancer and Prostatic Diseases. 24(1), pp. 35-48. https://doi.org/10.1038/s41391-020-00273-5

Exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in healthy older men

Holwerda, Andrew M., Trommelen, Jorn, Kouw, Imre W. K., Senden, Joan M., Goessens, Joy P. B., van Kranenburg, Janneau, Gijsen, Annemie P., Verdijk, Lex B. and van Loon, Luc J. C.. (2021). Exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in healthy older men. International Journal of Sport Nutrition and Exercise Metabolism. 31(3), pp. 317-226. https://doi.org/10.1123/ijsnem.2020-0222

Whey protein supplementation does not accelerate recovery from a single bout of eccentric exercise

Hilkens, Luuk, De Bock, Jolien, Kretzers, Joris, Kardinaal, Alwine F. M., Floris-Vollenbroek, Esther G., Scholtens, Petra A. M. J., Horstman, Astrid M. H., van Loon, Luc J. C. and van Dijk, Jan-Willem. (2021). Whey protein supplementation does not accelerate recovery from a single bout of eccentric exercise. Applied Physiology, Nutrition and Metabolism. 39(3), pp. 322-331. https://doi.org/10.1080/02640414.2020.1820184

Muscle fiber capillarization is associated with various indices of skeletal muscle mass in healthy, older men

Betz, M. W., Aussieker, T., Kruger, C. Q., Gorissen, S. H. M., van Loon, L. J. C. and Snijders, T.. (2021). Muscle fiber capillarization is associated with various indices of skeletal muscle mass in healthy, older men. Experimental Gerontology. 143, p. 111161. https://doi.org/10.1016/j.exger.2020.111161

Higher levels of physical activity are associated with greater fruit and vegetable intake in older adults

Van Loon, L.. (2021). Higher levels of physical activity are associated with greater fruit and vegetable intake in older adults. Journal of Nutrition, Health and Aging. 25(2), pp. 230-241. https://doi.org/10.1007/s12603-020-1520-3

Dietary protein intake does not modulate daily myofibrillar protein synthesis rates of loss of muscle mass and function during short-term immobilization in young men : a randomized controlled trial

Kilroe, Sean Paul, Fulford, Jonathan, Jackman, Sarah, Holwerda, Andrew, Gijsen, Annemie, van Loon, Luc and Wall, Benjamin Toby. (2021). Dietary protein intake does not modulate daily myofibrillar protein synthesis rates of loss of muscle mass and function during short-term immobilization in young men : a randomized controlled trial. The American Journal of Clinical Nutrition. 113(3), pp. 548-561. https://doi.org/10.1093/ajcn/nqaa136

Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight and obese men

Tsintzas, Kostas, Jones, Robert, Pabla, Pardeep, Mallinson, Joanne, Barrett, David A., Kim, Dong-Hyun, Cooper, Scott, Davies, Amanda, Taylor, Tariq, Chee, Carolyn, Gaffney, Christopher, van Loon, Luc J. C. and Stephens, Francis B.. (2020). Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight and obese men. American Journal of Physiology - Endocrinology and Metabolism. 318(3), pp. E417-E429. https://doi.org/10.1152/ajpendo.00344.2019

Exercising in isolation? The role of telehealth in exercise oncology during the COVID-19 pandemic and beyond

Bland, Kelcey A., Bigaran, Ashley, Campbell, Kristin L., Trevaskis, Mark and Zopf, Eva M.. (2020). Exercising in isolation? The role of telehealth in exercise oncology during the COVID-19 pandemic and beyond. Physical Therapy. 100(10), pp. 1713-1716. https://doi.org/10.1093/ptj/pzaa141

Aerobic exercise-induced changes in cardiorespiratory fitness in breast cancer patients receiving chemotherapy : A systematic review and meta-analysis

Maginador, Guilherme, Lixandrão, Manoel E., Bortolozo, Henrique I., Vechin, Felipe C., Sarian, Luís O., Derchain, Sophie, Telles, Guilherme D., Zopf, Eva, Ugrinowitsch, Carlos and Conceição, Miguel S.. (2020). Aerobic exercise-induced changes in cardiorespiratory fitness in breast cancer patients receiving chemotherapy : A systematic review and meta-analysis. Cancers. 12(8), p. 2240. https://doi.org/10.3390/cancers12082240

Prognostic markers of overall survival in cancer patients attending a cachexia support service : An evaluation of clinically assessed physical function, malnutrition and inflammatory status

Bland, Kelcey A., Zopf, Eva M., Harrison, Meg, Ely, Matthew, Cormie, Prue, Liu, E., Dowd, Anna and Martin, Peter. (2020). Prognostic markers of overall survival in cancer patients attending a cachexia support service : An evaluation of clinically assessed physical function, malnutrition and inflammatory status. Nutrition and Cancer. 73(8), pp. 1400-1410. https://doi.org/10.1080/01635581.2020.1800765

In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle

Petrick, Heather L., Brunetta, Henver S., Pignanelli, Chris, Nunes, Everson A., van Loon, Luc J. C., Burr, Jamie F. and Holloway, Graham P.. (2020). In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle. The Journal of Physiology. 598(21), pp. 4869-4885. https://doi.org/10.1113/JP280032

Casein ingestion does not increase muscle connective tissue protein synthesis rates

Trommelen, Jorn, Holwerda, Andrew M., Senden, Joan M., Goessens, Joy P. B., Van Kranenburg, Janneau, Gijsen, Annemie P., Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Casein ingestion does not increase muscle connective tissue protein synthesis rates. Medicine & Science in Sports & Exercise. 52(9), pp. 1983-1991. https://doi.org/10.1249/MSS.0000000000002337

The glycation level of milk protein strongly modulates post-prandial lysine availability in humans

Nyakayiru, Jean, van Lieshout, Glenn A. A., Trommelen, Jorn, van Kranenburg, Janneau, Verdijk, Lex B., Bragt, Marjolijn C. E. and van Loon, Luc J. C.. (2020). The glycation level of milk protein strongly modulates post-prandial lysine availability in humans. British Journal of Nutrition. 123(5), pp. 545-552. https://doi.org/10.1017/S0007114519002927

The concept of skeletal muscle memory : Evidence from animal and human studies

Snijders, Tim, Aussieker, Thorben, Holwerda, Andy, Parise, Gianni, van Loon, Luc J. C. and Verdijk, Lex B.. (2020). The concept of skeletal muscle memory : Evidence from animal and human studies. Acta Physiologica. 229(3), pp. 1-20. https://doi.org/10.1111/apha.13465

Temporal muscle-specific disuse atrophy during one week of leg immobilization

Kilroe, Sean P., Fulford, Jonathan, Jackman, Sarah R., van Loon, Luc J. C. and Wall, Benjamin T.. (2020). Temporal muscle-specific disuse atrophy during one week of leg immobilization. Medicine & Science in Sports & Exercise. 52(4), pp. 944-954. https://doi.org/10.1249/MSS.0000000000002200

Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission

Dirks, Marlou L., Miotto, Paula M., Goossens, Gijs H., Senden, Joan M., Petrick, Heather L., van Kranenburg, Janneau, van Loon, Luc J. C. and Holloway, Graham P.. (2020). Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. The Journal of Physiology. 598(1), pp. 123-137. https://doi.org/10.1113/JP278920

Protein type, protein dose, and age modulate dietary protein digestion and phenylalanine absorption kinetics and plasma phenylalanine availability in humans

Gorissen, Stefan H. M., Trommelen, Jorn, Kouw, Imre W. K., Holwerda, Andrew M., Pennings, Bart, Groen, Bart B. L., Wall, Benjamin T., Churchward-Venne, Tyler A., Horstman, Astrid M. H., Koopman, René, Burd, Nicholas A., Fuchs, Cas J., Dirks, Marlou L., Res, Peter T., Senden, Joan M. G., Steijns, Jan M. J. M., de Groot, Lisette C. P. G. M., Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Protein type, protein dose, and age modulate dietary protein digestion and phenylalanine absorption kinetics and plasma phenylalanine availability in humans. The Journal of Nutrition. 150(8), pp. 2041-2050. https://doi.org/10.1093/jn/nxaa024

Postexercise cooling impairs muscle protein synthesis rates in recreational athletes

Fuchs, Cas J., Kouw, Imre W. K., Churchward-Venne, Tyler A., Smeets, Joey S. J., Senden, Joan M., Lichtenbelt, Wouter D. van Marken, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Postexercise cooling impairs muscle protein synthesis rates in recreational athletes. The Journal of Physiology. 598(4), pp. 755-772. https://doi.org/10.1113/JP278996

Primary, Secondary, and Tertiary Effects of Carbohydrate Ingestion During Exercise

Ian Rollo, Javier T. Gonzalez, Cas J. Fuchs, Lucas Van Loon and Clyde Williams. (2020). Primary, Secondary, and Tertiary Effects of Carbohydrate Ingestion During Exercise. Sports Medicine. 50(11), pp. 1863-1871. https://doi.org/10.1007/s40279-020-01343-3

PRESENT 2020: Text Expanding on the Checklist for Proper Reporting of Evidence in Sport and Exercise Nutrition Trials

James A. Betts, Javier T. Gonzalez, Louise Burke, Graeme L. Close, Ina Garthe, Lewis J James, Asker E Jeukendrup, James P. Morton, David C Nieman, Peter Peeling, Stuart M Phillips, Trent Stellingwerff, Lucas Van Loon, Clyde Williams, Kathleen Woolf, Ronald J. Maughan and Greg Atkinson. (2020). PRESENT 2020: Text Expanding on the Checklist for Proper Reporting of Evidence in Sport and Exercise Nutrition Trials. International Journal of Sport Nutrition and Exercise Metabolism. 30(1), pp. 2-13. https://doi.org/10.1123/ijsnem.2019-0326

Mitochondrial ROS and Aging: Understanding Exercise as a Preventive Tool

Henver S Brunetta, Andrew M Holwerda, Luc Van Loon and Graham P Holloway. (2020). Mitochondrial ROS and Aging: Understanding Exercise as a Preventive Tool. Journal of Science in Sport and Exercise. 2, pp. 15-24. https://doi.org/10.1007/s42978-019-00037-1

Implementing Exercise in Healthcare Settings: The Potential of Implementation Science

Louise Czosnek, Nicole Rankin, Eva Zopf, Justin Richards, Simon Rosenbaum and Prue Cormie. (2020). Implementing Exercise in Healthcare Settings: The Potential of Implementation Science. Sports Medicine. 50, pp. 1-14. https://doi.org/10.1007/s40279-019-01228-0

Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps

N.R.W. Geiker, C. Mølgaard, S. Iuliano, R. Rizzoli, Y. Manios, L.J.C. van Loon, J.-M. Lecerf, G. Moschonis, J.-Y. Reginster, I. Givens and A. Astrup. (2020). Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps. Osteoporosis International. 31(4), pp. 601-615. https://doi.org/10.1007/s00198-019-05229-7

Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest

Gonzalez, Javier T., Dirks, Marlou L., Holwerda, Andrew M., Kouw, Imre W. K. and van Loon, Luc J. C.. (2020). Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest. European Journal of Applied Physiology. 120, pp. 2083-2094. https://doi.org/10.1007/s00421-020-04431-4

Impact of exercise-nutritional state interactions in patients with type 2 diabetes

Verboven, Kenneth, Wens, Inez, Vandenabeele, Frank, Stevens, An, Celie, Bert, Lapauw, Bruno, Dendale, Paul, van Loon, Luc J. C., Calders, Patrick and Hansen, Dominique. (2020). Impact of exercise-nutritional state interactions in patients with type 2 diabetes. Medicine and Science in Sports and Exercise. 52(3), pp. 720-728. https://doi.org/10.1249/MSS.0000000000002165

Could intramuscular storage of dietary nitrate contribute to its ergogenic effect? A mini-review

Jean Nyakayiru, Luc Van Loon and Lex B. Verdijk. (2020). Could intramuscular storage of dietary nitrate contribute to its ergogenic effect? A mini-review. Free Radical Biology & Medicine. 152, pp. 295-300. https://doi.org/10.1016/j.freeradbiomed.2020.03.025

Hot-water immersion does not increase postprandial muscle protein synthesis rates during recovery from resistance-type exercise in healthy, young males

Fuchs, Cas J., Smeets, Joey S. J., Senden, Joan M., Zorenc, Antoine H., Goessens, Joy P. B., van Marken Lichtenbelt, Wouter D., Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Hot-water immersion does not increase postprandial muscle protein synthesis rates during recovery from resistance-type exercise in healthy, young males. Journal of Applied Physiology. 128(4), pp. 1012-1022. https://doi.org/10.1152/japplphysiol.00836.2019

Endurance-type exercise increases bulk and individual mitochondrial protein synthesis rates in rats

Holwerda, Andrew M., Bouwman, Freek G., Nabben, Miranda, Wang, Ping, van Kranenburg, Janneau, Gijsen, Annemie P., Burniston, Jatin G., Mariman, Edwin C. M. and van Loon, Luc J. C.. (2020). Endurance-type exercise increases bulk and individual mitochondrial protein synthesis rates in rats. International Journal of Sport Nutrition and Exercise Metabolism. 30(2), pp. 153-164. https://doi.org/10.1123/ijsnem.2019-0281

End-stage renal disease patients lose a substantial amount of amino acids during hemodialysis

Hendriks, Floris K., Smeets, Joey S. J., Broers, Natascha J. H., van Kranenburg, Janneau M. X., van der Sande, Frank M., Kooman, Jeroen P. and van Loon, Luc J. C.. (2020). End-stage renal disease patients lose a substantial amount of amino acids during hemodialysis. The Journal of Nutrition. 150(5), pp. 1160-1166. https://doi.org/10.1093/jn/nxaa010

During hospitalization, older patients at risk for malnutrition consume <0.65 grams of protein per kilogram body weight per day

Weijzen, Michelle E. G., Kouw, Imre W. K., Geerlings, Phil, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). During hospitalization, older patients at risk for malnutrition consume <0.65 grams of protein per kilogram body weight per day. Nutrition in Clinical Practice. 35(4), pp. 655-663. https://doi.org/10.1002/ncp.10542

Dose-response effects of dietary protein on muscle protein synthesis during recovery from endurance exercise in young men : A double-blind randomized trial

Churchward-Venne, Tyler A., Pinckaers, Philippe J. M., Smeets, Joey S. J., Betz, Milan W., Senden, Joan M., Goessens, Joy P. B., Gijsen, Annemie P., Rollo, Ian, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Dose-response effects of dietary protein on muscle protein synthesis during recovery from endurance exercise in young men : A double-blind randomized trial. American Journal of Clinical Nutrition. 112(2), pp. 303-317. https://doi.org/10.1093/ajcn/nqaa073

Casein protein processing strongly modulates post-prandial plasma amino acid responses in vivo in humans

Trommelen, Jorn, Weijzen, Michelle E. G., van Kranenburg, Janneau, Ganzevles, Renate A., Beelen, Milou, Verdijk, Lex B. and van Loon, Luc J. C.. (2020). Casein protein processing strongly modulates post-prandial plasma amino acid responses in vivo in humans. Nutrients. 12(8), pp. 1-12. https://doi.org/10.3390/nu12082299

A nitrate-rich vegetable intervention elevates plasma nitrate and nitrite concentrations and reduces blood pressure in healthy young adults

van der Avoort, Cindy M. T., Jonvik, Kristin L., Nyakayiru, Jean, van Loon, Luc J. C., Hopman, Maria T. E. and Verdijk, Lex B.. (2020). A nitrate-rich vegetable intervention elevates plasma nitrate and nitrite concentrations and reduces blood pressure in healthy young adults. Journal of the Academy of Nutrition and Dietetics. 120(8), pp. 1305-1317. https://doi.org/10.1016/j.jand.2020.02.014

Exercise medicine for the management of androgen deprivation therapy-related side effects in prostate cancer

Cormie, Prue and Zopf, Eva M.. (2020). Exercise medicine for the management of androgen deprivation therapy-related side effects in prostate cancer. Urologic Oncology. 38(2), pp. 62 - 70. https://doi.org/10.1016/j.urolonc.2018.10.008

Voeding bij intensieve sportbeoefening

van Loon, L. J. C., Trommelen, J., van Erp-Baart, A. M. J. and Saris, W. H. M.. (2019). Voeding bij intensieve sportbeoefening. In In Former, Majorie, van Asseldonk, Gerdie, Drenth, Jacqueline and Schuurman, Caroelien (Ed.). Informatorium voor Voeding en Dietetiek - Supplement 100 - December 2018 pp. 65-88 Bohn Stafleu van Loghum. https://doi.org/10.1007/978-90-368-2223-7_5

Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates

Kilroe, Sean P., Fulford, Jonathan, Holwerda, Andrew M., Jackman, Sarah R., Lee, Benjamin P., Gijsen, Annemie P., van Loon, Luc J. C. and Wall, Benjamin T.. (2019). Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates. American Journal of Physiology - Endocrinology and Metabolism. 318(2), pp. E117-E130. https://doi.org/10.1152/ajpendo.00360.2019

The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation

Jorn Trommelen, Andrew M. Holwerda, Jean Nyakayiru, Stefan H M Gorissen, Olav Rooyackers, Nicholas A Burd, Yves Boirie and Luc J. C. Van Loon. (2019). The intrinsically labeled protein approach is the preferred method to quantify the release of dietary protein-derived amino acids into the circulation. American Journal of Physiology - Endocrinology and Metabolism. 317(3), pp. 433-434. https://doi.org/10.1152/ajpendo.00155.2019

Fructose co-ingestion to increase carbohydrate availability in athletes

Cas J. Fuchs, Javier T. Gonzalez and Luc J. C. Van Loon. (2019). Fructose co-ingestion to increase carbohydrate availability in athletes. The Journal of Physiology. 597(14), pp. 3549-3560. https://doi.org/10.1113/JP277116

Dietary Protein and Physical Activity Interventions to Support Muscle Maintenance in End-Stage Renal Disease Patients on Hemodialysis

Floris K. Hendriks, Joey S J Smeets, Frank M van der Sande, Jeroen P Kooman and Lucas Van Loon. (2019). Dietary Protein and Physical Activity Interventions to Support Muscle Maintenance in End-Stage Renal Disease Patients on Hemodialysis. Nutrients. 11(12), pp. 1-13. https://doi.org/10.3390/nu11122972

The Muscle Protein Synthetic Response to Meal Ingestion Following Resistance-Type Exercise

Jorn Trommelen, Milan W Betz and Luc Van Loon. (2019). The Muscle Protein Synthetic Response to Meal Ingestion Following Resistance-Type Exercise. Sports Medicine. 49(2), pp. 185-197. https://doi.org/10.1007/s40279-019-01053-5

Exercising to offset muscle mass loss in hemodialysis patients: The disconnect between intention and intervention

Colleen F. McKenna, Amadeo F. Salvador, Floris K. Hendriks, Alana P. Y. Harris, Luc J. C. Van Loon and Nicholas A. Burd. (2019). Exercising to offset muscle mass loss in hemodialysis patients: The disconnect between intention and intervention. Seminars in Dialysis. 32(4), pp. 379-385. https://doi.org/10.1111/sdi.12805

Perioperative nutritional supplementation and skeletal muscle mass in older hip-fracture patients

Irene Fleur Kramer, Taco J. Blokhuis, Lex B. Verdijk, Luc Van Loon and Martijn Poeze. (2019). Perioperative nutritional supplementation and skeletal muscle mass in older hip-fracture patients. Nutrition Reviews. 77(4), pp. 254-266. https://doi.org/10.1093/nutrit/nuy055

One week of step reduction lowers myofibrillar protein synthesis rates in young men

Shad, Brandon J., Thompson, Janice L., Holwerda, Andrew M., Stocks, Ben, Elhassan, Yasir S., Philp, Andrew, Van Loon, Luc J. C. and Wallis, Gareth A.. (2019). One week of step reduction lowers myofibrillar protein synthesis rates in young men. Medicine and Science in Sports and Exercise. 51(10), pp. 2125 - 2134. https://doi.org/10.1249/MSS.0000000000002034

Health benefits, safety and cost of physical activity interventions for mental health conditions: A meta-review to inform translation efforts

Czosnek, Louise, Lederman, Oscar, Cormie, Prue, Zopf, Eva M., Stubbs, Brendon and Rosenbaum, Simon. (2019). Health benefits, safety and cost of physical activity interventions for mental health conditions: A meta-review to inform translation efforts. Mental Health and Physical Activity. 16, pp. 140 - 151. https://doi.org/10.1016/j.mhpa.2018.11.001

Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men

Holwerda, Andrew M., Paulussen, Kevin J. M., Overkamp, Maarten, Goessens, Joy P. B., Kramer, Irene-Fleur, Wodzig, Will K. W. H., Verdijk, Lex B., de Groot, Lisette C.P.G.M. and van Loon, Luc J. C.. (2019). Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men. American Journal of Physiology - Endocrinology and Metabolism. 317(3), pp. 473 - 482. https://doi.org/10.1152/ajpendo.00073.2019

Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest

Dirks, Marlou L., Smeets, Joey S. J., Holwerda, Andrew M., Kouw, Imre W. K., Marzuca-Nassr, Gabriel N., Gijsen, Annemie P., Holloway, Graham P., Verdijk, Lex B. and van Loon, Luc J. C.. (2019). Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest. American Journal of Physiology - Endocrinology and Metabolism. 316(3), pp. 536 - 545. https://doi.org/10.1152/ajpendo.00378.2018

Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse

Kneppers, Anita, Leermakers, Pieter, Pansters, Nicholas, Backx, Evelien, Gosker, Harry, van Loon, Luc, Schols, Annemie, Langen, Ramon and Verdijk, Lex. (2019). Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse. The FASEB Journal. 33(1), pp. 1288 - 1298. https://doi.org/10.1096/fj.201701403RRR

Time-dependent regulation of postprandial muscle protein synthesis rates after milk protein ingestion in young men

Vliet, Stephan Van, Beals, Joseph W., Holwerda, Andrew M., Emmons, Russell S., Goessens, Joy P., Paluska, Scott A., Lisio, Michael De, van Loon, Luc J. C. and Burd, Nicholas A.. (2019). Time-dependent regulation of postprandial muscle protein synthesis rates after milk protein ingestion in young men. Journal of Applied Physiology. 127(6), pp. 1792 - 1801. https://doi.org/10.1152/japplphysiol.00608.2019

Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial

Mason, Shaun A., Rasmussen, Bodil, van Loon, Luc J. C., Salmon, Jo and Wadley, Glenn D.. (2019). Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. 21(3), pp. 674 - 682. https://doi.org/10.1111/dom.13571

Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle

Petrick, Heather L., Pignanelli, Christopher, Barbeau, Pierre-Andre, Churchward-Venne, Tyler A., Dennis, Kaitlyn M. J. H., van Loon, Luc J. C., Burr, Jamie F., Goossens, Gijs H. and Holloway, Graham P.. (2019). Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. The Journal of Physiology. 597(15), pp. 3985 - 3997. https://doi.org/10.1113/JP277765

The effect of minimally invasive surgical aortic valve replacement on postoperative pulmonary and skeletal muscle function

Boujemaa, Hajar, Yilmaz, Alaaddin, Robic, Boris, Koppo, Katrien, Claessen, Guido, Frederix, Ines, Dendale, Paul, Völler, Heinz, van Loon, Luc J. C. and Hansen, Dominique. (2019). The effect of minimally invasive surgical aortic valve replacement on postoperative pulmonary and skeletal muscle function. Experimental Physiology. 104(6), pp. 855 - 865. https://doi.org/10.1113/EP087407

Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men

Holwerda, Andrew M., Paulussen, Kevin J. M., Overkamp, Maarten, Goessens, Joy P. B., Kramer, Irene-Fleur, Wodzig, Will K. W. H., Verdijk, Lex B., de Groot, Lisette C. P. G. M. and Van Loon, Luc. (2019). Leucine co-ingestion augments the muscle protein synthetic response to the ingestion of 15 g protein following resistance exercise in older men. In In A. M. Holwerda (Ed.). Dietary protein to support active aging pp. 53 - 73 Maastricht University. https://doi.org/10.26481/dis.20190321ah

The effect of beetroot juice supplementation on dynamic apnea and intermittent sprint performance in elite female water polo playres

Jonvik, Kristin L., van Dijk, Jan Willem, Senden, Joan M. G., van Loon, Luc J. C. and Verdijk, Lex B.. (2018). The effect of beetroot juice supplementation on dynamic apnea and intermittent sprint performance in elite female water polo playres. International Journal of Sport Nutrition and Exercise Metabolism. 28(5), pp. 468-473. https://doi.org/10.1123/ijsnem.2017-0293

Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle

Holloway, Graham P., Holwerda, Andrew M., Miotto, Paula M., Dirks, Marlou L., Verdijk, Lex B. and Van Loon, Luc. (2018). Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle. Cell Reports. 22(11), pp. 2837 - 2848. https://doi.org/10.1016/j.celrep.2018.02.069

Daily resistance-type exercise stimulates muscle protein synthesis in vivo in young men

Holwerda, Andrew M., Paulussen, Kevin J. M., Overkamp, Maarten, Smeets, Joey S. J., Gijsen, Annemie P., Goessens, Joy P. B., Verdijk, Lex B. and Van Loon, Luc. (2018). Daily resistance-type exercise stimulates muscle protein synthesis in vivo in young men. Journal of Applied Physiology. 124(1), pp. 66 - 75. https://doi.org/10.1152/japplphysiol.00610.2017

Temporal response of angiogenesis and hypertrophy to resistance training in young men

Holloway, Tanya M., Snijders, Tim, van Kranenburg, Janneau, Van Loon, Luc and Verdijk, Lex B.. (2018). Temporal response of angiogenesis and hypertrophy to resistance training in young men. Medicine and Science in Sports and Exercise. 50(1), pp. 36 - 45. https://doi.org/10.1249/MSS.0000000000001409

Muscle atrophy due to nerve damage is accompanied by elevated myofibrillar protein synthesis rates

Langer, Henning, Senden, Joan M., Gijsen, Annemie P., Kempa, Stefan, van Loon, Luc and Spuler, Simone. (2018). Muscle atrophy due to nerve damage is accompanied by elevated myofibrillar protein synthesis rates. Frontiers in Physiology. 9(1220), pp. 1 - 10. https://doi.org/10.3389/fphys.2018.01220

Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET

Smeets, Joey S.J and Van Loon, Luc. (2018). Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET. Brain: a journal of neurology. 141(7), pp. 52 - 52. https://doi.org/10.1093/brain/awy119

Skeletal muscle fiber characteristics in patients with chronic heart failure: Impact of disease severity and relation with muscle oxygenation during exercise

Niemeijer, Victor M., Snijders, Tim, Verdijk, Lex B., Van Kranenburg, Janneau, Groen, Bart B.L., Holwerda, Andrew M., Spee, Ruud F., Wijn, Pieter F. F., van Loon, Luc and Kemps, Hareld M.C.. (2018). Skeletal muscle fiber characteristics in patients with chronic heart failure: Impact of disease severity and relation with muscle oxygenation during exercise. Journal of Applied Physiology. 125(4), pp. 1266 - 1276. https://doi.org/10.1152/japplphysiol.00057.2018

Dose-response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: a randomized controlled trial in older adults

Vaes, Anouk M.M., Tieland, Michael, de Regt, Margot F., Wittwer, Jonas, van Loon, Luc and de Groot, Lisette C.P.G.M.. (2018). Dose-response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: a randomized controlled trial in older adults. Clinical Nutrition. 37(3), pp. 808 - 814. https://doi.org/10.1016/j.clnu.2017.03.029

Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET

Increasing vegetable intake to obtain the health promoting and ergogenic effects of dietary nitrate

Van der Avoort, Cindy M. T., van Loon, Luc, Hopman, Maria T. and Verdijk, Lex B.. (2018). Increasing vegetable intake to obtain the health promoting and ergogenic effects of dietary nitrate. European Journal of Clinical Nutrition. 72, pp. 1485 - 1489. https://doi.org/10.1038/s41430-018-0140-z

Effects of creatine and carbohydrate loading on cycling time trial performance

Tomcik, Kristyen A., Camera, Donny, Bone, Julia L. L., Ross, Meg, Jeacocke, N. A., Tachtsis, Bill, Senden, Joan M., Van Loon, Luc, Hawley, John and Burke, Louise. (2018). Effects of creatine and carbohydrate loading on cycling time trial performance. Medicine and Science in Sports and Exercise. 50(1), pp. 141 - 150. https://doi.org/10.1249/MSS.0000000000001401

IOC consensus statement: dietary supplements and the high-performance athlete0306

Maughan, Ronald J., Burke, Louise, Dvorak, Jiri, Larson-Meyer, D. E., Peeling, Peter, Phillips, Stuart M., Rawson, Eric S., Walsh, Neil P., Garthe, Ina, Geyer, Hans, Meeusen, Romain, Van Loon, Luc, Shirreffs, Susan M., Spriet, Lawrence L., Stuart, Mark, Vernec, Alan, Currell, Kevin, Ali, Vidya M., Budgett, Richard, ... Engebretsen, Lars. (2018). IOC consensus statement: dietary supplements and the high-performance athlete0306. British Journal of Sports Medicine. 52(7), pp. 439 - 455. https://doi.org/10.1136/bjsports-2018-099027

The 2017 dutch physical activity guidelines

Weggemans, Rianne M., Backx, Frank J.G., Borghouts, Lars, Chinapaw, Mai J.M., Hopman, Maria T., Koster, Annemarie, Kremers, Stef, Van Loon, Luc, May, Anne M., Mosterd, Arend, van der Ploeg, Hidde, Takken, Tim, Visser, Marjolein, Wendel-Vos, Wanda and de Geus, Eco J.C.. (2018). The 2017 dutch physical activity guidelines. International Journal of Behavioral Nutrition and Physical Activity. 15(58), pp. 1 - 12. https://doi.org/10.1186/s12966-018-0661-9

Interventional strategies to combat muscle disuse atrophy in humans: Focus on neuromuscular electrical stimulation and dietary protein

Dirks, Marlou L., Wall, Benjamin T. and van Loon, Luc. (2018). Interventional strategies to combat muscle disuse atrophy in humans: Focus on neuromuscular electrical stimulation and dietary protein. Journal of Applied Physiology. 125(3), pp. 850 - 861. https://doi.org/10.1152/japplphysiol.00985.2016

IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete

Maughan, Ronald J., Burke, Louise, Dvorak, Jiri, Larson-Meyer, D. E., Peeling, Peter, Phillips, Stuart M., Rawson, Eric S., Walsh, Neil P., Garthe, Ina, Geyer, Hans, Meeusen, Romain, Van Loon, Luc, Shirreffs, Susan M., Spriet, Lawrence L., Stuart, Mark, Vernec, Alan, Currell, Kevin, Ali, Vidya M., Budgett, Richard, ... Engebretsen, Lars. (2018). IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete. International Journal of Sport Nutrition and Exercise Metabolism. 28(2), pp. 104 - 125. https://doi.org/10.1123/ijsnem.2018-0020

A novel in vitro model for the assessment of postnatal myonuclear accretion

Kneppers, Anita, Verdijk, Lex B., de Theije, Chiel, Corten, Mark, Gielen, Ellis, van Loon, Luc, Schols, Annemie and Langen, Ramon. (2018). A novel in vitro model for the assessment of postnatal myonuclear accretion. Skeletal Muscle. 8(4), pp. 1 - 13. https://doi.org/10.1186/s13395-018-0151-4

Protein supplementation after exercise and before sleep does not further augment muscle mass and strength gains during resistance exercise training in active older men

Holwerda, Andrew M., Overkamp, Maarten, Paulussen, Kevin J. M., Smeets, Joey S. J., Van Kranenburg, Janneau, Backx, E. M. P., Gijsen, Annemie P., Goessens, Joy P. B., Verdijk, Lex B. and van Loon, Luc. (2018). Protein supplementation after exercise and before sleep does not further augment muscle mass and strength gains during resistance exercise training in active older men. The Journal of Nutrition. 148(11), pp. 1723 - 1732. https://doi.org/10.1093/jn/nxy169

Protein content and amino acid composition of commercially available plant-based protein isolates

Gorissen, Stefan H. M., Crombag, Julie J. R., Senden, Joan M., Huub Waterval, W. A., Bierau, Jörgen, Verdijk, Lex B. and van Loon, Luc. (2018). Protein content and amino acid composition of commercially available plant-based protein isolates. Amino Acids. 50(12), pp. 1685 - 1695. https://doi.org/10.1007/s00726-018-2640-5

Leucine supplementation does not attenuate skeletal muscle loss during leg immobilization in healthy, young men

Backx, E. M. P., Horstman, Astrid M. H., Marzuca-Nassr, Gabriel N., Van Kranenburg, Janneau, Smeets, Joey S. J., Fuchs, Cas J., Janssen, Anniek A. W., de Groot, Lisette C. P. G. M., Snijders, Tim, Verdijk, Lex B. and van Loon, Luc. (2018). Leucine supplementation does not attenuate skeletal muscle loss during leg immobilization in healthy, young men. Nutrients. 10(635), pp. 1 - 12. https://doi.org/10.3390/nu10050635

Brain tissue plasticity: protein synthesis rates of the human brain0006

Smeets, Joey S. J., Horstman, Astrid M. H., Schijns, Olaf E. M. G., Dings, Jim T. A., Hoogland, Govert, Gijsen, Annemie P., Goessens, Joy P. K., Bouwman, Freek G., Wodzig, Will K. W. H., Mariman, Edwin C. and Van Loon, Luc. (2018). Brain tissue plasticity: protein synthesis rates of the human brain0006. Brain: a journal of neurology. 141(4), pp. 1122 - 1129. https://doi.org/10.1093/brain/awy015

Adipose tissue lipolytic inhibition enhances the glucoregulatory properties of exercise in type 2 diabetes patients

Hansen, Dominique, Verboven, Kenneth, van Dijk, Jan Willem, Zorenc, Antoine H., Minten, Lennert, Smeets, Kevin, Verdijk, Lex B. and Van Loon, Luc. (2018). Adipose tissue lipolytic inhibition enhances the glucoregulatory properties of exercise in type 2 diabetes patients. European Journal of Sport Science. 18(9), pp. 1245 - 1254. https://doi.org/10.1080/17461391.2018.1483428

Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats

Monaco, Cynthia, Miotto, Paula M., Huber, Jason S., Van Loon, Luc, Simpson, Jeremy A. and Holloway, Graham P.. (2018). Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315(2), pp. 191 - 204. https://doi.org/10.1152/ajpregu.00275.2017

The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease

Beijers, Rosanne J. H. C. G., Huysmans, Stephanie M. D., van de Bool, Coby, Kingma, Boris R. M., Verdijk, Lex B., Van Loon, Luc, Meex, Steven J. R., Gosker, Harry R. and Schols, Annemie M. W. J.. (2018). The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease. Clinical Nutrition. 37(6), pp. 1852 - 1861. https://doi.org/10.1016/j.clnu.2017.10.011

Repeated-sprint performance and plasma responses following beetroot juice supplementation do not differ between recreational, competitive and elite sprint athletes

Jonvik, Kristin L., Nyakayiru, Jean, van Dijk, Jan Willem, Maase, K., Ballak, S. B., Senden, Joan M., van Loon, Luc and Verdijk, Lex B.. (2018). Repeated-sprint performance and plasma responses following beetroot juice supplementation do not differ between recreational, competitive and elite sprint athletes. European Journal of Sport Science. 18(4), pp. 524 - 533. https://doi.org/10.1080/17461391.2018.1433722

Effects of KYUSHO JITSU on physical activity-levels and quality of life in breast cancer patients

Strunk, Maximilian A., Zopf, Eva, Steck, Jule, Hamacher, Stefanie, Hallek, Michael and Baumann, Freerk T.. (2018). Effects of KYUSHO JITSU on physical activity-levels and quality of life in breast cancer patients. In Vivo: international journal of experimental and clinical pathophysiology and drug research. 32(4), pp. 819 - 824. https://doi.org/10.21873/invivo.11313

Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET

Smeets, Joey S.J. and Van Loon, Luc. (2018). Reply: measurement of regional rates of protein synthesis in human brain in vivo with l-[1-11c]-leucine PET. Brain: a journal of neurology. 141(7), pp. 52 - 52. https://doi.org/10.1093/brain/awy119

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy

Nabben, Miranda, Schmitz, Joep P. J., Ciapaite, Jolita, le Clercq, Carlijn M. P., van Riel, Natal A., Haak, Harm R., Nicolay, Klaas, de Coo, Irenaeus F. M., Smeets, Hubert, Praet, Stephan F., van Loon, Lucas J. and Prompers, Jeanine J.. (2017). Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 312(5), pp. R689-R701. https://doi.org/10.1152/ajpregu.00264.2016

Detection of localized hepatocellular amino acid kinetics by using mass spectrometry imaging of stable isotopes

Arts, Martijn, Soons, Zita, Ellis, Shane R., Pierzchalski, Keely A., Balluff, Benjamin, Eijkel, Gert B., Dubois, Ludwig J., Lieuwes, Natasja G., Agten, Stijn M., Hackeng, Tilman M., Van Loon, Luc, Heeren, Ron M.A. and Damink, Steven W.O.. (2017). Detection of localized hepatocellular amino acid kinetics by using mass spectrometry imaging of stable isotopes. Angewandte Chemie. 56(25), pp. 7146 - 7150. https://doi.org/10.1002/anie.201702669

Post-exercise muscle glycogen resynthesis in humans

Burke, Louise M., van Loon, Luc J. C. and Hawley, John A.. (2017). Post-exercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055-1067. https://doi.org/0.1152/japplphysiol.00860.2016

The impact of dietary protein or amino acid supplementation on muscle mass and strength in elderly people: individual participant data and meta-analysis of rct's

Tieland, Michael, Franssen, Rinske, Dullemeijer, C., van Dronkelaar, C., Kim, H. K., Ispoglou, T., Zhu, Kun, Prince, R. L., Van Loon, Luc and de Groot, Lisette C.P.G.M.. (2017). The impact of dietary protein or amino acid supplementation on muscle mass and strength in elderly people: individual participant data and meta-analysis of rct's. Journal of Nutrition, Health and Aging. 21(9), pp. 994 - 1001. https://doi.org/10.1007/s12603-017-0896-1

Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis

Dirks, Marlou L., Groen, Bart B.L., Franssen, Rinske, van Kranenburg, Janneau and Van Loon, Luc. (2017). Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis. Journal of Applied Physiology. 122(1), pp. 20 - 27. https://doi.org/10.1152/japplphysiol.00331.2016

Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans

Snijders, Tim, Nederveen, Joshua P., Verdijk, Lex B., Houben, Alfons J.H.M., Goossens, Gijs H., Parise, Gianna and Van Loon, Luc. (2017). Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans. Physiological Reports. 5(10), pp. 1 - 5. https://doi.org/10.14814/phy2.13278

Sustainable impact of an individualized exercise program on physical activity level and fatigue syndrome on breast cancer patients in two German rehabilitation centers

Baumann, Freerk T., Bieck, Oliver, Oberste, Max, Kuhn, Rafaela, Schmitt, Joachim, Wentrock, Steffen, Zopf, Eva, Bloch, Wilhelm, Schüle, Klaus and Reuss-Borst, Monika. (2017). Sustainable impact of an individualized exercise program on physical activity level and fatigue syndrome on breast cancer patients in two German rehabilitation centers. Supportive Care in Cancer. 25(4), pp. 1047 - 1054. https://doi.org/10.1007/s00520-016-3490-x

Postexercise muscle glycogen resynthesis in humans

Burke, Louise, Van Loon, Luc and Hawley, John. (2017). Postexercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055 - 1067. https://doi.org/10.1152/japplphysiol.00860.2016

Consideration of insects as a source of dietary protein for human consumption

Churchward-Venne, T. A., Pinckaers, Philippe J. M., van Loon, Joop J. A. and Van Loon, Luc. (2017). Consideration of insects as a source of dietary protein for human consumption. Nutrition Reviews. 75(12), pp. 1035 - 1045. https://doi.org/10.1093/nutrit/nux057

Protein supplementation augments muscle fiber hypertrophy but does not modulate satellite cell content during prolonged resistance-type exercise training in frail elderly

Dirks, Marlou L., Tieland, Michael, Verdijk, Lex B., Losen, Mario, Nilwik, Rachel, Mensink, Marco, de Groot, Lisette C.P.G.M. and Van Loon, Luc. (2017). Protein supplementation augments muscle fiber hypertrophy but does not modulate satellite cell content during prolonged resistance-type exercise training in frail elderly. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 18(7), pp. 608 - 615. https://doi.org/10.1016/j.jamda.2017.02.006

Glucose plus fructose ingestion for post exercise recovery greater than the sum of its parts?

Gonzalez, Javier T., Fuchs, Cas J., Betts, James A. and Van Loon, Luc. (2017). Glucose plus fructose ingestion for post exercise recovery greater than the sum of its parts? Nutrients. 9(4), pp. 1 - 15. https://doi.org/10.3390/nu9040344

Twenty-four-hour biological variation profiles of cardiac troponin I in individuals with or without chronic kidney disease

Van Der Linden, Noreen, Hilderink, Judith M., Cornelis, Tom, Kimenai, Dorien M., Klinkenberg, Lieke J.J., Van Doorn, William P., Litjens, Elisabeth J.R., Van Suijlen, Jeroen D.E., Van Loon, Luc, Bekers, Otto, Kooman, Jeroen P. and Meex, Steven J.R.. (2017). Twenty-four-hour biological variation profiles of cardiac troponin I in individuals with or without chronic kidney disease. Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine. 63(10), pp. 1655 - 1656. https://doi.org/10.1373/clinchem.2017.275107

Dietary protein intake and distribution patterns of well-trained Dutch athletes

Gillen, Jenna B., Trommelen, Jorn, Wardenaar, Floris C., Brinkmans, Naomi Y.J., Versteegen, Joline J., Jonvik, Kristin L., Kapp, Christoph, de Vries, Jeanne, van den Borne, Joost J.G.C., Gibala, M. J. and Van Loon, Luc. (2017). Dietary protein intake and distribution patterns of well-trained Dutch athletes. International Journal of Sport Nutrition and Exercise Metabolism. 27(2), pp. 105 - 114. https://doi.org/10.1123/ijsnem.2016-0154

The impact of exercise on cancer mortality, recurrence, and treatment-related adverse effects

Cormie, Prue, Zopf, Eva, Zhang, Xiaochen and Schmitz, Kathryn H.. (2017). The impact of exercise on cancer mortality, recurrence, and treatment-related adverse effects. Epidemiologic Reviews. 39(1), pp. 71 - 92. https://doi.org/10.1093/epirev/mxx007

Differential effects of leucine and leucine-enriched whey protein on skeletal muscle protein synthesis in aged mice

Dijk, Francina J., van Dijk, Miriam, Walrand, Stéphane, Van Loon, Luc, van Norren, Klaske and Luiking, Yvette C.. (2017). Differential effects of leucine and leucine-enriched whey protein on skeletal muscle protein synthesis in aged mice. Clinical Nutrition ESPEN. 24, pp. 127 - 133. https://doi.org/10.1016/j.clnesp.2017.12.013

Extensive type ii muscle fiber atrophy in elderly female hip fracture patients

Kramer, Irene F., Snijders, Tim, Smeets, Joey S.J., Leenders, Marika, van Kranenburg, Janneau, den Hoed, Marcel, Verdijk, Lex B., Poeze, Martijn and Van Loon, Luc. (2017). Extensive type ii muscle fiber atrophy in elderly female hip fracture patients. The Journals of Gerontology: Series A. 72(10), pp. 1369 - 1375. https://doi.org/10.1093/gerona/glw253

Fructose and sucrose intake increase exogenous carbohydrate oxidation during exercise

Trommelen, Jorn, Fuchs, Cas J., Beelen, M, Lenaerts, Kaatje, Jeukendrup, A. E., Cermak, N. and Van Loon, Luc. (2017). Fructose and sucrose intake increase exogenous carbohydrate oxidation during exercise. Nutrients. 9(2), pp. 1 - 12. https://doi.org/10.3390/nu9020167

Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial

Kouw, Imre W.K., Holwerda, Andrew M., Trommelen, Jorn, Kramer, Irene Fleur, Bastiaanse, Jacqueline, Halson, Shona, Wodzig, Will K.W.H., Verdijk, Lex B. and Van Loon, Luc. (2017). Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial. The Journal of Nutrition. 147(12), pp. 2252 - 2261. https://doi.org/10.3945/jn.117.254532

Associations between aerobic exercise levels and physical and mental health outcomes in men with bone metastatic prostate cancer: A cross-sectional investigation

Zopf, Eva M., Newton, Robert, Taaffe, Dennis R., Spry, Nigel A., Cormie, Prue, Joseph, David, Chambers, Suzanne, Baumann, Freerk T., Bloch, W. and Galvao, Daniel. (2017). Associations between aerobic exercise levels and physical and mental health outcomes in men with bone metastatic prostate cancer: A cross-sectional investigation. European Journal of Cancer Care. 26(6), pp. 1 - 7. https://doi.org/10.1111/ecc.12575

Sodium nitrate ingestion increases skeletal muscle nitrate content in humans

Nyakayiru, Jean, Kouw, Imre W.K., Cermak, N, Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017). Sodium nitrate ingestion increases skeletal muscle nitrate content in humans. Journal of Applied Physiology. 123(3), pp. 637 - 644. https://doi.org/10.1152/japplphysiol.01036.2016

Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men

Tsintzas, Kostas, Stephens, F. B., Snijders, Tim, Wall, Benjamin T., Cooper, Scott, Mallinson, Joanne, Verdijk, Lex B. and Van Loon, Luc. (2017). Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Experimental Gerontology. 93, pp. 36 - 45. https://doi.org/10.1016/j.exger.2017.03.018

Commentaries on Viewpoint: A time for exercise: the exercise window

Boule, Normand G., Terada, Tasuku, Francois, Monique E., Hawley, John, Cotter, James D., Kruse, Nicholas T., McDonald, Matthew W., Olver, T D., Paoli, Antonio, Sacchetti, Massimo, Di Luigi, Luigi, van Dijk, Jan W., Van Loon, Luc, Yardley, Jane E., DiPietro, Loretta, Gribok, Andrei and Rumpler, William. (2017). Commentaries on Viewpoint: A time for exercise: the exercise window. Journal of Applied Physiology. 122(1), pp. 210 - 213. https://doi.org/10.1152/japplphysiol.00938.2016

No effect of acute and 6-day nitrate supplementation on VO2 and time-trial performance in highly trained cyclists

Nyakayiru, Jean, Jonvik, Kristin L., Pinckaers, Philippe J.M., Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017). No effect of acute and 6-day nitrate supplementation on VO2 and time-trial performance in highly trained cyclists. International Journal of Sport Nutrition and Exercise Metabolism. 27(1), pp. 11 - 17. https://doi.org/10.1123/ijsnem.2016-0034

Food ingestion in an upright sitting position increases postprandial amino acid availability when compared with food ingestion in a lying down position

Holwerda, Andrew M., Lenaerts, Kaatje, Bierau, Jörgen, Wodzig, Will K.W.H. and Van Loon, Luc. (2017). Food ingestion in an upright sitting position increases postprandial amino acid availability when compared with food ingestion in a lying down position. Applied Physiology, Nutrition and Metabolism. 42(7), pp. 738 - 743. https://doi.org/10.1139/apnm-2016-0522

Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players

Nyakayiru, Jean, Jonvik, Kristin L., Trommelen, Jorn, Pinckaers, Philippe J.M., Senden, Joan M., Van Loon, Luc and Verdijk, Lex B.. (2017). Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players. Nutrients. 9(3), pp. 1 - 10. https://doi.org/10.3390/nu9030314

Seasonal variation in vitamin d status in elite athletes: a longitudinal study

Backx, E. M.P., van der Avoort, Cindy van, Tieland, Michael, Maase, K., Kies, A. K., Van Loon, Luc, de Groot, Lisette C.P.G.M. and Mensink, M.. (2017). Seasonal variation in vitamin d status in elite athletes: a longitudinal study. International Journal of Sport Nutrition and Exercise Metabolism. 27(1), pp. 6 - 10. https://doi.org/10.1123/ijsnem.2016-0177

Glycemic control during consecutive days with prolongedwalking exercise in individuals with type 1 diabetes mellitus

van Dijk, Jan Willem, Eijsvogels, Thijs M., Nyakayiru, Jean, Schreuder, Tim H. A., Hopman, Maria T., Thijssen, Dick H. and Van Loon, Lucas. (2016). Glycemic control during consecutive days with prolongedwalking exercise in individuals with type 1 diabetes mellitus. Diabetes Research and Clinical Practice. 117, pp. 74 - 81. https://doi.org/10.1016/j.diabres.2016.04.053

May bed rest cause greater muscle loss than limb immobilization?

Dirks, M. L., Backx, E. M. P., Wall, B. T., Verdijk, L. B. and van Loon, L.. (2016). May bed rest cause greater muscle loss than limb immobilization? Acta Physiologica. 218(1), pp. 10-12. https://doi.org/10.1111/apha.12699

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study

Rozenberg, Robert, Mankowski, Robert T., van Loon, Luc, Langendonk, Janneke G., Sijbrands, Eric J. G., van den Meiracker, Anton H., Stam, Henk J. and Praet, Stephan F. E.. (2016). Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study. European Journal of Medical Research. 21(1), pp. 1 - 8. https://doi.org/10.1186/s40001-015-0194-5

Cardiac Troponin T and i Release after a 30-km Run

Klinkenberg, Lieke J. J., Luyten, Peter, Van Der Linden, Noreen, Urgel, Kim, Snijders, Daniëlle P. C., Knackstedt, Christian, Dennert, Robert, Kietselaer, Bastiaan L. J. H., Mingels, Alma M. A., Cardinaels, Eline P. M., Peeters, Frederique E. C. M., Van Suijlen, Jeroen D. E., Kate, Joop Ten, Marsch, Elke, Theelen, Thomas L., Sluimer, Judith C., Wouters, Kristiaan, Bekers, Otto, Bekkers, Sebastiaan C. A. M., ... Meex, Steven J. R.. (2016). Cardiac Troponin T and i Release after a 30-km Run. American Journal of Cardiology. 118(2), pp. 281 - 287. https://doi.org/10.1016/j.amjcard.2016.04.030

Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population

van der Linden, Noreen, Klinkenberg, Lieke J. J., Bekers, Otto, van Loon, Luc, Van Dieijen-Visser, Marja P., Zeegers, Maurice P. and Meex, Steven J. R.. (2016). Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population. Medicine. https://doi.org/10.1097/MD.0000000000005703

Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion

Wall, Benjamin T., Dirks, Marlou L., Snijders, Tim, Willem van Dijk, Jan, Fritsch, Mario, Verdijk, Lex B. and Van Loon, Luc. (2016). Short-term muscle disuse lowers myofibrillar protein synthesis rates and induces anabolic resistance to protein ingestion. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00227.2015

Impact of physical inactivity on the multifactorial process of developing cancer-related cognitive impairments

Pesendorfer, L. M., Zimmer, Philipp, Galvao, Daniel, Zopf, Eva M., Bloch, Wilhelm and Baumann, Freerk T.. (2016). Impact of physical inactivity on the multifactorial process of developing cancer-related cognitive impairments. Journal of Cancer Science and Therapy (online). 8(8), pp. 222 - 227. https://doi.org/10.4172/1948-5956.1000417

Impact of diet composition on blood glucose regulation

Russell, Wendy R., Baka, Athanasia, Bjorck, Inger, Delzenne, Nathalie, Gao, Dan, Griffiths, Helen R., Hadjilucas, Ellie, Juvonen, Kristiina, Lahtinen, Sampo, Lansink, Mirian, van Loon, Luc, Mykkanen, Hannu, Ostman, Elin, Riccardi, Gabrielle, Vinoy, Sophie and Weickert, Martin O.. (2016). Impact of diet composition on blood glucose regulation. Critical Reviews in Food Science and Nutrition. 56(4), pp. 541 - 590. https://doi.org/10.1080/10408398.2013.792772

The Martin Vigorimeter Represents a Reliable and More Practical Tool Than the Jamar Dynamometer to Assess Handgrip Strength in the Geriatric Patient

Sipers, Walther M. W. H., Verdijk, Lex B., Sipers, Simone J. E., Schols, Jos M. G. A. and Van Loon, Luc. (2016). The Martin Vigorimeter Represents a Reliable and More Practical Tool Than the Jamar Dynamometer to Assess Handgrip Strength in the Geriatric Patient. Journal of the American Medical Directors Association. 17(5), pp. 1 - 7. https://doi.org/10.1016/j.jamda.2016.02.026

Resistance training increases skeletal muscle capillarization in healthy older men

Verdijk, Lex B., Snijders, Tim, Holloway, Tanya M., Van Kranenburg, Janneau and van Loon, Luc. (2016). Resistance training increases skeletal muscle capillarization in healthy older men. Medicine and Science in Sports and Exercise. 48(11), pp. 2157 - 2164. https://doi.org/10.1249/MSS.0000000000001019

Habitual Dietary Nitrate Intake in Highly Trained Athletes

Jonvik, Kristin L., Nyakayiru, Jean, Willem van Dijk, Jan, Wardenaar, Floris C., Van Loon, Lucas and Verdijk, Lex B.. (2016). Habitual Dietary Nitrate Intake in Highly Trained Athletes. International Journal of Sport Nutrition and Exercise Metabolism. https://doi.org/10.1123/ijsnem.2016-0239

Protein intake and lean body mass preservation during energy intake restriction in overweight older adults

Backx, E. M. P., Tieland, Michael, Borgonjen-Van Den Berg, Karin J., Claessen, P. R., Van Loon, Lucas and de Groot, Lisette C.P.G.M.. (2016). Protein intake and lean body mass preservation during energy intake restriction in overweight older adults. International Journal of Obesity. https://doi.org/10.1038/ijo.2015.182

Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance-type exercise training

Snijders, Tim, Smeets, Joey S. J., Van Kranenburg, Janneau, Kies, A. K., Van Loon, Lucas and Verdijk, Lex B.. (2016). Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance-type exercise training. Acta Physiologica. https://doi.org/10.1111/apha.12609

Resistance exercise augments postprandial overnight muscle protein synthesis rates

Trommelen, Jorn, Holwerda, Andrew M., Kouw, Imre W. K., Langer, Henning, Halson, Shona L., Verdijk, Lex B. and van Loon, Luc J. C.. (2016). Resistance exercise augments postprandial overnight muscle protein synthesis rates. Medicine and Science in Sports and Exercise. 48(12), pp. 2517-2525. https://doi.org/10.1249/MSS.0000000000001045

Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning

Wall, Benjamin T., Burd, Nicholas A., Franssen, Rinske, Gorissen, Stefan H. M., Snijders, Tim, Senden, Joan M., Gijsen, Annemie P. and van Loon, Luc. (2016). Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning. American Journal of Physiology - Endocrinology and Metabolism. 311(6), pp. E964-E973. https://doi.org/10.1152/ajpendo.00325.2016

Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction

Klinkenberg, Lieke J. J., Wildi, Karin, Van Der Linden, Noreen, Kouw, Imre W. K., Niens, Marijke, Twerenbold, Raphael, Gimenez, Maria Rubini, Puelacher, Christian, Neuhaus, Jean Daniel, Hillinger, Petra, Nestelberger, Thomas, Boeddinghaus, Jasper, Grimm, Karin, Sabti, Zaid, Bons, Judith A. P., Van Suijlen, Jeroen D. E., Tan, Frans E. S., Kate, Joop Ten, Bekers, Otto, ... Meex, Steven J. R.. (2016). Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction. Clinical Chemistry. 62(12), pp. 1602 - 1611. https://doi.org/10.1373/clinchem.2016.257485

Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

Hangelbroek, Roland W. J., Fazelzadeh, Parastoo, Tieland, Michael, Boekschoten, Mark V., Hooiveld, Guido J. E. J., van Duynhoven, John P. M., Timmons, James A., Verdijk, Lex B., de Groot, Lisette C. P. G. M., Van Loon, Luc and Müller, Michael. (2016). Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness. Journal Cachexia Sarcopenia Muscle. 7(5), pp. 604 - 614. https://doi.org/10.1002/jcsm.12099

The impact of 1-year vitamin D supplementation on vitamin D status in athletes: A dose-response study

Backx, E. M. P., Tieland, Michael, Maase, K., Kies, A. K., Mensink, M., Van Loon, Luc and de Groot, Lisette C. P. G. M.. (2016). The impact of 1-year vitamin D supplementation on vitamin D status in athletes: A dose-response study. European Journal of Clinical Nutrition. 70(9), pp. 1009 - 1014. https://doi.org/10.1038/ejcn.2016.133

Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia

Reginster, Jean Yves, Cooper, Cyrus, Rizzoli, Rene, Kanis, John A., Appelboom, Geoff, Bautmans, Ivan, Bischoff-Ferrari, Heike A., Boers, Maarten, Brandi, Maria Luisa, Bruyère, Olivier, Cherubini, Antonio, Flamion, Bruno, Fielding, Roger A., Gasparik, Andrea Ildiko, Van Loon, Lucas, McCloskey, Eugene, Mitlak, Bruce, Pilotto, Alberto, Reiter-Niesert, Suzanne, ... Cruz-Jentoft, Alfonso J.. (2016). Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia. Aging Clinical and Experimental Research. https://doi.org/10.1007/s40520-015-0517-y

Hypoxia induces a prothrombotic state independently of the physical activity

Ninivaggi, Marisa, De Laat, Marieke, Lancé, Marcus M. D., Kicken, Cécile H., Pelkmans, Leonie, Bloemen, Saartje, Dirks, Marlou L., Van Loon, Luc, Govers-Riemslag, José W. P., Lindhout, Theo, Konings, Joke and De Laat, Bas. (2015). Hypoxia induces a prothrombotic state independently of the physical activity. PLoS ONE. 10(10), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0141797

Prolonged adaptation to a low or high protein diet does not modulate basal muscle protein synthesis rates: A substudy

Hursel, Rick, Martens, Eveline A. P., Gonnissen, Hanne K. J., Hamer, Henrike M., Senden, Joan M., Van Loon, Luc and Westerterp-Plantenga, Margriet S.. (2015). Prolonged adaptation to a low or high protein diet does not modulate basal muscle protein synthesis rates: A substudy. PLoS ONE. 10(9), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0137183

Can elite athletes benefit from dietary nitrate supplementation?

Jonvik, Kristin L., Nyakayiru, Jean, Van Loon, Luc and Verdijk, Lex B.. (2015). Can elite athletes benefit from dietary nitrate supplementation? Journal of Applied Physiology. 119(6), pp. 759 - 761. https://doi.org/10.1152/japplphysiol.00232.2015

Exercise strategies to optimize glycemic control in type 2 diabetes: A continuing glucose monitoring perspective

van Dijk, Jan Willem and Van Loon, Luc. (2015). Exercise strategies to optimize glycemic control in type 2 diabetes: A continuing glucose monitoring perspective. Diabetes Spectrum. 28(1), pp. 24 - 31. https://doi.org/10.2337/diaspect.28.1.24

Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion

Wall, Benjamin T., Gorissen, Stefan H. M., Pennings, Bart, Koopman, René, Groen, Bart B. L., Verdijk, Lex B. and Van Loon, Luc. (2015). Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion. PLoS ONE. 10(11), pp. 1 - 13. https://doi.org/10.1371/journal.pone.0140903

Exercise-induced natural killer cell activation is driven by epigenetic modifications

Zimmer, Philipp, Bloch, Wilhelm, Schenk, Alexander, Zopf, Eva M., Hildebrandt, U., Streckmann, F., Beulertz, J., Koliamitra, C., Schollmayer, Friederike and Baumann, F.. (2015). Exercise-induced natural killer cell activation is driven by epigenetic modifications. International Journal of Sports Medicine. 36(6), pp. 510 - 515. https://doi.org/10.1055/s-0034-1398531

Post-prandial protein handling: You are what you just ate

Groen, Bart B. L., Horstman, Astrid M. H., Hamer, Henrike M., De Haan, Michiel, Van Kranenburg, Janneau, Bierau, Jörgen, Poeze, Martijn, Wodzig, Will K. W. H., Rasmussen, Blake B. and van Loon, Luc. (2015). Post-prandial protein handling: You are what you just ate. PLoS ONE. 10(11), pp. 1 - 22. https://doi.org/10.1371/journal.pone.0141582

Recommendations for assessment methods for exercise trials with cancer patients

Scharhag-Rosenberger, F., Becker, T., Streckmann, F., Schmidt, K., Berling, A., Bernardi, A., Engeroff, T., Exner, A. K., Gutekunst, K., Hofmeister, D., Jensen, W., Kähnert, H., Kneis, S., Limbach, M., Mau-Möller, A., Röcker, K., Schmidt, M. E., Schmidt, T., Stöckel, T., ... Karen, Steindorf. (2014). Recommendations for assessment methods for exercise trials with cancer patients. Deutsche Zeitschrift fur Sportmedizin. 65(11), pp. 304 - 313. https://doi.org/10.5960/dzsm.2014.148

Physical activity and exercise recommendations for cancer patients during rehabilitation

Zopf, Eva M., Baumann, Freerk T. and Pfeifer, K.. (2014). Physical activity and exercise recommendations for cancer patients during rehabilitation. Rehabilitation (Germany). 53(1), pp. 2 - 7. https://doi.org/10.1055/s-0033-1334916

Dietary Protein as a Trigger for Metabolic Adaptation

Van Loon, Luc. (2014). Dietary Protein as a Trigger for Metabolic Adaptation. In In R. J. Maughan (Ed.). The Encyclopaedia of Sports Medicine: An IOC Medical Commission Publication pp. 147-155 Wiley-Blackwell.

The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans

Burd, N., Cermak, N., Kouw, Imre W. K., Gorissen, Stefan H. M., Gijsen, Annemie P. and Van Loon, Luc. (2014). The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans. Journal of Applied Physiology. 117(11), pp. 1363 - 1370. https://doi.org/10.1152/japplphysiol.00411.2014

The effect of a six-month resistance-type exercise training program on the course of high sensitive cardiac troponin T levels in (pre)frail elderly

Van Der Linden, Noreen, Tieland, Michael, Klinkenberg, Lieke J. J., Verdijk, Lex B., de Groot, Lisette C. P. G. M., Van Loon, Lucas, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2014). The effect of a six-month resistance-type exercise training program on the course of high sensitive cardiac troponin T levels in (pre)frail elderly. International Journal of Cardiology. 175(2), pp. 374 - 375. https://doi.org/10.1016/j.ijcard.2014.05.017

Feasibility of an isometric maximal voluntary contraction test in hematological cancer patients during thrombocytopenia

Zimmer, Philipp, Baumann, Freerk T., Ebel, Janis, Zopf, Eva Maria, Bloch, Wilhelm and Elter, Thomas. (2013). Feasibility of an isometric maximal voluntary contraction test in hematological cancer patients during thrombocytopenia. Journal of Sports Medicine. 2013(Article ID 470489), pp. 1-6. https://doi.org/10.1155/2013/470489

Kracht- en duurinspanning verbeteren 24-uurs bloedglucosehomeostase bij personen met een verminderde glucosetolerantie bij patiënten met type 2 diabetes

Jan Willem van Dijk, Ralph J F Manders, Kyra Tummers, A G Bonomi, Coen D A Stehouwer, Fred Hartgens and Luc Van Loon. (2013). Kracht- en duurinspanning verbeteren 24-uurs bloedglucosehomeostase bij personen met een verminderde glucosetolerantie bij patiënten met type 2 diabetes. Nederlands Tijdschrift voor Diabetologie. 11(2), pp. 52-53. https://doi.org/10.1007/s12467-013-0019-5

Voeding bij intensieve sportbeoefening

Van Loon, L., van Erp-Baart, A. M. J. and Saris, Wim H. M. (2013). Voeding bij intensieve sportbeoefening. In In Majorie Former (Ed.). Informatorium Voeding en Dietetiek - Voedingsleer pp. 547-568 Springer.

The role of amino acids in skeletal muscle adaptation to exercise

Aguirre, Nick, Van Loon, Lucas and Baar, Keith. (2013). The role of amino acids in skeletal muscle adaptation to exercise. In In E. Isolauri, P.M. Sherman and W. A. Walker (Ed.). Nestle Nutrition Institute workshop series pp. 85 - 102 S. Karger AG. https://doi.org/10.1159/000350261

Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake

Nabuurs, C. I., Choe, C. U., Veltien, A., Kan, H. E., Van Loon, Luc, Rodenburg, R. J. T., Matschke, J., Wieringa, B., Kemp, G. J., Isbrandt, D. and Heerschap, A.. (2013). Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake. Journal of Physiology. 591(2), pp. 571 - 592. https://doi.org/10.1113/jphysiol.2012.241760

Elderly men and women benefit equally from prolonged resistance-type exercise training

Leenders, Marika, Verdijk, Lex B., van der Hoeven, Letty, Van Kranenburg, Janneau, Nilwik, Rachel and Van Loon, Luc. (2013). Elderly men and women benefit equally from prolonged resistance-type exercise training. Journals of Gerontology: Series A Biological Sciences and Medical Sciences. 68(7), pp. 769 - 779. https://doi.org/10.1093/gerona/gls241

Validity and Reliability of Tools to Measure Muscle Mass, Strength, and Physical Performance in Community-Dwelling Older People: A Systematic Review

Mijnarends, Donja M., Meijers, Judith M. M., Halfens, Ruud J. G., Borg, Sovianne Ter, Luiking, Yvette C., Verlaan, Sjors, Schoberer, Daniela, Cruz-Jentoft, Alfonso J., Van Loon, Luc and Schols, Jos M. G. A.. (2013). Validity and Reliability of Tools to Measure Muscle Mass, Strength, and Physical Performance in Community-Dwelling Older People: A Systematic Review. Journal of the American Medical Directors Association. 14(3), pp. 170 - 178. https://doi.org/10.1016/j.jamda.2012.10.009

Substantial differences between organ and muscle specific tracer incorporation rates in a lactating dairy cow

Burd, N, Hamer, Henrike M., Pennings, Bart, Pellikaan, Wilbert F., Senden, Joan M., Gijsen, Annemie P. and Van Loon, Luc. (2013). Substantial differences between organ and muscle specific tracer incorporation rates in a lactating dairy cow. PLoS ONE. 8(6), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0068109

Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: A randomized trial

Klinkenberg, Lieke J. J., Res, Peter T., Haenen, Guido R., Bast, Aalt, Van Loon, Luc, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2013). Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: A randomized trial. PLoS ONE. 8(11), pp. 1 - 6. https://doi.org/10.1371/journal.pone.0079280

Limits of Human Endurance

Van Loon, Luc and Meeusen, Romain. (2012). Limits of Human Endurance S. Karger AG.

Nutritional approaches to treating sarcopenia

Paddon-Jones, Douglas and van Loon, Luc. (2012). Nutritional approaches to treating sarcopenia. In In Cruz-Jentoft, Alfonso J. and Morley, John E. (Ed.). Sarcopenia pp. 275-295 Wiley-Blackwell.

Clinical exercise interventions in prostate cancer patients-a systematic review of randomized controlled trials

Baumann, Freerk T., Zopf, Eva M. and Bloch, Wilhelm. (2012). Clinical exercise interventions in prostate cancer patients-a systematic review of randomized controlled trials. Supportive Care in Cancer. 20(2), pp. 221 - 233. https://doi.org/10.1007/s00520-011-1271-0

Strong link between basal and exercise-induced cardiac troponin T levels: Do both reflect risk?

Klinkenberg, Lieke J. J., Res, Peter T., Van Loon, Lucas, Van Dieijen-Visser, Marja P. and Meex, Steven J. R.. (2012). Strong link between basal and exercise-induced cardiac troponin T levels: Do both reflect risk? International Journal of Cardiology. 158(1), pp. 129 - 131. https://doi.org/10.1016/j.ijcard.2012.04.050

Implementation and scientific evaluation of rehabilitative sports groups for prostate cancer patients: Study protocol of the ProRehab Study

Zopf, Eva M., Braun, Moritz, Machtens, Stefan, Zumbé, Jürgen, Bloch, Wilhelm and Baumann, Freerk T.. (2012). Implementation and scientific evaluation of rehabilitative sports groups for prostate cancer patients: Study protocol of the ProRehab Study. BMC Cancer. 12(312), pp. 1 - 7. https://doi.org/10.1186/1471-2407-12-312

The single biopsy approach is reliable for the measurement of muscle protein synthesis rates in vivo in older men

Burd, N., Pennings, Bart, Groen, Bart B. L., Gijsen, Annemie P., Senden, Joan M. and Van Loon, Luc. (2012). The single biopsy approach is reliable for the measurement of muscle protein synthesis rates in vivo in older men. Journal of Applied Physiology. 113(6), pp. 896 - 902. https://doi.org/10.1152/japplphysiol.00513.2012

Inspanningstherapie bij type 2 diabetes: is dagelijkse inspanning noodzakelijk om glycemische controle te optimaliseren?

van Dijk, Jan W., Tummers, Kyra, Stehouwer, Coen D.A., Hartgens, Fred and van Loon, Luc. (2012). Inspanningstherapie bij type 2 diabetes: is dagelijkse inspanning noodzakelijk om glycemische controle te optimaliseren? Nederlands Tijdschrift voor Diabetologie. 10(2), pp. 60 - 61. https://doi.org/10.1007/s12467-012-0021-3

Protein Supplementation Improves Physical Performance in Frail Elderly People: A Randomized, Double-Blind, Placebo-Controlled Trial

Tieland, Michael, De Rest, Ondine Van, Dirks, Marlou L., Van Der Zwalu, Nikita L., Mensink, Marco, Van Loon, Luc and de Groot, Lisette C. P. G. M.. (2012). Protein Supplementation Improves Physical Performance in Frail Elderly People: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of the American Medical Directors Association. 13(8), pp. 720 - 726. https://doi.org/10.1016/j.jamda.2012.07.005

Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: Benefits of a moderate exercise intervention

Baumann, Freerk T., Zopf, Eva M., Nykamp, Eike, Kraut, Ludwig, Schüle, Klaus, Elter, Thomas, Fauser, Axel A. and Bloch, Wilhelm. (2011). Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: Benefits of a moderate exercise intervention. European Journal of Haematology. 87(2), pp. 148 - 156. https://doi.org/10.1111/j.1600-0609.2011.01640.x

Exercise-Induced splanchnic hypoperfusion results in gut dysfunction in healthy men

Wijck, Kim V., Lenaerts, Kaatje, Van Loon, Luc, Peters, Wilbert H. M., Buurman, Wim A. and Dejong, Cornelis H. C.. (2011). Exercise-Induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLoS ONE. 6(7), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0022366

Nutritional strategies to promote postexercise recovery

Beelen, M, Burke, Louise, Gibala, M and van Loon, Luc. (2010). Nutritional strategies to promote postexercise recovery. International Journal of Sport Nutrition and Exercise Metabolism. 20(6), pp. 515 - 532. https://doi.org/10.1123/ijsnem.20.6.515